Day: October 17, 2022

Conejos-Sanchez, I.; Gallon, E.; Nino-Pariente, A.; Smith, J. A.; De la Fuente, A. G.; Di Canio, L.; Pluchino, S.; Franklin, R. J. M.; Vicent, M. J. published the artcile< Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders>, Related Products of 2127-03-9, the main research area is polyornithine siRNA polyplex central nervous system disorder.

Gene silencing therapies have successfully suppressed the translation of target proteins, a strategy that holds great promise for the treatment of central nervous system (CNS) disorders. Advances in the current knowledge on multimol. delivery vehicles are concentrated on overcoming the difficulties in delivery of small interfering (si)RNA to target tissues, which include anatomical accessibility, slow diffusion, safety concerns, and the requirement for specific cell uptake within the unique environment of the CNS. The present work addressed these challenges through the implementation of polyornithine derivatives in the construction of polyplexes used as non-viral siRNA delivery vectors. Physicochem. and biol. characterization revealed biodegradability and biocompatibility of our polyornithine-based system and the ability to silence gene expression in primary oligodendrocyte progenitor cells (OPCs) effectively. In summary, the well-defined properties and neurol. compatibility of this polypeptide-based platform highlight its potential utility in the treatment of CNS disorders.

Nanoscale published new progress about Biocompatibility. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Related Products of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Al-Busaidi, Idris Juma; Ilmi, Rashid; Zhang, Danyang; Dutra, Jose D. L.; Oliveira, Willyan F.; Al Rasbi, Nawal K.; Zhou, Liang; Wong, Wai-Yeung; Raithby, Paul R.; Khan, Muhammad S. published the artcile< Synthesis and photophysical properties of ternary β-diketonate europium(III) complexes incorporating bipyridine and its derivatives>, COA of Formula: C10H8N2, the main research area is trifluoromethyl phenyl butanedione phenylethynyl bromo bipyridine europium preparation photophys; ternary beta diketonate europium bipyridine preparation photophys photoluminescence.

Two new octa-coordinated ternary europium(III) complexes of the type [Eu(btfa)3(Br2-bpy)] (Eu-1) and [Eu(btfa)3(PhE2-bpy)] (Eu-2) (where btfa = 4,4,4-trifluoro-1-phenyl-1,3-butanedione, Br2-bpy = 5,5′-dibromo-2,2′-bipyridine, PhE2-bpy 5,5′-bis(phenylethynyl)-2,2′-bipyridine) together with a previously reported complex [Eu(btfa)3(bpy)] (Eu-3) have been synthesized. The complexes have been characterized by anal. and spectroscopic methods. The photophys. properties of the complexes have also been analyzed both exptl. and theor. The contribution of each ligand to the sensitized Eu(III) photoluminescence (PL) has been analyzed and is discussed. An energy transfer (ET) mechanism is proposed and discussed for the sensitized Eu(III) emission using exptl. and theor. data. The Eu(III) complex incorporating the parent bpy showed impressive performance as a double-emitting layer (EML) red organic light emitting diodes (R-OLEDs).

Dyes and Pigments published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Houlihan, Joanna C. C.; Moratti, Stephen C.; Hanton, Lyall R. published the artcile< Formation of a robust, double-walled LiMOF from an L-shaped di-substituted N-heterocyclic adamantane-based ligand>, Related Products of 93-60-7, the main research area is preparation lithium copper zinc heterocyclic adamantane complex; crystal structure lithium copper zinc heterocyclic adamantane complex; lithium copper zinc heterocyclic adamantane MOF.

The properties of adamantane render it an attractive building block towards the synthesis of robust frameworks. This work describes the synthesis of the L-shaped 1,3-bis(3′-carboxypyridine)adamantane (L1) ligand and the corresponding Li(I), Zn(II) and Cu(II) frameworks. Three topol. analogous Li(I) frameworks LiMOF12, LiMOF30 and LiMOF50 are reported, with calculated solvent accessible void volumes of 46, 43 and 36%, resp. The reaction between the carboxylate groups of L1 and the Li(I) cations gave Li-carboxylate rods. The Li-carboxylate rods contributed to the formation of a double-walled MOF with large, open one dimensional channels. The synergistic effect of the double wall, lithium-carboxylate rods and the adamantane core itself, gave a robust network stable up to temperatures of 300-350° and a min. of three months stability in air. Furthermore, complexation of L1 with Cu(BF4)2·H2O and Zn(CF3SO3)2 provided a 2D → 3D interpenetrated network containing a classic dimeric copper paddle-wheel SBU, and an infinite 1D chain which extended into a 3D structure facilitated by hydrogen-bonding interactions, resp.

Dalton Transactions published new progress about Crystal structure. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Related Products of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hu, Jun-Chao; Sun, Shanshan; Li, Ming-De; Xia, Wu; Wu, Jin; Liu, Hongfang; Wang, Feng published the artcile< A biomimetic self-assembled cobaloxime@CdS/rGO hybrid for boosting photocatalytic H2 production>, Synthetic Route of 3731-53-1, the main research area is biomimetic cobaloxime CdS rGO hybrid photocatalytic hydrogen prduction.

A biomimetic CoPe@CdS/rGO hybrid that self-assembles via the integration of a mol. cobalt catalyst and CdS nano-semiconductor on reduced graphene oxide was constructed for boosting photocatalytic H2 production Photoinduced electron transfer from CdS/rGO to the mol. catalyst occurs and a long-lived charge-separation state forms for high H2 production

Chemical Communications (Cambridge, United Kingdom) published new progress about Attenuated-total-reflectance IR spectroscopy. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Synthetic Route of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Angnes, Ricardo A.; Oliveira, Juliana M.; Oliveira, Caio C.; Martins, Nelson C.; Correia, Carlos Roque D. published the artcile< Stereoselective Synthesis of Aryl Cyclopentene Scaffolds by Heck-Matsuda Desymmetrization of 3-Cyclopentenol>, COA of Formula: C13H15F3N2O, the main research area is arylcyclopentenol diastereoselective enantioselective preparation; arylcyclopentanone enantioselective preparation; Heck Matsuda desymmetrization cyclopentenol aryldiazonium salt palladium pyridinyloxazoline catalyst; diastereoselective enantioselective Heck Matsuda reaction aryldiazonium salt cyclopentenol; bromophenyl chlorophenyl cyclopentenol mol crystal structure; Heck reaction; aryldiazonium salts; chiral N,N ligands; desymmetrization; palladium.

In the presence of palladium bis(trifluoroacetate) and nonracemic (trifluoromethyl)pyridinyloxazoline I, aryldiazonium trifluoroborates RN2+ BF4- [R = 4-MeOC6H4, 2-MeOC6H4, 3,4-(MeO)2C6H3, 3,4,5-(MeO)3C6H2, 4-HOC6H4, 2-HOC6H4, Ph, 4-BrC6H4, 4-ClC6H4, 4-O2NC6H4, 3-O2NC6H4, 2-O2NC6H4, 4-F3CC6H4, 3-F3CC6H4, 2-F3CC6H4] underwent enantioselective Heck-Matsuda desymmetrization reactions with 3-cyclopenten-1-ol to give arylcyclopentenols II [R = 4-MeOC6H4, 2-MeOC6H4, 3,4-(MeO)2C6H3, 3,4,5-(MeO)3C6H2, 4-HOC6H4, 2-HOC6H4, Ph, 4-BrC6H4, 4-ClC6H4, 4-O2NC6H4, 3-O2NC6H4, 2-O2NC6H4, 4-F3CC6H4, 3-F3CC6H4, 2-F3CC6H4] in 20-70% yields and in 85-99% ee and (in some cases) nonracemic 3-arylcyclopentenones in 12-27% yields and in 17-93% ee. The hydroxy group of the cyclopentenol reactant acted as a directing group to control the relative stereochem. of the coupling reaction. The structures of II (R = 4-BrC6H4, 4-ClC6H4) were determined by X-ray crystallog.

Chemistry – A European Journal published new progress about Alcohols, unsaturated Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, COA of Formula: C13H15F3N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tunca, Ekrem; Bulbul, Metin; Ilkimen, Halil; Canlidinc, Rukiye Saygili; Yenikaya, Cengiz published the artcile< Investigation of the effects of the proton transfer salts of 2-aminopyridine derivatives with 5-sulfosalicylic acid and their Cu(II) complexes on cancer-related carbonic anhydrases: CA IX and CA XII>, Reference of 21901-29-1, the main research area is cancer sulfosalicylic acid aminopyridine carbonic anhydrase IX XII.

Abstract: Six novel proton transfer compounds (15-20) obtained from 5-sulfosalicylic acid (1) and 2-aminopyridine derivatives [2-amino-3-benzyloxypyridine (2), 2-amino-3-hydroxylpyridine (3), 2-amino-3-methylpyridine (4), 2-amino-3-nitropyridine (5), 2-amino-3-nitro-4-methylpyridine (6) and 2-amino-3-nitro-6-methylpyridine (7)] and their Cu(II) complexes (21-26) along with the Cu(II) complexes of 2-7 (9-14) have been prepared and characterized by spectroscopic techniques. The in vitro inhibition effects of all compounds on CA IX and CA XII isoenzymes as well as on hCA I and hCA II were investigated and the results were compared. The inhibition studies showed that the synthesized compounds are more selective to CA XII isoenzyme. The hydratase IC50 values of the compounds were determined as in the range of 15.61 ± 2.32 uM-99.02 ± 4.99 uM for hCA I, 22.36 ± 0.75 uM-77.03 ± 4.03 uM for hCA II, 23.90 ± 1.67 uM-138.63 ± 5.45 uM for CA IX, and 9.50 ± 1.16 uM-693.15 ± 8.96 uM for CA XII. The inhibition data have been analyzed using one-way anal. of variance for multiple comparisons (p < 0.0001). Chemical Papers published new progress about Enzyme inhibition kinetics. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Reference of 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tapanyigit, Ozan; Demirkol, Onur; Guler, Ece; Ersatr, Mehmet; Cam, Muhammet Emin; Giray, Elife Sultan published the artcile< Synthesis and investigation of anti-inflammatory and anticonvulsant activities of novel coumarin-diacylated hydrazide derivatives>, Product Details of C7H7NO2, the main research area is coumarin diacylated hydrazide derivative anticonvulsant anti inflammatory.

A number of novel coumarin derivatives synthesized by the reaction of 3-carbonyl chloride coumarin with some substituted aryl acid hydrazides to investigate their anti-inflammatory and anticonvulsant activities. Carrageenan (0.1 mL of 1%, w/v) was injected subplantarly in the right paw of rats to induce an acute model of inflammation. Anti-inflammatory efficacy was evaluated for 5 h at 3 different dosages 5, 10, 25 mg/kg. After that, the changes in the level of paw edema volumes and percentage inhibition of all groups were observed and the most effective coumarin derivative was found as N′-(2-hyroxybenzoyl)-2-oxo-2H-chromene-3-carbohydrazide. In addition, N′-(2-oxo-2H-chromene-3-carbonyl)nicotinohydrazide, (E)-N′-(3-(4-hydroxyphenyl)acryloyl)-2-oxo-2H-chromene-3-carbohydrazide, and N′-(5-amino-2-hydroxybenzoyl)-2-oxo-2H-chromone-3-carbohydrazide showed their anti-inflammatory effects in a dose-dependent manner. On the other hand, pentylenetetrazole (PTZ, 80 mg/kg, i.p.)-induced seizure model was used to investigate the anticonvulsant activities of six newly synthesized coumarin derivatives in mice. Hybrid compound of salicylic acid hydrazide and 3-carbonyl chloride coumarin was found the most promising anticonvulsant agent among all treatment groups according to the onset of seizure and survival rate. Moreover, (E)-N′-cinnamoyl-2-oxo-2H-chromene-3-carbohyrazide and (E)-N′-(3-(4-hyroxyphenyl)acryloyl)-2-oxo-2H-chromene-3-carbohydrazide has potential anticonvulsant efficiency in low doses (30 mg/kg). The anticonvulsant effect of these coumarin derivatives may be through enhanced GABA-mediated inhibition in the brain.

Arabian Journal of Chemistry published new progress about Anti-inflammatory agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Product Details of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Schuster, Georg; Lindner, Wolfgang published the artcile< Comparative characterization of hydrophilic interaction liquid chromatography columns by linear solvation energy relationships>, Related Products of 21876-43-7, the main research area is hydrophilic interaction liquid chromatog column linear solvation energy relationship; acid organic hydrophilic interaction LC linear solvation energy relation; base organic hydrophilic interaction LC linear solvation energy relation.

Twenty-two com. available and home-made stationary phases with different surface modifications were compared under hydrophilic interaction liquid chromatog. (HILIC) conditions. The column set comprised neutral, basic, acidic, zwitterionic and mixed surface modifications. Retention data of 68 differently structured test solutes were acquired to generate retention models based on a linear solvation energy relation (LSER) approach. A recently modified solvation parameter model with two addnl. mol. descriptors was evaluated in terms of its universal applicability when electrostatic forces are enabled in addition to predominant partition phenomena. The suggested method could not be confirmed to be a standardized way to characterize HILIC systems when different operating conditions are applied. However, the significant contribution of the recently introduced charge descriptors (D- and D+) on explaining the interactions within HILIC systems was confirmed. The solvation parameter model is a useful tool in column development, to affirm or dismiss the preceding educated guess on how certain immobilized ligands will behave. Acidic modified surfaces (stationary phases) exhibit a very small hydrogen bond acceptor property and are less versatile when it comes to an even distribution of solutes along the retention window. Also, basic and neutral columns are more preferable for HILIC applications and might explain why only a limited variety of strong acidic modified HILIC columns, although found in literature, are available com.

Journal of Chromatography A published new progress about Electrostatic force. 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Related Products of 21876-43-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

He, Qiao; Guo, Mingming; Jin, Tony Z.; Arabi, Saifanassour Ali; Liu, Donghong published the artcile< Ultrasound improves the decontamination effect of thyme essential oil nanoemulsions against Escherichia coli O157: H7 on cherry tomatoes>, Electric Literature of 123-03-5, the main research area is cherry tomato Escherichia coli thyme essential oil nanoemulsion decontamination; Antibacterial activity; Cherry tomato; E. coli O157:H7; Thyme essential oil nanoemulsion; Ultrasound.

Development of novel and effective decontamination technologies to ensure the microbiol. safety of fresh produce has gained considerable attention, mainly driven by numerous outbreaks. This work presented the first approach regarding to the application of the previously reported hurdle technologies on the sanitization of artificially contaminated cherry tomatoes. Thyme (Thymus daenensis) essential oil nanoemulsion (TEON, 8.28 nm in diameter with a narrow size distribution) was formulated via ultrasonic nanoemulsification, showing remarkably improved antimicrobial activity against Escherichia coli (E. coli) O157:H7, compared to the coarse emulsion. The antimicrobial effect of ultrasound (US), thyme essential oil nanoemulsion (TEON) and the combination of both treatments was assessed against E. coli O157:H7. The remarkable synergistic effects of the combined treatments were achieved, which decontaminated the E. coli populations by 4.49-6.72 log CFU/g on the surface of cherry tomatoes, and led to a reduction of 4.48-6.94 log CFU/sample of the total inactivation. TEON combined with US were effective in reducing the presence of bacteria in wastewater, which averted the potential detrimental effect of cross-contamination resulted from washing wastewater in fresh produce industry. Moreover, the treatments did not noticeably alter the surface color and firmness of cherry tomatoes. Therefore, ultrasound combined with TEON is a promising and feasible alternative for the reduction of microbiol. contaminants, as well as retaining the quality characteristics of cherry tomatoes.

International Journal of Food Microbiology published new progress about Antimicrobial agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Electric Literature of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Attatsi, Isaac Kwaku; Zhu, Weihua; Liang, Xu published the artcile< Noncovalent immobilization of Co(II) porphyrin through axial coordination as an enhanced electrocatalyst on carbon electrodes for oxygen reduction and evolution>, Category: pyridine-derivatives, the main research area is cobalt tetraphenylporphyrin carbon nanotube glassy carbon oxygen reduction evolution.

Catalysis of fuel-producing reactions can be transferred from homogeneous solution to a surface via attachment of the mol. catalyst. A pyrene-pyridine hybrid (Py-Py) was used as an axial ligand to bridge Co(II)tetraphenylporphyrin which was finally immobilized on carbon nanotubes via noncovalent interactions and further deposited on glassy carbon. This noncovalent immobilization of Co(II)porphyrin through axial coordination provides significantly enhanced electrochem. catalyzed oxygen reduction and oxygen evolution, illustrating a new insight into understanding surface catalysis.

New Journal of Chemistry published new progress about Bifunctional catalysts. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem