Day: October 13, 2022

Bahmani, Pegah; Maleki, Afshin; Rezaee, Reza; Mahvi, Amir Hossein; Khamforoush, Mehrdad; Dehestani Athar, Saeed; Daraei, Hiua; Gharibi, Fardin; McKay, Gordon published the artcile< Arsenate removal from aqueous solutions using micellar-enhanced ultrafiltration>, Quality Control of 123-03-5, the main research area is arsenate wastewater treatment micellar enhanced ultrafiltration; Arsenate removal; Micelle optimization; Polyacrylonitrile membrane; Surfactant enhancement; Ultrafiltration.

In this study, arsenate (As-V) removal using micellar enhanced ultrafiltration (MEUF) modified by cationic surfactants was studied by a dead-end polyacrylonitrile (PAN) membrane apparatus The UF membrane has been produced by a phase inversion process. The prepared membrane was characterized and analyzed for morphol. and membrane properties. The influence of operating parameters such as initial concentrations of As-V, surfactants, pH, membrane thickness, and co-existing anions on the removal of As-V, surfactant rejection, and permeate flux have been studied. The exptl. results show that from the two different cationic surfactants used the CPC (cetyl-pyridinium chloride) efficiency (91.7%) was higher than that of HTAB (hexadecyltrimethyl-ammonium bromide) (83.7%). The highest As-V removal was 100%, and was achieved using initial feed concentrations of 100-1000μg/L, at pH 7 with a membrane thickness of 150μm in a dead-end filtration system. This efficiency for As-V removal was similar to that obtained using a cross-flow system. Nevertheless, this flux reduction was less than the reduction achieved in the dead-end filtration process. The PAN fabricated membrane in comparison to the RO and NF processes selectively removed the arsenic and the anions, in the water taken from the well, and had no substantial effect on the cations.

Journal of Environmental Health Science and Engineering published new progress about Cationic surfactants. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Quality Control of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Husain, Sajid; Krishnamurthy, A. S. R.; Sarma, P. Nageswara published the artcile< Separation and identification of chloropyridine isomers and quantitative determination of pentachloropyridine in chlorinated pyridine residues by gas chromatography-mass spectrometry>, Formula: C5HCl4N, the main research area is chloropyridine gas chromatog mass spectrometry.

Chloropyridine isomers (2,3,5-trichloropyridine 2,4,6-trichloropyridine, 2,3,4,6-tetrachloropyridine. 2,3,5,6-Tetrachloropyridine, and pentachloropyridine) were separated and identified by gas chromatog.-mass spectrometry in chlorinated pyridine residue. Stainless steel columns packed with 3% or 10% DEGA on Chromosorb WAW or PAW were used. Chloropyridine are intermediates in the preparation of pesticides, herbicides, dyes, pharmaceuticals, and plastics.

Journal of Chromatography published new progress about 14121-36-9. 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Formula: C5HCl4N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Seo, Hyun Wook; Seo, Joon Pyung; Cho, Yuri; Ko, Eunkyong; Kim, Yoon Jun; Jung, Guhung published the artcile< Cetylpyridinium chloride interaction with the hepatitis B virus core protein inhibits capsid assembly>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is cetylpyridinium chloride hepatitis virus protein capsid assembly; Antiviral; Capsid assembly inhibitor; Cetylpyridinium chloride (CPC); Drug synergism; Hepatitis B virus (HBV).

Hepatitis B virus (HBV) infection is a major risk factor for chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC) worldwide. While multiple hepatitis B drugs have been developed, build up of drug resistance during treatment or weak efficacies observed in some cases have limited their application. Therefore, there is an urgent need to develop substitutional pharmacol. agents for HBV-infected individuals. Here, we identified cetylpyridinium chloride (CPC) as a novel inhibitor of HBV. Using computational docking of CPC to core protein, microscale thermophoresis anal. of CPC binding to viral nucleocapsids, and in vitro nucleocapsid formation assays, we found that CPC interacts with dimeric viral nucleocapsid protein (known as core protein or HBcAg) specifically. Compared with other HBV inhibitors, such as benzenesulfonamide (BS) and sulfanilamide (SA), CPC achieved significantly better reduction of HBV particle number in HepG2.2.15 cell line, a derivative of human HCC cells that stably expresses HBV. CPC also inhibited HBV replication in mouse hydrodynamic model system. Taken together, our results show that CPC inhibits capsid assembly and leads to reduced HBV biogenesis. Thus, CPC is an effective pharmacol. agent that can reduce HBV particles.

Virus Research published new progress about Animal gene, CYP2D6 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Peez, Theodor; Schmalz, Veronika; Harms, Klaus; Koert, Ulrich published the artcile< Synthesis of Naphthocyclobutenes from α-Naphthyl Acrylates by Visible-Light Energy-Transfer Catalysis>, Category: pyridine-derivatives, the main research area is naphthocyclobutene stereoselective preparation; iridium photocatalyst stereoselective photocyclization naphthylacrylate; visible light energy transfer catalysis stereoselective photocyclization naphthylacrylate.

Me (α-naphthyl)acrylates bearing an ortho-substituent with a hydrogen atom such as I produce naphthocyclobutenes such as II by photocyclization in the presence of the iridium photocatalyst Ir(Fppy)3 under blue LED irradiation This reaction can be described as a carbon analog of the Norrish-Yang reaction; upon triplet excitation of the acrylate, 1,5-hydrogen atom transfer occurs to form a 1,4-diradical which cyclizes to form a cyclobuta-fused arene. In five of six cases where stereoselectivity was possible, the products were formed with diastereoselectivities up to >20:1.

Organic Letters published new progress about Cyclization catalysts, stereoselective (photo-). 370878-69-6 belongs to class pyridine-derivatives, and the molecular formula is C33H21F3IrN3, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sun, Xianwei; Admane, Prasad; Starosolski, Zbigniew A.; Eriksen, Jason L.; Annapragada, Ananth V.; Tanifum, Eric A. published the artcile< 1-Indanone and 1,3-indandione Derivatives as Ligands for Misfolded α-Synuclein Aggregates>, Formula: C11H16BNO2, the main research area is Parkinson Alzheimer disease brain alpha synuclein SAR indandione; α-synuclein flurescent probes; α-synuclein imaging probes; α-synuclein ligands; α-synuclein selective molecules.

The development of imaging agents for in vivo detection of alpha-synuclein (α-syn) pathologies faces several challenges. A major gap in the field is the lack of diverse mol. scaffolds with high affinity and selectivity to α-syn fibrils for in vitro screening assays. Better in vitro scaffolds can instruct the discovery of better in vivo agents. We report the rational design, synthesis, and in vitro evaluation of a series of novel 1-indanone and 1,3-indandione derivatives from a Structure-Activity Relationship (SAR) study centered on some existing α-syn fibril binding ligands. Our results from fibril saturation binding experiments show that two of the lead candidates compounds 8 and 32 bind α-syn fibrils with binding constants (Kd) of 9.0 and 18.8 nM, resp., and selectivity of greater than 10x for α-syn fibrils compared with amyloid-β (Aβ) and tau fibrils. Our results demonstrate that the lead ligands avidly label all forms of α-syn on PD brain tissue sections, but only the dense core of senile plaques in AD brain tissue, resp. These results are corroborated by ligand-antibody colocalization data from Syn211, which shows immunoreactivity toward all forms of α-syn aggregates, and Syn303, which displays preferential reactivity toward mature Lewy pathol. Our results reveal that 1-indanone derivatives have desirable properties for the biol. evaluation of α-synucleinopathies.

ChemMedChem published new progress about Alzheimer disease. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Formula: C11H16BNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Abdul Rub, Malik; Alabbasi, Abdulrahman; Azum, Naved; Asiri, Abdullah M. published the artcile< Aggregation and surface phenomena of amitriptyline hydrochloride and cationic benzethonium chloride surfactant mixture in different media>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is amitriptyline hydrochloride benzethonium chloride surface phenomena aggregation.

Mixed association behavior of cationic nature of drug amitriptyline hydrochloride (AMHCl) and surfactant benzethonium chloride (BTC) have been studied at five mole fractions of BTC (α1) via surface tension (ST) and fluorescence methods at 298.15 K in occurrence of three dissimilar media (H2O, electrolyte (NaCl), urea (UR)) to evaluate the interactions present amongst them. The evaluated values of critical micelle concentration (cmc) come out beneath the values of cmcid (ideal cmc value) demonstrating attractive interactions amongst the studied constituents (AMHCl and BTC) within mixed micelles. Electrolyte decreases the cmc value of the system while the effect of UR is found to increase in cmc. The micellar mole fraction of BTC (XR1) analyzed by the Rubingh model in solution mixture, mole fraction at mixed monolayer (Xσ1) determined by Rosen model and argued in detail. The interaction parameter in the solution mixture (βRb) and at the interfacial surface (βσ) is constantly achieved neg. in the entire cases. Activity coefficients of the mixed micellar system (fRb1 (BTC) and fRb2 (AMHCl)) and mixed monolayer (fσ1 (BTC) and fσ2 (AMHCl)) were forever less than one telling the nonideal behavior of systems. Various surface parameters have been estimated along with various thermodn. parameters have also been assessed.

Journal of Molecular Liquids published new progress about Aggregation. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Lin; Zhang, Ling; Chen, Qian; Li, Linlin; Jiang, Jian; Sun, Hao; Zhao, Chong; Yang, Yuanyong; Li, Chun published the artcile< Cinchona-Alkaloid-Derived NNP Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones>, Application of C7H7NO, the main research area is cinchona alkaloid based NNP ligand catalyst preparation DFT; chiral secondary alc enantioselective preparation; ketone hydrogenation iridium cinchona alkaloid based NNP ligand.

Herein, a series of novel and easily accessed cinchona-alkaloid-based NNP ligands I [R = cyclohexyl, Ph, 2-MeOC6H4, etc.; R1 = H, MeO] was developed in two steps. By combining [Ir(COD)Cl]2, 39 ketones including aromatic, heteroaryl, and alkyl ketones were hydrogenated, all affording valuable chiral secondary alcs. with 96.0-99.9% ee. A plausible reaction mechanism was discussed by NMR, HRMS, DFT and an activating model involving trihydride was verified.

Organic Letters published new progress about Cinchona alkaloids Role: CAT (Catalyst Use), PRP (Properties), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application of C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dalal, Anuj; Nehra, Kapeesha; Hooda, Anjli; Singh, Devender; Jakhar, Komal; Kumar, Sumit published the artcile< Preparation and photoluminescent characteristics of green Tb(III) complexes with β-diketones and N donor auxiliary ligands>, Product Details of C10H8N2, the main research area is terbium benzoylacetophenone bipyridine complex preparation band gap electrochem; Thermal stability color terbium benzoylacetophenone bipyridine.

This paper presents four octa coordinated ternary terbium complexes based on 2-benzoylacetophenone (BAP) and other auxiliary ligands. For characterization purpose, elemental anal., electrochem. study, thermal anal. and spectroscopic investigations were carried out in detail. Optical band gap (3-4 eV) of complexes was determined from Tauc’s relation. Upon excitation in UV region, emission spectra of complexes demonstrate peaks of Tb3+ ion at ∼616 nm, 589 nm, 548 nm, and 492 nm, attributed to 5D4 → 7FJ (J = 3 to 6) resp. due to energy transfer from ligand to Tb(III) ion via antenna effect. Peak at 548 nm corresponding to 5D4 → 7F5 is responsible for bright green emission of synthesized terbium complexes. CIE color coordinates and color purity further corroborate the green emission of Tb3+ complexes. The complexes were found to be quite stable as studied by thermal anal. The outcomes of characterizations have demonstrated that these complexes could behave as good contenders in lighting systems and displays owing to their photometric characteristics.

Inorganic Chemistry Communications published new progress about Color. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Product Details of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Penning, Miriam; Christoffers, Jens published the artcile< Synthesis of Regioisomeric Pyrido[c]azocanones from Azaindanone Derivatives>, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate, the main research area is pyridoazocanone regioisomer preparation.

A ring enlargement reaction with methylamine gave new pyrido[2,3-c]-, pyrido[3,4-c]- and pyrido[3,2-c]azocanone derivatives from cyclic β-oxo esters with a cyclopentapyridine skeleton and a 1,4-diketone moiety. The starting materials for this ring transformation were either prepared from halogenopyridine carboxylates by Heck reaction and subsequent hydrogenation, or (halogenomethyl)pyridine carboxylates were submitted to SN reaction with di-Et malonate. Both routes were completed by Dieckmann condensation to build the cyclic β-oxo ester structure and alkylation with phenacylbromide to install the 1,4-diketone motif.

European Journal of Organic Chemistry published new progress about Heterocyclic compounds, nitrogen Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Junlei; Hou, Baoshan; Xiang, Jun; Chen, Xuedong; Gu, Tingyue; Liu, Hongfang published the artcile< The performance and mechanism of bifunctional biocide sodium pyrithione against sulfate reducing bacteria in X80 carbon steel corrosion>, Quality Control of 3811-73-2, the main research area is sulfate reducing bacteria corrosion carbon steel sodium pyrithione inhibitor.

Anti-bacterial and anti-corrosion properties of sodium pyrithione (SPT) were studied using exptl. methods and quantum chem. calculations SPT at 80 mg/L reduced planktonic and sessile sulfate reducing bacteria (SRB) on X80 carbon steel to undetectable levels. The corrosion inhibition efficiency of SPT against microbiol. influenced corrosion exceeded 80% based on weight loss, which was corroborated by electrochem. data. Mol. modeling showed that SPT mol. provided electrons to the unoccupied orbitals of the Fe surface with a large binding energy of SPT on the Fe (1 1 0) plane, which favored SPT adsorption on the carbon steel.

Corrosion Science published new progress about Adsorption. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Quality Control of 3811-73-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem