Day: October 14, 2022

《Synthesis, pharmacophores, and mechanism study of pyridin-2(1H)-one derivatives as regulators of translation initiation factor 3a》 was published in Archiv der Pharmazie (Weinheim, Germany) in 2013. These research results belong to Zhu, Weixing; Shen, Jie; Li, Qianbin; Pei, Qi; Chen, Jun; Chen, Zhuo; Liu, Zhaoqian; Hu, Gaoyun. Computed Properties of C13H11NO3 The article mentions the following:

Twenty-seven 1,5-disubstituted-pyridin-2(1H)-one derivatives were synthesized and evaluated for their anticancer and antifibrosis activity by A549 and NIH3T3 cell viability assays, resp. To study the selectivity between the cancer and fibrosis cell lines, pharmacophore models (F1-F4) were built in advance for compounds with pyridin-2(1H)-one scaffold, which revealed the relationship between the occupation of the aromatic sub-site F4 and potent anti-cancer activity. The relationship between structure and anti-cancer activity for all target compounds is also reported herein: 1-Phenyl-5-((m-tolylamino)methyl)pyridine-2(1H)-one (22) displayed both potency and selectivity (IC50 = 0.13 mM) toward the A549 cell line through the inhibition of translation initiation, especially by eIF3a suppression, and can be treated as a lead for the design of novel eIF3a regulators and anti-lung cancer agents. In the part of experimental materials, we found many familiar compounds, such as Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate(cas: 77837-09-3Computed Properties of C13H11NO3)

Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate(cas: 77837-09-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Computed Properties of C13H11NO3 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Zinc Photocages with Improved Photophysical Properties and Cell Permeability Imparted by Ternary Complex Formation》 was written by Basa, Prem N.; Barr, Chelsea A.; Oakley, Kady M.; Liang, Xiaomeng; Burdette, Shawn C.. Application of 1539-42-0This research focused onzinc photocage photophys cell permeability ternary complex; crystal structure. The article conveys some information:

Photocaged complexes can control the availability of metal ions to interrogate cellular signaling pathways. The authors describe a new photocage, {bis[(2-pyridyl)methyl]amino}(9-oxo-2-xanthenyl)acetic acid (XDPAdeCage, 1), which utilizes a 2-xanthone acetic acid group to mediate a photodecarboxylation reaction. XDPAdeCage photolyzes with a quantum yield of 27%, and binds Zn2+ with 4.6 pM affinity, which decreases by over 4 orders of magnitude after photolysis. For comparison to the previous approach to Zn2+ release via photodecarboxylation, the analogous photocage {bis[(2-pyridyl)methyl]amino}(m-nitrophenyl)acetic acid (DPAdeCage, 2), which uses a m-nitrobenzyl chromophore, was also prepared and characterized. The advantages of the 2-xanthone acetic acid chromophore include red-shifted excitation and a higher extinction coefficient at the preferred uncaging wavelength. The neutral ternary complex of [Zn(XDPAdeCage)]+ with the anionic ligand pyrithione is membrane permeable, which circumvents the need to utilize invasive techniques to introduce intracellular Zn2+ fluctuations. Using fluorescent imaging, the authors have confirmed transport of Zn2+ across membranes; in addition, RT-PCR experiments demonstrate changes in expression of Zn2+-responsive proteins after photolysis. The experimental process involved the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Application of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridineOn September 16, 2020 ,《Multichromic Monolayer Terpyridine-Based Electrochromic Materials》 was published in ACS Applied Materials & Interfaces. The article was written by Laschuk, Nadia O.; Ahmad, Rana; Ebralidze, Iraklii I.; Poisson, Jade; Easton, E. Bradley; Zenkina, Olena V.. The article contains the following contents:

The article describes novel electrochromic materials (ECMs) that are based on a monolayer consisting of two or three isostructural metal complexes of 4′-(pyridin-4-yl)-2,2′:6′,2′′-terpyridine simultaneously deposited on surface-enhanced support. The support was made by screen printing of indium tin oxide (ITO) nanoparticles on ITO-glass and has a surface area sufficient for a monolayer to give color visible to the naked eye. The ability to sep. electrochem. address the oxidation state of the metal centers on the surface (i.e., Co2+/Co3+, Os2+/Os3+, and Fe2+/Fe3+) provides an opportunity to achieve several distinct color-to-color transitions, thus opening the door for constructing monolayer-based multicolor ECMs. The results came from multiple reactions, including the reaction of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Reference of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Reference of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridineThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hedou, Damien; Voisin-Chiret, Anne Sophie published an article in European Journal of Organic Chemistry. The title of the article was 《Br vs. TsO Chemoselective Suzuki-Miyaura Cross-Coupling Reaction on Nicotinaldehyde Moiety for the Preparation of 2,3,5-Trisubstituted Pyridines》.Recommanded Product: (6-Chloro-5-methylpyridin-3-yl)boronic acid The author mentioned the following in the article:

Br vs. TsO chemoselective pallado-catalyzed Suzuki-Miyaura reaction has been developed from the 5-bromo-2-tosyloxynicotinaldehyde for the preparation of polysubstituted pyridines. This methodol. has been applied for the preparation of a terpyridine aldehyde, as a versatile precursor of potential Mcl-1 (Induced myeloid leukemia cell differentiation protein) inhibitors. The synthesis of pyridoclax (I), our lead compound which demonstrated efficacy for the treatment of chemoresistant ovarian cancer, has also been achieved via the palladium-catalyzed cross-coupling reaction in 5 steps from 3,5-dibromo-2-hydroxypyridine with 50% overall yield.(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0Recommanded Product: (6-Chloro-5-methylpyridin-3-yl)boronic acid) was used in this study.

(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: (6-Chloro-5-methylpyridin-3-yl)boronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jia, Meng-Ze; Cui, Jing-Wang; Rao, Cai-Hui; Chen, Yun-Rui; Yao, Xin-Rong; Zhang, Jie published an article in ACS Sustainable Chemistry & Engineering. The title of the article was 《Switchable ROS Species Regulation Facilitates the Selective Oxidation of Benzyl Alcohols Enabled by an Organic Photocatalyst》.Name: 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine The author mentioned the following in the article:

Benefiting from the regulation of ROS species through a simple and feasible strategy, an efficient and switchable photocatalytic protocol for the chemoselective synthesis of aldehydes and carboxylic acids via oxidation of primary alcs. under mild conditions was developed. Using the pyridinium derivative as a metal-free organic photocatalyst, a variety of benzyl alcs. can be converted into aldehydes or carboxylic acids under an air atm. at room temperature with high selectivity and yield via simple solvent regulation. A feasible tandem reaction combining the pyridinium-catalyzed alc.-to-aldehyde conversion and catalyst-free photoinduced oxidation of aromatic aldehydes provides a powerful and efficient approach for the one-pot oxidation of benzyl alcs. to carboxylic acids, while a small amount of water can effectively regulate the competition of electron transfer and energy transfer and inhibit the generation of carboxylic acids, facilitating highly efficient and selective oxidation of alcs. to aldehydes. In the experimental materials used by the author, we found 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Name: 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Name: 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kumar, Mopidevi Manikanta; Raj, C. Retna published an article on February 22 ,2019. The article was titled 《Carbothermal-Reduction-Assisted Phosphidation of Cobalt Affords Mesoporous Nitrogen-Doped Carbon-Embedded CoP Nanoelectrocatalysts for the Oxygen Reduction Reaction》, and you may find the article in ACS Applied Nano Materials.Computed Properties of C20H14N4 The information in the text is summarized as follows:

We demonstrate a new facile single-step synthesis of mesoporous nitrogen-doped carbon-embedded cobalt phosphide (NC-CoP) nanoparticles using a single-source precursor of the cobalt(II) bis(terpyridine)-based complex ([Co(pyterpy)2](PF6)2) by carbothermal reduction Phosphidation of cobalt is achieved with the hexafluorophosphate counteranion of the precursor complex for the first time. Polypyridyl complexes such as [Co(bpy)3](PF6)2 and [Co(terpy)2](PF6)2 do not yield the desired CoP. The at. percent of carbon in the precursor complex controls the growth of CoP. The as-synthesized NC-CoP has a large surface area of 120 m2/g and shows excellent electrocatalytic activity toward the oxygen reduction reaction (ORR). It is highly durable and favors the four-electron pathway for the reduction of oxygen to water at low overpotential. The synergistic effect between NC and CoP facilitates the electron-transfer kinetics for ORR. In addition to this study using 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine, there are many other studies that have used 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Computed Properties of C20H14N4) was used in this study.

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Computed Properties of C20H14N4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Luo, Dexia; Guo, Shengxin; He, Feng; Chen, Shunhong; Dai, Ali; Zhang, Renfeng; Wu, Jian published an article in Journal of Agricultural and Food Chemistry. The title of the article was 《Design, Synthesis, and Bioactivity of α-Ketoamide Derivatives Bearing a Vanillin Skeleton for Crop Diseases》.Safety of 4-Amino-2-picoline The author mentioned the following in the article:

A series of novel α-ketoamide derivatives bearing a vanillin skeleton were designed and synthesized. Bioactivity tests on virus and bacteria were performed. The results indicated that some compounds exhibited excellent antitobacco mosaic virus (TMV) activities, such as compound I exhibited an inactivation activity of 90.1% and curative activity of 51.8% and compound II exhibited a curative activity of 54.8% at 500μg mL-1, which is equivalent to that of the com. ningnanmycin (inactivation of 91.9% and curative of 51.9%). Moreover, the in vitro antibacterial activity test illustrated that compounds showed much higher activities than com. thiodiazole copper, which could be used as lead compounds or potential candidates. The findings of transmission electron microscopy and mol. docking indicated that the synthesized compounds exhibited strong and significant binding affinity to the TMV coat protein and could obstruct the self-assembly and increment of TMV particles. This study revealed that α-ketoamide derivatives bearing a vanillin skeleton could be used as a novel potential pesticide for controlling the plant diseases. In the part of experimental materials, we found many familiar compounds, such as 4-Amino-2-picoline(cas: 18437-58-6Safety of 4-Amino-2-picoline)

4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Safety of 4-Amino-2-picoline

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wu, Jing-wei; Yin, Ling; Liu, Yu-qiang; Zhang, Huan; Xie, Ya-fei; Wang, Run-ling; Zhao, Gui-long published an article on February 1 ,2019. The article was titled 《Synthesis, biological evaluation and 3D-QSAR studies of 1,2,4-triazole-5-substituted carboxylic acid bioisosteres as uric acid transporter 1 (URAT1) inhibitors for the treatment of hyperuricemia associated with gout》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.HPLC of Formula: 39856-58-1 The information in the text is summarized as follows:

Bromonaphthylmethyltriazolyl thioether lesinurad analogs and bioisosteres such as I were prepared as inhibitors of uric acid transporter 1 (URAT1) for potential use in treating hyperuricemia and gout. I inhibited URAT1 with an IC50 value of 32 nM, 225-fold lower than lesinurad. The pharmacophore for the lesinurad analogs was determined using a 3D-QSAR pharmacophore model; the hypothesis was validated by three methods (cost anal., Fisher’s randomization and leave-one-out). In addition to this study using 2-Bromopyridin-3-amine, there are many other studies that have used 2-Bromopyridin-3-amine(cas: 39856-58-1HPLC of Formula: 39856-58-1) was used in this study.

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).HPLC of Formula: 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2011,Liu, Jingying; Zhu, Lin; Ploessl, Karl; Lieberman, Brian P.; Kung, Hank F. published 《Synthesis and evaluation of novel N-fluoropyridyl derivatives of tropane as potential PET imaging agents for the dopamine transporter》.Bioorganic & Medicinal Chemistry Letters published the findings.Product Details of 13534-97-9 The information in the text is summarized as follows:

A series of novel N-fluoropyridyl-containing tropane derivatives, e.g., I, were synthesized and their binding affinities for the dopamine transporter (DAT), serotonin transporter (SERT) and norepinephrine (NET) were determined via competitive radioligand binding assays. Among these derivatives, compound I showed the highest binding affinity to DAT (Ki = 4.1 nM), and selectivity for DAT over SERT (5-fold) and NET (16-fold). Compound I was radiolabeled with Fluorine-18 in two steps. Regional brain distribution and ex vivo autoradiog. studies of [18F]I demonstrated that the ligand was selectively localized in the striatum region, where DAT binding sites are highly expressed. [18F]I may be useful as a potential radioligand for imaging DATs with PET. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9Product Details of 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Product Details of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2013,Dai, Jian-Jun; Fang, Chi; Xiao, Bin; Yi, Jun; Xu, Jun; Liu, Zhao-Jing; Lu, Xi; Liu, Lei; Fu, Yao published 《Copper-Promoted Sandmeyer Trifluoromethylation Reaction》.Journal of the American Chemical Society published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

A copper-promoted trifluoromethylation reaction of aromatic amines is described. This transformation proceeds smoothly under mild conditions and exhibits good tolerance of many synthetically relevant functional groups. It provides an alternative approach for the synthesis of trifluoromethylated arenes and heteroarenes. It also constitutes a new example of the Sandmeyer reaction. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9Category: pyridine-derivatives)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem