Day: October 12, 2022

Duong, Vincent K.; Horan, Alexandra M.; McGarrigle, Eoghan M. published the artcile< Synthesis of Pyridylsulfonium Salts and Their Application in the Formation of Functionalized Bipyridines>, Recommanded Product: 2-Bromo-N,N-dimethylpyridin-4-amine, the main research area is pyridylsulfide diphenyliodonium triflate copper selective arylation; pyridylsulfonium trifluoromethanesulfonate preparation; halopyridine organolithium pyridylsulfonium coupling; bipyridine preparation.

An S-selective arylation of pyridylsulfides with good functional group tolerance was developed. To demonstrate synthetic utility, the resulting pyridylsulfonium salts were used in a scalable transition-metal-free coupling protocol, yielding functionalized bipyridines with extensive functional group tolerance. This modular methodol. permits selective introduction of functional groups from com. available pyridyl halides, furnishing sym. and unsym. 2,2′- and 2,3′-bipyridines. Iterative application of the methodol. enabled the synthesis of a functionalized terpyridine with three different pyridine components.

Organic Letters published new progress about Arylation. 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Recommanded Product: 2-Bromo-N,N-dimethylpyridin-4-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Deady, Leslie W.; Korytsky, Olga L.; Rowe, Jeffrey E. published the artcile< Substituent effects on the isomer ratios in the rearrangement of some 2- and 4-nitraminopyridines>, SDS of cas: 21901-29-1, the main research area is substituent effect rearrangement nitraminopyridine.

The preparation and rearrangement in 92% H2SO4 of I-III (R = H, Me, MeO, Br, Cl, CO2H) were investigated. The product isomer ratios can be explained by differential electronic stabilization of the appropriate σ complexes for aromatic nitration and steric effects seem relatively unimportant. Deuteration [3-D in I, R = Me] had no effect on the product distribution.

Australian Journal of Chemistry published new progress about Rearrangement. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, SDS of cas: 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bhattacharya, Ritwick; Chatterjee, Arnab; Chatterjee, Soumendranath; Saha, Nimai Chandra published the artcile< Acute toxicity and impact of sublethal exposure to commonly used surfactants sodium dodecyl sulphate, cetylpyridinium chloride and sodium laureth sulphate on oxidative stress enzymes in oligochaete worm Branchiura sowerbyi (Beddard, 1892)>, Category: pyridine-derivatives, the main research area is Branchiura oxidative stress sodium dodecyl sulfate cetylpyridinium chloride toxicity.

The current study aimed to determine the detrimental effects of sodium dodecyl sulfate (SDS), cetylpyridinium chloride (CPC), and sodium laureth sulfate (SLES) on survival rate and oxidative stress enzymes in Branchiura sowerbyi (Beddard, 1892). The 96 h LC50 values of SDS, CPC and SLES to Branchiura sowerbyi were estimated to be 8.27, 0.12 and 19.58 mg/L, resp. Moreover, surfactant toxicity was projected using general threshold survival models (GUTS) in terms of required data sets and fit performance. The result suggested that GUTS-IT (individual tolerance) model can better predict the survival rate observed in Branchiura sowerbyi for surfactant exposure than the GUTS-SD (stochastic death) model. Sublethal levels of SDS, CPC and SLES (10% and 30% of the 96 h LC50 value) elicited substantial changes in oxidative stress enzymes over the 14-day exposure period. Superoxide dismutase (SOD), reduced glutathione (GSH), glutathione S-transferase (GST) and glutathione peroxidase (GPx) demonstrated a significant increasing trend initially followed by a subsequent declining trend, but the levels of catalase (CAT), as well as malondialdehyde (MDA), increased significantly throughout the periods of exposure. The consequences of SDS, CPC and SLES on Branchiura sowerbyi were evaluated using a correlation matrix, principal component anal., and integrated biomarker response assessment. These findings suggest that SDS, CPC and SLES exposure detrimentally affect survival rate and alter the levels of oxidative stress enzymes in Branchiura sowerbyi.

Aquaculture Research published new progress about Biomarkers. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

McCann, Scott D.; Reichert, Elaine C.; Arrechea, Pedro Luis; Buchwald, Stephen L. published the artcile< Development of an Aryl Amination Catalyst with Broad Scope Guided by Consideration of Catalyst Stability>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is dialkylbiaryl monosphosphine ligand preparation amination coupling catalyst.

The authors have developed a new dialkylbiaryl monophosphine ligand, GPhos, that supports a palladium catalyst capable of promoting carbon-nitrogen cross-coupling reactions between a variety of primary amines and aryl halides; in many cases, these reactions can be carried out at room temperature The reaction development was guided by the idea that the productivity of catalysts employing BrettPhos-like ligands is limited by their lack of stability at room temperature Specifically, it was hypothesized that primary amine and N-heteroaromatic substrates can displace the phosphine ligand, leading to the formation of catalytically dormant palladium complexes that reactivate only upon heating. This notion was supported by the synthesis and kinetic study of a putative off-cycle Pd complex. Consideration of this off-cycle species, together with the identification of substrate classes that are not effectively coupled at room temperature using previous catalysts, led to the design of a new dialkylbiaryl monophosphine ligand. An Ot-Bu substituent was added ortho to the dialkylphosphino group of the ligand framework to improve the stability of the most active catalyst conformer. To offset the increased size of this substituent, the authors also removed the para i-Pr group of the non-phosphorus-containing ring, which allowed the catalyst to accommodate binding of even very large α-tertiary primary amine nucleophiles. In comparison to previous catalysts, the GPhos-supported catalyst exhibits better reactivity both under ambient conditions and at elevated temperatures Its use allows for the coupling of a range of amine nucleophiles, including (1) unhindered, (2) five-membered-ring N-heterocycle-containing, and (3) α-tertiary primary amines, each of which previously required a different catalyst to achieve optimal results.

Journal of the American Chemical Society published new progress about Amination. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Huang, Haw-Tyng; Zhu, Li; Ward, Matthew D.; Wang, Tao; Chen, Bo; Chaloux, Brian L.; Wang, Qianqian; Biswas, Arani; Gray, Jennifer L.; Kuei, Brooke; Cody, George D.; Epshteyn, Albert; Crespi, Vincent H.; Badding, John V.; Strobel, Timothy A. published the artcile< Nanoarchitecture through Strained Molecules: Cubane-Derived Scaffolds and the Smallest Carbon Nanothreads>, Recommanded Product: 2-Mercaptopyridinen-oxide sodiumsalt, the main research area is cubane derived scaffold carbon nanothread.

Relative to the rich library of small-mol. organics, few examples of ordered extended (i.e., nonmol.) hydrocarbon networks are known. In particular, sp3 bonded, diamond-like materials represent appealing targets because of their desirable mech., thermal, and optical properties. While many covalent organic frameworks (COFs)-extended, covalently bonded, and porous structures-have been realized through mol. architecture with exceptional control, the design and synthesis of dense, covalent-extended solids has been a longstanding challenge. We report the preparation of a sp3-bonded, low-dimensional hydrocarbon synthesized via high-pressure, solid-state diradical polymerization of cubane (C8H8), which is a saturated, but immensely strained, cage-like mol. Exptl. measurements show that the obtained product is crystalline with 3-dimensional order that appears to largely preserve the basic structural topol. of the cubane mol. precursor and exhibits high hardness (comparable to fused quartz) and thermal stability ≤300°. Among the plausible theor. candidate structures, 1-dimensional carbon scaffolds comprising 6- and 4-membered rings that pack within a pseudosquare lattice provide the best agreement with exptl. data. These diamond-like mol. rods with extraordinarily small thickness are among the smallest members in the carbon nanothread family, and calculations indicate 1 of the stiffest 1-dimensional systems known. These results present opportunities for the synthesis of purely sp3-bonded extended solids formed through the strain release of saturated mols., as opposed to only unsaturated precursors.

Journal of the American Chemical Society published new progress about Compression. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Recommanded Product: 2-Mercaptopyridinen-oxide sodiumsalt.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dimkov, Aleksandar; Gjorgievska, Elizabeta; Nicholson, John W. published the artcile< The release of chloride ions from conventional glass-ionomer cements>, SDS of cas: 123-03-5, the main research area is benzalkonium cetylpyridinium chloride glass ionomer cement antimicrobial compound.

The objective of this study was to determining the level of released chloride ions from conventional glass-ionomer cements incorporated with two different types of antimicrobial agents – cetylpyridinium chloride and benzalkonium chloride, as well as to see the influence of incorporated antimicrobial agents on the process of chloride ions releasing. Two conventional glass-ionomer cements ChemFlex and Fuji IX were incorporated with a different percentage of the antimicrobial agents. The specimens were prepared according to the British Standards Institution Specifications for Dental Glass Ionomer Cements. 84 samples in total (4 × 6 mm) were prepared – by six specimens of the conventional glass-ionomer cements Fuji IX and ChemFlex with various concentrations of antimicrobial agents added – 1 %, 2 % and 3 %, i.e. six samples for each antimicrobial agent and each concentration level, as well as, by other six samples of the same cements without any antimicrobial agents, to be used as a control group. The measurements were performed at 14 successive time intervals started in zero time and finished after seven days. The results obtained speak of a continual release of chloride ions from both analyzed glass-ionomer cements with the addition of antimicrobial compounds, as well as with no antimicrobial compound incorporated.

Ceramics-Silikaty published new progress about Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, SDS of cas: 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wei, Chenyang; Liu, Zhengping; Tan, Hongwei; Huang, Liyan; Li, Jun published the artcile< A non-metal route to realize the bio-based polyester of poly(hexylene succinate): preparation conditions, side-reactions and mechanism in sulfonic acid-functionalized Bronsted acidic ionic liquids>, Related Products of 21876-43-7, the main research area is surlfuric acid functionalized ionic liquid catalyst polyhexylene succinate preparation.

A biodegradable linear bio-based polyester of poly(hexylene succinate) was effectively prepared in non-metal sulfonic acid-functionalized Bronsted acidic ionic liquids (SFBAILs) as both the catalyst and the polymerization medium, and the processes of polycondensation and post-polycondensation in SFBAILs were also investigated. In addition, the side reactions which were detrimental to the growth of Mw of poly(hexylene succinate) were evaluated and the synthesis mechanism of poly(hexylene succinate) catalyzed by SFBAILs was discussed with the help of DFT calculations The result shows that both the imidazole ring and the sulfonic group on cations of SFBAILs play an important role in the catalytic process.

RSC Advances published new progress about Acidity. 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Related Products of 21876-43-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Singh, Kamaljeet; Trinh, Winston; Weaver, Jimmie D. published the artcile< Elusive thermal [2+2] cycloaddition driven by visible light photocatalysis: tapping into strain to access C2-symmetric tricyclic rings>, HPLC of Formula: 370878-69-6, the main research area is thermal cycloaddition visible light photocatalysis strain sym tricyclic ring.

A mild and operationally simple methodol. is reported for the synthesis of cyclobutane rings imbedded within a C2-sym. tricyclic framework. The method uses visible light and an iridium-based photocatalyst to drive the oft-stated “”forbidden”” thermal [2 + 2] cycloaddition of cycloheptenes and analogs. Importantly, it generates cyclobutane with four new stereocenters with excellent stereoselectivity, and perfect regioselectivity. The reaction is propelled forward when the photocatalyst absorbs a visible light photon, which transfers this energy to the cycloheptene. Key to success is, upon excitation to the triplet via sensitization from the photocatalyst, the double bond isomerizes to give the transient, highly strained, trans-cycloheptene. The trans-cycloheptene undergoes a strain relieving thermal, intermol. [π2s + π2a] cycloaddition with another cis-cycloheptene. X-ray anal. reveals that the major product is the head-to-head, C2-sym. all trans-cyclobutane. Addnl., a dramatic display structural complexity enhancement is observed with the use of chiral cycloheptenols possessing one stereocenter, which results in the formation of cyclobutanes with six contiguous stereocenters with good to excellent diastereocontrol, and can be used to isolate single stereoisomers of stereochem. complex cyclobutanes in good yield.

Organic & Biomolecular Chemistry published new progress about Cis-trans isomerization. 370878-69-6 belongs to class pyridine-derivatives, and the molecular formula is C33H21F3IrN3, HPLC of Formula: 370878-69-6.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Xia; Yang, Qiu-Xia; Long, Cheng-Yu; Tan, Yan; Qu, Yi-Xin; Su, Min-Hui; Huang, Si-Jie; Tan, Weihong; Wang, Xue-Qiang published the artcile< Anticancer-Active N-Heteroaryl Amines Syntheses: Nucleophilic Amination of N-Heteroaryl Alkyl Ethers with Amines>, Electric Literature of 22961-45-1, the main research area is heteroaryl alkyl ether amine nucleophilic amination; amine heteroaryl preparation anticancer activity green chem.

A mild amination protocol of N-heteroaryl alkyl ethers with various amines is described. This transformation is achieved by utilizing simple and readily available base as promoter via C-O bond cleavage, offering a new amination strategy to access several anticancer-active compounds This work is highlighted by the excellent functional group compatibility, scalability, wide substrate scope, and easy derivatization of a variety of drugs.

Organic Letters published new progress about Alkyl aryl ethers Role: RCT (Reactant), RACT (Reactant or Reagent) (heteroaryl). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Electric Literature of 22961-45-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aramesh-Boroujeni, Zahra; Jahani, Shohreh; Khorasani-Motlagh, Mozhgan; Kerman, Kagan; Noroozifar, Meissam published the artcile< Evaluation of DNA, BSA binding, DNA cleavage and antimicrobial activity of ytterbium(III) complex containing 2,2′-bipyridine ligand>, Product Details of C10H8N2, the main research area is albumin DNA ytterbium antimicrobial activity; Antibacterial activity; binding interaction; bovine serum albumin; fish salmon-DNA; molecular docking; ytterbium(III) complex.

In order to estimate the biol. potential of a synthesized complex [Yb(bpy)2Cl3.OH2] where bpy is 2,2′-bipyridine, its binding behavior with fish salmon-DNA and bovine serum albumin were studied by different kinds of spectroscopy and mol. modeling methods. This complex was selected for its antibacterial and antifungal activities as well as the DNA cleavage activities were examined by agarose gel electrophoresis. The analyses of fluorescence data at four temperatures were done in order to evaluate the binding and thermodn. parameters of the interaction of Yb(III) complex with DNA and BSA. The exptl. results indicated that the major binding modes were based on groove binding with DNA and BSA. In addition, iodide quenching studies, ethidium bromide (EtBr) exclusion assay, ionic strength effect, CD, and viscosity studies reflected the binding of Yb(III) complex explicitly with the FS-DNA mainly in a groove binding mode. Moreover, mol. docking studies indicated that this complex was bound to the minor groove of DNA and to polar and apolar residues located in the subdomain IB of BSA (site 3). Also, the results of competitive experiments assessed site 3 of BSA as the most probable binding site for this complex. The mol. docking results were in good agreement with our exptl. results. From both exptl. and docking results, the binding constant values displayed the remarkably high affinity of Yb(III) complex to DNA as well as BSA.Communicated by Ramaswamy H. Sarma

Journal of Biomolecular Structure and Dynamics published new progress about Acinetobacter baumannii. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Product Details of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem