Day: October 17, 2022

Rashed, Nurnobi Md.; Masuda, Koichiro; Ichitsuka, Tomohiro; Koumura, Nagatoshi; Sato, Kazuhiko; Kobayashi, Shu published the artcile< Zirconium Oxide-Catalyzed Direct Amidation of Unactivated Esters under Continuous-Flow Conditions>, Product Details of C7H7NO2, the main research area is amine ester zirconium catalyst amidation green chem; amide preparation.

A sustainable and environmentally benign direct amidation reaction of unactivated esters with amines was developed in a continuous-flow system. A com. available amorphous zirconium oxide was found to be an efficient catalyst for this reaction. While the typical amidation of esters with amines required a stoichiometric amount of a promoter or metal activator, the present continuous-flow method enabled the direct amidation reaction under additive-free conditions with an extensive diversity towards various functional groups. High yields of the products were obtained with a nearly equimolar proportion of starting materials to reduce byproduct formation, which rendered this process applicable for use in a sequential-flow system.

Advanced Synthesis & Catalysis published new progress about Amidation. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Product Details of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sun, Yi; Hu, Xueyan; Guo, Du; Shi, Chao; Zhang, Chunling; Peng, Xiaoli; Yang, Hua; Xia, Xiaodong published the artcile< Disinfectant Resistance Profiles and Biofilm Formation Capacity of Escherichia coli Isolated from Retail Chicken>, Formula: C21H38ClN, the main research area is resistance biofilm formation Escherichia chicken; biofilm formation capacity; disinfectant resistance; disinfectant-resistant genes.

Disinfectant resistance and biofilm formation capacity are two important characteristics that contribute to the persistence of microorganisms in food processing environments and contamination of food products. This study investigated the susceptibility of 510 Escherichia coli isolates against 5 disinfectants and the prevalence of 10 disinfectant-resistant genes in these isolates. The biofilm formation capacity of 194 isolates was determined, and the correlation between disinfectant resistance and biofilm formation was analyzed. The minimal inhibitory concentrations (MICs) of cetyltrimethylammonium bromide (CTAB), benzalkonium chloride (BC), cetylpyridinium chloride, and chlorhexidine (CHX) against isolates were 32-512, 16-256, 32-256, and 2-32 mg/L, resp. The MICs of triclosan against 88.43% of isolates were 8-1,024 mg/L, while the MICs for the rest of isolates exceed 2,048 mg/L. The presence of ydgE, ydgF, and qacF genes was significantly correlated with the CHX resistance of E. coli isolates, while the presence of qacF and qacEΔ1 genes was significantly correlated with CTAB and BC resistance, resp. The biofilm formation capacity (adjusted optical d. value) was pos. correlated with BC resistance (r = 0.201, p < 0.01) and showed no correlation with other disinfectants. The presence of sugE(p) was pos. correlated with biofilm formation, while four genes were neg. correlated with biofilm formation. This study provides useful data on disinfectant resistance and biofilm formation capacity of E. coli contaminating poultry products, which could be helpful in guiding proper disinfectant usage and establishing effective biofilm eradication strategy in food industry. Microbial Drug Resistance (New Rochelle, NY, United States) published new progress about Biofilms (microbial). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Formula: C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shahsavari, Hamid R.; Babadi Aghakhanpour, Reza; Biglari, Abbas; Niazi, Maryam; Mastrorilli, Piero; Todisco, Stefano; Gallo, Vito; Lalinde, Elena; Moreno, M. Teresa; Gimenez, Nora; Halvagar, Mohammad Reza published the artcile< C(sp2)-C(sp2) Reductive Elimination from a Diarylplatinum(II) Complex Induced by a S-S Bond Oxidative Addition at Room Temperature>, Product Details of C10H8N2S2, the main research area is arylplatinum benzothiazolethiolate pyridinethiolate preparation crystal structure; crystal structure diarylplatinum benzothiazolethiolate pyridinethiolate dinuclear platinum lantern complex; mol structure diarylplatinum benzothiazolethiolate pyridinethiolate dinuclear platinum lantern complex; dinuclear platinum lantern complex preparation crystal structure; diarylplatinum complex oxidative addition benzothiazolethiolate pyridinethiolate.

The synthesis and characterization of three six-coordinated Pt(IV) complexes [Pt(Ar)2(S[symbol omitted]N)2] (S[symbol omitted]N = Sbt, benzothiazole-2-thiolate, Ar = p-MeC6H4 (1a), C6F5 (1b); S[symbol omitted]N = Spy, 2-pyridinethiolate, Ar = p-MeC6H4 (1c)) is described. Of these, 1a undergoes, at room temperature and within 18 h, a remarkable C-C reductive elimination process between the aryl ligands to give, as the final products, the stable binuclear lantern complex [Pt2(Sbt)4] (2a) and 4,4′-dimethylbiphenyl. Differently from 1a, solutions of 1b,c are indefinetively stable up to 60° and do not undergo reductive elimination. Complexes 1a-c and 2a were characterized by IR and NMR spectroscopy, high-resolution mass spectrometry, and single-crystal x-ray crystallog. (1b,c and 2a). 1H-19F HOESY experiments on 1b demonstrated the presence of a through-space coupling between proximal F and H atoms of the mol. that are separated by six bonds but are in close spatial proximity.

Organometallics published new progress about Crystal structure. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Product Details of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Yibiao; Huang, Shuo; Liao, Chunshu; Shao, Yan; Chen, Lu published the artcile< Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridines and acetamidine hydrochloride>, Quality Control of 22280-62-2, the main research area is aminopyridine preparation chemoselective green chem; fluoropyridine acetamidine hydrochloride amination.

An efficient method for the synthesis of 2-aminopyridine derivatives I (R = 3-I, 3-Cl-5-I, 5-NO2-6-CH3, etc.; R1 = NH2) through the nucleophilic substitution and hydrolysis of 2-fluoropyridines I (R1 = F) and acetamidine hydrochloride under catalyst-free conditions has been developed. This amination uses inexpensive acetamidine hydrochloride as the ammonia source and has the advantages of high yield, high chemoselectivity and wide substrate adaptability. The results suggest that other N-heterocycles containing fluorine substituents such as 5-chloro-2,4-difluoropyrimidine and 2-fluoropyrazine can also complete the reaction via these reaction conditions and yield the target products 5-chloro-4-fluoropyrimidin-2-amine and pyrazin-2-amine resp.

Organic & Biomolecular Chemistry published new progress about Amination (chemoselective). 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Quality Control of 22280-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zeng, Xiaojun; Yan, Wenhao; Zacate, Samson B.; Cai, Aijie; Wang, Yufei; Yang, Dongqi; Yang, Kundi; Liu, Wei published the artcile< Copper-Catalyzed Deaminative Difluoromethylation>, SDS of cas: 3731-53-1, the main research area is copper catalyst deaminative difluoromethylation alkyl amine; copper; deamination; difluoromethylation; homogeneous catalysis; pyridinium salts.

The difluoromethyl group (CF2H) is considered to be a lipophilic and metabolically stable bioisostere of an amino (NH2) group. Therefore, methods that can rapidly convert an NH2 group into a CF2H group would be of great value to medicinal chem. The authors report herein an efficient Cu-catalyzed approach for the conversion of alkyl pyridinium salts, which can be readily synthesized from the corresponding alkyl amines, to their alkyl difluoromethane analogs. This method tolerates a broad range of functional groups and can be applied to the late-stage modification of complex amino-containing pharmaceuticals.

Angewandte Chemie, International Edition published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, SDS of cas: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lv, Tengteng; Dai, Fa; Zhuang, Qiuting; Zhao, Xuelin; Shao, Yina; Guo, Ming; Lv, Zhimeng; Li, Chenghua; Zhang, Weiwei published the artcile< Outer membrane protein OmpU is related to iron balance in Vibrio alginolyticus>, Electric Literature of 366-18-7, the main research area is Vibrio outer membrane porin iron; Iron balance; OmpU; Vibrio alginolyticus.

Outer membrane protein U (OmpU) is a major porin from Vibrio alginolyticus and has been considered a vaccine candidate against infection by V. alginolyticus. After pre-incubated with polyclonal antibody against rOmpU, V. alginolyticus showed a 78% decrease in extracellular iron level, suggesting that interruption of OmpU could increase intracellular iron level. The mRNA expression of ompU under iron-limited conditions was determined using real-time reverse transcriptase PCR. The mRNA level of ompU was downregulated to 0.27-, 0.036- and 0.019-fold after the addition of the iron chelator 2,2′-bipyridyl for 10, 30 and 60 min, resp. In addition, the promoter of ompU contained a ferric uptake regulator (Fur) binding site, which revealed the potential regulation of ompU by Fur and iron. Fur from V. alginolyticus was purified and used for electrophoretic mobility shift assay. The result showed that in the absence of Fe2+, purified recombinant Fur could specifically bind to the promoter DNA of ompU, while in the presence of Fe2+, the binding of Fur and the promoter DNA was suppressed. Our study preliminarily explored the function of OmpU in iron balance in V. alginolyticus, and these findings were helpful in understanding iron metabolism in V. alginolyticus.

Microbiological Research published new progress about Major outer membrane porins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Electric Literature of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Jianguo; Chen, Jia-Yi; Jia, Mengjing; Ming, Bangrong; Jia, Jiong; Liao, Rong-Zhen; Tung, Chen-Ho; Wang, Wenguang published the artcile< Ni-O Cooperation versus Nickel(II) Hydride in Catalytic Hydroboration of N-Heteroarenes>, Quality Control of 93-60-7, the main research area is cyclopentadienyl nickel phosphinophenolate preparation catalyst hydroboration heteroarene pyridine kinetics; crystal structure cyclopentadienyl nickel phosphinophenolate phosphinothiophenolate complex borate adduct; mol structure cyclopentadienyl nickel phosphinophenolate phosphinothiophenolate complex borate adduct; potential energy surface nickel phosphinophenolate catalyst hydroboration pyridine.

An air-stable half-sandwich Ni(II) complex bearing a phosphinophenolato ligand, Cp*Ni(1,2-Ph2PC6H4O) (1), was designed and synthesized for activation of HBpin and catalytic hydroboration of N-heteroarenes such as pyridine. Through addition of the H-B bond across the Ni-O bond, 1 reacts with HBpin to afford an 18-electron Ni(II)-H intermediate [H1(Bpin)] featuring an O-stabilized B moiety, which readily reduces pyridine analogs to give the 1,2-hydroborated product, thus accomplishing the catalytic cycle under mild conditions. The necessity of the phosphinophenolato ligand to deliver the boryl group was manifested by the clear difference in the activity of 1 and Cp*NiH(PPh3) (3H) in catalytic hydroborations. The latter lacks a functional O atom and is inert to process the catalysis.

ACS Catalysis published new progress about Aromatic hydrocarbons Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent) (N-heteroarenes). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Quality Control of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hou, Lixia; Zhang, Yujin; Li, Cuicui; Wang, Xuede; Wang, Selina C. published the artcile< Determination of main bitter compounds in soaked and germinated sesame pastes>, HPLC of Formula: 93-60-7, the main research area is sesame paste germination soaking bitter compound determination; bitterness; germination; non-volatile; sesame pastes; volatile compounds.

The flavor and taste of the foods play an important or even a decisive role in the acceptance and preference of the consumers. It was found that the sesame paste prepared with the germinated sesame seeds was bitter in our previous experiment In the study, the volatile and non-volatile bitter-taste components of the sesame paste samples were comprehensively analyzed. 2-methylbutanal, hexanal, acetic acid, and butyric acid were the predominant volatile compounds in the soaked and germinated sesame pastes. Oxalate was significantly reduced by the germination (p < 0.05). The contents of sesaminoltriglucoside in sesame pastes ranged from 129.04 to 217.57μg/g. Both total and individual free amino acid contents increased with the prolongation of the germinating time. The bitter-taste amino acid Arg had the highest score of Taste Activity Value for the bitterest sample made from the seeds germinated for 36 h. The bitter-tasting Arg was first reported to impart a bitter taste to the germinated sesame paste. Journal of Oleo Science published new progress about Acids Role: ANT (Analyte), FFD (Food or Feed Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, HPLC of Formula: 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mei, Tian-Sheng; Patel, Harshkumar H.; Sigman, Matthew S. published the artcile< Enantioselective construction of remote quaternary stereocentres>, Quality Control of 1416819-91-4, the main research area is trisubstituted alkenyl alc arylboronic acid palladium relay Heck arylation; aryl carbonyl compound quaternary carbon substituted stereoselective preparation.

Small mols. that contain all-carbon quaternary stereocenters-carbon atoms bonded to four distinct carbon substituents-are found in many secondary metabolites and some pharmaceutical agents. The construction of such compounds in an enantioselective fashion remains a long-standing challenge to synthetic organic chemists. In particular, methods for synthesizing quaternary stereocenters that are remote from other functional groups are underdeveloped. Here we report a catalytic and enantioselective intermol. Heck-type reaction of trisubstituted-alkenyl alcs. with aryl boronic acids. This method provides direct access to quaternary all-carbon-substituted β-, γ-, δ-, ε- or ζ-aryl carbonyl compounds, because the unsaturation of the alkene is relayed to the alc., resulting in the formation of a carbonyl group. The scope of the process also includes incorporation of pre-existing stereocenters along the alkyl chain, which links the alkene and the alc., in which the stereocenter is preserved. The method described allows access to diverse mol. building blocks containing an enantiomerically enriched quaternary center.

Nature (London, United Kingdom) published new progress about Alkenyl alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Quality Control of 1416819-91-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Hao; Gao, Ang; Liu, Xiu-Yan; Ding, Chang-Hua; Xu, Bin; Hou, Xue-Long published the artcile< Kinetic Resolution of 5-Substituted Cyclohexenols by Palladium-Catalyzed Asymmetric Redox-Relay Heck Reaction>, Name: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole, the main research area is cyclohexenol arylboronic acid palladium catalyst Heck reaction kinetic resolution; aryl cyclohexanone cyclohexenol preparation enantioselective diastereoselective.

The kinetic resolution of 2-substituted-cyclohexenols via palladium-catalyzed asym. redox-relay Heck reaction was realized, providing optically active 2-substituted cyclohexenols and trans-3,5-disubstituted cyclohexan-1-ones in high yield and good enantioselectivities with an S factor up to 22.

Synthesis published new progress about Cyclic ketones Role: BYP (Byproduct), PRP (Properties), PUR (Purification or Recovery), SPN (Synthetic Preparation), PREP (Preparation). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Name: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem