Day: October 12, 2022

Khalaf, Mai M.; Gouda, Mohamed; Shalabi, Kamal; Shaaban, Saad; Abd El-Lateef, Hany M. published the artcile< Structural and Adsorptive Characteristics of 2D Multilayer Nanoflakes of NiCo Phosphates for Chromium(VI) Removal: Experimental and Monte Carlo Simulations>, Category: pyridine-derivatives, the main research area is multilayer nanoflake nickel cobalt phosphate chromium adsorption wastewater modeling.

Metal phosphates are efficient adsorbent materials for heavy elements present in industrial effluents because of their promising properties. Hexachromium ions are among the most dangerous contaminants owing to their harmful properties and non-degradability. Accordingly, the present work offers a simplified study of the preparation of bimetallic phosphate materials from nickel cobalt phosphate (NiCo-Ph) based on the sol-gel method in an equimolar ratio. Characterization of the bulk, crystal phase, texture profile, and nanosize of NiCo-Ph was carried out using various techniques such as Fourier transform IR spectroscopy, X-ray diffraction, XPS, nitrogen adsorption-desorption isotherm measurements, field emission SEM, transmission electron microscopy, and Raman spectroscopy. In this regard, the adsorption performance of NiCo-Ph was exemplified through six batch experiments, elucidating the impacts of the sorbent dose, initial concentration of pollutants, sorption time, temperature, pH, and shaking rate. According to UV/vis spectrophotometry measurements and their related calculations of NiCo-Ph, the maximum removal efficiency (RE %) of 92% and adsorption capacity (qm) of 37 mg/g were achieved at pH = 6, a dose of 5.0 g/L, 100 mg/L of [Cr(VI)], 300 rpm, adsorption time of 60 min, and 298 K. Monte Carlo simulations were also carried out to correlate the exptl. data with theor. calculations that provided a higher neg. value (-911.62 kcal mol-1) for the adsorption energy of Cr(VI) in acidic medium. The adsorbent NiCo-Ph prepared by this direct method is therefore recommended for the quantification of Cr(VI) under slightly acidic solutions and at room temperature, which can maintain its efficiency even up to six cycles.

ACS Omega published new progress about Adsorbents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Shaohui; Yang, Denghui; Wu, Xiaojun; Yi, Zhengfei; Wang, Yang; Xin, Suhua; Wang, Dong; Tian, Mingxing; Li, Tao; Qi, Jingjing; Ding, Chan; Yu, Shengqing published the artcile< The ferric uptake regulator represses type VI secretion system function by binding directly to the clpV promoter in Salmonella enteric serovar Typhimurium>, Application of C10H8N2, the main research area is Fur; S. Typhimurium; clpV ; regulation; type VI secretion system.

Type VI secretion systems (T6SSs) are highly conserved and complex protein secretion systems that deliver effector proteins into eukaryotic hosts or other bacteria. T6SSs are regulated precisely by a variety of regulatory systems, which enables bacteria to adapt to varied environments. A T6SS within Salmonella pathogenicity island 6 (SPI-6) is activated during infection, and it contributes to the pathogenesis, as well as interbacterial competition, of Salmonella enterica serovar Typhimurium (S. Typhimurium). However, the regulation of the SPI-6 T6SS in S. Typhimurium is not well understood. In this study, we found that the SPI-6 T6SS core gene clpV was significantly upregulated in response to the iron-depleted condition and during infection. The global ferric uptake regulator (Fur) was shown to repress the clpV expression in the iron-replete medium. Moreover, electrophoretic mobility shift and DNase I footprinting assays revealed that Fur binds directly to the clpV promoter region at multiple sites spanning the transcriptional start site. We also observed that the relieving of Fur-mediated repression on clpV contributed to the interbacterial competition activity and pathogenicity of S. Typhimurium. These findings provide insights into the direct regulation of Fur in the expression and functional activity of SPI-6 T6SS in S. Typhimurium and thus help to elucidate the mechanisms of bacterial adaptability and virulence.

Infection and Immunity published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Hong; Li, Ridong; Ning, Xianling; Zhao, Xuyang; Jin, Yan; Yin, Yuxin published the artcile< Synthesis and anti-tumor efficacy of novel 2, 4-diarylaminopyrimidine derivatives bearing N-(3-pyridinylmethyl) urea moiety as anaplastic lymphoma kinase inhibitors>, Safety of Pyridin-4-ylmethanamine, the main research area is chloro amino pyrimidinylamino methoxyphenyl pyridinylmethyl urea preparation; antitumor activity anaplastic lymphoma kinase inhibition SAR docking cytotoxicity; ALK inhibitor; Anti-proliferation activity; NSCLC; Structure modification.

A series of novel 2,4-diarylaminopyrimidine derivatives I [R = 3,5-dimethoxyphenyl, 6-quinolyl, 3-methoxy-4-morpholino-Ph, etc.] possessing a unique N-(3-pyridinylmethyl)urea moiety as ALK inhibitors were synthesized. The most promising analog compound I [R = 3-methoxy-4-morpholino-phenyl] significantly inhibited proliferation of ALK pos. H3122 and Karpas-299 cells with IC50 values about 10 nM, which were comparable with pos. control LDK378. Compound I [R = 3-methoxy-4-morpholino-phenyl] suppressed phosphorylation of ALK and its downstream proteins and showed low cytotoxicity on normal human primary fibroblast cells (BJ cells). The binding mode of compound I [R = 3-methoxy-4-morpholino-phenyl] was proposed by docking simulation, which explains the important role of N-(3-pyridinylmethyl)urea moiety. Furthermore, compound I [R = 3-methoxy-4-morpholino-phenyl] exhibited favorable liver microsomal stability and significant efficacy in H3122 xenograft mice model. Interestingly, compound I [R = 3-methoxy-4-morpholino-phenyl] also showed broader anti-proliferative activity on other human tumor cell lines, which was different from other ALK inhibitors.

European Journal of Medicinal Chemistry published new progress about Amines Role: ADV (Adverse Effect, Including Toxicity), PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Safety of Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Chaojie; Wei, Zhangwen; Pan, Mei; Deng, Haiying; Jiang, Jijun; Su, Chengyong published the artcile< Structural tuning of coordination polymers by 4-connecting metal node and secondary building process>, Synthetic Route of 3731-53-1, the main research area is transition metal pyridylmethylnaphthalenediimide coordination polymer preparation crystal structure.

Five transition metal coordination polymers, {[Cu(4-pmntd)2(NO3)2]•2CHCl3}n (1), {[Cu(4-pmntd)2(NO3)2]·3C7H8}n (2), {[Cu(4-pmntd)2(CF3SO3)(H2O)]·CF3SO3·H2O·MeOH}n (3), [Cd(4-pmntd)2]n·nSiF6·x(MeOH)·y(CHCl3) (4), and [Zn(4-pmntd)2(CF3SO3)2]n·x(solvent) (5), were obtained from a ditopic ligand, N,N’-bis(4-pyridylmethyl)naphthalene diimide (4-pmntd). Either sql- or dia- structures are generated from four connecting coordination nodes of the metal centers. While delicate interpenetration and structural tuning in these complexes is achieved by the different conformations and spatially extending geometries adopted by the ligand and secondary building process induced by pillar-like anions.

Chinese Chemical Letters published new progress about Coordination polymers Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Synthetic Route of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Haward, Simon J.; Kitajima, Naoyuki; Toda-Peters, Kazumi; Takahashi, Tsutomu; Shen, Amy Q. published the artcile< Flow of wormlike micellar solutions around microfluidic cylinders with high aspect ratio and low blockage ratio>, SDS of cas: 123-03-5, the main research area is wormlike micellar solution flow microfluidic cylinder.

We employ time-resolved flow velocimetry and birefringence imaging methods to study the flow of a well-characterized shear-banding wormlike micellar solution around a novel glass-fabricated microfluidic circular cylinder. In contrast with typical microfluidic cylinders, our geometry is characterized by a high aspect ratio α = H/W = 5 and a low blockage ratio β = 2r/W = 0.1, where H and W are the channel height and width, and the cylinder radius r = 20μm. The small cylinder radius allows access up to very high Weissenberg numbers 1.9 ≤ Wi = λMU/r ≤ 3750 while inertial effects remain entirely negligible (Reynolds number, Re < 10-4). At low Wi values, the flow remains steady and sym. and a birefringent region (indicating micellar alignment and tensile stress) develops downstream of the cylinder. Above a critical value Wic ≈ 60 the flow transitions to a steady asym. state, characterized as a supercritical pitchfork bifurcation, in which the fluid takes a preferential path around one side of the cylinder. At a second critical value Wic2 ≈ 130, the flow becomes time-dependent, with a characteristic frequency f0 ≈ 1/λM. This initial transition to time dependence has characteristics of a subcritical Hopf bifurcation. Power spectra of the measured fluctuations become complex as Wi is increased further, showing a gradual slowing down of the dynamics and emergence of harmonics. Soft Matter published new progress about Algorithm. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, SDS of cas: 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pesti, Jaan A.; Huhn, George F.; Yin, Jianguo; Xing, Yide; Fortunak, Joseph M.; Earl, Richard A. published the artcile< Efficient Pyridinylmethyl Functionalization: Synthesis of 10,10-Bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone (DMP 543), an Acetylcholine Release Enhancing Agent>, COA of Formula: C6H6FNO, the main research area is methylpyridine chlorination; pyridylmethyl methanesulfonate preparation alkylation reagent; fluoropyridinylmethylanthrone preparation; anthrone bisfluoropyridinylmethyl preparation.

2-Fluoro-4-methylpyridine is efficiently functionalized by chlorination, hydrolysis and methanesulfonylation into the novel alkylating agent 2-Fluoro-4-methanesulfonylmethylpyridine. This mesylate is used for the bisalkylation of anthrone under carefully defined conditions to prepare the title compound, a cognition enhancer drug candidate. This process proceeds in up to 37% overall yield and is adaptable for large scale synthesis. The chlorination of other methylpyridines was also investigated.

Journal of Organic Chemistry published new progress about Chlorination. 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, COA of Formula: C6H6FNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Arshad, Zarina; Saied, Sumayya; Ali, Basharat; Salar, Uzma; Tauseef, Saima; Arshia; Ajaz, Munazza; Khan, Uroosa; Haider, Syed Moazzam; Taha, Muhammad; Khan, Khalid Mohammed published the artcile< Synthesis of N'-nicotinoyl sulfonohydrazides and their antimicrobial activity>, Formula: C7H7NO2, the main research area is nicotinoyl sulfonohydrazide preparation antibacterial antifungal.

N’-Nicotinoyl sulfonohydrazide derivatives I [R = Me, Ph, 2-O2NC6H4, etc.] were synthesized from nicotinyl hydrazide and evaluated for their antimicrobial potential against Gram pos. bacterial strains (Bacillus cereus, Bacillus subtilis, Corynebacterium diphtheriae, Staphylococcus fecalis, Staphylococcus aureus and MRSA (Methicillin-resistant Staphylococcus aureus)) and Gram neg. bacterial strains (Escherichia.coli, Pseudomonas aeruginosa, Salmonella ParatyphiB, Salmonella tyhpi). Compound I [R = 2-OH-3,5-diClC6H2] showed outstanding antibacterial activity against Staphylococcus fecalis and compounds I [R = 2-O2NC6H4, 2-OH-3,5-diClC6H2] were found to be moderately activite against Salmonella Paratyphi B, shown by their zone of inhibition values. In addition to that compond I [R = Me] also showed moderate activity against Escherichia coli. All derivatives I were also subjected for the evaluation of their antifungal activity against Saccharomyces cerevisiae, Microsporum canin, Rhizopus, Aspergillus niger, Candida albicans and Candida tropicalis. Compound I [R = 2-OH-3,5-diClC6H2] showed promising antifungal activity against Rhizopus sp. and compounds I [R = Me, 2,4-di-MeOC6H3] showed moderate antifungal potential against Microsporum canis, Aspergillus niger and Candida tropicalis.

Journal of the Chemical Society of Pakistan published new progress about Antibacterial agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Jian-Wei; Xiong, Yuan; Wang, Feng; Zhang, Fu-Mao; Yang, Xiaodi; Lin, Guo-Qiang; Tian, Ping; Ge, Guangbo; Gao, Dingding published the artcile< Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CLpro inhibitors for treating COVID-19>, Related Products of 396092-82-3, the main research area is dihydrophenanthrene derivative SARS CoV2 coronavirus 3CLpro inhibitor COVID19; 9,10-Dihydrophenanthrenes; COVID-19; SARS-CoV-2 3CL(pro); Structure-activity relationships.

The epidemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now spread worldwide and efficacious therapeutics are urgently needed. 3-Chymotrypsin-like cysteine protease (3CLpro) is an indispensable protein in viral replication and represents an attractive drug target for fighting COVID-19. Herein, we report the discovery of 9,10-dihydrophenanthrene derivatives as non-peptidomimetic and non-covalent inhibitors of the SARS-CoV-2 3CLpro. The structure-activity relationships of 9,10-dihydrophenanthrenes as SARS-CoV-2 3CLpro inhibitors have carefully been investigated and discussed in this study. Among all tested 9,10-dihydrophenanthrene derivatives, C1 and C2 display the most potent SARS-CoV-2 3CLpro inhibition activity, with IC50 values of 1.55 ± 0.21μM and 1.81 ± 0.17μM, resp. Further enzyme kinetics assays show that these two compounds dose-dependently inhibit SARS-CoV-2 3CLprovia a mixed-inhibition manner. Mol. docking simulations reveal the binding modes of C1 in the dimer interface and substrate-binding pocket of the target. In addition, C1 shows outstanding metabolic stability in the gastrointestinal tract, human plasma, and human liver microsome, suggesting that this agent has the potential to be developed as an orally administered SARS-CoV-2 3CLpro inhibitor.

European Journal of Medicinal Chemistry published new progress about Anticoronaviral agents. 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Related Products of 396092-82-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gu, Yiting; Shen, Yangyang; Zarate, Cayetana; Martin, Ruben published the artcile< A Mild and Direct Site-Selective sp2 C-H Silylation of (Poly)Azines>, Product Details of C6H4F3N, the main research area is silylation pyridine pyrimidine pyrazine quinoline silyl dioxaborolane reagent; base promoted silylation azine borylsilane regioselective orthogonal process.

A base-mediated protocol that allows for the site-selective sp2 C-H silylation of pyridines, pyrazines, pyridazines, pyrimidines and quinolines by Et3SiBpin is described. The substitution typically proceeds in 4- or 2-position of the pyridine ring. This method is distinguished by its mild conditions, simplicity and excellent site-selective modulation for a diverse set of azines, even in the context of late-stage functionalization, while exhibiting orthogonal reactivity with classical silylation reactions.

Journal of the American Chemical Society published new progress about Boronic acids, esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (borylsilanes). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Product Details of C6H4F3N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cai, Hongyun; Datta Khanal, Hari; Rok Lee, Yong published the artcile< Iodine-Catalyzed Annulations of 2-Amino Carbonyls for Diverse 1-Azaxanthones, Quinolines, and Naphthyridines>, COA of Formula: C6H6N2O, the main research area is amino formylchromone enamine iodine catalyst tandem cycloaddition green chem; azaxanthone preparation; carbonyl aniline enamine iodine catalyst tandem cycloaddition green chem; quinoline preparation; aminonicotinaldehyde enamine iodine catalyst tandem cycloaddition green chem; naphthyridine preparation.

An efficient and facile iodine-catalyzed reaction of 2-amino carbonyls with β-enamino esters or β-enaminones afforded 1-azaxanthones, quinolines and naphthyridines in good to excellent yields. This novel catalytic [4+2] annulation reaction proceeded through a cascade I2-activation, Michael addition, intramol. aldol reaction and aromatization.

Asian Journal of Organic Chemistry published new progress about [4+2] Cycloaddition reaction. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, COA of Formula: C6H6N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem