Day: October 18, 2022

Li, Jing; Zheng, Jiayi; Peng, Xiaoqian; Dai, Zongren; Liu, Weizhen; Deng, Hong; Xi, Beidou; Lin, Zhang published the artcile< NaCl recovery from organic pollutants-containing salt waste via dual effects of aqueous two-phase systems (ATPS) and crystal regulation with acetone>, Name: 6-Chloropyridin-2-ol, the main research area is sodium chloride recovery acetone organic pollutant industrial salt waste.

A large amount of salt waste accompanied with contaminants (e.g., organic pollutants) is produced in chem. production process, causing serious environmental hazards and waste of salt resources. However, there have been few satisfactory treatments for this hazardous waste until now. In this work, a novel strategy for NaCl recovery and organic pollutants removal from the salt waste containing pyridine derivatives was developed by using acetone in salt waste solution The results showed NaCl was effectively recovered (recovery rate, 99.12%), and the TOC value of its saturated solution was reduced from 806.2 to 145.4 mg/L, below the limits (200 mg/L) for chlorine gas and caustic soda production in chlorine alkali plant. Moreover, no pyridine derivatives can be identified through Fourier transform IR spectroscopy (FTIR) test. Mechanism anal. demonstrated the dual effects of acetone as following: (1) acetone and NaCl formed aqueous two-phase systems (ATPS) to remove organic pollutants; 2) acetone, as a crystal regulator, induced NaCl crystals to recrystallize in cubic morphol. with a smooth surface, which enhanced the removal of pollutants. Besides, the acetone-water phase split facilitated the separation of organic pollutants as well as the reuse of acetone. This work proposes a promising and feasible method for salt waste to remove organic pollutants and recover recrystallized NaCl solids, and also provides new insights into the function of acetone on the crystal regulation of salts.

Journal of Cleaner Production published new progress about Centrifugation. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Name: 6-Chloropyridin-2-ol.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Ying; Du, Na; Song, Shue; Hou, Wanguo published the artcile< Adsorption of Cetylpyridinium Chloride at Silica Nanoparticle/Water Interfaces (I): Dependence of Adsorption Equilibrium on Particle Size>, SDS of cas: 123-03-5, the main research area is adsorption cetylpyridinium chloride silica nanoparticle size water interface equilibrium.

In the current work, a size-effect model was developed to describe the particle size-dependence of adsorption at solid/liquid interfaces. A parameter, ΔQad, was introduced, defined as the change of the product of the solid/liquid interfacial tension and the molar volume of solid surface components caused by adsorption. The model predicts that with a decrease in particle radius (r), the saturation adsorption amount per unit area (Γm, mol/m2) decreases, while the change of the adsorption equilibrium constant (Kad) is determined by the ΔQad, namely, it decreases if ΔQad > 0 but increases if ΔQad < 0. There exists a critical r at which the saturation adsorption amount per unit mass (Γmg, mol/g) attains a maximum In addition, the adsorption of cetylpyridinium chloride (CPyCl), a cationic surfactant, on silica nanoparticles with different r (ca. 6-61 nm) values was determined at 298 K and pH 9, showing an obvious size-dependence. With a decrease in r, Kad and Γm decrease, indicating a decrease in the affinity of silica particles toward CPyCl. The size-dependent adsorption data can be well described using our model. Adsorption can affect the molar volume of the solid surface phase, which plays an important role in the size-dependence of adsorption. This work provides a better understanding of the size-dependent adsorption phenomenon at solid/liquid interfaces. Langmuir published new progress about Adsorption. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, SDS of cas: 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Leong, Bi-Xiang; Lee, Jiawen; Li, Yan; Yang, Ming-Chung; Siu, Chi-Kit; Su, Ming-Der; So, Cheuk-Wai published the artcile< A Versatile NHC-Parent Silyliumylidene Cation for Catalytic Chemo- and Regioselective Hydroboration>, Application of C7H7NO2, the main research area is silyliumylidene cation catalyzed regioselective hydroboration carbon dioxide carbonyl compound; pyridine derivative regioselective hydroboration silyliumylidene cation catalyst; formoxyborane regioselective preparation; borate ester regioselective preparation; boryldihydropyridine regioselective preparation.

This study describes the 1st use of a Si(II) complex, NHC-parent silyliumylidene cation complex [(IMe)2SiH]I (1, IMe = :C{N(Me)C(Me)}2) as a versatile catalyst in organic synthesis. Complex 1 (loading: 10 mol %) was shown to act as an efficient catalyst (reaction time: 0.08 h, yield: 94%, TOF = 113.2 h-1; reaction time: 0.17 h, yield: 98%, TOF = 58.7 h-1) for the selective reduction of CO2 with pinacolborane (HBpin) to form the primarily reduced formoxyborane [pinBOC(O)H]. The activity is better than the currently available base-metal catalysts used for this reaction. It also catalyzed the chemo- and regioselective hydroboration of carbonyl compounds and pyridine derivatives to form borate esters and N-boryl-1,4-dihydropyridine derivatives with quant. conversions, resp. Mechanistic studies show that the Si(II) center in complex 1 activated the substrates and then mediated the catalytic hydroboration. Complex 1 was slightly converted into the NHC-borylsilyliumylidene complex [(IMe)2SiBpin]I (3) in the catalysis, which was also able to mediate the catalytic hydroboration.

Journal of the American Chemical Society published new progress about Boranes Role: SPN (Synthetic Preparation), PREP (Preparation) (borate esters, boryldihydropyridines). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ceglowski, Michal; Marien, Yoshi W.; Smeets, Sander; De Smet, Lieselot; D′hooge, Dagmar R.; Schroeder, Grzegorz; Hoogenboom, Richard published the artcile< Molecularly Imprinted Polymers with Enhanced Selectivity Based on 4-(Aminomethyl)pyridine-Functionalized Poly(2-oxazoline)s for Detecting Hazardous Herbicide Contaminants>, HPLC of Formula: 3731-53-1, the main research area is molecularly imprinted polymer aminomethylpyridine functionalized polyoxazoline detecting herbicide contaminant; trichlorophenoxyacetate adsorption molecularly imprinted polymer adsorbent.

The detection of hazardous compounds is of importance to control (drinking) water quality. Here, we report the development of poly(2-oxazoline)-based molecularly imprinted polymers (MIPs) for the detection of 2,4,5-trichlorophenoxyacetic acid (2,4,5-T). In view of enhanced selectivity of the MIPs, it was hypothesized that incorporation of pyridine groups would lead to stronger interactions with 2,4,5-T. The synthesis of 4-(aminomethyl)pyridine (4-AMP)-functionalized poly(2-methoxycarbonylpropyl-2-oxazoline)s with various degrees of modification was, therefore, investigated via stoichiometric and kinetic control over the functionalization degree. The mol. imprinting of 2,4,5-T is performed by direct amidation of the Me ester side chains with diethylenetriamine. The exptl. data of 2,4,5-T adsorption were interpreted with various models to quantify the adsorption thermodn. and kinetics. The best fit was obtained for a single-site Langmuir model, indicating uniform binding site energies. A further investigation shows that the maximum adsorption capacity is reached at low 4-AMP modification degrees, whereas greater adsorption energies and higher selectivities are observed for higher 4-AMP modification degrees. Finally, the developed 4-AMP-modified MIP adsorbents were successfully used for quantification of 2,4,5-T by direct anal. with ambient mass spectrometry. In comparison with the pure analyte solution, the detection limits decreased by three orders of magnitude.

Chemistry of Materials published new progress about Adsorbents. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oyamada, Nobuaki; Minamimoto, Hiro; Murakoshi, Kei published the artcile< Room-Temperature Molecular Manipulation via Plasmonic Trapping at Electrified Interfaces>, Safety of 2,2′-Bipyridine, the main research area is plasmonic trapping electrified interface Raman spectra optical tweezers.

For the motion control of individual mols. at room temperature, optical tweezers could be one of the best approaches to realize desirable selectivity with high resolution in time and space. Because of phys. limitations due to the thermal fluctuation, optical manipulation of small mols. at room temperature is still a challenging subject. The difficulty of the manipulation also emerged from the variation of mol. polarizability depending on the choice of mols. as well as the mol. orientation to the optical field. In this article, we have demonstrated plasmonic optical trapping of small size mols. with less than 1 nm at the gap of a single metal nanodimer immersed in an electrolyte solution In situ electrochem. surface-enhanced Raman scattering measurements prove that a plasmonic structure under electrochem. potential control realizes not only the selective mol. condensation but also the formation of unique mixed mol. phases which is distinct from those under a thermodn. equilibrium Through detailed analyses of optical trapping behavior, we established the methodol. of plasmonic optical trapping to create the novel adsorption isotherm under applying an optical force at electrified interfaces.

Journal of the American Chemical Society published new progress about Chemical potential. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Singh, Malvinder P.; Joseph, Tomi; Kumar, Surat; Bathini, Yadagiri; Lown, J. William published the artcile< Synthesis and sequence-specific DNA binding of a topoisomerase inhibitory analog of Hoechst 33258 designed for altered base and sequence recognition>, COA of Formula: C6H7N3O2, the main research area is topoisomerase inhibitor DNA binding preparation; DNA binding Hoechst 33258 analog sequence; safety benzoyl peroxide explosive; health hazard methoxymethyl chloride nitrobenzene.

The preparation and DNA binding characteristics of a structural analog of Hoechst 33258 bearing 2 pyridine N atoms are described. The 1H NMR signals of the complex formed between the new ligand I and decadeoxyribonucleotide d(CATGGCCATG)2 were assigned by employing 1- and 2-dimensional NMR techniques. Intermol. nuclear Overhauser effects (NOE) between the ligand and the DNA receptor fragment confirm that the ligand binds in the minor groove of the DNA, interacting with the centrally located 5′-GGCCA segment. In contrast to the steric interaction between the benzimidazole rings of the parent Hoechst 33258 mol. and the guanine 2-NH2 groups, which renders it G·C avoiding and thus A·T base pair preferring, the ligand I described here overcomes these unfavorable interactions and instead exhibits a marked preference for G·C base pairs. This behavior appears to arise from addnl. stabilization due to H-bonding with the guanine 2-NH2 groups. Although a ligand-induced distortion at the binding site is qual. assessable, the overall B-type conformation of the DNA fragment is retained upon complexation. The structural conclusions drawn from the NOE-NMR evidence were confirmed by mol. mechanics and mol. modeling studies. Safety in the use of methoxymethyl chloride and nitrobenzene, suspected toxins and benzyl peroxide, a potential explosive, is emphasized.

Chemical Research in Toxicology published new progress about DNA, complexes Role: BIOL (Biological Study). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, COA of Formula: C6H7N3O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Qin, Yin; Li, Yilin; Guo, Kaimeng; Tang, Huabiao; Hou, Lifen; Li, Gang published the artcile< Water-assisted proton conductivity of two highly stable imidazole multi-carboxylate-based MOFs>, Safety of 2,2′-Bipyridine, the main research area is crystal structure manganese zinc carboxylimidazoledicarboxylate bipyridine metal organic framework; manganese zinc carboxylimidazoledicarboxylate bipyridine MOF preparation proton conductivity.

Two new chain-like metal-organic frameworks (MOFs), {[Mn(o-CPhH2IDC)(4.4′-bipy)0.5(H2O)2]·3H2O}n (1) (o-CPhH4IDC = 2-phenyl(2-carboxyl)-1-H-imidazole-4,5-dicarboxylic acid; 4,4′-bipy = 4,4′-bipyridine) and {[Zn5(o-CPhH2IDC)2(o-CPhHIDC)2(2,2′-bipy)5]·5H2O}n (2) (2,2′-bipy = 2,2′-bipyridine) were designed and solvothermally or hydrothermally synthesized and structurally characterized. By SEM determinations and PXRD analyses, the high H2O stability and acid and alkali resistance of both MOFs were determined The affluent H-bond networks inside the frameworks formed by imidazole multi-carboxylate ligands and H2O mols. would favor the transfer of protons. Also, the temperature- and humidity-dependent proton conduction properties of the two MOFs were demonstrated. Also, the proton conducting mechanisms will be highlighted herein.

New Journal of Chemistry published new progress about Activation energy (proton conductivity). 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dziuganowska, Zofia A.; Slepokura, Katarzyna; Volle, Jean-Noel; Virieux, David; Pirat, Jean-Luc; Kafarski, Pawel published the artcile< Structural Analogues of Selfotel>, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate, the main research area is phosphonate pyridinecarboxylic piperidinecarboxylic preparation phosphonylation bromopyridine hydrogenation; NMDA antagonist library phosphonate pyridinecarboxylic piperidinecarboxylic acid preparation activity; crystal structure phosphonate pyridinecarboxylic piperidinecarboxylic acid NMDA antagonist; mol structure phosphonate pyridinecarboxylic piperidinecarboxylic acid NMDA antagonist.

A small library of phosphonopiperidylcarboxylic acids, analogs of NMDA antagonist selfotel (CGS 19755), was synthesized. First, the series of aromatic esters was obtained via a palladium-catalyzed cross-coupling reaction (Hirao coupling) of dialkyl phosphites with bromopyridinecarboxylates, followed by their hydrolysis. Then, hydrogenation of the resulting phosphonopyridylcarboxylic acids over PtO2 yielded the desired phosphonopiperidylcarboxylic acids. NMR studies indicated that the hydrogenation reaction proceeds predominantly by cis addition Several compounds were obtained as monocrystal structures. Preliminary biol. studies performed on cultures of neurons suggest that the obtained compounds possess promising activity toward NMDA receptors.

Journal of Organic Chemistry published new progress about Carboxylic esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Recommanded Product: Methyl 3-bromo-2-pyridinecarboxylate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Munoz-Basagoiti, J.; Perez-Zsolt, D.; Leon, R.; Blanc, V.; Raich-Regue, D.; Cano-Sarabia, M.; Trinite, B.; Pradenas, E.; Blanco, J.; Gispert, J.; Clotet, B.; Izquierdo-Useros, N. published the artcile< Mouthwashes with CPC Reduce the Infectivity of SARS-CoV-2 Variants In Vitro>, Formula: C21H38ClN, the main research area is cetylpyridinium chloride mouthwash virucide COVID19; COVID-19; airborne transmission; cellular infection; coronaviruses; oral hygiene; virucide.

Oral mouthwashes decrease the infectivity of several respiratory viruses including SARS-CoV-2. However, the precise agents with antiviral activity in these oral rinses and their exact mechanism of action remain unknown. Here we show that cetylpyridinium chloride (CPC), a quaternary ammonium compound in many oral mouthwashes, reduces SARS-CoV-2 infectivity by inhibiting the viral fusion step with target cells after disrupting the integrity of the viral envelope. We also found that CPC-containing mouth rinses decreased more than a thousand times the infectivity of SARS-CoV-2 in vitro, while the corresponding vehicles had no effect. This activity was effective for different SARS-CoV-2 variants, including the B.1.1.7 or Alpha variant originally identified in United Kingdom, and in the presence of sterilized saliva. CPC-containing mouth rinses could therefore represent a cost-effective measure to reduce SARS-CoV-2 infectivity in saliva, aiding to reduce viral transmission from infected individuals regardless of the variants they are infected with.

Journal of Dental Research published new progress about Antiviral agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Formula: C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hikawa, Hidemasa; Nakayama, Taku; Nakamura, Shunki; Kikkawa, Shoko; Azumaya, Isao published the artcile< Dehydrative amination of benzhydrols with electron-withdrawing group-substituted 2-aminopyridines utilizing Au(III)/TPPMS catalyst system in water>, HPLC of Formula: 21901-29-1, the main research area is benzyl aminopyridine preparation; benzhydrol aminopyridine dehydrative amination gold sodium diphenylphosphinobenzene sulfonate water.

Authors report a method for gold(III)/sodium diphenylphosphinobenzene-3-sulfonate (TPPMS)-catalyzed direct amination of benzhydrols using 2-aminopyridines with poor nucleophilic character in water. Various functional groups such as electron-withdrawing nitro, cyano and halogen groups were tolerated well to form the desired N-benzylated 2-aminopyridine compounds On the basis of mechanistic studies including kinetic profiles, Hammett study and isotope effects, authors propose a pathway in which a Lewis acidic gold cation species activates the sp3 C-O bond of the alc. in the rate-determining step.

Organic & Biomolecular Chemistry published new progress about Amination (dehydrative). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, HPLC of Formula: 21901-29-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem