Day: October 14, 2022

In 2019,Beilstein Journal of Organic Chemistry included an article by Kennedy, Sean H.; Gasonoo, Makafui; Klumpp, Douglas A.. Recommanded Product: 2,6-Dibromopyridine. The article was titled 《Superelectrophilic carbocations: preparation and reactions of a substrate with six ionizable groups》. The information in the text is summarized as follows:

A substrate was prepared having two triarylmethanol centers and four pyridine-type substituent groups. Upon ionization in Bronsted superacid CF3SO3H, the substrate underwent two types of reactions. In presence of only the superacid, highly ionized intermediate(s) provided a double cyclization product having two pyrido[1,2-a]indole rings I. With added benzene, an arylation product II was obtained. A mechanism was proposed involving tetra-, penta-, or hexacationic species. In addition to this study using 2,6-Dibromopyridine, there are many other studies that have used 2,6-Dibromopyridine(cas: 626-05-1Recommanded Product: 2,6-Dibromopyridine) was used in this study.

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Recommanded Product: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Optical Materials (Amsterdam, Netherlands) included an article by Liang, Aihui; Liu, Zhiqian; Liu, Dewang; Cai, Ping; Wang, Zhiping; Zhou, Wenjing; Hu, Sifan; Tang, Jun; Zhang, Xiaolan; Cai, Mingzhong. COA of Formula: C5H3Br2N. The article was titled 《Novel dinuclear cyclometalated Platinum(II) complex as orange phosphorescent emitters for single-emitting-layer white polymer light-emitting diodes》. The information in the text is summarized as follows:

Novel binuclear platinum complex (FPT)2Pt2(diPic) and mononuclear platinum complex (FPT)Pt(Pic) were designed and synthesized, where FPT is N-(4-(6-(9,9-diethyl-9H-fluoren-2-yl)pyridin-3-yl)phenyl)-N-phenylbenzenamine, diPic is 3-(6-(2-carboxypyridin-3-yloxy)hexyloxy)picolinic acid, and Pic is picolinic acid. The photophys., electrochem. and thermal properties, as well as electroluminescent (EL) properties for both platinum(II) complexes were studied. Compared to (FPT)Pt(Pic), (FPT)2Pt2(diPic) exhibited stronger phosphorescent emission in PL spectra and higher ΦPL, owing to the enhanced spin-orbit interaction of platinum centers. Moreover, the monochromatic devices based on (FPT)2Pt2(diPic) showed better EL properties than (FPT)Pt(Pic). Based on that, the single-emissive-layer WPLEDs using (FPT)2Pt2(diPic) as orange emitter and FIrpic as blue emitter were also obtained. The WPLEDs show best performances with a maximal LE of 1.3 cd/A, and a CIE coordinates of (0.35, 0.37) which is very close to the pure white emission. Work is still underway to improve the device efficiency and color purity of these iridium and platinum complexes co-doped WPLEDs. The results came from multiple reactions, including the reaction of 2,5-Dibromopyridine(cas: 624-28-2COA of Formula: C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,European Journal of Organic Chemistry included an article by Tang, Shaojian; Wei, Wenjing; Yin, Dan; Poznik, Michal; Chruma, Jason J.. Application of 128071-75-0. The article was titled 《Palladium-Catalyzed Decarboxylative Generation and Propargylation of 2-Azaallyl Anions》. The information in the text is summarized as follows:

A palladium-catalyzed decarboxylative propargylation (DcPg) of propargyl 2,2-diphenylglycinate imines was developed for the synthesis of [((diphenylmethylene)amino)alkynyl]arenes (Ph2)C=NCH(Ar)CH2C≡CR [R = Me, Et, TMS; Ar = 4-CNC6H4, 2-BrC6H4, 3-pyridyl, etc.]. In this process, the nature of the propargyl ester and aryl imine components, as well as the catalyst system and solvent had a significant impact on the ratio of desired propargylated products vs. allene and/or diene side products that arose via different modes of C-C bond formation. The resulting propargylated products were transformed readily into useful (Z)-homoallylic amines. Moreover, the regioisomeric diene products could be converted to pharmaceutically-relevant diarylmethyl imines via a two-step Diels-Alder/oxidation process. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Application of 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application of 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Halide-Rebound Polymerization of Twisted Amides》 were Fu, Liangbing; Xu, Mizhi; Yu, Jiyao; Gutekunst, Will R.. And the article was published in Journal of the American Chemical Society in 2019. Recommanded Product: Pyridin-3-ylboronic acid The author mentioned the following in the article:

The first living polymerization of twisted amides is reported, achieved using simple primary alkyl iodides as initiators. Polymerization occurs through a halide-rebound mechanism in which the nucleophilic twisted amide is quaternized and subsequently ring-opened by the iodide counterion. The covalent electrophilic polymerization generates polymers with living chain ends that are both isolable and stable to ambient conditions, enabling the synthesis of block polymers. This presents a new class of polymers for study that possess high glass transition temperatures and robust thermal stability. The results came from multiple reactions, including the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Recommanded Product: Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Recommanded Product: Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Iron(II)-Based Metalloradical Activation: Switch from Traditional Click Chemistry to Denitrogenative Annulation》 were Roy, Satyajit; Khatua, Hillol; Das, Sandip Kumar; Chattopadhyay, Buddhadeb. And the article was published in Angewandte Chemie, International Edition in 2019. Application In Synthesis of 2-Bromo-5-methylpyridine The author mentioned the following in the article:

A unique concept for the intermol. denitrogenative annulation of 1,2,3,4-tetrazoles and alkynes was discovered by using a catalytic amount of Fe(TPP)Cl and Zn dust. The reaction precludes the traditional, more favored click reaction between an organic azide and alkynes, and instead proceeds by an unprecedented metalloradical activation. The method is anticipated to advance access to the construction of important basic nitrogen heterocycles, which will in turn enable discoveries of new drug candidates. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-methylpyridine(cas: 3510-66-5Application In Synthesis of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Application In Synthesis of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Design, synthesis, and evaluation of anticancer potential of some new benzopyran Schiff base derivatives》 was published in Indian Journal of Heterocyclic Chemistry in 2020. These research results belong to Kumar, Piyush; Rahman, Azizur Md.; Wal, Pranay; Singh, Kuldeep. Name: 4-Acetylpyridine The article mentions the following:

The present study was carried out to design, synthesize, and evaluate the anticancer activity of newly synthesized benzopyran Schiff bases I [R1 = Me, R2 = Ph, 4-ClC6H4, 2-pyridyl, etc.; R1 = R2 = Ph; R1R2C = adamantan-2-ylidene] on MCF-7 and MDA-MB-231 cell lines. Docking studies, in silico absorption, distribution, metabolism, elimination (ADME), and predicted toxicity studies have also been performed. Designed compounds I were synthesized by condensation of the substituted Trolox hydrazide with various ketones. All synthesized compounds I were tested on MCF-7 and MDA-MB-231 cell lines for anticancer activity. All compounds I, except for I (R1 = Me; R2 = 2-naphthyl) showed better docking scores than standard The majority of the compounds displayed good to potent anticancer activity on MCF-7 and MDA-MB-231 cell lines. After reading the article, we found that the author used 4-Acetylpyridine(cas: 1122-54-9Name: 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Name: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Coumarin substituted symmetric diaminopyridine molecules: Synthesis, mesomorphic characterizations and DFT studies》 was published in Journal of Molecular Liquids in 2020. These research results belong to Mohammad, AbdulKarim-Talaq; Al-Mohammed, Mohammad Hameed; Srinivasa, H. T.; Ameen, Wissam Ahmed. Electric Literature of C5H7N3 The article mentions the following:

Synthesis and characterization of 2,6-diaminopyridine bearing sym. substituted coumarins I [R = n-pentyl, n-octyl, n-nonanyl, etc.] from a lateral side of the mols. was reported. All the mols. I were characterized by standard spectroscopic methods such as IR spectroscopy and NMR spectroscopy techniques. Mesomorphic properties were evaluated by the differential scanning calorimetry and the polarized optical microscope. The measurements showed that the lower members did not favor liquid crystal formation, while higher members were exhibiting liquid crystalline, namely nematic mesophase. The DFT computations manifest the nature of liquid crystal geometrical aspects. The experimental process involved the reaction of 2,6-Diaminopyridine(cas: 141-86-6Electric Literature of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Electric Literature of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Visible-Light-Enabled Ortho-Selective Aminopyridylation of Alkenes with N-Aminopyridinium Ylides》 was published in Journal of the American Chemical Society in 2020. These research results belong to Moon, Yonghoon; Lee, Wooseok; Hong, Sungwoo. COA of Formula: C6H4N2 The article mentions the following:

By utilizing an underexplored reactivity mode of N-aminopyridinium ylides, we developed the visible-light-induced ortho-selective aminopyridylation of alkenes via radical-mediated 1,3-dipolar cycloaddition The photocatalyzed single-electron oxidation of N-aminopyridinium ylides generates the corresponding radical cations that enable previously inaccessible 1,3-cycloaddition with a broader range of alkene substrates. The resulting cycloaddition adducts rapidly undergo subsequent homolytic cleavage of the N-N bond, conferring a substantial thermodn. driving force to yield various β-aminoethylpyridines. Remarkably, amino and pyridyl groups can be installed into both activated and unactivated alkenes with modular control of ortho-selectivity and 1,2-syn-diastereoselectivity under metal-free and mild conditions. Combined exptl. and computational studies are conducted to clarify the detailed reaction mechanism and the origins of site selectivity and diastereoselectivity. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanopyridine(cas: 100-48-1COA of Formula: C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.COA of Formula: C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis and antifungal activity of imidazo[1,2-b]pyridazine derivatives against phytopathogenic fungi》 was written by Fan, Lingling; Luo, Zhongfu; Li, Yi; Liu, Xinyun; Fan, Judi; Xue, Wei; Tang, Lei; Li, Yong. Formula: C5H6BNO2 And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020. The article conveys some information:

A series of 3,6-disubstituted imidazo[1,2-b]pyridazine derivatives were synthesized and characterized with spectroscopic analyses. The antifungal activities of these compounds against nine phytopathogenic fungi were evaluated by the mycelium growth rate method. The in vitro antifungal bioassays indicated that most of compounds displayed excellent and broad-spectrum antifungal activities. Especially, compounds 6-chloro-3-phenylimidazo[1,2-b]pyridazine, 6-chloro-3-(2-fluorophenyl)imidazo[1,2-b]pyridazine, 6-chloro-3-(2-chlorophenyl)imidazo[1,2-b]pyridazine, 6-chloro-3-(thiophen-3-yl)imidazo[1,2-b]pyridazine and 6-methoxy-3-phenylimidazo[1,2-b]pyridazine exhibited 1.9-25.5 fold more potent than the com. available fungicide hymexazol against Corn Curvalaria Leaf Spot (CL), Alternaria alternate (AA), Pyricularia oryzae (PO) and Alternaria brassicae (AB) strains. Structure-activity relation anal. showed that the enhanced antifungal activity is significantly affected by the substituents on the benzene ring and pyridazine ring. After reading the article, we found that the author used Pyridin-3-ylboronic acid(cas: 1692-25-7Formula: C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis of Pd@graphene oxide framework nanocatalyst with enhanced activity in Heck-Mizoroki cross-coupling reaction》 was written by Shekarizadeh, Arezoo; Azadi, Roya. Computed Properties of C5H5BrN2 And the article was included in Applied Organometallic Chemistry in 2020. The article conveys some information:

A new method was developed for producing a catalyst involving a Pd nanoparticle (NP) embedded in a graphene oxide framework (Pd@GOF) with ordered macro- and mesoporous structures. First, 5,5′-diamino-2,2′-bipyridine was selected as crosslinking for covalent modification of GO nanosheets to prepare a 3-dimensional (3D) framework with interlayer spaces in which well-dispersed and ultra-small Pd NPs in situ grew and embedded the framework. The synthesized nanopores 3D Pd@GOF can act as nanoreactors to help the reaction substrates thoroughly come into contact with the surface of Pd NPs, thereby exhibiting high activity toward the Heck reaction, rarely reported concerning Pd NPs supported on 1-side functionalized graphene. The Pd@GOF catalyst can be used 10 times without any significant loss in the catalytic activity, confirming the long-term stability of this catalyst. The covalently assembled GOF was proposed as a universal platform for hosting noble metal NPs to construct the desired metal@GOF nanocatalyst with improved activity and stability that can be used in a broad range of practical applications. In the part of experimental materials, we found many familiar compounds, such as 6-Bromopyridin-3-amine(cas: 13534-97-9Computed Properties of C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Computed Properties of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem