Day: October 12, 2022

Stapleton, David; Gao, Guang; Michell, Belinda J.; Widmer, Jane; Mitchelhill, Ken; Teh, Trazel; House, Colin M.; Witters, Lee A.; Kemp, Bruce E. published the artcile< Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase>, Name: 3-Bromo-1H-pyrrolo[3,2-c]pyridine, the main research area is AMP activated protein kinase subunit sequence; rat AMP activated protein kinase subunit; pig AMP activated protein kinase subunit; Snf1 kinase interacting protein homolog mammal; yeast CAT3 Snf4p homolog rat pig; Sip1p GAL38 yeast homolog rat pig.

The 5′-AMP-activated protein kinase is responsible for the regulation of fatty acid synthesis by phosphorylation and inactivation of acetyl-CoA carboxylase. The porcine liver 5′-AMP-activated protein kinase 63-kDa catalytic subunit co-purifies 14,000-fold with a 38- and 40-kDa protein (Mitchelhill, K. I. et al. (1994) J. Biol. Chem. 269, 2361-2364). The 63-kDa subunit is homologous to the Saccharomyces cerevisiae Snf1 protein kinase, which regulates gene expression during glucose derepression. Peptide amino acid and polymerase chain reaction-derived partial cDNA sequences of both the pig and rat liver enzymes show that the 38-kDa protein is homologous to Snf4p (CAT3) and that the 40-kDa protein is homologous to the Sip1p/Spm/GAL83 family of Snf1p interacting proteins. Sucrose d. gradient and crosslinking experiments with purified 5′-AMP-activated protein kinase suggest that both the 38- and 40- kDa proteins associate tightly with the 63-kDa catalytic polypeptide in either a heterotrimeric complex or in dimeric complexes. The 40-kDa subunit is autophosphorylated within the 63-kDa subunit complex. The sequence relationships between the mammalian 5′-AMP-activated protein kinase and yeast Snf1p extend to the subunit proteins consistent with conservation of the functional roles of these polypeptides in cellular regulation by this family of metabolite-sensing protein kinases.

Journal of Biological Chemistry published new progress about Phosphorylation, autophosphorylation. 23612-36-4 belongs to class pyridine-derivatives, and the molecular formula is C7H5BrN2, Name: 3-Bromo-1H-pyrrolo[3,2-c]pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Meng, Fei published the artcile< Aggregation induced emission-active molecules bearing tunable singlet oxygen generation: The different length alkyl chain matters>, Electric Literature of 350-03-8, the main research area is AIE PDT photosensitizer prepnh singlet oxygen cancer; Aggregation induced emission; Alkyl chain; Molecular design strategy; Tunable (1)O(2) yield.

The efficiency of singlet oxygen (1O2) can be subtly regulated by mol. alkyl chain length according to ΔEST (the energy gap between S1 and T1 states). Which offer a strategy to adjust the 1O2 yield of photosensitizers (PSs) by mol. design strategy. Herein, three PSs (MZ1 ∼ MZ3) were constructed of β-terpyridine derivatives, which possess different length alkyl chain (Bu, hexyl, and octyl group) with tunable 1O2 yield (3.366, 2.461 and 0.963). Based on studies that PSs with aggregation induced emission (AIE) characteristics showed effective emission intensity and high 1O2 yield. Subsequently, Photodynamic therapy (PDT) in vitro was further investigated. MZ1 showed relatively highest 1O2 yield, considerable cellular uptake and effective cell apoptosis upon light irradiation

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Aggregation-induced emission. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Electric Literature of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kang, Ji-Hoon published the artcile< Understanding inactivation of Listeria monocytogenes and Escherichia coli O157:H7 inoculated on romaine lettuce by emulsified thyme essential oil>, Product Details of C21H38ClN, the main research area is Listeria monocytogenes Escherichia coli romaine lettuce emulsified TEO; Cetylpyridinium chloride; Foodborne pathogen; Microbial adhesion; Romaine lettuce; Thyme essential oil emulsion; Washing effectiveness.

Effects of thyme essential oil (TEO) emulsion (TEE) with cationic charge formulated using cetylpyridinium chloride (CPC) on attachment strength and inactivation of Listeria monocytogenes and Escherichia coli O157:H7 on romaine lettuce surface were examined in this study. Regardless of the inoculation time (2 h and 24 h), pathogen attachment was stronger on the adaxial surface of the romaine lettuce than on the abaxial surface because of the lower roughness of the former. Moreover, attachment strength increased with increasing inoculation time. TEE washing had the strongest inhibitory effect on pathogen attachment at 2 h when compared with that of TEO, CPC, and sodium hypochlorite (SH), demonstrating a 3.32 and 2.53 log-reduction in the size of the L. monocytogenes and E. coli O157:H7 populations, resp., compared to the control samples. Addnl., the TEE washing effects were maintained even after inoculation for 24 h, and it decreased attachment to adaxial surface of the samples. These results indicate that TEE could be a good alternative to SH in improving the microbiol. safety of romaine lettuce.

Food Microbiology published new progress about Contact angle. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Product Details of C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Szuroczki, Peter; Samson, Judit; Kollar, Laszlo published the artcile< Synthesis of 5-Carboxamidotriazoles via Azide-Alkyne Cycloaddition-Aminocarbonylation Sequence>, Electric Literature of 3731-53-1, the main research area is benzyl iodotriazole preparation amine carbon monoxide aminocarbonylation; amido benzyl triazole preparation.

5-Carboxamidotriazoles were prepared in the palladium-catalyzed aminocarbonylation of the corresponding iodotriazole using various amines as N-nucleophiles under mild reaction conditions. The iodoheteroarene substrates were obtained in good yields in copper-catalyzed azide-alkyne cycloaddition of iodoalkynes (2′-iodophenylacetylene and Et iodopropiolate) and benzyl azide.

ChemistrySelect published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Electric Literature of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Horan, Alexandra M.; Duong, Vincent K.; McGarrigle, Eoghan M. published the artcile< Synthesis of Bis-heteroaryls Using Grignard Reagents and Pyridylsulfonium Salts>, Related Products of 581-47-5, the main research area is bis heteroaryl preparation; halopyridine pyridylsulfonium salt coupling reaction.

Herein ligand-coupling reactions of Grignard reagents with pyridylsulfonium salts I (R = H, Br, Me, trifluoromethyl; R1 = H, OMe, CN, Br, etc.; R2 = H, trifluoromethyl; R3 = H, Me; R2R3 = -(CH=CH-CH=CH)-) and phenyl(pyrimidin-2-yl)(p-tolyl)sulfonium trifluoromethanesulfonate are reported. The method has wide functional group tolerance and enables the formation of bis-heterocycle linkages including 2,4′-bipyridines, 2,3′-bipyridines, and 2,2′-bipyridines, as well as pyridines linked to pyrimidines, pyrazines, isoxazoles, and benzothiophenes II (R4 = 2-fluoropyridin-4-yl, pyrazin-2-yl, dimethyl-1,2-oxazol-4-yl, 1-benzothiophen-2-yl, etc.). The methodol. was successfully applied to the synthesis of the natural products caerulomycin A and E.

Organic Letters published new progress about Coupling reaction. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Related Products of 581-47-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Alsaoub, Sabine; Conzuelo, Felipe; Gounel, Sebastien; Mano, Nicolas; Schuhmann, Wolfgang; Ruff, Adrian published the artcile< Introducing Pseudocapacitive Bioelectrodes into a Biofuel Cell/Biosupercapacitor Hybrid Device for Optimized Open Circuit Voltage>, Product Details of C10H6Cl2N2, the main research area is bioelectrode biofuel cell biosupercapacitor open circuit voltage.

We report the fabrication of a polymer/enzyme-based biosupercapacitor (BSC)/biofuel cell (BFC) hybrid device with an optimized cell voltage that can be switched on demand from energy conversion to energy storage mode. The redox polymer matrixes used for the immobilization of the biocatalyst at the bioanode and biocathode act simultaneously as electron relays between the integrated redox enzymes and the electrode surface (BFC) and as pseudocapacitive charge storing elements (BSC). Moreover, owing to the self-charging effect based on the continuously proceeding enzymic reaction, a Nernstian shift in the pseudocapacitive elements, i.e., in the redox polymers, at the individual bioelectrodes leads to a maximized open circuit voltage of the device in both operating modes. Comparison with a conventional fuel cell design, i.e., using redox mediators with redox potentials that are close to the potentials of the used redox proteins, indicates that the novel hybrid device shows a similar voltage output. Moreover, our results demonstrate that the conventional design criteria commonly used for the development of redox polymers for the use in biofuel cells have to be extended by considering the effect of a Nernstian shift towards the potentials of the used biocatalysts in those pseudocapacitive elements.

ChemElectroChem published new progress about Acinetobacter calcoaceticus. 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Product Details of C10H6Cl2N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sultan, Madiha; Kanavarioti, Anastassia published the artcile< Nanopore device-based fingerprinting of RNA oligos and microRNAs enhanced with an Osmium tag>, Name: 2,2′-Bipyridine, the main research area is RNA miRNA osmium nanopore device based fingerprinting.

Protein and solid-state nanopores are used for DNA/RNA sequencing as well as for single mol. anal. We proposed that selective labeling/tagging may improve base-to-base resolution of nucleic acids via nanopores. We have explored one specific tag, the Osmium tetroxide 2,2′-bipyridine (OsBp), which conjugates to pyrimidines and leaves purines intact. Earlier reports using OsBp-tagged oligodeoxyribonucleotides demonstrated proof-of-principle during unassisted voltage-driven translocation via either alpha-Hemolysin or a solid-state nanopore. Here we extend this work to RNA oligos and a third nanopore by employing the MinION, a com. available device from ONT. Conductance measurements demonstrate that the MinION visibly discriminates oligoriboadenylates with sequence A15PyA15, where Py is an OsBp-tagged pyrimidine. Such resolution rivals traditional chromatog., suggesting that nanopore devices could be exploited for the characterization of RNA oligos and microRNAs enhanced by selective labeling. This observation leads to the conjecture that the MinION/OsBp platform senses a 2-nucleotide sequence, in contrast to the reported 5-nucleotide sequence with native nucleic acids. Such improvement in sensing, enabled by the presence of OsBp, may enhance base-calling accuracy in enzyme-assisted DNA/RNA sequencing.

Scientific Reports published new progress about Fingerprint sensors. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Name: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hoque, Emdadul Md; Hassan, Mirja Mahamudul Md; Chattopadhyay, Buddhadeb published the artcile< Remarkably Efficient Iridium Catalysts for Directed C(sp2)-H and C(sp3)-H Borylation of Diverse Classes of Substrates>, SDS of cas: 329214-79-1, the main research area is directed CH borylation aromatic heterocyclic compound iridium cyclooctadiene catalyst.

Here we describe the discovery of a new class of C-H borylation catalysts and their use for regioselective C-H borylation of aromatic, heteroaromatic, and aliphatic systems. The new catalysts have Ir-C(thienyl) or Ir-C(furyl) anionic ligands instead of the diamine-type neutral chelating ligands used in the standard C-H borylation conditions. It is reported that the employment of these newly discovered catalysts show excellent reactivity and ortho-selectivity for diverse classes of aromatic substrates with high isolated yields. Moreover, the catalysts proved to be efficient for a wide number of aliphatic substrates for selective C(sp3)-H bond borylations. Heterocyclic mols. are selectively borylated using the inherently elevated reactivity of the C-H bonds. A number of late-stage C-H functionalization have been described using the same catalysts. Furthermore, we show that one of the catalysts could be used even in open air for the C(sp2)-H and C(sp3)-H borylations enabling the method more general. Preliminary mechanistic studies suggest that the active catalytic intermediate is the Ir(bis)boryl complex, and the attached ligand acts as bidentate ligand. Collectively, this study underlines the discovery of new class of C-H borylation catalysts that should find wide application in the context of C-H functionalization chem.

Journal of the American Chemical Society published new progress about Aromatic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, SDS of cas: 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Amu; Liu, Ya-Zhou; Shen, Zhongke; Qiao, Zeen; Ma, Xiaofeng published the artcile< Regioselective Synthesis of Pyrazolo[1,5-a]pyridine via TEMPO-Mediated [3 + 2] Annulation-Aromatization of N-Aminopyridines and α,β-Unsaturated Compounds>, HPLC of Formula: 350-03-8, the main research area is pyridiniumamine trimethylbenzenesulfonate alkene TEMPO catalyst regioselective annulation aromatization; pyrazolopyridine preparation.

A TEMPO-mediated [3 + 2] annulation-aromatization protocol for the preparation of pyrazolo[1,5-a]pyridines from N-aminopyridines and α,β-unsaturated compounds were developed. The procedure offered multisubstituted pyrazolo[1,5-a]pyridines in good to excellent yield with high and predictable regioselectivity. The modification of marketed drugs including Loratadine, Abiraterone and Metochalcone, a one-pot three-step gram scale synthesis of key intermediate for the preparation of Selpercatinib were demonstrated. Mechanism studies showed that TEMPO served both as a Lewis acid and as an oxidant.

Organic Letters published new progress about [3+2] Cycloaddition reaction (regioselective). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, HPLC of Formula: 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kokhan, Serhii O.; Valter, Yevheniia B.; Tymtsunik, Andriy V.; Komarov, Igor V.; Grygorenko, Oleksandr O. published the artcile< 3-Carboxy-/3-Aminobicyclo[1.1.1]pentane-Derived Sulfonamides and Sulfonyl Fluorides - Advanced Bifunctional Reagents for Organic Synthesis and Drug Discovery>, Computed Properties of 3811-73-2, the main research area is carboxy aminobicyclopentane derived sulfonamide sulfonyl fluoride preparation.

A convenient approach to 1,3-bifunctional sulfonyl fluorides, sulfonamides and sulfinates bearing a bicyclo[1.1.1]pentane unit attached to the sulfur atom and (protected) amino or carboxyl group is described. The method relied on photochem. decomposition of Barton [1-hydroxypyridine-2(1H)-thione] esters of the corresponding carboxylic acids as the key step, followed by oxidation and cleavage of the 2-pyridyl moiety. The title building blocks were obtained on a gram scale, and their utility was demonstrated by preparation of an isosteric analog of classical sulfonamide anitibiotic sulfanilamide, as well as some other common chem. modifications.

European Journal of Organic Chemistry published new progress about Sulfinates Role: SPN (Synthetic Preparation), PREP (Preparation). 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Computed Properties of 3811-73-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem