Month: September 2022

At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. Recommanded Product: 2-Bromo-6-methylpyridine.

Wan, Lin-Xi;Zhen, Yong-Qi;He, Zhen-Xiang;Zhang, Yang;Zhang, Lan;Li, Xiaohuan;Gao, Feng;Zhou, Xian-Li research published 《 Late-Stage Modification of Medicine: Pd-Catalyzed Direct Synthesis and Biological Evaluation of N-Aryltacrine Derivatives》, the research content is summarized as follows. A new series of N-aryltacrine derivatives was designed and synthesized as cholinesterase inhibitors by the late-stage modification of tacrine, using the palladium-catalyzed Buchwald-Hartwig cross-coupling reaction. In vitro inhibition assay against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) demonstrated that most of the synthesized compounds had potent AChE inhibitory activity with neg. inhibition of BuChE. Among them, N-(4-(trifluoromethyl)phenyl)-tacrine (I) and N-(4-methoxypyridin-2-yl)-tacrine (II) showed the most potent activity against AChE (IC₅₀ values of 1.77 and 1.48μM, resp.). The anti-AChE activity of I and II was 3.5 times more than that of tacrine (IC₅₀ value of 5.16μM). Compound II also displayed anti-BuChE activity with an IC₅₀ value of 19.00μM. Cell-based assays against HepG2 and SH-SY5Y cell lines revealed that II had significantly lower hepatotoxicity compared to tacrine, with addnl. neuroprotective activity against H₂O₂-induced damage in SH-SY5Y cells. The advantages including synthetic accessibility, high potency, low toxicity, and adjunctive neuroprotective activity make compound II a new promising multifunctional candidate for the treatment of Alzheimer’s disease.

5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., Recommanded Product: 2-Bromo-6-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Recommanded Product: 5-Bromopicolinaldehyde.

Lv, Jie;Li, Qianqian;Wang, Jinglan;Xu, Shengxian;Zhao, Feng;He, Haifeng;Wang, Yibo research published 《 Orange-red emissive Cu(I) complexes bearing Schiff base ligands: Synthesis, structures, and photophysical properties》, the research content is summarized as follows. Herein, the three novel copper(I) complexes bearing Schiff base ligands of the types [Cu(Phen-PyMethylene-Adam-Amine)(POP)]PF₆ (P1), [Cu(Methoxyl-Phen-PyMethylene-Adam-Amine)(POP)]PF₆ (P2), and [Cu(TriflMethyl-Phen-PyMethylene-Adam-Amine)(POP)]PF₆ (P3) (Phen-PyMethylene-Adam-Amine = ((5-phenylpyridin-2-yl)methylene)adamantan-1-amie, Methoxyl-Phen-PyMethylene-Adam-Amine = ((5-(4-methoxyphenyl)pyridin-2-yl)methylene)adamantan-1-amine, TriflMethyl-Phen-PyMethylene-Adam-Amine = ((5-(4-(trifluoromethyl)phenyl)pyridin-2-yl)methylene)adamantan-1-amine,POP = bis[2-diphenylphosphino]phenyl-ether) have been prepared and studied. Incorporation of the bulky adamantyl group into the complexes can enhance the stability of the complexes. The different electron-donating/withdrawing groups such as -H, -OCH₃, and -CF₃ substituents were functionalized onto the pyridine ring part of Schiff base ligands to tune the emission behavior of the resulting Schiff base Cu(I) complexes. All complexes exhibit the lowest energy metal-to-ligand charge transfer (MLCT) characters in 400-450 nm region showing a slight blue-shift of the absorption wavelengths in the order P3 > P1 > P2. Organe-red emissions at 611-619 nm with photoluminescence quantum yields (PLQY) of 1.0-1.3% can be observed in the solid state. Addnl., the photophys. properties were also studied theor. using d. functional theory (DFT) and time dependent DFT.

Recommanded Product: 5-Bromopicolinaldehyde, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. For this reason, pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Recommanded Product: Pyridine-3-sulfonyl chloride.

Kan, Chun;Song, Fan;Shao, Xiaotao;Wu, Linyun;Zhu, Jing research published 《 Fe(III) induced fluorescent probe based on triamine and rhodamine derivatives and its applications in biological imaging》, the research content is summarized as follows. It is important to design a sensitive and efficient probe for detecting Fe³⁺ in environment and organisms. In this work, a rhodamine-based probe (RBTN) was designed by acylation reaction at high temperature RBTN has a good specific fluorescence sensing for Fe³⁺ in the EtOH/H₂O (1:1, volume/volume, HEPES, 0.5 mM, pH = 7.3) solution The reversibility between RBTN and Fe³⁺ was confirmed by adding Na₄P₂O₇. At the same time, RBTN has a lower detection limit, as low as 0.148 μM. In addition, RBTN can be used to detect Fe³⁺ in environmental water samples, and the recovery rate of Fe³⁺ is higher. Finally, biol. experiments confirmed that RBTN could be used to detect Fe³⁺ in cells, vivo and plant tissues.

Recommanded Product: Pyridine-3-sulfonyl chloride, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem