Day: October 13, 2022

《Rapid development of a bromochloropyridine regioisomer purity method enabled by strategic LC screening》 was published in Journal of Pharmaceutical and Biomedical Analysis in 2020. These research results belong to Borges-Munoz, Amaris; Li, Li; Tattersall, Peter. Product Details of 53939-30-3 The article mentions the following:

With the intent to provide aligned, impactful, and efficient strategies for liquid chromatog. method development, tier-based stationary/mobile phase screening workflows have been implemented in the Chem. Process Development department at Bristol Myers Squibb. These workflows are utilized as tools that enable more rapid method generation for early to mid-stage clin. development programs. An illustrative example of applying this approach was the method development for 3-bromo-2-chloropyridine and six of its positional isomeric impurities. Several parameters (gradient time, flow rate, column geometry, particle size, temperature, and solvent effects) were evaluated to achieve a baseline resolved separation for this challenging mixture The impact that the screening workflows have regarding timesavings, effort, and resourcing to develop and optimize this LC method will be discussed. In the experiment, the researchers used 5-Bromo-2-chloropyridine(cas: 53939-30-3Product Details of 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Product Details of 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Ryan, Christopher A.; Baskevics, Vladislavs; Katkevics, Martins; Rozners, Eriks published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《2-Guanidyl pyridine PNA nucleobase for triple-helical Hoogsteen recognition of cytosine in double-stranded RNA》.Related Products of 141-86-6 The author mentioned the following in the article:

In triplex-forming peptide nucleic acid, a novel 2-guanidyl pyridine nucleobase (V) enables recognition of up to two cytosine interruptions in polypurine tracts of dsRNA by engaging the entire Hoogsteen face of C-G base pair. Ab initio and mol. dynamics simulations provided insights into H-bonding interactions that stabilized V·C-G triplets. Our results provided insights for future design of improved nucleobases, which is an important step towards the ultimate goal of recognition of any sequence of dsRNA. In the experiment, the researchers used many compounds, for example, 2,6-Diaminopyridine(cas: 141-86-6Related Products of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Related Products of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 4,4′-Dimethyl-2,2′-bipyridineIn 2020 ,《Identification of descriptors for structure-activity relationship in ruthenium (II) mixed compounds with antiparasitic activity》 appeared in European Journal of Medicinal Chemistry. The author of the article were Cedillo-Gutierrez, Erika Lorena; Hernandez-Ayala, Luis Felipe; Torres-Gutierrez, Carolina; Reina, Miguel; Flores-Alamo, Marcos; Carrero, Julio C.; Ugalde-Saldivar, Victor M.; Ruiz-Azuara, Lena. The article conveys some information:

Herein is presented the synthesis, characterization, electrochem. studies, DFT calculations and in vitro evaluation of amoebicidal activity in trophozoites of Entamoeba histolytica of twenty ruthenium(II) mixed compounds with general formulas: [Ru(pdto)(E-E)]Clx (E-E bidentate, either neutral or neg. charged ligands). For compounds under study, O-O, N-O and N-N auxiliary donor ligands demonstrate to have a crucial impact on the electronic properties and that it is possible to modulate the antiparasitic activity. Among analyzed complexes, only four present a better performance compared to typically used metronidazole drug (IC50 < 6.80μmol/L) to treat amebiasis disease. For studied compounds, structure-activity relations are strongly determined by either the redox potential (E1/2) of RuII/RuIII and calculated molar volume (V) of the complexes. The experimental part of the paper was very detailed, including the reaction process of 4,4'-Dimethyl-2,2'-bipyridine(cas: 1134-35-6Quality Control of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Quality Control of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Boiledieu, William; De Abreu, Maxime; Cuyamendous, Claire; Lamaa, Diana; Belmont, Philippe; Brachet, Etienne published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Photoredox synthesis of 6- and 7-membered ring scaffolds via N-centered radicals》.Electric Literature of C6H4BrNO The author mentioned the following in the article:

N-Containing heterocycles are important scaffolds due to their ubiquitous presence in bioactive compounds Their synthesis has been considered as an important research field. In this work authors report the access to 6- and 7-membered rings via a photoinduced strategy. To authors knowledge, this work represents the first example of photo-induced 7-endo-trig cyclization with N-centered radicals. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Electric Literature of C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Electric Literature of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《H3PW12O40: an efficient and green catalyst for the facile and selective oxidation of sulfides to sulfoxides, applied to the last step of the synthesis of omeprazole》 was published in Iranian Journal of Chemistry & Chemical Engineering in 2017. These research results belong to Esfandyari, Maryam; Heravi, Majid; Oskooie, Hossein; Fotouhi, Lida; Tajbakhsh, Mahmood; Bamoharram, Fatemeh. Name: 2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine The article mentions the following:

Omeprazole, (6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole) is a well-established prescribed drug, exhibits proton pump inhibitor activity. In this work, a novel, facile, economical and selective oxidation approach using H3PW12O40 as Keggin type heteropolyacids along with H2O2 in the last step of the conventional synthesis of this compound as well as its derivatives under environmental-benign conditions, is reported. This protocol can be well adopted for pilot plant scale giving a high pure pharmacopeia grade material. Our synthetic route involves the use of various heteropolyacids as heterogeneous catalysts. Due to the obtained results, it was concluded that Keggin type heteropolyacid , is an effective catalyst for this purpose. The optimized condition for the last step of this synthesis was applied to the synthesis of lansoprazole, pantoprazole, and rabeprazole. The experimental part of the paper was very detailed, including the reaction process of 2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine(cas: 153476-68-7Name: 2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine)

2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine(cas: 153476-68-7) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Name: 2-(Chloromethyl)-3,5-dimethyl-4-nitropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 138219-98-4On November 25, 2013 ,《Structure-Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators》 appeared in Journal of Chemical Information and Modeling. The author of the article were Chalikiopoulos, Alexander; Thiele, Stefanie; Malmgaard-Clausen, Mikkel; Rydberg, Patrik; Isberg, Vignir; Ulven, Trond; Frimurer, Thomas M.; Rosenkilde, Mette M.; Gloriam, David E.. The article conveys some information:

Chemokine receptors are involved in trafficking of leukocytes and represent targets for autoimmune conditions, inflammatory diseases, viral infections, and cancer. We recently published CCR1, CCR8, and CCR5 agonists and pos. modulators based on a three metal-ion chelator series: 2,2′-bipyridine, 1,10-phenanthroline, and 2,2′;6′,2”-terpyridine. Here, we have performed an in-depth structure-activity relationship study and tested eight new optimized analogs. Using d. functional theory calculations we demonstrate that the chelator zinc affinities depend on how electron-donating and -withdrawing substituents modulate the partial charges of chelating nitrogens. The zinc affinity was found to constitute the major factor for receptor potency, although the activity of some chelators deviate suggesting favorable or unfavorable interactions. Hydrophobic and halogen substituents are generally better accommodated in the receptors than polar groups. The new analog brominated terpyridine (29) resulted in the highest chelator potencies observed so far CCR1 (EC50: 0.49 μM) and CCR8 (EC50: 0.28 μM). Furthermore, we identified the first selective CCR5 agonist chelator, meta dithiomethylated bipyridine (23). The structure-activity relationships contribute to small-mol. drug development, and the novel chelators constitute valuable tools for studies of structural mechanisms for chemokine receptor activation. The results came from multiple reactions, including the reaction of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4HPLC of Formula: 138219-98-4)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. HPLC of Formula: 138219-98-4 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Fang, Xiangqing; Xu, Jiajia; Qi, Wu; Yang, Liguo; Ya, Li published 《Crystal structure of catena-poly[(μ2-dicyanamido-κ2N:N’)-(μ2-2-(pyridin-2-yl)ethan-1-olato-κ3N,O:O’)copper(II)], C9H8CuN4O》.Zeitschrift fuer Kristallographie – New Crystal Structures published the findings.Formula: C7H9NO The information in the text is summarized as follows:

C9H8CuN4O, triclinic, P1̅ (number 2), a = 7.6740(6) Å, b = 8.6401(8) Å, c = 8.8869(9) Å, α = 109.201(2)°, β = 106.629(1)°, γ = 105.410(1)°, V = 489.21(8) Å3, Z = 2, Rgt(F) = 0.0406, wRref(F2) = 0.0993, T = 298(2) K. After reading the article, we found that the author used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Ragupathi, Ayyakkannu; Sagadevan, Arunachalam; Charpe, Vaibhav Pramod; Lin, Chun-Cheng; Hwu, Jih-Ru; Hwang, Kuo Chu. Reference of 4-Ethynylpyridine. The article was titled 《Visible-light-driven copper-catalyzed aerobic oxidative cascade cyclization of N-tosylhydrazones and terminal alkynes: regioselective synthesis of 3-arylcoumarins》. The information in the text is summarized as follows:

Regioselective green synthesis of 3-arylcoumarins I [R1 = H, 6-Me, 6-Br, etc.; R2 = H, 3-MeOC6H4, 4-Py, etc.; R3 = H, Me, Ph] as sustainable process was carried out via visible-light-driven copper catalyzed aerobic oxidative cascade cyclization of N-tosylhydrazones with terminal alkynes. This operationally simple methodol. was successfully proceeded well to afford biol. active compounds, such as monoamine oxidase B inhibitor I [R1 = 6-Me; R2 = 3-MeOC6H4; R3 = H] and horseradish peroxidase inhibitor I [R1 = 6-OH; R2 = 2-HOC6H4; R3 = H] in satisfactory yields under mild conditions. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Reference of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Reference of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Sanchez, Monica L. K.; Wu, Chang-Hao; Adams, Michael W. W.; Dyer, R. Brian. Reference of 4,4′-Dimethyl-2,2′-bipyridine. The article was titled 《Optimizing electron transfer from CdSe QDs to hydrogenase for photocatalytic H2 production》. The information in the text is summarized as follows:

A series of viologen related redox mediators of varying reduction potential has been characterized and their utility as electron shuttles between CdSe quantum dots and hydrogenase enzyme has been demonstrated. Tuning the mediator LUMO energy optimizes the performance of this hybrid photocatalytic system by balancing electron transfer rates of the shuttle. In the experimental materials used by the author, we found 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Reference of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Reference of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Superstructural diversity in salt-cocrystals: higher-order hydrogen-bonded assemblies formed using U-shaped dications and with assistance of π–π stacking》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Yelgaonkar, Shweta P.; Kiani, Daniyal; Baltrusaitis, Jonas; MacGillivray, Leonard R.. COA of Formula: C7H5N The article mentions the following:

Salt cocrystals with components that assemble by hydrogen bonds and aromatic anion-mol. stacks (π–π stacks) are reported. U-shaped bipyridines and an isocoumarin carboxylic acid self-assemble to form 5-, 6-, and 10-component aggregates with components in double and quadruple face-to-face stacks. DFT calculations support the π–π stacks to help stabilize the salt cocrystals. The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7COA of Formula: C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.COA of Formula: C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem