Day: October 12, 2022

Beak, Peter; Lee, Jae-Keun; McKinnie, B. Gary published the artcile< Methylation of protomeric ambident nucleophiles with methyl fluorosulfonate: a regiospecific reaction>, Application of C6H6ClNO, the main research area is methylation methyl fluorosulfate regiospecificity; nucleophile methylation regiospecific.

Methylation of 15 protomeric ambident nucleophiles with MeOSO2F occurred regiospecifically at the heteroatom remote from the mobile proton. In most cases the fluorosulfonate salts thus obtained were isolated, identified by NMR spectroscopy, and converted to the neutral methylated derivatives by aqueous base. The compounds studied include 5 of the 9 possible systems X:YZH ⇌ HXY:Z in which Y is C and X and Z are O, N and/or S. In 12 cases the reaction was synthetically useful, although it was sometimes necessary to remove the excess MeOSO2F prior to treatment with base. Three cases give mixtures of methylated products, a result established for the case of 2-pyridone as due to proton transfer from the initial regiospecifically-formed salt.

Journal of Organic Chemistry published new progress about 13472-84-9. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Application of C6H6ClNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lan, Xiao-Bing; Ye, Zongren; Huang, Ming; Liu, Jiahao; Liu, Yan; Ke, Zhuofeng published the artcile< Nonbifunctional Outer-Sphere Strategy Achieved Highly Active α-Alkylation of Ketones with Alcohols by N-Heterocyclic Carbene Manganese (NHC-Mn)>, Formula: C7H7NO, the main research area is ketone alc NHC manganese alkylation catalyst; alkylated ketone preparation; amino benzyl alc ketone NHC manganese Friedlander annulation catalyst; quinoline preparation.

The unusual nonbifunctional outer-sphere strategy was successfully utilized in developing an easily accessible N-heterocyclic carbene manganese (NHC-Mn) system for highly active α-alkylation of ketones with alcs. This system was efficient for a wide range of ketones and alcs. under mild reaction conditions, and also for the green synthesis of quinoline derivatives The direct outer-sphere mechanism and the high activity of the present system demonstrate the potential of nonbifunctional outer-sphere strategy in catalyst design for acceptorless dehydrogenative transformations.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Formula: C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Z. J.; Michniak-Kohn, B. published the artcile< Flavosomes, novel deformable liposomes for the co-delivery of anti-inflammatory compounds to skin>, Safety of 1-Hexadecylpyridin-1-ium chloride, the main research area is antiinflammatory drug NSAID topical flavonoid liposome skin permeation deformability; Deformable liposomes; Ex vivo skin permeation; Flavonoid; Flavosome; Meloxicam; Transfersome.

Flavosomes, novel deformable liposomes for the topical delivery of anti-inflammatory compounds have been developed and characterized in this study. The carriers were prepared by incorporating flavonoids, specifically quercetin and dihydroquercetin, into transfersome and evaluated as a potential topical delivery system for meloxicam (MX), a potent hydrophobic NSAID (non-steroidal anti-inflammatory drug). Characterization of the flavosomes was conducted in terms of their vesicle size, zeta potential, entrapment efficiency and deformability index. Ex vivo skin permeation and confocal laser scanning microscopy studies demonstrated that the flavosome formulations improved the skin permeation of meloxicam compared to that for transfersomes. The dermal and transdermal delivery of meloxicam using these formulations has the potential of being a promising alternative to conventional oral delivery of non-steroidal anti-inflammatory drugs (NSAIDs) with enhanced local and systemic onset of action and reduced gastrointestinal side effects.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about Biological permeation. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Safety of 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ashimori, Atsuyuki; Ono, Taizo; Uchida, Takeshi; Ohtaki, Yutaka; Fukaya, Chikara; Watanabe, Masahiro; Yokoyama, Kazumasa published the artcile< Novel 1,4-dihydropyridine calcium antagonists. I. Synthesis and hypotensive activity of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives>, Application In Synthesis of 131747-55-2, the main research area is antihypertensive pyridyldihydropyridinedicarboxylate; pyridyldihydropyridine derivative hypotensive activity; calcium antagonist pyridyldihydropyridinedicarboxylate.

A series of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives I (R = H, halo, CF3, etc.) were synthesized and their hypotensive effects examined Several compounds have a hypotensive activity parallel to that of nicardipine; the 4-(3-trifluoromethyl-2-pyridyl) and 4-(2-trifluoromethyl-3-pyridyl) derivatives, in particular, had approx. twice the duration of nicardipine, and the 4-(4-cyano-2-pyridyl) derivative had the most potent hypotensive activity of all the derivatives synthesized.

Chemical & Pharmaceutical Bulletin published new progress about Antihypertensives. 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Application In Synthesis of 131747-55-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kucharska, E.; Michalski, J.; Sasiadek, W.; Talik, Z.; Bryndal, I.; Hanuza, J. published the artcile< Vibrational spectra, crystal structure, DFT quantum chemical calculations and conformation of the hydrazo - bond in 6-methyl-3-nitro-2-(2-phenylhydrazinyl)pyridine>, Computed Properties of 19346-45-3, the main research area is crystal structure methylnitro phenylhydrazinyl pyridine; vibrational spectra ethylnitro phenylhydrazinyl pyridine; DFT ethylnitro phenylhydrazinyl pyridine.

The crystal and mol. structures of 6-methyl-3-nitro-2-(2-phenylhydrazinyl)pyridine (6-methyl-3-nitro-2-phenylhydrazopyridine) have been determined by X-ray diffraction and quantum chem. DFT anal. The crystal is monoclinic, space group C2/c, with Z = 8 formula units in the elementary unit cell of dimensions a = 16.791(4), b = 6.635(2), c = 21.704(7) Å, β = 100.54(3)°. The mol. consists of two nearly planar pyridine subunits. A conformation of the linking hydrazo-bridge CNHNHC is bend and the dihedral angle between the planes of the Ph and pyridine rings is 88.2(5)°. The hydrogen bonding of the type NH···N and possibly also CH···O favors a dimer formation in the crystal structure. The dimers are further linked by a NH···O hydrogen bond, so forming a layer parallel to the ab plane. The mol. structure of the studied compound has been determined using the DFT B3LYP/6-311G(2d,2p) approach and compared to that derived from X-ray studies. The IR and Raman wavenumbers have been calculated for the optimized geometry of a possible monomer structural model but the possibility of the dimer formation through the NH···N hydrogen bond has also been considered. The structural and vibrational properties of the intra-mol. NH···O interaction are described.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about Crystal structure. 19346-45-3 belongs to class pyridine-derivatives, and the molecular formula is C6H5FN2O2, Computed Properties of 19346-45-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kulkarni, Santosh S.; Newman, Amy Hauck published the artcile< Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists>, Name: 6-Amino-3-nitro-2-picoline, the main research area is quinoline benzothiazole preparation glutamate receptor antagonist SAR; pyridothiazole imidazopyridine preparation glutamate receptor antagonist SAR.

Investigation of a series of heterobicyclic compounds with essential pharmacophoric features of the metabotropic glutamate receptor 5 (mGluR5) antagonists MPEP and MTEP provided novel structural templates with sub-micromolar affinities at the mGluR5. Compound I showed antagonist activity (IC50 = 0.26 μM) in the functional assay measuring hydrolysis of phosphoinositide and may provide a new lead for further SAR investigation.

Bioorganic & Medicinal Chemistry Letters published new progress about Metabotropic glutamate receptors, group I, mGluR5 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Name: 6-Amino-3-nitro-2-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Xiaojie; Popli, Henna; Kwon, Ohyun; Malissa, Hans; Pan, Xin; Park, Bumwoo; Choi, Byoungki; Kim, Sunghan; Ehrenfreund, Eitan; Boehme, Christoph; Vardeny, Z. Valy published the artcile< Isotope Effect in the Magneto-Optoelectronic Response of Organic Light-Emitting Diodes Based on Donor-Acceptor Exciplexes>, Safety of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is OLED magneto optoelectronic response donor acceptor exciplex; Rabi oscillations; electrically detected magnetic resonance; exciplexes; magneto-electroluminescence; organic light-emitting diodes (OLEDs); reverse intersystem crossing.

The isotope effect is studied in the magneto-electroluminescence (MEL) and pulsed elec. detected magnetic resonance of organic light-emitting diodes based on thermally activated delayed fluorescence (TADF) from donor-acceptor exciplexes that are either protonated (H) or deuterated (D). It is found that at ambient temperature, the exchange of H to D has no effect on the spin-dependent current and MEL responses in the devices. However, at cryogenic temperatures, where the reverse intersystem crossing (RISC) from triplet to singlet exciplex diminishes, a pronounced isotope effect is observed These results show that the RISC process is not governed by the hyperfine interaction as thought previously, but proceeds through spin-mixing in the triplet exciplex. The observations are corroborated by elec. detected transient spin nutation experiments that show relatively long dephasing time at ambient temperature, and interpreted in the context of a model that involves exchange and hyperfine interactions in the spin triplet exciplex. These findings deepen the understanding of the RISC process in TADF materials.

Advanced Materials (Weinheim, Germany) published new progress about Activation energy (of conductivity). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Safety of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Owada, Tsukasa; Sasabe, Hisahiro; Sukegawa, Yoshihito; Watanabe, Taiki; Maruyama, Tomohiro; Watanabe, Yuichiro; Yokoyama, Daisuke; Kido, Junji published the artcile< A terpyridine-modified chrysene derivative as an electron transporter to improve the lifetime in phosphorescent OLEDs>, SDS of cas: 329214-79-1, the main research area is terpyridine chrysene derivative electron transporter phosphorescent organic LED lifetime.

A terpyridine-modified chrysene derivative, abbreviated as B3TPyC, was designed and developed to be used as electron-transport layers (ETLs) toward the construction of highly stable phosphorescent OLEDs. A green phosphorescent OLED with a B3TPyC ETL exhibited a low turn-on voltage of 2.4 V at 1 cd m-2 and an external quantum efficiency of 17.5% at 1000 cd m-2 with a long operation lifetime at 50% of the initial luminance (LT50) of over 258 h at c.d. 25 mA cm-2 (an initial luminance of ∼12,000 cd m-2), which corresponds to a LT50 of 19,000 h at 1000 cd m-2. This is >1.5 times longer than the time of luminance decay provided by the phenylpyridine counterpart named B3PyPC. These results clearly show the potential and usefulness of terpyridine-based chrysene derivatives to be applied in high-performance OLEDs with high operational stability.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Atomic force microscopy. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, SDS of cas: 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem