Day: October 13, 2022

Elawa, Sherif; Mirdell, Robin; Farnebo, Simon; Tesselaar, Erik published the artcile< Skin blood flow response to topically applied methyl nicotinate: Possible mechanisms.>, Synthetic Route of 93-60-7, the main research area is capillary capacity; laser speckle contrast imaging; methyl nicotinate; microcirculation; tissue viability.

BACKGROUND: Methyl nicotinate (MN) induces a local cutaneous erythema in the skin and may be valuable as a local provocation in the assessment of microcirculation and skin viability. The mechanisms through which MN mediates its vascular effect are not fully known. The aim of this study was to characterize the vasodilatory effects of topically applied MN and to study the involvement of nitric oxide (NO), local sensory nerves, and prostaglandin-mediated pathways. METHODS: MN was applied on the skin of healthy subjects in which NO-mediated (L-NMMA), nerve-mediated (lidocaine/prilocaine), and cyclooxygenase-mediated (NSAID) pathways were selectively inhibited. Microvascular responses in the skin were measured using laser speckle contrast imaging (LSCI). RESULTS: NSAID reduced the MN-induced perfusion increase with 82% (P < .01), whereas lidocaine/prilocaine reduced it with 32% (P < .01). L-NMMA did not affect the microvascular response to MN. CONCLUSION: The prostaglandin pathway and local sensory nerves are involved in the vasodilatory actions of MN in the skin. Skin research and technology : International Society for Skin Imaging (ISSI) published new progress about 93-60-7. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Synthetic Route of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wu, Gaorong; Fu, Xiaopan; Wang, Yangyang; Deng, Kezuan; Zhang, Lili; Ma, Tao; Ji, Yafei published the artcile< C-H Borylation of Diphenylamines through Adamantane-1-carbonyl Auxiliary by BBr3>, Category: pyridine-derivatives, the main research area is ortho carbon hydrogen bond borylation phenylamine adamantanecarbonyl directed; isotope effect borylation kinetics phenylamine adamantanecarbonyl directed; boronate ester phenylamine derivative preparation reactivity; crystal structure chlorophenyl dioxaborolanylphenyl adamantanecarboxamide; mol structure chlorophenyl dioxaborolanylphenyl adamantanecarboxamide.

A method for ortho-C-H borylation of diphenylamines using BBr3 as the B source is reported. The noncatalytic adamantane-1-carbonyl directed reaction exhibited site exclusivity and good functional group tolerance. Generally, the borylation occurred at the more electron-rich aromatic ring and the borylated products could be converted to various useful intermediates. Besides, the derived arylation and removal of auxiliary of the product could be achieved in a 1-pot fashion.

Organic Letters published new progress about Addition reaction kinetics (borylation). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

An, Ju Hyeon; Kim, Kyu Dong; Lee, Jun Hee published the artcile< Highly Chemoselective Deoxygenation Of N-Heterocyclic N-Oxides Using Hantzsch Esters As Mild Reducing Agents>, Computed Properties of 93-60-7, the main research area is deoxygenated nitrogen heterocycle green preparation chemoselective; heterocycle nitrogen oxide deoxygenation Hantzsch ester metallaphotocatalyst.

A highly chemoselective room-temperature deoxygenation method applicable to various functionalized N-heterocyclic N-oxides via visible light-mediated metallaphotoredox catalysis using Hantzsch esters as the sole stoichiometric reductant to afford deoxygenated N-heterocycles I [R = 6-OMe, 6-Cl, 2-Ph, etc.], II [R1 = H, 5-Br; X = CH, N] and III [R2 = 3-Ph, 2,6-Cl2, pyridin-2-yl, etc.] were reported. Despite the feasibility of catalyst-free conditions, most of these deoxygenations could be completed within a few minutes using only a tiny amount of a catalyst. This technol. also allowed for multigram-scale reactions even with an extremely low catalyst loading of 0.01 mol %. The scope of this scalable and operationally convenient protocol encompassed a wide range of functional groups, such as amides, carbamates, esters, ketones, nitrile groups, nitro groups and halogens, which provided access to the corresponding compounds I, II and III in good to excellent yields (an average of an 86.8% yield for a total of 45 examples).

Journal of Organic Chemistry published new progress about Amine oxides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (heteroarene). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Computed Properties of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Carnizello, Andrea P.; Alves, Jacqueline M.; Pereira, Daiane E.; Campos, Jacqueline C. L.; Barbosa, Marilia I. F.; Batista, Alzir A.; Tavares, Denise C. published the artcile< Study of the cytotoxic and genotoxic potential of the carbonyl ruthenium(II) compound, ct-[RuCl(CO)(dppb)(bipy)]PF6 [dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2′-bipyridine], by in vitro and in vivo assays>, SDS of cas: 366-18-7, the main research area is cytotoxicity genotoxicity carbonyl ruthenium assay; carbonyl ruthenium complexes; comet assay; genotoxic potential; micronucleus test.

Considering the promising previous results of ct-[RuCl(CO)(dppb)(bipy)]PF6 (where dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2′-bipyridine) as an antitumor agent, novel biol. assays evaluating its toxicogenic potential were performed. The genotoxicity of the compound was evaluated by the in vitro micronucleus test (V79, Chinese hamster lung fibroblasts; HepG2, hepatocellular carcinoma cells), in vivo bone marrow micronucleus test and comet assay in hepatocytes (Swiss mice). The animals were treated with 0.63, 1.25, 2.5 and 5.0 mg/kg body weight (bw) of the compound Neg. (water) and pos. (cisplatin, 1.5 mg/kg bw; Me methanesulfonate, 40 mg/kg bw) controls were included. The parameters considered in the comet assay were the percentage of tail DNA, tail moment and tail length. The results of the in vitro micronucleus tests showed the absence of genotoxicity in V79 cells, while the compound was genotoxic in HepG2 cells at a concentration of 1.25 microM. In the in vivo micronucleus test, the compound was not genotoxic at the different doses evaluated. In the comet assay, only the dose of 5.0 mg/kg bw resulted in a significant increase in the frequency of DNA damage in hepatocytes when compared to the neg. control. The genotoxic effect observed in HepG2 cells and in the liver comet assay indicates that the compound was metabolized by hepatic cells.

Journal of Applied Toxicology published new progress about Analysis. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, SDS of cas: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yakhontov, L. N.; Azimov, V. A.; Lapan, E. I. published the artcile< Reactivity of isomeric azaindoles>, HPLC of Formula: 23612-36-4, the main research area is indoles aza; pyridines; azaindoles; furopyridines; pyrrolopyridines; pyridines pyrrolo.

Treatment of the pyridine I (R = 6-Cl) with NH3 in EtOH 4 hrs. at 200° yielded 71.5% 5-azaindoline (II) (R = 6-Cl, R1 = H), m. 106-7° (EtOAc), b1·5 152-4°. The azabenzofuran III (R = 6-OH) heated 8 hrs. at 190° with 3 molar equivalents PhCH2NH2 yielded 72% II (R = 6-OH, R1 = CH2Ph), m. 187-8° (dioxane), transformed by heating 5 hrs. at 150° with POCl3 into II (R = 6-Cl, R1 = CH2Ph), m. 75-6° (EtOAc). This reduced over Pd-C gave II (R = R1 = H) (IV), m. 102-3° (C6H12), dehydrogenated by heating 15 min. (N atm.) with 9% Pd-C at 2 5-25° to yield 70.5% 5-azaindole (V), m. 109.5-10.0° (H2O). III (R = OH) heated 8 hrs. at 250° with PhNH2 gave 78.8% II (R = 6-OH, R1 = Ph), m. 215-16° (EtOH), converted via II (R = 6-Cl, R1 = Ph), m. 99-100° (EtOH) into II (R = H, R1 = Ph), m. 59-60° (petroleum ether) and dehydrogenated at 255-65° to yield 80.7% 1-phenyl-5-azaindole (VI), m. 58-9° (petroleum ether). Condensation of 2-methyl-3-nitropyridine with (CO2Et)2 in the presence of EtOK in C6H6 at 25° 24 hrs. and the product, 70% Et3-nitro-2-pyridylpyruvate, m. 126-7°, reduced in EtOH over 9% Pd-C gave quant. Et 4-azaindole-2-carboxylate, m. 173-3.5°, saponified to 4-azaindole-2-carboxylic acid (VII), m. 302-3° (decomposition). Similarly, 2-methyl-3-nitro-6-ethoxypyridine, m. 39-40°, gave 58.8% Et 3-nitro-6-ethoxy-2-pyridylpyruvate, m. 131-2° (alc.), which gave 93% Et 5-ethoxy-4-azaindole-2-carboxylate, m. 148-9.5° (alc.) and then, via the corresponding acid, m. 300° (decomposition), 5-ethoxy-4-azaindole (VIII), m. 148-50°. Nitration, bromination, cyanomethylation and the Mannich reaction were used as electrolytic substitution reactions and carried out under conditions which had given the best yields for the corresponding 7-azaindole derivatives The cyanomethylated products were converted into azoindolyl-3-acetic acids. The Mannich reactions were carried out with 20% paraformaldehyde and 3 molar equivalents Me2NH.-HCl in refluxing BuOH; % yields and m.p. for the 3-substituted products were tabulated. π-Electron d. effects were discussed.

Tetrahedron Letters published new progress about Reactivity (chemical). 23612-36-4 belongs to class pyridine-derivatives, and the molecular formula is C7H5BrN2, HPLC of Formula: 23612-36-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Qiu, Xu; Yang, Xiaoxue; Zhang, Yiqun; Song, Song; Jiao, Ning published the artcile< Efficient and practical synthesis of unsymmetrical disulfides via base-catalyzed aerobic oxidative dehydrogenative coupling of thiols>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is disulfide green preparation; thiol oxidative dehydrogenative coupling base catalyst.

An efficient M2CO3-catalyzed (M = K or Cs) aerobic cross dehydrogenative coupling reaction of thiols to afford unsym. disulfides RSSR1 [R = 4-MeC6H4, 2-pyridyl, 4-ClC6H4CH2, etc.; R1 = t-Bu, Bn, 2-naphthyl, etc.] was described. The high atom-economy, easy accessibility of catalyst, O2 as the ideal green oxidant, mild reaction conditions and broad substrate scope demonstrated that the present methodol. as a green, attractive and practical approach to disulfides.

Organic Chemistry Frontiers published new progress about Disulfides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guo, Zi-Qiong; Xu, Hui; Wang, Xing; Wang, Zhen-Yu; Ma, Biao; Dai, Hui-Xiong published the artcile< C3-Arylation of indoles with aryl ketones via C-C/C-H activations>, Application In Synthesis of 1428537-19-2, the main research area is arylindole preparation regioselective; indole aryl ketone arylation palladium catalyst carbon hydrogen activation.

C3-Arylation of indoles with aryl ketones is accomplished via palladium-catalyzed ligand-promoted Ar-C(O) cleavage and subsequent C-H arylation of indole. Various (hetero)aryl ketones are compatible in this reaction, affording the corresponding 3-arylindoles in moderate to good yields. Further introduction of an indole moiety into the natural products desoxyestrone and evodiamine demonstrate the synthetic utility of this protocol.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1428537-19-2 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Application In Synthesis of 1428537-19-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lin, Qiao; Fu, Yue; Liu, Peng; Diao, Tianning published the artcile< Monovalent Nickel-Mediated Radical Formation: A Concerted Halogen-Atom Dissociation Pathway Determined by Electroanalytical Studies>, HPLC of Formula: 366-18-7, the main research area is monovalent Nickel Mediated radical; concerted Halogen Atom dissociation pathway electroanal.

The recent success of nickel catalysts in stereoconvergent cross-coupling and cross-electrophile coupling reactions partly stems from the ability of monovalent nickel species to activate C(sp3) electrophiles and generate radical intermediates. This electroanal. study of the commonly applied (bpy)Ni catalyst elucidates the mechanism of this critical step. Data rule out outer-sphere electron transfer and two-electron oxidative addition pathways. The linear free energy relationship between rates and the bond-dissociation free energies, the electronic and steric effects of the nickel complexes and the electrophiles, and DFT calculations support a variant of the halogen-atom abstraction pathway, the inner-sphere electron transfer concerted with halogen-atom dissociation This mechanism accounts for the observed reactivity of different electrophiles in cross-coupling reactions and provides a mechanistic rationale for the chemoselectivity obtained in cross-electrophile coupling over homocoupling.

Journal of the American Chemical Society published new progress about Computational chemistry. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, HPLC of Formula: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Chih-Feng; Cheng, Zhihua; O’Callahan, Brian T.; Crampton, Kevin T.; Jones, Matthew R.; El-Khoury, Patrick Z. published the artcile< Tip-Enhanced Multipolar Raman Scattering>, Safety of 1-Hexadecylpyridin-1-ium chloride, the main research area is Tip Enhanced multipolar raman scattering; image thiobenzonitrile functionalized plasmonic gold nanocubes.

We record nanoscale chem. images of 4-thiobenzonitrile (TBN)-functionalized plasmonic gold nanocubes via tip-enhanced Raman spectroscopy (TERS). The spatially averaged optical response is dominated by conventional (dipolar) TERS scattering from TBN but also contains weaker spectral signatures in the 1225-1500 cm-1 region. The weak optical signatures dominate several of the recorded single-pixel TERS spectra. We can uniquely assign these Raman-forbidden transitions to multipolar Raman scattering, which implicates spatially varying enhanced elec. field gradients at plasmonic tip-sample nanojunctions. Specifically, we can assign observations of tip-enhanced elec. dipole-magnetic dipole as well as elec. dipole-elec. quadrupole driven transitions. Multipolar Raman scattering and local optical field gradients both need to be understood and accounted for in the interpretation of TERS spectral images, particularly in ongoing quests aimed at chem. reaction mapping via TERS.

Journal of Physical Chemistry Letters published new progress about Density functional theory (PBE). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Safety of 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Deping; Liu, Wenwu; Huang, Yaoguan; Liu, Mingyue; Tian, Caizhi; Lu, Hongyuan; Jia, Hui; Xu, Zihua; Ding, Huaiwei; Zhao, Qingchun published the artcile< Facile synthesis of C1-substituted β-carbolines as CDK4 inhibitors for the treatment of cancer>, Quality Control of 3731-53-1, the main research area is beta carboline preparation SAR antitumor human CDK4 inhibitor; CDK4; HCT116; Harmine; β-carboline.

Cyclin-dependent kinase 4 (CDK4), which is involved in dynamic regulation of cell cycle, has gained particularly attention for its role in controlling tumor growth. Increasing evidence showed that β-carboline derivatives have the potential to inhibit CDK4. Herein, on the basis of previous work, authors designed and synthesized a series of novel β-carbolines and evaluated their antitumor activity. Among them, compounds I and II, with the most potent anti-proliferative activity and CDK4 enzymic inhibition activity, were selected for further pharmacol. research in vitro and in vivo. The results in vitro showed that I and II exhibited potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. In vivo, I showed significant tumor growth inhibition in HCT116 tumor xenograft model without causing significant weight loss and toxicity consistent with the acute toxicity test. In addition, silico study showed I and II not only have good biol. actions, but also acceptable predicted ADME and physicochem. properties. Taken together, compounds I and II could be selected for further modification and preclin. evaluation.

Bioorganic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Quality Control of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem