Day: October 13, 2022

Evjen, Sigvart; Loege, Oda Siebke; Fiksdahl, Anne; Knuutila, Hanna K. published the artcile< Aminoalkyl-Functionalized Pyridines as High Cyclic Capacity CO2 Absorbents>, Computed Properties of 3731-53-1, the main research area is aminoalkyl functionalized pyridines high cyclic capacity carbon dioxide absorbent.

Recent years have witnessed a growing academic interest in the development of new CO2 capture solvents to reduce the capture costs. This study focused on nine picolylamines (three com. and six synthesized) and one imidazole-amine, most of which have not previously been reported as amine absorbents. The solvent performance was evaluated by measuring the absorption capacity, desorption tendency, and pKa. Several of the amines demonstrated CO2 cyclic capacity significantly higher than that of 30 wt % MEA due to very lean CO2 loadings, driven by low amine pKa. The lean loadings can potentially mitigate solvent degradation At the same time, absorption rates comparable to 30 wt % MEA were obtained for 3 M picolylamines. The results demonstrate the promising nature of picolylamines and derivatives for CO2 capture.

Energy & Fuels published new progress about Absorbents. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Computed Properties of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gunzner-Toste, Janet; Zhao, Guiling; Bauer, Paul; Baumeister, Timm; Buckmelter, Alexandre J.; Caligiuri, Maureen; Clodfelter, Karl H.; Fu, Bang; Han, Bingsong; Ho, Yen-Ching; Kley, Nikolai; Liang, Xiaorong; Liederer, Bianca M.; Lin, Jian; Mukadam, Sophie; O’Brien, Thomas; Oh, Angela; Reynolds, Dominic J.; Sharma, Geeta; Skelton, Nicholas; Smith, Chase C.; Sodhi, Jasleen; Wang, Weiru; Wang, Zhongguo; Xiao, Yang; Yuen, Po-wai; Zak, Mark; Zhang, Lei; Zheng, Xiaozhang; Bair, Kenneth W.; Dragovich, Peter S. published the artcile< Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties>, Reference of 56622-54-9, the main research area is urea containing nicotinamide phosphoribosyltransferase inhibitor reduced CYP2C9 inhibition preparation; pharmacokinetic antitumor activity urea containing benzenesulfonamide.

Potent, reversible inhibition of the cytochrome P 450 CYP2C9 isoform was observed in a series of urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. This unwanted property was successfully removed from the described inhibitors through a combination of structure-based design and medicinal chem. activities. An optimized compound, I, which did not inhibit CYP2C9 exhibited potent anti-NAMPT activity (BC NAMPT IC50 = 3 nM; A2780 antiproliferative IC50 = 70 nM), good mouse PK properties, and was efficacious in an A2780 mouse xenograft model. The crystal structure of this compound in complex with the NAMPT protein is also described.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 56622-54-9 belongs to class pyridine-derivatives, and the molecular formula is C7H10N2, Reference of 56622-54-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Xin-Yue; Zhang, Ming; Liu, Zhong; He, Jia-Hao; Wang, Xiao-Chen published the artcile< C3-Selective Trifluoromethylthiolation and Difluoromethylthiolation of Pyridines and Pyridine Drugs via Dihydropyridine Intermediates>, Electric Literature of 581-47-5, the main research area is trifluoromethylthiopyridine preparation one pot regioselective; pyridine trifluoromethylthiolation difluoromethylthiolation hydroboration oxidative aromatization; difluoromethylthiopyridine preparation regioselective one pot.

Herein, authors report a method for unprecedented C3-selective C-H tri- and difluoromethylthiolation of pyridines. The method relies on borane-catalyzed pyridine hydroboration for generation of nucleophilic dihydropyridines; these intermediates react with trifluoromethylthio and difluoromethylthio electrophiles to form functionalized dihydropyridines, which then undergo oxidative aromatization. The method can be used for late-stage functionalization of pyridine drugs for the generation of new drug candidates.

Journal of the American Chemical Society published new progress about Aromatization. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Electric Literature of 581-47-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Santana, Francielli Sousa; Briganti, Matteo; Cassaro, Rafael A. Allao; Totti, Federico; Ribeiro, Ronny Rocha; Hughes, David L.; Nunes, Giovana Gioppo; Reis, Dayane Mey published the artcile< An oxalate-bridged copper(II) complex combining monodentate benzoate, 2,2' -bipyridine and aqua ligands: synthesis, crystal structure and investigation of magnetic properties>, Safety of 2,2′-Bipyridine, the main research area is dinuclear copper(II); ferromagnetic interaction; magnetic properties; noncovalent interaction.

A dinuclear copper(II) complex of formula [{Cu(bipy)(bzt)(OH2)}2(μ-ox)] (1) (where bipy = 2,2′ -bipyridine, bzt = benzoate and ox = oxalate) was synthesized and characterised by diffractometric (powder and single-crystal XRD) and thermogravimetric (TG/DTG) analyses, spectroscopic techniques (IR, Raman, ESR spectroscopy (EPR) and electronic spectroscopy), magnetic measurements and d. functional theory (DFT) calculations The anal. of the crystal structure revealed that the oxalate ligand is in bis(bidentate) coordination mode between two copper(II) centers. The other four positions of the coordination environment of the copper(II) ion are occupied by one water mol., a bidentate bipy and a monodentate bzt ligand. An inversion center located on the ox ligand generates the other half of the dinuclear complex. Intermol. hydrogen bonds and π-π interactions are responsible for the organization of the mols. in the solid state. Molar magnetic susceptibility and field dependence magnetization studies evidenced a weak intramol.-ferromagnetic interaction (J = +2.9 cm-1) between the metal ions. The sign and magnitude of the calculated J value by d. functional theory (DFT) are in agreement with the exptl. data.

Molecules published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kuehn, Laura; Huang, Mingming; Radius, Udo; Marder, Todd B. published the artcile< Copper-catalysed borylation of aryl chlorides>, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, the main research area is catalytic borylation aryl chloride preparation arylboronic acid copper NHC; copper NHC catalyst borylation aryl chloride pinacoldiboronate.

We report herein the first Cu-catalyzed borylation of a wide range of aryl chlorides with different electronic and steric properties using a readily prepared NHC-stabilized Cu catalyst and KOtBu as the base with B2pin2 (pin = pinacolato) as the boron reagent. The aryl chlorides are converted into their corresponding arylboronic esters in good yields. The new procedure shows broad functional group tolerance, and B2neop2 (neop = neopentyl glycolato) can also be applied as the boron reagent.

Organic & Biomolecular Chemistry published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Recommanded Product: 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Werner, Erik W.; Mei, Tian-Sheng; Burckle, Alexander J.; Sigman, Matthew S. published the artcile< Enantioselective Heck Arylations of Acyclic Alkenyl Alcohols Using a Redox-Relay Strategy>, Name: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole, the main research area is beta gamma delta aryl ketone aldehyde enantioselective regioselective preparation; allylic homoallylic alc enantioselective Heck reaction aryldiazonium salt; palladium pyridinyloxazolidine catalyst enantioselective Heck reaction aryldiazonium salt alkenol; stereospecificity Heck reaction aryldiazonium salt alkenol olefin geometry; safety aryldiazonium salt potential explosive.

Nonracemic β-, γ-, and δ-aryl ketones such as (S)-4-MeO2CC6H4CHMeCH2COMe were prepared in 52-85% yields, 90:10-99:1 er, and with high regioselectivities by Heck reactions of phenyldiazonium tetrafluoroborate or aryldiazonium hexafluorophosphates (generated from the corresponding arylamines) with acyclic allylic, homoallylic, or bishomoallylic alcs. such as (E)-MeCH(OH)CH:CHMe in the presence of tris(dibenzylideneacetone)dipalladium [Pd2(dba)3] and the nonracemic trifluoropyridinyl oxazolidine I. I and Pd2(dba)3 imparted notable regioselectivity during migratory insertion and promoted migration of alkene unsaturation toward the alc. to form ketones or aldehydes. (E)- and (Z)-allylic and homoallylic alcs. underwent stereospecific Heck reactions to give enantiomeric products; the alc. stereochem. in the racemic unsaturated alcs. did not affect the enantioselectivities of their reactions. The aryldiazonium salts used as reactant can be explosive and should be handled with caution.

Science (Washington, DC, United States) published new progress about Alcohols, unsaturated Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Name: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Juma, Jamil A. published the artcile< The effect of organic additives in electrodeposition of Co from deep eutectic solvents>, Application In Synthesis of 93-60-7, the main research area is cobalt chloride organic additive deep eutectic solvent electrodeposition.

A range of organic/ inorganic additives have traditionally been added to electroplating solutions to improve brightness and encourage leveling. A limited number of studies have shown that some brighteners function in ionic liquids In this study the effect of four additives; nicotinic acid (NA), Me nicotinate (MN), 5,5-di-Me hydantoin (DMH) and boric acid (BH), have been measured on the electrodeposition of cobalt in the 1choline chloride (ChCl): 2 ethylene glycol (EG) based deep eutectic solvent (DES). In general the addition of these additives causes the deposition potential of Co to be shifted to more neg. over-potentials. No apparent change in speciation and coordination environment around the CoII center was observed The surface morphol. was significantly changed by the addition of each of the additives, suggesting that they function by modifying the double layer. The nucleation and growth mechanism of Co deposition was found to change in the presence of these additives. Flat, shiny and high uniform cobalt layers were obtained with the additives whereas in their absence the deposit was black and dull. The additives significantly increased the hardness of the cobalt deposit and this was shown to be related to the crystal structure of the deposit which was determined using XRD.

Arabian Journal of Chemistry published new progress about Brightening agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Ya-Lan; Pang, Jin-Yu; Lou, Ji-Cong; Sun, Wen-Wu; Liu, Ji-Kai; Wu, Bin published the artcile< Chemo- and Site-Selective Fischer Esterification Catalyzed by B(C6F5)3>, SDS of cas: 53636-56-9, the main research area is ester preparation chemoselective; carboxylic acid alc Fischer esterification tris pentafluorophenyl borane catalyst.

A direct and catalytic dehydrative esterification of carboxylic acids RC(O)OH [R = hept-1-yn-1-yl, 2-(naphthalen-2-yl)ethyl, (1-methyl-1H-indol-3-yl)methyl, 1-([(benzyloxy)carbonyl]amino)ethyl, etc.] with alcs. R1OH (R1 = Et, cyclohexyl, 2,3-dihydroxypropyl, etc.) is described. B(C6F5)3 is shown to be a highly effective catalyst for the Fischer esterification, providing esters RC(O)OR1 in high to excellent yields. This esterification shows excellent chemo- and site-selective monoesterification of various polyols R1OH without any protection step, including bio-derived mol. glycerol.

Asian Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, SDS of cas: 53636-56-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tyagi, Adish; Karmakar, Gourab; Mandal, B. P.; Dutta Pathak, Dipa; Wadawale, Amey; Kedarnath, G.; Srivastava, A. P.; Jain, Vimal K. published the artcile< Di-tert-butyltin(IV) 2-pyridyl and 4,6-dimethyl-2-pyrimidyl thiolates: versatile single source precursors for the preparation of SnS nanoplatelets as anode material for lithium ion batteries>, Computed Properties of 3811-73-2, the main research area is pyrimidylthiolate tin sulfide nanoplatelet lithium ion battery anode.

New air and moisture stable di-tert-butyltin complexes derived from 2-mercaptopyridine (HSpy), [tBu2Sn(Spy)2], [tBu2Sn(Cl)(Spy)] and 4,6-dimethyl-2-mercaptopyrimidine (HSpymMe2) [tBu2Sn(Cl)(SpymMe2)], have been prepared and utilized as single-source mol. precursors for the preparation of orthorhombic SnS nanoplatelets by a hot injection method and thin films by aerosol assisted chem. vapor deposition (AACVD). The complexes were characterized by NMR (1H, 13C, 119Sn) and elemental anal. and their structures were unambiguously established by the single crystal X-ray diffraction technique. Thermolysis of these complexes in oleylamine (OAm) produced SnS nanoplatelets. The morphologies, elemental compositions, phase purity and crystal structures of the resulting Oam-capped nanoplatelets were determined by electron microscopy (SEM, TEM), energy dispersive X-ray spectroscopy (EDS) and pXRD, while the band gaps of the nanoplatelets were evaluated by diffuse reflectance spectroscopy (DRS) and were blue shifted relative to the bulk material. The morphol. and preferential growth of the nanoplatelets were found to be significantly altered by the nature of the mol. precursor employed. The synthesized SnS nanoplatelets were evaluated for their performance as anode material for lithium ion batteries (LIBs). A cell comprised of an SnS electrode could be cycled for 50 cycles. The rate capability of SnS was investigated at different current densities in the range 0.1 to 0.7 A g-1 which revealed that the initial capacity could be regained.

Dalton Transactions published new progress about Battery anodes. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Computed Properties of 3811-73-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Jiancheng; Zheng, Xiangui; Li, Jiongxian; Li, Xiuyan; Lu, K. published the artcile< Electrodeposited Al mesocrystal with high thermal stability and high hardness>, SDS of cas: 93-60-7, the main research area is thermal stability aluminum mesocrystal high hardness electrodeposited.

Mesocrystal, composed of same-oriented nanocrystals separated by organics, is a promising structure for superior chem. and mech. properties, in which the high d. of nanocrystal-organic interfaces plays a crucial role. The stability of the interfaces determines the service temperature and strength of the material. Here, we synthesized aluminum mesocrystal using electrodeposition in ionic liquids with Me nicotinate additive and investigated its thermal and mech. stability. In contrast to the low stability of nanograined metals and nanoporous metals with comparable grain sizes, the Al mesocrystal is found to be stable up to 320°C (0.63 Tm, Tm: the m.p.) and has a recorded high hardness of 2.27 GPa. The high stability originates from the suppression of migration and free diffusion of the interfaces.

Scripta Materialia published new progress about Electrodeposition. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, SDS of cas: 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem