Day: October 13, 2022

Fan, Qianqian; Si, Yubing; Guo, Wei; Fu, Yongzhu published the artcile< Insight into Chemical Reduction and Charge Storage Mechanism of 2,2'-Dipyridyl Disulfide toward Stable Lithium-Organic Battery>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is chem reduction dipyridyl disulfide lithium organic redox flow battery.

In lithium-organic batteries, organic cathode materials could dissolve in a liquid electrolyte and diffuse through the porous separator to the active lithium-metal anode, resulting in cycling instability. However, 2,2′-dipyridyl disulfide (PyDS) can be cycled 5 times better than di-Ph disulfide (PDS) although both are soluble We believe this is related to their reactivity with lithium (Li0). Herein, we investigate the chem. reduction of PyDS by lithiated carbon paper (Li-CP) in ether electrolyte. It is found that only 6.3% of PyDS was reduced by Li-CP after 10 days, unlike PDS. Exptl. and computational results show that PyDS mols. are ionized by lithium ions of lithium salts delocalizing the charge on pyridine rings of PyDS, which can momentarily store Li0, thus keeping the S-S bond inert in chem. reaction with Li0. This finding is successfully utilized in a membrane-free redox flow battery with PyDS catholyte, showing long cycle life with high energy d. and energy efficiency. This work reveals the interesting charge storage mechanism and the different activity of organodisulfides toward electrochem. reduction and chem. reduction due to the organic groups, which can provide guidance for the design of stable lithium-organic batteries.

Journal of Physical Chemistry Letters published new progress about Battery capacity. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yi, Sijia; Kim, Sun-Young; Vincent, Michael P.; Yuk, Simseok A.; Bobbala, Sharan; Du, Fanfan; Scott, Evan Alexander published the artcile< Dendritic peptide-conjugated polymeric nanovectors for non-toxic delivery of plasmid DNA and enhanced non-viral transfection of immune cells>, COA of Formula: C10H8N2S2, the main research area is dendritic peptide polymeric nanovector toxic delivery plasmid DNA; plasmid DNA immune cell nonviral transfection; Biological sciences; Biotechnology; Drug delivery system; Health sciences; Immunology.

Plasmid DNA (pDNA) transfection is advantageous for gene therapies requiring larger genetic elements, including “”all-in-one”” CRISPR/Cas9 plasmids, but is limited by toxicity as well as poor intracellular release and transfection efficiency in immune cell populations. Here, we developed a synthetic non-viral gene delivery platform composed of poly(ethylene glycol)-b-poly(propylene sulfide) copolymers linked to a cationic dendritic peptide (DP) via a reduceable bond, PEG-b-PPS-ss-DP (PPDP). A library of self-assembling PPDP polymers was synthesized and screened to identify optimal constructs capable of transfecting macrophages with small (pCMV-DsRed, 4.6 kb) and large (pL-CRISPR.EFS.tRFP, 11.7 kb) plasmids. The optimized PPDP construct transfected macrophages, fibroblasts, dendritic cells, and T cells more efficiently and with less toxicity than a com. Lipo2K reagent, regardless of pDNA size and under standard culture conditions in the presence of serum. The PPDP technol. described herein is a stimuli-responsive polymeric nanovector that can be leveraged to meet diverse challenges in gene delivery.

iScience published new progress about Blood serum. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, COA of Formula: C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Graca, Catia A. L.; Mendes, Maria Anita; Teixeira, Antonio Carlos S. C.; Velosa, Adriana Correia de published the artcile< Anoxic degradation of chlorpyrifos by zerovalent monometallic and bimetallic particles in solution>, Safety of 6-Chloropyridin-2-ol, the main research area is chlorpyrifoszerovalent monometallic bimetallic particle anoxic degradation; Bimetallic particles; Chlorpyrifos; Reductive degradation; Zerovalent copper; Zerovalent metals.

The degradation of highly toxic and persistent chlorinated organic compounds by zerovalent metals (ZVMs) has received considerable attention for in situ groundwater remediation. Due to its abundance and low toxicity, iron has been mostly applied for such purposes, despite several limitations, such as rapid surface passivation and little efficacy towards certain contaminants. Given that, we evaluated monometallic zerovalent iron (ZVI), copper (ZVC) and zinc (ZVZ), and bimetallic copper-coated ZVI (ZVI/Cu) and ZVZ (ZVZ/Cu) for anoxic reductive degradation of chlorpyrifos (CP). Two approaches to enhance metal reactivity were investigated: the synthesis of bimetallic particles with copper and the comparison between micro and nanoparticles. All of the tested monometallic and bimetallic particles dechlorinated the target mol., although complete chlorine removal was not achieved by any metal during the 30-d treatment period. Coating the zerovalent monometallic particles with copper enhanced reactivity. Reactivity was ZVC > ZVZ > ZVI for monometallic particles and ZVZ/Cu > ZVI/Cu for bimetallic microparticles. The anal. of the degradation products indicated the presence of dechlorinated compounds as well as 3,5,6-trichloro-2-pyridinol, a hydrolysis product.

Chemosphere published new progress about Decomposition (anoxic). 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Safety of 6-Chloropyridin-2-ol.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Elawa, Sherif; Mirdell, Robin; Tesselaar, Erik; Farnebo, Simon published the artcile< The microvascular response in the skin to topical application of methyl nicotinate: Effect of concentration and variation between skin sites>, HPLC of Formula: 93-60-7, the main research area is skin microvascular response methyl nicotinate.

Me nicotinate (MN) induces a local cutaneous erythema in the skin and may be used as a local provocation in the assessment of microcirculation and skin viability. The aims were to measure the effects of increasing doses of MN, to find the concentration that yields the most reproducible effect from day to day and between sites, and to study the variation between skin sites. Microvascular responses to topically applied MN at different concentrations were measured in 12 subjects on sep. days and on contralateral sides, using laser speckle contrast imaging (LSCI). MN effects were measured in four different body sites. At 20 mmol/L, the response to MN was most reproducible day-to-day and site-to-site, and resulted in a plateau response between 5 and 20 min after application. The skin region of the lower back had a lower perfusion value compared to the epigastric region (p = 0.007). When responses were compared to nearby, unprovoked areas, a significantly larger increase in perfusion was seen in the forearm, compared to all other anatomical sites (p < 0.03). A concentration of 20 mmol/L MN generated the most reproducible microvascular response in the skin. The response varies between different body sites. Microvascular Research published new progress about Anatomy (anatomical site). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, HPLC of Formula: 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhong, Rui; Wei, Zeyuan; Zhang, Wei; Liu, Shun; Liu, Qiang published the artcile< A Practical and Stereoselective In Situ NHC-Cobalt Catalytic System for Hydrogenation of Ketones and Aldehydes>, Name: 1-(Pyridin-3-yl)ethanone, the main research area is cobalt complex catalyst preparation; secondary alc primary preparation diastereoselective; ketone hydrogenation cobalt catalyst; aldehyde hydrogenation cobalt catalyst.

Herein, a practical in situ catalytic system generated by easily available pincer NHC precursors, CoCl2 and a base enabled efficient and high-yielding hydrogenation of a broad range of ketones and aldehydes (over 50 examples and a maximum turnover number [TON] of 2,610) to afford alcs. was reported. This was the first example of NHC-Co-catalyzed hydrogenation of C=O bonds using flexible pincer NHC ligands consisting of a N-H substructure. Diastereodivergent hydrogenation of substituted cyclohexanone derivatives was also realized by fine-tuning of the steric bulk of pincer NHC ligands. Addnl., a bis(NHCs)-Co complex was successfully isolated and fully characterized and it exhibited excellent catalytic activity that equals that of the in-situ-formed catalytic system.

Chem published new progress about Alcohols Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Name: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Jing; Chen, Le; Liu, Ying; Olajide, Tosin Michael; Jiang, Yuanrong; Cao, Wenming published the artcile< Identification of key aroma-active compounds in beef tallow varieties using flash GC electronic nose and GC x GC-TOF/MS>, Reference of 93-60-7, the main research area is aroma active compound beef GC electronic nose.

To uncover the integral flavor characteristics and individual odor active compounds in tallow derived from different beef fats: inguinal (IF), omental (OF), and perirenal fats (PF), we used flash GC electronic nose (flash GC E-nose) to analyze and characterize the samples. GC x GC-TOF/MS identified and quantified 195 volatile compounds with significant differences amongst the three kinds of fats. There were 45 important odorants (ROAV > 0.1) containing 23 key odorants (ROAV > 1), of which 43, 34, 35 important odorants were found in IF, OF, and PF, resp. Our results showed that the key odorants overall probably contribute to a fatty and sweat acid smell in IF, a meaty and slightly sweet taste in OF, and sweetness and slightly meaty taste in PF. Elucidating the distribution of key odorants in beef tallow from different parts of animals could provide a scientific basis for formulating and selecting raw materials of high-quality beef tallow flavor products.

European Food Research and Technology published new progress about Acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Reference of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Abou-Elkhair, Reham A. I.; Hassan, Abdalla E. A.; Boykin, David W.; Wilson, W. David published the artcile< Lithium Hexamethyldisilazane Transformation of Transiently Protected 4-Aza/Benzimidazole Nitriles to Amidines and their Dimethyl Sulfoxide Mediated Imidazole Ring Formation>, Safety of 2-Amino-3-nitro-6-picoline, the main research area is lithium hexamethyldisilazane transiently protected azabenzimidazole nitrile; DMSO imidazole ring formation; amidine preparation.

Trimethylsilyl-transient protection successfully allowed the use of lithium hexamethyldisilazane to prepare benzimidazole (BI) and 4-azabenzimidazole (azaBI) amidines from nitriles in 58-88% yields. This strategy offers a much better choice to prepare BI/azaBI amidines than the lengthy, low-yielding Pinner reaction. Synthesis of aza/benzimidazole rings from aromatic diamines and aldehydes was affected in DMSO in 10-15 min, while known procedures require long time and purification These methods are important for the BI/azaBI-based drug industry and for developing specific DNA binders for expanded therapeutic applications.

Organic Letters published new progress about Amidines Role: SPN (Synthetic Preparation), PREP (Preparation). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Safety of 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Grushin, Vladimir V.; Herron, Norman; LeCloux, Daniel D.; Marshall, William J.; Petrov, Viacheslav A.; Wang, Ying published the artcile< New, efficient electroluminescent materials based on organometallic Ir complexes>, Product Details of C33H21F3IrN3, the main research area is crystal structure iridium cyclometalated fluorinated arylpyridine complex; mol structure iridium cyclometalated fluorinated arylpyridine complex; electroluminescent fluorinated organometallic iridium compound preparation; LED photoluminescence luminescence iridium cyclometalated fluorinated arylpyridine complex; reduction potential cyclometalated fluorinated iridium arylpyridine complex; oxidation potential cyclometalated fluorinated iridium arylpyridine complex; fluorinated cyclometalated arylpyridine iridium complex preparation electroluminescent property; phenylpyridine cyclometalated fluorinated iridium complex preparation electroluminescent property; pyridine phenyl cyclometalated fluorinated iridium complex preparation electroluminescent property.

Reaction of aqueous IrCl3 with fluorinated 2-arylpyridines in the presence of AgO2CCF3 afforded fifteen fac-tris-cyclometalated arylpyridine Ir complexes (e.g., I) exhibiting excellent processing and electroluminescent properties which can be fine-tuned via systematic control of the nature and position of the substituents on the aromatic rings. Single-crystal x-ray structures were obtained for I and three other analogous cyclometalated arylpyridine Ir complexes. Nearly all the arylpyridine Ir complexes exhibited fully reversible reduction and oxidation waves.

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystal structure. 370878-69-6 belongs to class pyridine-derivatives, and the molecular formula is C33H21F3IrN3, Product Details of C33H21F3IrN3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mangas-Sanchez, Juan; Sharma, Mahima; Cosgrove, Sebastian C.; Ramsden, Jeremy I.; Marshall, James R.; Thorpe, Thomas W.; Palmer, Ryan B.; Grogan, Gideon; Turner, Nicholas J. published the artcile< Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases>, Category: pyridine-derivatives, the main research area is ketone ammonia fungal aminase catalyst enantioselective reductive amination; amine preparation.

The structural and biochem. characterization as well as synthetic applications of two RedAms from Neosartorya spp. was described. (NfRedAm and NfisRedAm) that displayed a distinctive activity amongst fungal RedAms, namely a superior ability to use ammonia as the amine partner. Using these enzymes, The synthesis of a broad range of primary amines, with conversions up to >97% and excellent enantiomeric excess was demonstrated . Temperature dependent studies showed that these homologues also possess greater thermal stability compared to other enzymes within this family. Their synthetic applicability was further demonstrated by the production of several primary and secondary amines with turnover numbers (TN) up to 14 000 as well as continous flow reactions, obtaining chiral amines such as (R)-2-aminohexane in space time yields up to 8.1 g L-1 h-1. The remarkable features of NfRedAm and NfisRedAm highlight their potential for wider synthetic application as well as expanding the biocatalytic toolbox available for chiral amine synthesis.

Chemical Science published new progress about Amines Role: BPN (Biosynthetic Preparation), RCT (Reactant), BIOL (Biological Study), PREP (Preparation), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Carson, Matthew W.; Giese, Matthew W.; Coghlan, Michael J. published the artcile< An Intra/Intermolecular Suzuki Sequence to Benzopyridyloxepines Containing Geometrically Pure Exocyclic Tetrasubstituted Alkenes>, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate, the main research area is bromopyridine alkyne pinacolatodiboron stereoselective diboration; aryloxy bromopyridine vinylpinacol boronic ester intramol Suzuki coupling palladium; benzopyridyloxepine dioxaborolanylethylidene iodoarene Suzuki coupling palladium; benzylidenyl benzopyridyloxepine derivative preparation; palladium Suzuki couplibng catalyst.

A route to enable the preparation of 5-benzylidenyl-benzopyridyloxepine analogs, e.g., I (R1 = Me, Et, i-Pr; R2 = H, F, MeO), was developed to continue our research in the field of nuclear hormone receptor modulators. The key steps are: 1. a syn-stereoselective diboration of a tethered aryl alkyne; 2. an intramol. Suzuki cross-coupling reaction, which forms in a stereo- and regiocontrolled fashion, the 5-exoalkylidenyl 7-membered ring imbedded within the core of the scaffold and; 3. an intermol. Suzuki to furnish the final tetra-substituted olefinic benzopyridyloxepines.

Organic Letters published new progress about Aliphatic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (pyridylmethyl). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem