Day: October 13, 2022

Kelly, Terence A.; McNeil, Daniel W.; Rose, Janice M.; David, Eva; Shih, Cheng-Kon; Grob, Peter M. published the artcile< Novel Non-Nucleoside Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase. 6. 2-Indol-3-yl- and 2-Azaindol-3-yldipyridodiazepinones>, Recommanded Product: 3-Bromo-1H-pyrrolo[3,2-c]pyridine, the main research area is indolyldipyridodiazepinone preparation HIV1 reverse transcriptase inhibitor; HIV1 reverse transcriptase inhibitor indolyldipyridodiazepinone structure.

Modification of the non-nucleoside inhibitor of HIV-1 reverse transcriptase nevirapine (Viramune) by incorporation of a 2-indolyl substituent confers activity against several mutant forms of the enzyme.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 23612-36-4 belongs to class pyridine-derivatives, and the molecular formula is C7H5BrN2, Recommanded Product: 3-Bromo-1H-pyrrolo[3,2-c]pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Handa, Sachin; Andersson, Martin P.; Gallou, Fabrice; Reilly, John; Lipshutz, Bruce H. published the artcile< HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-catalyzed Cross-Couplings in Water at Room Temperature>, HPLC of Formula: 13472-84-9, the main research area is monophosphine palladium catalyst coupling Suzuki Miyaura; E Factor; Suzuki-Miyaura coupling; green chemistry; ligand design; micellar catalysis.

The new monophosphine ligand HandaPhos was identified such that when complexed in a 1:1 ratio with Pd(OAc)2, enables Pd-catalyzed cross-couplings to be run using ≤1000 ppm of this pre-catalyst. Applications to Suzuki-Miyaura reactions involving highly functionalized reaction partners are demonstrated, all run using environmentally benign nanoreactors in water at ambient temperatures Comparisons with existing state-of-the-art ligands and catalysts are discussed herein.

Angewandte Chemie, International Edition published new progress about Cross-coupling reaction. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, HPLC of Formula: 13472-84-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Budweg, Svenja; Wei, Zhihong; Jiao, Haijun; Junge, Kathrin; Beller, Matthias published the artcile< Iron-PNP-Pincer-Catalyzed Transfer Dehydrogenation of Secondary Alcohols>, SDS of cas: 350-03-8, the main research area is iron PNP pincer catalyst transfer dehydrogenation secondary alc; ketone preparation mol modeling; homogeneous catalysis; iron; oxidation; pincer ligands; transfer dehydrogenation.

The well-defined iron PNP pincer complex catalyst [Fe(H)(BH4)(CO)(HN{CH2CH2P(iPr)2}2)] was used for the catalytic dehydrogenation of secondary alcs. to give the corresponding ketones. Using acetone as inexpensive hydrogen acceptor enables the oxidation with good to excellent yields. DFT computations indicate an outer-sphere mechanism and support the importance of an acceptor to achieve this transformation under milder conditions.

ChemSusChem published new progress about Dehydrogenation catalysts. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, SDS of cas: 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cadena, Myrna; Froenicke, Lutz; Britton, Monica; Settles, Matthew L.; Durbinjohnson, Blythe; Kumimoto, Emily; Gallardo, Rodrigo A.; Ferreiro, Aura; Chylkova, Tereza; Zhou, Huaijun; Pitesky, Maurice published the artcile< Transcriptome analysis of Salmonella heidelberg after exposure to cetylpyridinium chloride, acidified calcium hypochlorite, and peroxyacetic acid>, Formula: C21H38ClN, the main research area is transcriptome cetylpyridinium chloride calcium hypochlorite peroxyacetic acid Salmonella infection; Differential gene expression; Disinfectant; Poultry processing; RNA sequencing.

The application of RNA sequencing in com. poultry could facilitate a novel approach toward food safety with respect to identifying conditions in food production that mitigate transcription of genes associated with virulence and survivability. In this study, we evaluated the effects of disinfectant exposure on the transcriptomes of two field isolates of Salmonella Heidelberg (SH) isolated from a com. broiler processing plant in 1992 and 2014. The isolates were each exposed sep. to the following disinfectants commonly used in poultry processing: cetylpyridinium chloride (CPC), acidified calcium hypochlorite (aCH), and peroxyacetic acid (PAA). Exposure times were 8 s with CPC to simulate a poultry processing dipping station or 90 min with aCH and PAA to simulate the chiller tank in a poultry processing plant at 4°C. Based on comparison with a publicly available annotated SH reference genome with 5,088 genes, 90 genes were identified as associated with virulence, pathogenicity, and resistance (VPR). Of these 90 VPR genes, 9 (10.0%), 28 (31.1%), and 1 (1.1%) gene were upregulated in SH 2014 and 21 (23.3%), 26 (28.9%), and 2 (2.2%) genes were upregulated in SH 2014 challenged with CPC, aCH, and PAA, resp. This information and previously reported MICs for the three disinfectants with both SH isolates allow researchers to make more accurate recommendations regarding control methods of SH and public health considerations related to SH in food production facilities where SH has been isolated. For example, the MICs revealed that aCH is ineffective for SH inhibition at regulatory levels allowed for poultry processing and that aCH was ineffective for inhibiting SH growth and caused an upregulation of VPR genes.

Journal of Food Protection published new progress about Cell invasion. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Formula: C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lemaalem, M.; Ahfir, R.; Derouiche, A.; Filali, M. published the artcile< Static and dynamic properties of decane/water microemulsions stabilized by cetylpyridinium chloride cationic surfactant and octanol cosurfactant>, Electric Literature of 123-03-5, the main research area is decane water microemulsion stabilized cetylpyridinium chloride surfactant.

Mol. dynamics simulation (MD) is used to study the static and dynamic properties of pos. charged decane/water microemulsions, for various volume fractions φ (2.8%, 6.98%, 14%, and 26.5%). An effective hybrid potential combining three potentials, namely the hard-sphere repulsive potential, the van der Waals attractive potential, and the Yukawa repulsive potential, is used to describe the microemulsion interactions. The microemulsion shape is determined using the renormalized spectra in Porod representation. The appropriate potential parameters are tested using the Ornstein-Zernike integral equation approach with the Hypernetted Chain (HNC) closure relation by a comparison between the structure factor calculated from HNC and that obtained from Small Angle Neutron Scattering experiments (SANS). Thus, the micro arrangements of microemulsions have been analyzed using the pair correlation function g(r) and the structure factor S(q) obtained from HNC, SANS, and MD simulation using these parameters. The microemulsion dynamic properties were discussed using the mean-square displacement (MSD) and the diffusion coefficient Dc calculated from MD simulations.

RSC Advances published new progress about Biocompatible materials. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Electric Literature of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Klake, Raphael K.; Gargaro, Samantha L.; Gentry, Skyler L.; Elele, Sharon O.; Sieber, Joshua D. published the artcile< Development of a Strategy for Linear-Selective Cu-Catalyzed Reductive Coupling of Ketones and Allenes for the Synthesis of Chiral γ-Hydroxyaldehyde Equivalents>, HPLC of Formula: 350-03-8, the main research area is chirality hydroxyaldehyde linear preparation copper catalyst reductive coupling equivalent; ketone allene reductive coupling copper catalyst.

The authors report the development of a stereoselective method for the allylation of ketones using N-substituted allyl equivalent generated from a chiral allenamide. By choice of the appropriate ligand for the Cu-catalyst, high linear selectivity can be obtained with good diastereocontrol. This methodol. allows access to chiral γ-hydroxyaldehyde equivalent that were applied in the synthesis of chiral γ-lactones and 2,5-disubstitued tetrahydrofurans.

Organic Letters published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation) (γ-Hydroxyaldehyde). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, HPLC of Formula: 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sun, Manman; Wu, Haijian; Xia, Xiangyu; Chen, Weida; Wang, Zhiming; Yang, Jianguo published the artcile< Asymmetric Palladium-Catalyzed C-H Functionalization Cascade for Synthesis of Chiral 3,4-Dihydroisoquinolones>, Formula: C13H15F3N2O, the main research area is sulfonylbenzamide diene palladium bond activation enantioselective allylation cascade green; dihydroisoquinolone stereoselective preparation.

A palladium-catalyzed C-H functionalization/intramol. asym. allylation cascade of N-sulfonyl benzamides with 1,3-dienes has been developed. In the presence of a chiral pyridine-oxazoline ligand, this protocol enables the synthesis of chiral 3,4-dihydroisoquinolones, e.g., I, in yields of up to 83% with enantioselectivities of up to 96%, using environmentally friendly air as the terminal oxidant.

Journal of Organic Chemistry published new progress about 1,3-Alkadienes Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Formula: C13H15F3N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Echterhoff, Antje K. C.; Yogendra, Sivathmeehan; Koesters, Jutta; Fischer, Roland; Weigand, Jan J. published the artcile< A versatile protocol for the synthesis of pyrazolyl-substituted pyridinium and guanidinium salts from pyridone and urea derivatives>, HPLC of Formula: 73018-09-4, the main research area is pyridinium pyrazolyl guanidinium triflate preparation crystal structure; tripyridyl phosphite preparation crystal structure.

The trication I was used as a convenient pyrazolyl-transfer reactant to convert 2-pyridone, 4-pyridone and urea derivatives such as benzimidazol-2-one and theobromine to their pyrazolyl substituted triflate salts, e.g., II. The conversion represented a new, efficient and highly functional group-compatible approach that yielded the desired products conveniently and in high yields. Typically the reaction proceeded via exchange of carbonyl oxygen atom of the substrate for pyrazolyl moiety. However, for the structurally related 3-hydroxypyridines, a different reaction pathway occurred giving tripyridyl phosphites, e.g., III which was explained by the lactam-lactim tautomerism of the substrate. The structural arrangements of most of the products were confirmed by X-ray crystallog. anal.

European Journal of Organic Chemistry published new progress about Crystal structure. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, HPLC of Formula: 73018-09-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wythe, L. A.; Dittoe, D. K.; Feye, K. M.; Olson, E. G.; Perry, L. M.; Ricke, S. C. published the artcile< Reduction of Salmonella Infantis on skin-on, bone-in chicken thighs by cetylpyridinium chloride application and the impact on the skin microbiota>, Application of C21H38ClN, the main research area is cetylpyridinium chloride chicken thigh Salmonella infantis skin microbiota; 16S rDNA; Salmonella Infantis; cetylpyridinium chloride; peroxyacetic acid; poultry.

Salmonella Infantis has been the etiol. agent of numerous foodborne outbreaks of nontyphoidal Salmonella. Consequently, there is an emergent need to mitigate Salmonella Infantis among poultry. Thus, this study evaluated the efficacy of cetylpyridinium chloride (CPC) vs. peroxyacetic acid (PAA), on bone-in, skin-on chicken thighs for the reduction of Salmonella and changes in the microbiota. Exactly 100 skin-on, bone-in chicken thighs (2 trials, 0 and 24 h, k = 5, n = 5, N = 50) were inoculated with 108 CFU/mL of a nalidixic acid resistant strain of S. Infantis for an attachment of 106 CFU/g. Thighs were treated with 20 s part dips (350 mL): a no inoculum, no treatment control (NINTC); no treatment control (NTC); tap water (TW); TW+CPC; TW+PAA. Following treatment, thighs were rinsed in 150 mL of nBPW, and rinsates were collected. Rinsates were spot plated for Salmonella and aerobic bacteria (APC). Log10 transformed counts were analyzed using a mixed-effects model (random effect = trial) with means separated using Tukey’s HSD (P ≤ 0.05). The genomic DNA of rinsates was extracted, and the 16S rDNA was sequenced on an Illumina MiSeq. Microbiota data were analyzed using QIIME2, with data considered significant at P ≤0.05 (main effects) and Q≤0.05 (pairwise differences). Treatment x time interactions were observed for both Salmonella and APC (P < 0.05). The treatment of thighs with PAA and CPC reduced Salmonella and APC in respect to the controls. Numerically, thighs treated with CPC had less Salmonella (4.29 log10CFU/g) and less APC (4.56log10CFU/g) at 24 h than all other treatments (P > 0.05). Differences in diversity metrics were not consistently observed between treatments; however, in trial 2, the NTC treated thighs were different than those treated with CPC (P < 0.05; Q < 0.05). In both trials, ANCOM, the anal. of microbiome compositional profiles, revealed shifts at both the phylum and order levels with thighs being different in the relative abundances of Proteobacteria (P < 0.05). In conclusion, treatment of skin-on poultry parts with CPC may reduce the risk of foodborne outbreaks caused by Salmonella Infantis. Poultry Science published new progress about Acidobacteria. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Application of C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Jun; Xu, Guan-Cheng; Zhang, Yan-Ping; Luo, Hua-Ying; Li, Jin-Yao; Zhang, Li; Jia, Dian-Zeng published the artcile< Copper(II) complexes with 4-acyl pyrazolone derivatives and diimine coligands: synthesis, structural characterization, DNA binding and antitumor activity>, Product Details of C10H8N2, the main research area is antitumor agent copper dipyridyl pyrazolone salicylidene derived complex; crystal structure copper dipyridyl pyrazolone salicylidene derived complex preparation; electrochem redox potential copper dipyridyl pyrazolone salicylidene derived complex.

Three mixed-ligand Cu(II) complexes [Cu(L)(bpy)] (1), [Cu(L)(phen)] (2) and [Cu(L)(dpq)]·CHCl3 (3) have been synthesized and fully characterized, where H2L = N-(1-phenyl-3-methyl-4-(4-fluorobenzoyl)-5-pyrazolone)-2-salicylidene hydrazide, bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline and dpq = dipyrido[3,2-d:2′,3′-f]quinoxaline. Single crystal x-ray diffraction anal. revealed that complexes 1-3 have mononuclear structure and the Cu(II) ions are located in a five-coordinated distorted square pyramidal geometry. The interaction of the compounds with herring sperm DNA has been studied by absorption titration, ethidium bromide displacement experiments and electrochem. studies. All the compounds could interact intercalatively with DNA, and complex 3 shows the highest DNA binding ability, followed by 2, 1 and H2L. Complexes 1-3 exhibit excellent cytotoxicity against cervical cancer HeLa cells and human esophageal cancer Eca-109 cells. Complex 3 displays the best activity for both cancer cell lines, and the IC50 values are 4.37 ± 0.08 μM and 3.68 ± 0.14 μM for HeLa and Eca-109 cells, resp., which are ∼13 times lower than that of the com. antitumor drug cisplatin. Moreover, complex 3 dose-dependently induces Eca-109 cell apoptosis characterized by nuclear morphol. changes and increased Annexin V+ cells, suggesting that complex 3 inhibited the proliferation of Eca-109 cells by induction of apoptosis. In conclusion, the mixed-ligand complex 3 might be a potential antitumor drug.

New Journal of Chemistry published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Product Details of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem