Day: October 12, 2022

Choi, Hyukjae; Lee, Wonhwa; Kim, Eonmi; Ku, Sae-Kwang; Bae, Jong-Sup published the artcile< Inhibitory effects of collismycin C and pyrisulfoxin A on particulate matter-induced pulmonary injury>, Name: 2,2′-Bipyridine, the main research area is pulmonary injury collismycin C pyrisulfoxin A particulate matter; Akt; Collismycin C; Particulate matter; Pyrisulfoxin A; Vascular permeability.

Inhalation of fine particulate matter (PM2.5) is associated with elevated pulmonary injury caused by the loss of vascular barrier integrity. Marine microbial natural products isolated from microbial culture broths were screened for pulmonary protective effects against PM2.5. Two 2,2′-bipyridine compounds isolated from a red alga-associated Streptomyces sp. MC025-collismycin C (2) and pyrisulfoxin A (5)-were found to inhibit PM2.5-mediated vascular barrier disruption. To confirm the inhibitory effects of collismycin C and pyrisulfoxin A on PM2.5-induced pulmonary injury. In this study, we investigated the beneficial effects of collismycin C and pyrisulfoxin A on PM-induced lung endothelial cell (EC) barrier disruption and pulmonary inflammation. Permeability, leukocyte migration, proinflammatory protein activation, reactive oxygen species (ROS) generation, and histol. were evaluated in PM2.5-treated ECs and mice. Collismycin C and pyrisulfoxin A significantly scavenged PM2.5-induced ROS and inhibited the ROS-induced activation of p38 mitogen-activated protein kinase as well as activated Akt, which helped in maintaining endothelial integrity, in purified pulmonary endothelial cells. Furthermore, collismycin C and pyrisulfoxin A reduced vascular protein leakage, leukocyte infiltration, and proinflammatory cytokine release in the bronchoalveolar lavage fluid of PM-treated mice. These data suggested that collismycin C and pyrisulfoxin A might exert protective effects on PM-induced inflammatory lung injury and vascular hyperpermeability.

Phytomedicine published new progress about Bronchoalveolar lavage fluid. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Name: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wandas, M.; Lorenc, J.; Kucharska, E.; Maczka, M.; Hanuza, J. published the artcile< Molecular structure and vibrational spectra of 3 (or 4 or 6)-methyl-5-nitro-2-pyridinethiones: FT-IR, FT-Raman and DFT quantum chemical calculations>, Recommanded Product: 2-Amino-3-nitro-6-picoline, the main research area is structure vibrational spectra methylnitropyridinethione FT IR Raman DFT quantum.

IR and Raman spectra (RS) of polycrystalline 3-(or 4 or 6)-methyl-5-nitro-2-pyridinethione were measured and analyzed by d. functional theory (DFT) quantum chem. calculations The B3LYP/6-311G(2d,2p) approach was applied for both the thiol and thione tautomers due to the possibility of the formation of these two thiole forms. Mol. structures of these compounds were optimized starting from different mol. geometries of the thiol group and thione group. Two conformations of the 2-mercaptopyridine, trans and cis, were taken into account. The studied compounds appear in the solid state in the thione form. The effect of the hydrogen-bond formation in the studied compounds was considered.

Journal of Raman Spectroscopy published new progress about Conformation. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Recommanded Product: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhao, Huaxin; Ma, Guobin; Xie, Xiaojuan; Wang, Yong; Hao, Jian; Wan, Wen published the artcile< Pd(II)-Catalyzed decarboxylative meta-C-H difluoromethylation>, Name: 2,4-Bipyridine, the main research area is difluoroacetic acid arylpyridine decarboxylative meta selective difluoromethylation palladium catalyst.

A palladium(II)-catalyzed decarboxylative meta-selective C-H difluoromethylation of arenes has been developed from easily accessible difluoroacetic acids. Initial mechanistic studies disclosed that a migratory insertion is involved in this meta-C-H functionalization.

Chemical Communications (Cambridge, United Kingdom) published new progress about Fluoromethylation (decarboxylative). 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Name: 2,4-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pan, Sheng-Dong; Shen, Hao-Yu; Zhou, Li-Xin; Chen, Xiao-Hong; Zhao, Yong-Gang; Cai, Mei-Qiang; Jin, Mi-Cong published the artcile< Controlled synthesis of pentachlorophenol-imprinted polymers on the surface of magnetic graphene oxide for highly selective adsorption>, Synthetic Route of 14121-36-9, the main research area is pentachlorophenol imprinted polymer surface magnetic graphene oxide adsorption.

A novel, well-designed magnetic graphene oxide sheet embedded with core-shell molecularly imprinted polymer microspheres (MGO@MIP) was controllably synthesized via a reflux-precipitation polymerization and surface imprinting technique. The as-prepared MGO@MIP was fully characterized and the specific selectivity and remarkable adsorption capacity to pentachlorophenol (PCP) are closely related to the synergetic effect of hydrogen bonding and π-π interactions, which are strongly associated with the solution pH and the distribution of magnetic microspheres on the surface of GO sheets. Under the optimal conditions, i.e., pH of 4.0 and a ratio of monomers to Fe3O4 of 15, the maximum adsorption capacity and the imprinting factor (α) of MGO@MIP towards PCP were 789.4 mg g-1 and 4.36, resp. The newly synthesized MGO@MIPs proved to be a great adsorbent for PCP in environmental water.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about Adsorption. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Synthetic Route of 14121-36-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shiao, Min Jen; Shyu, Li Ming; Tarng, Kai Yih; Ma, Ying Tsun published the artcile< A convenient synthesis of halogenated 2-chloropyridines by transformation of halogenated 2-methoxypyridines under Vilsmeier-Haack conditions>, SDS of cas: 13472-84-9, the main research area is Vilsmeir halomethoxypyridine; chlorination halomethoxypyridine; chloropyridine.

The title compounds I (R = Cl; R1 = H, R2 = 3-Cl, 5-Cl, 6-Cl, 3-Br, 5-Br, 6-Br) were conveniently synthesized by reaction of 2-methoxypyridines I (R = OMe) under Vilsmeier-Haack conditions.

Synthetic Communications published new progress about Chlorination. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, SDS of cas: 13472-84-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Jian; Jian, Tianying; Guo, Liangqin; Atanasova, Tzvetomira; Nargund, Ravi P. published the artcile< Preparation of 3,4-fused-spiro[furan-5(5H),4'-piperidin]-2-one>, Related Products of 53636-56-9, the main research area is halo heteroaromatic Suzuki coupling iodolactonization dioxaborolanyl pyridine carboxylate; triflate heteroaromatic Suzuki coupling iodolactonization dioxaborolanyl pyridine carboxylate; fused spiro furanone piperidine preparation.

A general method for the preparation of various 3,4-fused-spiro[furan-5(5H),4′-piperidin]-2-ones with high yield was reported. The formation of spiro[furanone-piperidine] structure was achieved by a Suzuki coupling, followed by an iodolactonization reaction.

Tetrahedron Letters published new progress about Carboxylic esters Role: RCT (Reactant), RACT (Reactant or Reagent) (heteroaromatic). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Related Products of 53636-56-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhong, Jia-Yu; Cui, Xing-Jun; Zhan, Jun-Kun; Wang, Yan-Jiao; Li, Shuang; Lin, Xiao; Xiang, Qun-Yan; Ni, Yu-Qing; Liu, Le; Liu, You-Shuo published the artcile< LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells>, Category: pyridine-derivatives, the main research area is lncRNA Bhlhe40 glucose calcification senescence vascular smooth muscle cell; Bhlhe40; VSMC calcification/senescence; diabetes; lncRNA-ES3; microRNA; vascular aging.

Long noncoding RNAs (lncRNAs) have been investigated as novel regulatory mols. involved in diverse biol. processes. Our previous study demonstrated that lncRNA-ES3 is associated with the high glucose-induced calcification/senescence of human aortic vascular smooth muscle cells (HA-VSMCs). However, the mechanism of lncRNA-ES3 in vascular calcification/aging remained largely unknown. Here, we report that the expression of basic helix-loop-helix family member e40 (Bhlhe40) was decreased significantly in HA-VSMCs treated with high glucose, whereas the expression of basic leucine zipper transcription factor (BATF) was increased. Overexpression of Bhlhe40 and inhibition of BATF alleviated calcification/senescence of HA-VSMCs, as confirmed by Alizarin Red S staining and the presence of senescence-associated β-galactosidase-pos. cells. Moreover, we identified that Bhlhe40 regulates lncRNA-ES3 in HA-VSMCs by binding to the promoter region of the lncRNA-ES3 gene (LINC00458). Upregulation or inhibition of lncRNA-ES3 expression significantly promoted or reduced calcification/senescence of HA-VSMCs, resp. Addnl., we identified that lncRNA-ES3 functions in this process by suppressing the expression of miR-95-5p, miR-6776-5p, miR-3620-5p, and miR-4747-5p. The results demonstrate that lncRNA-ES3 triggers gene silencing of multiple miRNAs by binding to Bhlhe40, leading to calcification/senescence of VSMCs. Our findings suggest that pharmacol. interventions targeting lncRNA-ES3 may be therapeutically beneficial in ameliorating vascular calcification/aging.

Annals of the New York Academy of Sciences published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (CEBPE). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bhattacharyya, Manjit K.; Gogoi, Anshuman; Chetry, Sanjib; Dutta, Debajit; Verma, Akalesh K.; Sarma, Bipul; Franconetti, Antonio; Frontera, Antonio published the artcile< Antiproliferative evaluation and supramolecular association in Mn(II) and Zn(II) bipyridine complexes: Combined experimental and theoretical studies>, SDS of cas: 366-18-7, the main research area is manganese methylbenzoate bipyridine complex preparation crystal mol structure antiproliferative; zinc pyridinedicarboxylate bipyridine complex preparation crystal mol structure antiproliferative; Apoptosis; Cooperativity; Cytotoxicity; Docking; T-cell lymphoma; π–π stacking.

Two new coordination complexes viz. [Mn2(μ-O,O’-4-Mebz)2(bpy)2(μ2-H2O)(4-Mebz)2] (1) and [Zn(bpy)(pdc)(H2O)]·3.5H2O (2) (where bpy = 2,2′-bipyridine, 4-Mebz = 4-Me benzoate and pdc = 2,6-pyridine dicarboxylate) were synthesized and structurally characterized by single crystal x-ray diffraction, FT-IR, electronic spectroscopy, Thermogravimetric Anal. (TGA) and Powder x-ray diffraction (PXRD) techniques. Complex 1 consists of a dinuclear Mn(II) unit bridged by a solvent water mol. while 2 is a mononuclear complex. The supramol. assemblies found in the solid state of both complexes have been described. In 2, several π-stacking interactions modes have been further studied using D. Functional Theory (DFT) calculations Furthermore, the activity of the complexes against a few pathogenic bacteria has been studied and confirmed. Finally, the antiproliferative activities of both complexes have been studied in T-cell lymphoma cell line by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, apoptosis assay and mol. docking simulation. Both the complexes exhibit gratifying cytotoxicity through apoptotic cell death with negligible cytotoxicity (∼5-10%) in normal cells. It is worth mentioning that Mn(II) and Zn(II) complexes exhibit interaction modes with highly expressed cancer target proteins under study with higher binding affinity and the results are comparable with reference inhibitors.

Journal of Inorganic Biochemistry published new progress about Antibacterial agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, SDS of cas: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Shuni; Yang, Hong; Su, Mingbo; Lian, Fulin; Cong, Zhanqing; Wei, Rongrui; Zhou, Yubo; Li, Xingjun; Zheng, Xingling; Li, Chunpu; Fu, Xuhong; Han, Xu; Shi, Qiongyu; Li, Cong; Zhang, Naixia; Geng, Meiyu; Liu, Hong; Li, Jia; Huang, Xun; Wang, Jiang published the artcile< 5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma>, Formula: C6H8N2, the main research area is aminonaphthalene sulfonamide preparation NSD2 inhibitor SAR antitumor apoptosis human; 5-Aminonaphthalene derivatives; HTS; Inhibitor; Methyltransferase; Multiple myeloma; NSD2.

Using high-throughput screening (HTS) with biol. analyzes, a series of 5-aminonaphthalene derivatives such as I [X = CO, SO2; R1 = NHCH2Ph, NHPh, NHCH2(4-FC6H4), etc.; R2 = H, NH2, NMe2, etc.] were designed and synthesized as novel NSD2 inhibitors. Among all the prepared compounds, I [R1 = NHCH2Ph, R2 = NH2] displayed a good NSD2 inhibitory activity (IC50 = 2.7μM) and selectivity against both SET-domain-containing and non-SET-domain-containing methyltransferases. Preliminary research indicated the inhibition mechanism of compound I [X = SO2, R1 = NHCH2Ph, R2 = NH2 (II)] by significantly suppressed the methylation of H3K36me2. Compound II specifically inhibited the proliferation of the human B cell precursor leukemia cell line RS4:11 and the human myeloma cell line KMS11 by inducing cell cycle arrest and apoptosis with little cytotoxicity. It was reported that the anti-cancer effect of compound II was partly achieved by completely suppressing the transcriptional activation of NSD2-targeted genes.

European Journal of Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hou, Xiaoya; Zhou, Sen; Li, Yuli; Guo, Minjie; Zhao, Wentao; Tang, Xiangyang; Wang, Guangwei published the artcile< Synthesis of Indolizines from Pyridinium Salts and Ethyl Bromodifluoroacetate>, COA of Formula: C7H7NO2, the main research area is indolizine synthesis annulation pyridinium salt bromodifluoroacetate.

Here we present a novel annulation of pyridinium salts with BrCF2CO2Et to access the indolizine derivatives with high efficiency. The α substitution of pyridine plays a key role in determining the reaction pathways. Various types of indolizines can be conveniently accessed from easily available pyridinium salts under mild and simple reaction conditions.

Organic Letters published new progress about Cyclization, regioselective. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, COA of Formula: C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem