Day: October 13, 2022

Margonis, Caroline M.; Ho, Marissa; Travis, Benjamin D.; Brennessel, William W.; McNamara, William R. published an article in 2021. The article was titled 《Iron polypyridyl complex adsorbed on carbon surfaces for hydrogen generation》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Product Details of 1539-42-0 The information in the text is summarized as follows:

A series of homogeneous Fe(III) complexes were recently reported that are active for electrocatalytic hydrogen generation. Herein we report a naphthalene-terminated Fe(III) complex for use in the functionalization of glassy carbon surfaces for electrocatalytic hydrogen generation with retention of catalytic activity. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Product Details of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Product Details of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C5H6BNO2In 2020 ,《Synthesis and characterization of high affinity fluorogenic α-synuclein probes》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Lengyel-Zhand, Zsofia; Ferrie, John J.; Janssen, Bieneke; Hsieh, Chia-Ju; Graham, Thomas; Xu, Kui-ying; Haney, Conor M.; Lee, Virginia M.-Y.; Trojanowski, John Q.; Petersson, E. James; Mach, Robert H.. The article contains the following contents:

Fluorescent small mols. are powerful tools for imaging α-synuclein pathol. in vitro and in vivo. In this work, we explore benzofuranone as a potential scaffold for the design of fluorescent α-synuclein probes. These compounds have high affinity for α-synuclein, show fluorescent turn-on upon binding to fibrils, and display different binding to Lewy bodies, Lewy neurites and glial cytoplasmic inclusion pathologies in post-mortem brain tissue. These studies not only reveal the potential of benzofuranone compounds as α-synuclein specific fluorescent probes, but also have implications for the ways in which α-synucleinopathies are conformationally different and display distinct small mol. binding sites. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Synthetic Route of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Synthetic Route of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis, characterization and introduction of a new ion-coordinating ruthenium sensitizer dye in quasi-solid state TiO2 solar cells》 was published in Journal of Photochemistry and Photobiology, A: Chemistry in 2011. These research results belong to White, Ryan C.; Benedetti, Joao E.; Goncalves, Agnaldo D.; Romao, Wanderson; Vaz, Boniek G.; Eberlin, Marcos N.; Correia, Carlos R. D.; De Paoli, Marco A.; Nogueira, Ana F.. Application of 138219-98-4 The article mentions the following:

A new ion-coordinating heteroleptic ruthenium(II) dye was synthesized by attaching two crown ether moieties in the 4,4′ positions of one of the bipyridine ligands. This new dye (named as RC730) was characterized by UV-Vis spectroscopy, CHN elemental anal., NMR and electrospray ionization Fourier transform-ion cyclotron resonance mass spectrometry (ESI FT-ICR MS). In order to investigate the properties of these ion-coordinating species, dye-sensitized solar cells were assembled with a gel polymer electrolyte based on two different cations: lithium and sodium. The devices were characterized by J-V curves under 100 mW cm-2, incident photon to current conversion efficiency spectra (IPCE) and photovoltage decay transients under open-circuit conditions. The solar cells based on the new heteroleptic dye provided higher photocurrent and photovoltage when lithium was used in the electrolyte instead of sodium cations, reaching overall conversion efficiencies up to 2%. This behavior might be related to the ability of the ion-coordinating RC730 dye to trap Li ions, minimizing the conduction band edge shift. When the polymer electrolyte based on lithium is used, the IPCE spectra show a maximum efficiency of 31% at the maximum absorption peak of the RC730 dye (ca. 530 nm). After reading the article, we found that the author used 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Application of 138219-98-4)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Application of 138219-98-4 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Satpathi, Bishnupada; Wagulde, Siddhant V.; Ramasastry, S. S. V. published 《An enantioselective organocatalytic intramolecular Morita-Baylis-Hillman (IMBH) reaction of dienones, and elaboration of the IMBH adducts to fluorenones》.Chemical Communications (Cambridge, United Kingdom) published the findings.Recommanded Product: 128071-75-0 The information in the text is summarized as follows:

An enantioselective organocatalytic intramol. Morita-Baylis-Hillman (IMBH) reaction of dienones is reported for the first time. This has been achieved by incorporating entropy and synergy considerations during the substrate design. The reaction conditions are thoroughly verified for an efficient synthesis of highly functionalized cyclopenta-fused arenes and heteroarenes in excellent yields and enantioselectivities. The synthetic utility of the IMBH-adducts has been demonstrated by transforming them into 3,4-disubstituted fluorenones in a serendipitous manner. In the experiment, the researchers used 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Fluoroalkyl sulfides as photoredox-active coupling reagents for alkene difunctionalization》 was written by Kosobokov, Mikhail D.; Zubkov, Mikhail O.; Levin, Vitalij V.; Kokorekin, Vladimir A.; Dilman, Alexander D.. Electric Literature of C33H24IrN3 And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

A visible-light-promoted fluoroalkylation-thiolation of alkenes is described. A 4-tetrafluoropyridinylthio fragment serves as a photoredox-active group in the initiation step and undergoes a radical group transfer, which is important for the reaction efficiency. In the primary products, the pyridinylthio substituent may be further functionalized via radical processes or an aromatic substitution reaction. The experimental process involved the reaction of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Electric Literature of C33H24IrN3)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C33H24IrN3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Zheng; Xu, Yanqi; Xu, Huandi; Cui, Mengyuan; Liu, Tianguang; Ren, Xiangyu; Sun, Jianfei; Deng, Dawei; Gu, Yueqing; Wang, Peng published their research in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2021. The article was titled 《A dicyanomethylene-4H-pyran-based fluorescence probe with high selectivity and sensitivity for detecting copper (II) and its bioimaging in living cells and tissue》.Computed Properties of C6H5NO2 The article contains the following contents:

Copper (Cu) plays a significant role in the process of oxygenic photosynthesis in living systems. The detection of copper ion (Cu2+) is valuable and meaningful for further studying the functions of Cu2+ under physiol. and pathol. conditions. A novel fluorescence probe DCM-Cu (I) based on the near-IR (NIR) fluorophore dicyanomethylene-4H-pyran (DCM) was designed for Cu2+ detection. The probe DCM-Cu possessed characteristic of “”turn-on”” fluorescent signal in the presence of Cu2+ through the enhanced ICT process. It exhibited satisfactory sensitivity and selectivity toward Cu2+. A good linear correlation was observed between the concentrations of Cu2+ and the fluorescence intensities at 700 nm. The detection limit (LOD) of DCM-Cu toward Cu2+ is 2.54 × 10-8 M. Importantly, DCM-Cu was successfully applied in the detection of Cu2+ in living MCF-7 cells and tumor tissue with low cytotoxicity. Therefore, this probe would have the potential to monitor cellular Cu2+ in the living system and be applied to the diagnosis of related diseases. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Computed Properties of C6H5NO2) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Computed Properties of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens》 was written by Koh, Cho Yeow; Kallur Siddaramaiah, Latha; Ranade, Ranae M.; Nguyen, Jasmine; Jian, Tengyue; Zhang, Zhongsheng; Gillespie, J. Robert; Buckner, Frederick S.; Verlinde, Christophe L. M. J.; Fan, Erkang; Hol, Wim G. J.. Category: pyridine-derivativesThis research focused onTrypanosoma histidyl tRNA synthetase crystal structure inhibitor Chagas antiparasitics; fragment-based crystallographic cocktail screening; inhibitor of histidyl-tRNA synthetase; reactive fragment; structure-guided drug discovery; trypanosomiasis. The article conveys some information:

American trypanosomiasis, commonly known as Chagas disease, is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. The chronic form of the infection often causes debilitating morbidity and mortality. However, the current treatment for the disease is typically inadequate owing to drug toxicity and poor efficacy, necessitating a continual effort to discover and develop new antiparasitic therapeutic agents. The structure of T. cruzi histidyl-tRNA synthetase (HisRS), a validated drug target, has previously been reported. Based on this structure and those of human cytosolic HisRS, opportunities for the development of specific inhibitors were identified. Here, efforts are reported to identify small mols. that bind to T. cruzi HisRS through fragment-based crystallog. screening in order to arrive at chem. starting points for the development of specific inhibitors. T. cruzi HisRS was soaked into 68 different cocktails from the Medical Structural Genomics of Pathogenic Protozoa (MSGPP) fragment library and diffraction data were collected to identify bound fragments after soaking. A total of 15 fragments were identified, all bound to the same site on the protein, revealing a fragment-binding hotspot adjacent to the ATP-binding pocket. On the basis of the initial hits, the design of reactive fragments targeting the hotspot which would be simultaneously covalently linked to a cysteine residue present only in trypanosomatid HisRS was initiated. Inhibition of T. cruzi HisRS was observed with the resultant reactive fragments and the anticipated binding mode was confirmed crystallog. These results form a platform for the development of future generations of selective inhibitors for trypanosomatid HisRS.6-Bromopyridin-3-amine(cas: 13534-97-9Category: pyridine-derivatives) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Zirconium bistriazolylpyridine phosphonate materials for efficient, selective An(III)/Ln(III) separations》 was written by Veliscek-Carolan, Jessica; Rawal, Aditya. Electric Literature of C5H3Br2NThis research focused onzirconium triazolylpyridinephosphonate complex preparation porosity adsorption surface structure. The article conveys some information:

Direct synthesis of ZrCl4 and bistriazolylpyridine phosphonate has produced novel sorbent materials that, for the first time, demonstrate selective extraction of Am(III) in the presence of excess Eu(III). Further, the high ligand content of these materials affords them high extraction efficiencies. In the part of experimental materials, we found many familiar compounds, such as 2,6-Dibromopyridine(cas: 626-05-1Electric Literature of C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Electric Literature of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridineOn November 20, 2021 ,《Coordination-driven self-assembly of nanoZnO hybrids with tripodal zinc terpyridyl-viologen complex multilayers and their photochromic properties》 appeared in Colloids and Surfaces, A: Physicochemical and Engineering Aspects. The author of the article were Xian, Yu; Ma, Dong-Mei; Liu, Jian-Hong; Qian, Dong-Jin. The article conveys some information:

Viologen (VIO) functionalized nanomaterials and supramol. systems have attracted much attention because of their well reversible redox properties, unique photo-/electrochromic and radical-rich features that resulting in potential applications in the fields of coloration and memory devices, energy conversion and biomimetic chem. Here, a tripodal terpyridyl-viologen (TPyVIO) multidentate ligand was newly synthesized, which was then used as a linker, together with Zn2+ ion as a connector, to construct Zn-TPyVIO multilayers on the surfaces of nanoZnO particles to produce nanoZnO@(Zn-TPyVIO)n hybrids by a layer-by-layer (LBL) technique. Luminescent emission of nanoZnO semiconductors was largely quenched in the nanoZnO@(Zn-TPyVIO)n hybrids, attributed to a quick electron transfer from the conduction band of excited nanoZnO particles to viologens; this electron transfer process resulted in the formation of colored monovalent viologen radical cations. Reversible redox couple was recorded for the glass carbon electrode modified by the nanohybrids, with the cationic and anionic potentials at approx. – 0.78– 0.84 and – 0.63–0.73 mV (vs Hg/Hg2Cl2), resp. Finally, it was revealed that the nanoZnO@(Zn-TPyVIO)n hybrids displayed well photochromic behaviors under light radiation. The experimental part of the paper was very detailed, including the reaction process of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Application In Synthesis of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Application In Synthesis of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Study Protocol for a Randomized Controlled Trial Evaluating the Effectof Chromium Picolinate Supplementation on Gene Expression of TumorNecrosis Factor-α and DNA Damage in Metabolic Syndrome Patients.》 was written by Mozaffari-Khosravi, Hassan; Jambarsan, Sara; Karimpour, Fazad; Hosseini, Seyyed Ebrahim; Kour, Behrooz Ebrahimzadeh. Application In Synthesis of Picolinic acid And the article was included in Saudi journal of kidney diseases and transplantation in 2021. The article conveys some information:

Metabolic syndrome (MS) is caused by environmental factors as well as genetic. Human studies of efficacy of chromium for glucose and lipid metabolism and insulin function is not still definitive. Furthermore, the effect of chromium supplementation on the expression of inflammatory genes in patients with MS has not been studied. We will assess effects of chromium picolinate supplementation on gene expression of tumor necrosis factor-α (TNF-α) and DNA damage in MS patients. In this triple-blind randomized placebo-controlled clinical trial, 48 MS patients will be randomly assigned into two groups to receive daily 400 μg chromium picolinate supplement or placebo for 12 weeks. The outcome measures include of change in fasting blood sugar, glycosylated hemoglobin A1C, inflammatory biomarkers, lipid profile, blood pressure, gene expression of TNF-α, and 8-hydroxy-deoxyguanosine concentration as DNA damage biomarker, will be quantified at baseline and end of intervention. This protocol was approved by Institutional Research Ethics Committee School of Public Health Shahid Sadoughi University of Medical Sciences (Approval ID: IR.SSU.SPH.REC.1399.141). In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Application In Synthesis of Picolinic acid) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Application In Synthesis of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem