Day: October 17, 2022

Kumar, Sonu; Sarmah, Manash P.; Reddy, Yella; Bhatt, Ashish; Kant, Ravi published the artcile< A one-step synthesis of substituted benzo- and pyridine-fused 1H-imidazoles>, Electric Literature of 3731-53-1, the main research area is aryl benzoimidazole preparation; fluoronitrobenzene amine cyclization microwave irradiation; imidazopyridine aryl preparation; amine nitrofluoropyrdine cyclization microwave irradiation.

A one-step microwave accelerated synthesis of substituted benzo- and pyridine-fused 1H-imidazoles were described. Mechanistically, the reaction proceeded by reacting substituted 2-fluoronitrobenzene and substituted arylamine through the formation of N-hydroxy intermediate, which at higher temperature cleaved to afford the desired product. This approach achieved reductions in reaction times, higher yields, cleaner reactions than the previously described synthetic processes.

Synthetic Communications published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Electric Literature of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Huang, Zhi; Zhou, Wei; Li, Yongtao; Cao, Mei; Wang, Tianqi; Ma, Yakun; Guo, Qingxiang; Wang, Xin; Zhang, Chao; Zhang, Chenglan; Shen, Wenzhi; Liu, Yanhua; Chen, Yanan; Zheng, Jianyu; Yang, Shengyong; Fan, Yan; Xiang, Rong published the artcile< Novel hybrid molecule overcomes the limited response of solid tumours to HDAC inhibitors via suppressing JAK1-STAT3-BCL2 signalling>, Reference of 220731-04-4, the main research area is breast ovarian cancer HDAC inhibitor JAK1 STAT3 BCL2 signaling; CDK4/6; HDAC1; JAK1; inhibitor; solid tumour.

Despite initial progress in preclin. models, most known histone deacetylase inhibitors (HDACis) used as a single agent have failed to show clin. benefits in nearly all types of solid tumors. Hence, the efficacy of HDACis in solid tumors remains uncertain. Herein, we developed a hybrid HDAC inhibitor that sensitized solid tumors to HDAC-targeted treatment. Methods: A hybrid mol., Roxyl-zhc-84 was designed and synthesized with novel architecture. The pharmacokinetics and toxicity of Roxyl-zhc-84 were analyzed. Results: Roxyl-zhc-84 showed excellent pharmacokinetics and low toxicity. The novel hybrid inhibitor Roxyl-zhc-84 induced cell apoptosis and G1-phase arrest in breast cancer and ovarian cancer cell lines. In three mouse models, oral administration of Roxyl-zhc-84 led to significant tumor regression without obvious toxicity. Moreover, Roxyl-zhc-84 dramatically improved the limited response of traditional HDAC inhibitors in solid tumors via overcoming JAK1-STAT3-BCL2-mediated drug resistance. Roxyl-zhc-84 treatment exhibited vastly superior efficacy than the combination of HDAC and JAK1 inhibitors both in vitro and in vivo. Conclusion: Concurrent inhibition of HDAC and CDK using Roxyl-zhc-84 with addnl. JAK1 targeting resolved the limited response of traditional HDAC inhibitors in solid tumors via overcoming JAK1-STAT3-BCL2-mediated drug resistance, providing a rational multi-target treatment to sensitize solid tumors to HDACi therapy.

Theranostics published new progress about Acetylated histone H3 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 220731-04-4 belongs to class pyridine-derivatives, and the molecular formula is C10H15N3O2, Reference of 220731-04-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tatikonda, Rajendhraprasad; Cametti, Massimo; Kalenius, Elina; Famulari, Antonino; Rissanen, Kari; Haukka, Matti published the artcile< Mononuclear Ru(II) PolyPyridyl Water Oxidation Catalysts Decorated with Perfluoroalkyl C8H17-Tag Bearing Chains>, Application In Synthesis of 1762-41-0, the main research area is mononuclear ruthenium polypyridyl complex preparation crystal mol structure; water oxidation catalyst decorated perfluoroalkyl polypyridyl mononuclear ruthenium complex; perfluoroundecyl polypyridyl ruthenium complex preparation crystal mol structure.

A set of novel polypyridyl Ru(II) complexes 1-7, decorated with one, two or three C8F17 tags have been synthesized and characterized by NMR, UV/Vis spectroscopy and, in the case of series of complexes 1-3, 5 and 7 by x-ray diffraction on single crystals. Solid state structures of 3, 5 and 7 were also subjected to computational DFT study in order to gain insights into the effect of a different number of perfluorinated tags on their stability in the solid-state. The complexes are stable in solution under strongly oxidative conditions, do keep catalytic activity in their aquo forms (1′-7′) comparing well with parent complex 8′, and their amphiphilic nature could allow for their incorporation in fluorous media and interfaces.

European Journal of Inorganic Chemistry published new progress about Crystal structure. 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Application In Synthesis of 1762-41-0.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Day, Jon I.; Singh, Kamaljeet; Trinh, Winston; Weaver, Jimmie D. published the artcile< Visible Light Mediated Generation of trans-Arylcyclohexenes and Their Utilization in the Synthesis of Cyclic Bridged Ethers>, Name: Ir(p-F-ppy)3, the main research area is visible light mediated generation trans arylcyclohexene; cyclic bridged ether preparation reaction mechanism hydrogen bonding.

While accessible via UV-irradiation of cis-cyclohexene, trans-cyclohexene has thus far been an investigation driven by curiosity, and due primarily to its short lifespan, has until recently not been employed for productive synthesis. Herein, we present straightforward conditions that provide access to a class of trans-arylcyclohexenes and demonstrate their utility in the formation of oxabicyclic ethers, which are otherwise inaccessible from the corresponding cis-cyclohexene. A key challenge to utilizing the incredible ca. 52 kcal/mol strain energy of trans-cyclohexene to drive synthesis was overcoming its short lifetime. Herein, we show that preorganization via hydrogen bonding between the substrate and the reaction partner prior to isomerization is a viable strategy to overcome the inherently short lifetime of trans-cyclohexene.

Journal of the American Chemical Society published new progress about Bridged bicyclic compounds Role: SPN (Synthetic Preparation), PREP (Preparation). 370878-69-6 belongs to class pyridine-derivatives, and the molecular formula is C33H21F3IrN3, Name: Ir(p-F-ppy)3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ngo, Khang; Collins-Kautz, Chelsey; Gerstenecker, Stefan; Wagner, Bjoern; Heine, Andreas; Klebe, Gerhard published the artcile< Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins?>, Product Details of C6H8N2, the main research area is Protein Induced ligand protonation trypsin thrombin.

Trypsin and thrombin, structurally similar serine proteases, recognize different substrates; thrombin cleaves after Arg, whereas trypsin cleaves after Lys/Arg. Both recognize basic substrate headgroups via Asp189 at the bottom of the S1 pocket. By crystallog. and isothermal titration calorimetry (ITC), we studied a series of D-Phe/D-DiPhe-Pro-(amino)pyridines. Identical ligand pairs show the same binding poses. Surprisingly, one ligand binds to trypsin in protonated state and to thrombin in unprotonated state at P1 along with differences in the residual solvation pattern. While trypsin binding is mediated by an ordered water mol., in thrombin, water is scattered over three hydration sites. Although having highly similar S1 pockets, our results suggest different electrostatic properties of Asp189 possibly contributing to the selectivity determinant. Thrombin binds a specific Na+ ion next to Asp189, which is absent in trypsin. The electrostatic properties across the S1 pocket are further attenuated by charged Glu192 at the rim of S1 in thrombin, which is replaced by uncharged Gln192 in trypsin.

Journal of Medicinal Chemistry published new progress about Enzyme functional sites, active. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Product Details of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Singh, Malvinder P.; Bathini, Yadagiri; Lown, J. William published the artcile< Site selective alkoxymethylation of imidazo[4,5-b]pyridines: structural analysis by high field NMR methods>, Product Details of C6H7N3O2, the main research area is alkylation alkoxymethylation imidazopyridine regiochem; aryl imidazopyridine preparation structure; tautomer nucleophile alkoxymethylation regiochem imidazopyridine; solvent effect alkoxymethylation benzimidazole methoxyphenyl; benzimidazole alkoxymethyl methoxyphenyl mol structure; mol structure alkoxymethyl methoxyphenyl imidazopyridine.

The alkylation reactions of 2-aryl-1(3)H-imidazo[4,5-b]pyridines (equivalent to 1-deazapurines) with alkoxymethyl chlorides and bromoacetonitrile are described. The structural assignments of the products were made using 2-dimensional 1H-1H NOE (NOESY) and selective INEPT (INAPT) 13C NMR experiments using polarization transfer from C-bound hydrogens in the alkyl side chains to selected 13C resonances via long-range 3JCH couplings. Although 3 isomeric N-alkyl derivatives could arise from a single heterocycle based on considerations of tautomeric equilibrium, however, the reactions exhibit marked site selectivity even under quite different reaction conditions. Thus, N-3 alkyl derivatives are produced exclusively in basic (Et3N/NaH) nonpolar media following an SEE2cB mechanism. Solvent effects are evident in a loss of N-3 vs. N-1 selectivity for alkylation when the polar aprotic solvent DMF is used. Under neutral conditions direct alkylation occurs at the N-4 position following an SE2′ mechanism. The overall site selectivity appears to be governed by the relative reactivity of individual nucleophilic sites rather than the tautomeric composition in solution The regioselective alkoxymethylation of 2-(4-methoxyphenyl)benzimidazole, and methyl-2-(4-methoxyphenyl)imidazopyridines I (R = hydrogen, methyl; X = CH, N) were reported. Bis(imidazo[4,5-b]pyridine analogs of Hoechst 33258 were prepared

Heterocycles published new progress about Molecular structure. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Product Details of C6H7N3O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kuwata, Yoshiyuki; Sonoda, Motohiro; Tanimori, Shinji published the artcile< Facile Synthesis of Phenanthridinone Alkaloids via Suzuki-Miyaura Cross-coupling>, Electric Literature of 53636-56-9, the main research area is phenanthridinone alkaloid crinasiadine dihydrobicolorine trisphaeridine bicolorine facile synthesis; aminophenylboronic acid Suzuki Miyaura cross coupling bromobenzoate bromoheteroarenecarboxylate.

Phenanthridinone alkaloids crinasiadine (I) and N-alkylcrinasiadines II [R = CH2CH2CHMe2, CH2CH2CO2Et, CH2CH2Ph, CH2CH2CH2CO2Et] have been synthesized based on palladium-catalyzed tandem C-C and C-N bond formation starting from 2-aminophenylboronic acid and 2-bromobenzoate in short steps. Related alkaloids, 5,6-dihydrobicolorine (III), trisphaeridine (IV), and bicolorine (V) have also been synthesized.

Journal of Heterocyclic Chemistry published new progress about Alkaloids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (phenanthridine). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Electric Literature of 53636-56-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Keawkim, Kannika; Na Jom, Kriskamol published the artcile< Metabolomics and flavoromics analysis of chemical constituent changes during roasting of germinated Sacha inchi (Plukenetia volubilis L.)>, Related Products of 93-60-7, the main research area is metabolome flavorome roasting browning germination Plukenetia.

This study examined the changes in metabolites together with the flavor profiles of germinated Sacha inchi seeds during roasting by using gas chromatog. The results indicated that roasting partially increased the browning index, amino acid levels, total phenolic content, and antioxidant capacity, but slightly decreased the levels of reducing sugars. Oxidized and rancid compounds were significantly decreased at a 180 °C roasting temperature Pyrazine, furan, and pyrrole were Maillard reaction products that were increased at 180 °C of roasting. Roasting at 145 °C for 45 min after germination for 4 days was determined to be the optimal conditions for roasting germinated Sacha inchi seeds, which reduced the off-flavor and burned taste. The roasted germinated Sacha inchi seed contains higher amino acids than raw seed, which could be used as an alternative source for food products and supplements. In addition, the roasted germinated seeds at 4 days were recommended for food applications.

Food Chemistry: X published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Related Products of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sanders, Georgine M.; Van Dijk, M.; Van der Plas, H. C. published the artcile< Reactions of haloquinolizinium bromides with diethylamine>, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate, the main research area is quinolizinium bromide diethylamine reaction.

The reactions of quinolizinium bromide (QB) and its four monobromo derivatives with diethylamine have been investigated. For Br in position 2 or 4, substitution is the main process, whereas for Br in positions 1 and 3 quant. ring opening is found. The substituted pyridylbutadienes formed by ring opening, are cis-trans-butadienes, which isomerize into the all-trans forms. The steric course of the ring opening is explained.

Journal of Heterocyclic Chemistry published new progress about 53636-56-9. 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Serrano-Ruiz, Juan Carlos; Campelo, Juan M.; Francavilla, Matteo; Romero, Antonio A.; Luque, Rafael; Menendez-Vazquez, Carmen; Garcia, Ana B.; Garcia-Suarez, Eduardo J. published the artcile< Efficient microwave-assisted production of furfural from C5 sugars in aqueous media catalyzed by Broensted acidic ionic liquids>, SDS of cas: 21876-43-7, the main research area is ionic liquid xylose hydrolysis dehydration catalyst furfural microwave.

Small amounts of SO3H-functionalized room temperature synthesized ionic liquids efficiently dehydrate aqueous xylose to furfural under microwave heating at mild reaction conditions. The RT-ionic liquid catalysts were also found to be effective catalysts for the two step one-pot simultaneous hydrolysis and dehydration of a lignocellulosic waste biorefinery-derived syrup enriched in C5 sugar oligomers.

Catalysis Science & Technology published new progress about Bronsted acidity. 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, SDS of cas: 21876-43-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem