Day: October 13, 2022

Bairagi, Pallab Kumar; Goyal, Arpit; Verma, Nishith published the artcile< Methyl nicotinate biomarker of tuberculosis voltammetrically detected on cobalt nanoparticle-dispersed reduced graphene oxide-based carbon film in blood>, Quality Control of 93-60-7, the main research area is methyl nicotinate biomarker graphene oxide carbon cobalt nanoparticle tuberculosis.

Me nicotinate (MN), a metabolite of Mycobacterium tuberculosis, is an important biomarker of tuberculosis (TB). An effective measurement of MN can provide an early detection of TB, before it becomes life threatening. In this study, a cobalt (Co) and reduced graphene oxide (rGO) dispersed N-doped phenolic polymer precursor-based carbon film is used as the biosensor electrode to detect and measure MN in human blood for the first time. The Co nanoparticles are successfully used as the nonbiol. recognition element of MN. Doping of the carbon film with N-heteroatom using melamine increases the film electro-conductivity Using differential pulse voltammetry, the sensor electrode exhibits excellent linearity (0.9925) over 0.05-14 mg L-1MN concentrations (S/N ratio = 3), with high sensitivity (1735.2μA mM-1 cm-2) and low detection limit (0.0004 mM). The sensor also shows good selectivity and high recovery for MN. Most importantly, the sensor successfully confirms its clin. applicability when tested in the synthetic clin. MN solutions (RSD < 6.5%). The method and materials developed in this study have paved a new platform for developing similar biosensors using non-biol. components for chronic diseases such as typhoid and kidney-dysfunction. Sensors and Actuators, B: Chemical published new progress about Blood. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Quality Control of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pramanik, Bapan; Das, Saurav; Das, Debapratim published the artcile< Aggregation-directed High Fidelity Sensing of Picric Acid by a Perylenediimide-based Luminogen>, Related Products of 3731-53-1, the main research area is aggregation directed fluorescent sensor picric acid perylenediimide luminogen; aggregation caused quenching; chemosensor; explosive sensor; perylenediimide; picric acid.

Widespread use of picric acid (PA) in chem. industries and deadly explosives poses dreadful impact on all living creatures as well as the natural environment and has raised global concerns that necessitate the development of fast and efficient sensing platforms. To address this issue, herein, we report a perylenediimide-peptide conjugate, PDI-1 (I), for detection of PA in methanol. The probe displays typical aggregation caused quenching (ACQ) behavior and exhibits a fluorescence “”turn-off”” sensory response towards PA which is unaffected by the presence of other interfering nitroarom. compounds The sensing mechanism involves PA induced aggregation of the probe into higher order tape like structures which leads to quenching of emission. The probe possesses a low detection limit of 5.6 nM or 1.28 ppb and a significantly high Stern-Volmer constant of 6.87×104 M-1. It also exhibits conducting properties in the presence of PA vapors and thus represents a prospective candidate for vapor phase detection of PA. This is, to the best of our knowledge, the first example of a perylenediimide based probe that demonstrates extremely specific, selective and sensitive detection of PA and thus grasps the potential for application in practical scenarios.

Chemistry – An Asian Journal published new progress about Aggregation. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Su, Xuxian; Wang, Wen-Jin; Cao, Qian; Zhang, Hang; Liu, Bin; Ling, Yuyi; Zhou, Xiaotong; Mao, Zong-Wan published the artcile< A Carbonic Anhydrase IX (CAIX)-Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti-Tumor Immunity>, Formula: C6H8N2, the main research area is CAIX ruthenium photosensitizer preparation cancer PDT pyroptosis immunity; anti-tumor immunity; carbonic anhydrase IX targeting; metallodrugs; photodynamic therapy; pyroptosis.

An ideal cancer treatment should not only destroy primary tumors but also improve the immunogenicity of the tumor microenvironment to achieve a satisfactory anti-tumor immune effect. We designed a carbonic anhydrase IX (CAIX)-anchored rhenium(I) photosensitizer, named CA-Re, that not only performs type-I and type-II photodynamic therapy (PDT) with high efficiency under hypoxia (nanomolar-level phototoxicity), but also evokes gasdermin D (GSDMD) mediated pyroptotic cell death to effectively stimulate tumor immunogenicity. CA-Re could disrupt and self-report the loss of membrane integrity simultaneously. This promoted the maturation and antigen-presenting ability of dendritic cells (DCs), and fully activated T cells dependent adaptive immune response in vivo, eventually eliminating distant tumors at the same time as destroying primary tumors. To the best of our knowledge, CA-Re is the first metal complex-based pyroptosis inducer.

Angewandte Chemie, International Edition published new progress about Adaptive immunity. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dai, Qiang; Li, Wenbo; Li, Zhiming; Zhang, Junliang published the artcile< P-Chiral Phosphines Enabled by Palladium/Xiao-Phos-Catalyzed Asymmetric P-C Cross-Coupling of Secondary Phosphine Oxides and Aryl Bromides>, Recommanded Product: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole, the main research area is phosphine chiral palladium catalyzed arylation phosphine oxide aryl bromide; chiral aryldiphosphine oxide preparation crystal structure; mol structure chiral aryl diphosphine oxide palladium sulfinamidephosphine; palladium sulfinamidephosphine chiral complex preparation crystal structure.

The development of transition-metal-catalyzed methods for the synthesis of P-chiral phosphine derivatives poses a considerable challenge. Herein, the authors present a direct Pd/Xiao-Phos-catalyzed cross-coupling reaction of easily accessible secondary phosphine oxides and aryl bromides, which provides rapid access to P-chiral phosphine oxides. The reaction proceeds efficiently with a wide array of reaction partners to deliver various tertiary phosphine oxides in up to 96% yield and 97% ee. Also, the synthesis of DiPAMP ligand and its analogs was also realized, which demonstrates a suitable pathway to switching the branched chain of DiPAMP.

Journal of the American Chemical Society published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Recommanded Product: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Takale, Balaram S.; Thakore, Ruchita R.; Handa, Sachin; Gallou, Fabrice; Reilly, John; Lipshutz, Bruce H. published the artcile< A new, substituted palladacycle for ppm level Pd-catalyzed Suzuki-Miyaura cross couplings in water>, Recommanded Product: 3-Chloro-2-methoxypyridine, the main research area is biarene preparation green chem; halide aryl boronic acid Suzuki Miyaura coupling palladium catalyst.

A newly engineered palladacycle that contains substituents on the biphenyl rings along with the ligand HandaPhos is especially well-matched to an aqueous micellar medium, enabling valued Suzuki-Miyaura coupling of aryl halides RX (R = 2-O2NC6H4, 1-benzothiophen-2-yl, 2-fluoropyridin-3-yl, etc.; X = Cl, Br, I) and aryl boronic acids R1B(OH)2 (R1 = 4-ClC6H4, 1-benzofuran-2-yl, pyren-1-yl, etc.) to be run not only in water under mild conditions, but at 300 ppm of Pd catalyst. This general methodol. has been applied to several targets in the pharmaceutical area. Multiple recyclings of the aqueous reaction mixture involving both the same as well as different coupling partners are demonstrated. Low temperature microscopy (cryo-TEM) indicates the nature and size of the particles acting as nanoreactors. Importantly, given the low loadings of Pd invested per reaction, ICP-MS analyses of residual palladium in the products show levels to be expected that are well within FDA allowable limits.

Chemical Science published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Recommanded Product: 3-Chloro-2-methoxypyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Jiao; Chen, Kai; Zhang, Guo; Yang, Qiu-Yuan; Li, Yue-Shan; Huang, Shen-Zhen; Wang, Yan-Lin; Yang, Wei; Jiang, Xiao-Juan; Yan, Heng-Xiu; Zhu, Jing-Qiang; Xiang, Rong; Luo, You-Fu; Li, Wei-Min; Wei, Yu-Quan; Li, Lin-Li; Yang, Sheng-Yong published the artcile< Structural optimization and structure-activity relationship studies of N-phenyl-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-amine derivatives as a new class of inhibitors of RET and its drug resistance mutants>, Application In Synthesis of 22280-62-2, the main research area is phenyldihydro pyrimido oxazinamine derivative preparation RET inhibitor cancer; Drug resistance mutant; Medullary thyroid cancer; RET kinase; Structure-activity relationship.

The RET tyrosine kinase is an important therapeutic target for medullary thyroid cancer (MTC), and drug resistance mutations of RET, particularly V804M and V804L, are a main challenge for the current targeted therapy of MTC based on RET inhibitors. In this investigation, we report the structural optimization and structure-activity relationship studies of N-phenyl-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-amine derivatives as a new class of RET inhibitors. Among all the obtained kinase inhibitors, 1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-((6,7,8,9-tetrahydropyrimido[5,4-b][1,4]oxazepin-4-yl)amino)phenyl)urea (17d) is a multi-kinase inhibitor and potently inhibits RET and its drug resistance mutants. It showed IC50 (half maximal inhibitory concentration) values of 0.010 μM, 0.015 μM, and 0.009 μM against RET-wild-type, RET-V804M, and RET-V804L, resp. 17d displayed significant anti-viability potencies against various RET-driving tumor cell lines. In a xenograft mouse model of NIH3T3-RET-C634Y, 17d exhibited potent in vivo anti-tumor activity, and no obvious toxicity was observed Mechanisms of action were also investigated by Western blot and immunohistochem. assays. Collectively, 17d could be a promising agent for the treatment of MTC, hence deserving a further investigation.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Application In Synthesis of 22280-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shi, Yinyin; Wang, Yue; Huang, Zhefan; Zhang, Fangjun; Shao, Yinlin published the artcile< tBuOLi-Promoted Hydroboration of Esters and Epoxides>, Computed Properties of 93-60-7, the main research area is ester lactone epoxide hydroboration chemoselective lithium tertbutoxide catalyst; alc preparation.

Com. available and inexpensive lithium tert-butoxide (tBuOLi) acts as a good precatalyst for the hydroboration of esters, lactones, and epoxides using pinacolborane as a borylation agent. Functional groups such as cyano-, nitro-, amino-, vinyl, and alkynyl are unaffected under the presented hydroboration process, representing high chemoselectivity. This transformation has also been effectively applied to the synthesis of key intermediates of Erlotinib and Cinacalcet. Preliminary investigations of the mechanism show that the hydroboration proceeds through the in situ formed BH3 species.

ACS Omega published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Computed Properties of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bej, Raju; Ghosh, Suhrit published the artcile< Glutathione Triggered Cascade Degradation of an Amphiphilic Poly(disulfide)-Drug Conjugate and Targeted Release>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is glutathione cascade amphiphile polydisulfide drug conjugate targeting.

A bioreducible poly(disulfide)-derived amphiphilic block copolymer-drug conjugate (loading content 31%) was synthesized by post-polymerization modification. It shows redox-responsive polymersome assembly in water with aggregation induced emission property arising from the appended Camptothecin (CPT) drug. Glutathione (GSH), a tripeptide overexpressed in cancer cells, triggers a cascade reaction resulting in simultaneous degradation of the polymer backbone (consisting of disulfide linkage) and the release of the pendant drug. The cascade reaction involves GSH trigger cleavage of the backbone disulfide bond producing free thiol followed by its intrachain nucleophilic attack to the adjacent carbonate group that links the appended drug mol. The polymeric pro-drug exhibits killing efficiency to a cancer cell with remarkably low IC50 value of 3.1μg/mL (based on the CPT concentration) while it shows negligible toxicity to a normal cell up to polymer concentration 300μg/mL.

Bioconjugate Chemistry published new progress about Aggregation-induced emission. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rutgeerts, Laurens A. J.; Soultan, Al Halifa; Subramani, Ramesh; Toprakhisar, Burak; Ramon, Herman; Paderes, Monissa C.; De Borggraeve, Wim M.; Patterson, Jennifer published the artcile< Robust scalable synthesis of a bis-urea derivative forming thixotropic and cytocompatible supramolecular hydrogels>, Reference of 3731-53-1, the main research area is bis urea derivative nanofiber supramol hydrogel gelator cytocompatibility.

Synthetic hydrogels address a need for affordable, industrially scalable scaffolds for tissue engineering. Herein, a novel low mol. weight gelator is reported that forms self-healing supramol. hydrogels. Its robust synthesis can be performed in a solvent-free manner using ball milling. Strikingly, encapsulated cells spread and proliferate without specific cell adhesion ligands in the nanofibrous material.

Chemical Communications (Cambridge, United Kingdom) published new progress about Biocompatibility. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Reference of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hajos, G.; Riedl, Z. published the artcile< Product class 5: azaindolizines with two nitrogen atoms in the five-membered ring>, Synthetic Route of 22280-62-2, the main research area is review azaindolizine preparation.

A review of preparation of azaindolizines with two nitrogen atoms in the five-membered ring. Covered reactions include ring-closure, substituent modification, substitution reactions, and other miscellaneous methods.

Science of Synthesis published new progress about Cyclization. 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Synthetic Route of 22280-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem