Day: October 13, 2022

In 2016,Bremer, Paul T.; Xue, Song; Janda, Kim D. published 《Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain》.Chemical Communications (Cambridge, United Kingdom) published the findings.Recommanded Product: 29682-15-3 The information in the text is summarized as follows:

In developing small-mol. inhibitors of botulinum neurotoxin serotype A light chain (BoNT/A LC), substituted picolinic acids were identified. Extensive investigation into the SAR of the picolinic acid scaffold revealed 5-(1-butyl-4-chloro-1H-indol-2-yl)picolinic acid (I), which possessed low micromolar activity against BoNT/A. Kinetic and docking studies demonstrated binding of I to the β-exosite: a largely unexplored site on the LC that holds therapeutic relevance for botulism treatment. After reading the article, we found that the author used Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Recommanded Product: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Larpent, Patrick; Jouaiti, Abdelaziz; Kyritsakas, Nathalie; Hosseini, Mir Wais. COA of Formula: C7H5N. The article was titled 《Molecular tectonics: from a rigid achiral organic tecton to 3D chiral Co and Fe coordination networks》. The information in the text is summarized as follows:

An achiral organic tecton bearing four coordinating sites of the pyridyl type gives iso-structural 3D helical coordination polymers when combined with Co(SCN)2 and Fe(SCN)2 achiral neutral complexes. Their formation occurs during the self-assembly process in the solid state, which leads to crystals composed of homochiral coordination polymers. The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7COA of Formula: C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. COA of Formula: C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Expanding the repertoire of nitrilases with broad substrate specificity and high substrate tolerance for biocatalytic applications》 was written by Sunder, Avinash Vellore; Shah, Shikha; Rayavarapu, Pratima; Wangikar, Pramod P.. Computed Properties of C6H4N2 And the article was included in Process Biochemistry (Oxford, United Kingdom) in 2020. The article conveys some information:

Enzymic conversion of nitriles to carboxylic acids by nitrilases has gained significance in the green synthesis of several pharmaceutical precursors and fine chems. Although nitrilases from several sources have been characterized, there exists a scope for identifying broad spectrum nitrilases exhibiting higher substrate tolerance and better thermostability to develop industrially relevant biocatalytic processes. Through genome mining, we have identified nine novel nitrilase sequences from bacteria and evaluated their activity on a broad spectrum of 23 industrially relevant nitrile substrates. Nitrilases from Zobellia galactanivorans, Achromobacter insolitus and Cupriavidus necator were highly active on varying classes of nitriles and applied as whole cell biocatalysts in lab scale processes. Z. galactanivorans nitrilase could convert 4-cyanopyridine to achieve yields of 1.79 M isonicotinic acid within 3 h via fed-batch substrate addition The nitrilase from A. insolitus could hydrolyze 630 mM iminodiacetonitrile at a fast rate, effecting 86% conversion to iminodiacetic acid within 1 h. The arylaliph. nitrilase from C. necator catalyzed enantioselective hydrolysis of 740 mM mandelonitrile to (R)-mandelic acid in 4 h. Significantly high product yields suggest that these enzymes would be promising additions to the suite of nitrilases for upscale biocatalytic application. In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1Computed Properties of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Computed Properties of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Weixiang; Tang, Shuihua; Huang, Qiankuan; Zhang, Qian; Tang, Zhen; Yang, Shuang published their research in Journal of Materials Science: Materials in Electronics in 2021. The article was titled 《Highly effective Fe-N-C electrocatalysts toward oxygen reduction reaction originated from 2,6-diaminopyridine》.Quality Control of 2,6-Diaminopyridine The article contains the following contents:

Fe-N-C electrocatalysts have been intensively studied due to their extraordinary catalytic activity toward oxygen reduction reaction (ORR). Here we prepare a Fe-N-C electrocatalyst through cost-effective and nontoxic precursors of 2,6-diaminopyridine (DAP) and FeCl3, where iron ions react with DAP to formed Fe-Nx species first, followed by polymerization and pyrolysis. X-ray diffraction patterns display no obvious Fe2O3 peaks observed in the catalyst as the nominal content of iron addition is less than 10 wt%. XPS spectra indicate that the catalyst has rich pyridinic nitrogen, graphitic nitrogen and Fe-Nx species, which are considered as active sites for ORR. Therefore the catalyst demonstrates an excellent catalytic activity with an onset potential of about 0.96 V, half-wave potential of about 0.84 V, and a limiting c.d. of 5.8 mA cm-2, better than com. Pt/C catalyst in an alk. medium. Furthermore its stability is also much more excellent than that of Pt/C. This work provides a strategy to synthesize universal M-N-C catalysts.2,6-Diaminopyridine(cas: 141-86-6Quality Control of 2,6-Diaminopyridine) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Quality Control of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Meena, Priyanka; Ayushee; Patel, Monika; Verma, Akhilesh K. published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Transition-metal-free regioselective hydroamination of styrenes with amino-heteroarenes》.Safety of 6-Bromopyridin-3-amine The author mentioned the following in the article:

The base-mediated anti-Markovnikov hydroamination of functionally varied styrenes with amino-substituted pyridines, quinoline, pyrimidine, pyrazine with excellent regioselectivity to afford arylalkyl nitrogen heterocycles I [R1 = H, 4-Me, 6-Me, 4-CF3, etc; R2 = H, 4-Me, 4-Cl, etc.] and II [R3 = Ph, 4-MeC6H4, 1-naphthyl, 4-tBuC6H4; X = N; Y = N] was described. Double hydroamination was observed chemoselectively on the secondary amine, leaving the primary amine intact. The results came from multiple reactions, including the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Safety of 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Safety of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Al-Sayed, Emir; Tanuhadi, Elias; Giester, Gerald; Rompel, Annette published an article in Acta Crystallographica, Section C: Structural Chemistry. The title of the article was 《Synthesis and characterization of the ′Japanese rice-ball′-shaped Molybdenum Blue Na4-[Mo2O2(OH)4(C6H4NO2)2]2[Mo120Ce6O366H12(OH)2(H2O)76]-200H2O》.Recommanded Product: 98-98-6 The author mentioned the following in the article:

The hybridized lanthanide-containing molybdenum blue (Ln-MB) wheel Na4[Mo2O2(OH)4(C6H4NO2)2]2[Mo120Ce6O366H12(OH)2(H2O)76]∼200H2O ({Mo2(C6H4NO2)2}2{Mo120Ce6}) was assembled in an aqueous one-pot synthesis. The Ln-MB was hybridized with 2-picolinic acid through the generation of the organometallic counter-ion [Mo2O2(OH)4(C6H4NO2)2]2+. Control experiments demonstrated that the position of the carboxylic acid group (2-position to the N atom) in the hybridization component is critical in yielding single crystals of Ln-MB. In addition to single-crystal X-ray diffraction (XRD) anal., which revealed a ′Japanese rice-ball′-shaped Ln-MB as the anion, elemental analyses, IR spectroscopy, and thermogravimetric anal. (TGA) were performed to confirm its structure and composition Bond-valence-sum calculations (BVS) revealed that ({Mo2(C6H4NO2)2}2{Mo120Ce6}) is composed of a 24-electron reduced anionic ring, which was confirmed by Vis-NIR spectroscopy. The results came from multiple reactions, including the reaction of Picolinic acid(cas: 98-98-6Recommanded Product: 98-98-6)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Recommanded Product: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《High-turnover visible-light photoreduction of CO2 by a Re(I) complex stabilized on dye-sensitized TiO2》 were Ha, Eun-Gyeong; Chang, Jeong-Ah; Byun, Sung-Min; Pac, Chyongjin; Jang, Dong-Myung; Park, Jeunghee; Kang, Sang Ook. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2014. Name: 4,4′-Bis(chloromethyl)-2,2′-bipyridine The author mentioned the following in the article:

Hybrid systems prepared by fixing a Re(I) complex and a dye on three types of TiO2 nanoparticles in two different ways commonly revealed persistent photocatalysis of the CO2 reduction to CO with no leveling-off tendency under visible-light irradiation in DMF, giving a turnover number of ≥435. The experimental process involved the reaction of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Name: 4,4′-Bis(chloromethyl)-2,2′-bipyridine)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Name: 4,4′-Bis(chloromethyl)-2,2′-bipyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Colak, Alper Tolga; Gunay, Handan; Temel, Ersin; Buyukgungor, Orhan; Colak, Ferdag published 《Synthesis, crystal structures, characterization and antimicrobial activities of 5-hydroxyisophthalate complexes》.Transition Metal Chemistry (Dordrecht, Netherlands) published the findings.Quality Control of 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:

Two 5-hydroxyisophthalate complexes of nickel(II), formulated as [Ni(μ-Hhip)(2-hepy)2]n (1) and [Ni2(μ-Hhip)2(dap)4]n (2) (H3hip = 5-hydroxyisophthalic acid, 2-hepy = 2-(2-hydroxyethyl)pyridine, dap = 1,3-diaminopropane), have been synthesized and characterized by chem. and spectroscopic methods. The mol. structures of the complexes have been determined by single-crystal x-ray diffraction anal. The Ni(II) centers have distorted octahedral geometries in both crystals. Furthermore, both complexes have 1D chain structures in which the individual chains are linked together via hydrogen bonds to give 3D frameworks. Evaluation of the complexes by the agar diffusion method showed that they have weak antibiotic activities against the tested microorganisms. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Quality Control of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Quality Control of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Gibson, Maya Z.; Nguyen, Minh A.; Zingales, Sarah K. published 《Design, Synthesis, and Evaluation of (2-(Pyridinyl)methylene)-1-tetralone Chalcones for Anticancer and Antimicrobial Activity》.Medicinal Chemistry (Sharjah, United Arab Emirates) published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

Background: Chalcones, natural products produced by plants as a natural defense mechanisms against various pathogens, are mols. with structures that include two aromatic rings joined by an α, β unsaturated carbonyl system. Previous research has demonstrated that chalcones exhibit a wide variety of biol. activities, including anticancer, antifungal, and antibiotic properties. Objective: Our goal is to synthesize novel heterocyclic-containing chalcones and have their biol. activities evaluated. Methods Sixteen chalcones were synthesized by the crossed aldol condensation of substituted tetralones with substituted pyridinylaldehydes. The products were purified by recrystallization in MeOH/H2O and characterized by 1H NMR, 13C NMR, and HRMS. Anticancer assays were performed by NCI (National Cancer Institute) against the NCI-60 panel of 60 different human cancer cell lines, including leukemia, non-small-cell lung cancer, colon, central nervous system, melanoma, ovarian, renal, prostate, and breast cancer. Antimicrobial assays were performed by COADD (Community for Open Antimicrobial Drug Discovery) against Escherichia coli, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus, Cryptococcus neoformans var. grubii, and Candida albicans. Result: Chalcone 3d had demonstrated growth inhibition greater than 60% against a variety of cancers: leukemia (MOLT-4, SR), non-small cell lung cancer (NCI-H522), colon cancer (HCT- 116), prostate cancer (DU-145), and breast cancer (MCF7, MDA-MB-468) and was also cytotoxic to three different cell lines (CCRF-CEM, RPMI-8226, and KM12). 5c was active against leukemia (CCRF-CEM, RPMI-8226, SR) and breast cancer (MCF7) and 5e was active only against leukemia (RPMI-8226, SR). 5h was partially active and the best compound with growth inhibition of MRSA by 75%. 3b was the best compound against EC, KP, and PA and 3f had the greatest activity against AB. For fungi, 3f and 3e demonstrated the best growth inhibition. Conclusion: A small library of heterocyclic-containing chalcones was developed and initial screening demonstrates modest activity against cancers, bacteria, and fungi. In the experiment, the researchers used many compounds, for example, 2-Bromonicotinaldehyde(cas: 128071-75-0Category: pyridine-derivatives)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Enzyme Inhibition and Medicinal Chemistry included an article by Elie, Jonathan; Vercouillie, Johnny; Arlicot, Nicolas; Lemaire, Lucas; Bidault, Rudy; Bodard, Sylvie; Hosselet, Christel; Deloye, Jean-Bernard; Chalon, Sylvie; Emond, Patrick; Guilloteau, Denis; Buron, Frederic; Routier, Sylvain. Related Products of 128071-75-0. The article was titled 《Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [18F] PET tracer》. The information in the text is summarized as follows:

A series of novel derivatives exhibiting high affinity and selectivity towards the COX-2 enzyme in the (aza) indazole series was developed. A short synthetic route involving a bromination/arylation sequence under microwave irradiation and direct C-H activation were established in the indazole and azaindazole series resp. In vitro assays were conducted and structural modifications were carried out on these scaffolds to furnish compound which exhibited effective COX-2 inhibitory activity, with IC50 values of 0.409 μM and an excellent selectivity vs. COX-1. Radiolabeling of this most potent derivative [18F] was achieved after boron ester release and the tracer was evaluated in vivo in a rat model of neuroinflammation. All chem., radiochem. and biol. exptl. data are discussed. The experimental part of the paper was very detailed, including the reaction process of 2-Bromonicotinaldehyde(cas: 128071-75-0Related Products of 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Related Products of 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem