Day: October 18, 2022

Abramovitch, Rudolph A.; Helmer, Friederike; Liveris, M. published the artcile< Aromatic substitution. XVIII. Kinetics of reactions between some halopyridines and -picolines and their N-oxides with methoxide ion in methanol and in dimethyl sulfoxide. Effect of alkyl groups on rates and orientation in nucleophilic aromatic substitution>, Safety of 3-Chloro-2-methoxypyridine, the main research area is SUBSTITUTION AROM KINETICS; PIRIDINES SUBSTITUTION; KINETICS SUBSTITUTION AROM; AROM SUBSTITUTION KINETICS.

The rates and activation parameters for the reactions of 2-fluoro-, 2-chloro-, 2-bromo-, 2-chloro-3-methyl-, 2-chloro-5-methyl-, 2-bromo-3-methyl-, 2-bromo-5-methyl-, 2,3-dichloro-, 2,5-dichloro-, 2-chloro-3-nitro-, and 2-chloro-5-nitropyridines, and of 2-bromo-, 2-bromo-3-methyl-, and 2-bromo-5-methylpyridine N-oxides with MeOK in methanol were determined and compared. The kinetics of the reaction of 2-bromo-, 2-bromo-3-methyl-, and 2-bromo-5-methyl-pyridine and methoxide ion in Me2SO containing small amounts of methanol were also determined; the rates were very sensitive to the methanol concentration The rates were in the order 2-halo- > 2-halo-3-methyl- > 2-halo-5-methyl-, and were dependent upon Eact when the halogen was Br but upon ΔS when it was Cl. The effects of the β-substituent in the pyridine nucleus upon the orthopara ratios are discussed in terms of their effects upon the energies and entropies of activation. 29 references.

Journal of the Chemical Society [Section] B: Physical Organic published new progress about Activation energy. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Safety of 3-Chloro-2-methoxypyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zeng, Haisu; Wu, Jing; Li, Sihan; Hui, Christina; Ta, Anita; Cheng, Shu-Yuan; Zheng, Shengping; Zhang, Guoqi published the artcile< Copper(II)-Catalyzed Selective Hydroboration of Ketones and Aldehydes>, Application In Synthesis of 350-03-8, the main research area is divalent copper catalyzed chemoselective hydroboration ketone aldehyde; nonanuclear copper complex one pot self assembly preparation.

A novel nonanuclear copper(II) complex obtained by a facile one-pot self-assembly was found to catalyze the hydroboration of ketones and aldehydes with the absence of an activator under mild, solvent-free conditions. The catalyst is air- and moisture-stable, displaying high efficiency (1980 h-1 turnover frequency, TOF) and chemoselectivity on aldehydes over ketones and ketones over imines. This represents a rare example of divalent copper catalyst for the hydroboration of carbonyls.

Organic Letters published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application In Synthesis of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nisbet, Matthew L.; Hiralal, Emily; Poeppelmeier, Kenneth R. published the artcile< Crystal structures of three copper(II)-2,2′-bipyridine (bpy) compounds, [Cu(bpy)2(H2O)]-[SiF6]·4H2O, [Cu(bpy)2(TaF6)2] and [Cu(bpy)3][TaF6]2 and a related coordination polymer,[Cu(bpy)(H2O)2SnF6]n>, COA of Formula: C10H8N2, the main research area is copper bipyridine compound coordination polymer crystal structure; copper; crystal structure; d0 early transition metal; hydro­thermal synthesis; main group; racemic compounds.

We report the hydrothermal syntheses and crystal structures of aquabis(2,2′-bipyridine-κ2N,N′)copper(II) hexafluoridosilicate tetrahydrate, [Cu(bpy)2(H2O)]-[SiF6]·4H2O (bpy is 2,2′-bipyridine, C10H8N2), (I), bis(2,2′-bipyridine-3κ2N,N′)-di-μ-fluorido-1:3κ2F:F;2:3κ2F:F-decafluorido-1κ5F,2κ5F-ditantalum(V)copper(II),[Cu(bpy)2(TaF6)2], (II), tris(2,2′-bipyridine-κ2N,N′)copper(II) bis[hexafluoridotantalate(V)], [Cu(bpy)3][TaF6]2, (III), and catena-poly[[diaqua(2,2′-bipyridine-κ2N,N′)copper(II)]-μ-fluorido-tetrafluoridotin-μ-fluorido], [Cu(bpy)(H2O)2SnF6]n, (IV). Compounds (I), (II) and (III) contain locally chiral copper coordination complexes with C2, D2, and D3 symmetry, resp. The extended structures of (I) and (IV) are consolidated by O-H····F and O-H····O hydrogen bonds. The structure of (III) was found to be a merohedral (racemic) twin.

Acta Crystallographica, Section E: Crystallographic Communications published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hayashi, Mikihiro; Kimura, Takahiro; Oba, Yuta; Takasu, Akinori published the artcile< One-Pot Synthesis of Dual Supramolecular Associative PMMA-Based Copolymers and the Precise Thermal Property Tuning>, Recommanded Product: Pyridin-4-ylmethanamine, the main research area is onepot dual supramol associative PMMA copolymer.

Dual supramol. associative polymers have attracted attention for efficient phys. property modification. Herein, a one-pot synthesis of dual supramol. associative poly(Me methacrylate)-based copolymers via reversible addition fragmentation chain transfer (RAFT) copolymerization using a novel methacrylate-type monomer (coded as UP-MA) bearing a urea bond and a pendant pyridine group is demonstrated. UP-MA is synthesized by reacting 4-picolylamine and 2-isocyanatoethyl methacrylate. The subsequent RAFT copolymerization of UP-MA and Me methacrylate (MMA) can be performed by directly adding MMA, a chain transfer agent, and a radical initiator into the reaction solution of UP-MA. The estimated values of radical reactivity ratio (r) for UP-MA and MMA are close to unity, attaining a nearly ideal random sequence of the dual supramol. associative units in the copolymer chain. By blending a metal salt into the random copolymer, coordination bonds between the salt and the pyridine groups are formed, and the urea groups simultaneously form hydrogen bonds, generating a dual supramol. associative network. Precise tuning of the thermal property is realized by changing the fraction of the metal salt and associative groups in the copolymers.

Macromolecular Chemistry and Physics published new progress about Glass transition temperature. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Recommanded Product: Pyridin-4-ylmethanamine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zheng, Danqing; Studer, Armido published the artcile< Asymmetric Synthesis of Heterocyclic γ-Amino-Acid and Diamine Derivatives by Three-Component Radical Cascade Reactions>, Safety of 3-(Methoxycarbonyl)pyridine, the main research area is asym synthesis heterocyclic amino acid diamine multicomponent radical cascade; Brønsted acids; amino acids; asymmetric synthesis; photochemistry; radicals.

An enantioselective three-component radical reaction of quinolines or pyridines with enamides and α-bromo carbonyl compounds by dual photoredox and chiral Bronsted acid catalysis is presented. A range of valuable chiral γ-amino-acid derivatives are accessible in high chemo-, regio-, and enantioselectivity from simple, readily available starting materials under mild reaction conditions. Using the same strategy, the asym. synthesis of 1,2-diamine derivatives is also reported. Thus, e.g., 4-methylquinoline + N-vinylacetamide + Me bromoacetate → I (88%, 96:4 er).

Angewandte Chemie, International Edition published new progress about Carbonyl compounds (organic), halo carbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent) (quinoline/pyridine + N-vinylacetamide + α-bromo carbonyl compound → γ-amino acid). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Safety of 3-(Methoxycarbonyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Saud, Zack; Tyrrell, Victoria J.; Zaragkoulias, Andreas; Protty, Majd B.; Statkute, Evelina; Rubina, Anzelika; Bentley, Kirsten; White, Daniel A.; Rodrigues, Patricia Dos Santos; Murphy, Robert C.; Kofeler, Harald; Griffiths, William J.; Alvarez-Jarreta, Jorge; Brown, Richard William; Newcombe, Robert G.; Heyman, James; Pritchard, Manon; Mcleod, Robert WJ.; Arya, Arvind; Lynch, Ceri-Ann; Owens, David; Jenkins, P. Vince; Buurma, Niklaas J.; O’Donnell, Valerie B.; Thomas, David W.; Stanton, Richard J. published the artcile< The SARS-CoV2 envelope differs from host cells, exposes procoagulant lipids, and is disrupted in vivo by oral rinses>, Related Products of 123-03-5, the main research area is lipidome cetylpyridinium chloride oral rinse phospholipid SARSCoV2 envelope; CPC; aminophospholipids; cetylpyridinium chloride; clinical trials; coagulation; inflammation; lipidomics; mouthwash; phospholipids; virology.

The lipid envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an essential component of the virus; however, its mol. composition is undetermined Addressing this knowledge gap could support the design of antiviral agents as well as further our understanding of viral-host protein interactions, infectivity, pathogenicity, and innate immune system clearance. Lipidomics revealed that the virus envelope comprised mainly phospholipids (PLs), with little cholesterol or sphingolipids, indicating significant differences from host membranes. Unlike cellular membranes, procoagulant amino-PLs were present on the external side of the viral envelope at levels exceeding those on activated platelets. Accordingly, virions directly promoted blood coagulation. To investigate whether these differences could enable selective targeting of the viral envelope in vivo, we tested whether oral rinses containing lipid-disrupting chems. could reduce infectivity. Products containing PL-disrupting surfactants (such as cetylpyridinium chloride) met European virucidal standards in vitro; however, components that altered the critical micelle concentration reduced efficacy, and products containing essential oils, povidone-iodine, or chlorhexidine were ineffective. This result was recapitulated in vivo, where a 30-s oral rinse with cetylpyridinium chloride mouthwash eliminated live virus in the oral cavity of patients with coronavirus disease 19 for at least 1 h, whereas povidone-iodine and saline mouthwashes were ineffective. We conclude that the SARS-CoV-2 lipid envelope (i) is distinct from the host plasma membrane, which may enable design of selective antiviral approaches; (ii) contains exposed phosphatidylethanolamine and phosphatidylserine, which may influence thrombosis, pathogenicity, and inflammation; and (iii) can be selectively targeted in vivo by specific oral rinses.

Journal of Lipid Research published new progress about Antiviral agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Related Products of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Elvidge, J. A.; Zaidi, N. A. published the artcile< Heterocyclic syntheses with malonyl chloride. IX. 2-Substituted 4-chloro-6-pyrimidones from certain nitriles>, Application of C5HCl4N, the main research area is nitriles malonyl chloride; malonyl chloride nitriles; pyrimidines; pyridines.

Chloroacetonitrile with malonyl chloride yielded 2,3-dichloro-4,6-dihydroxypyridine (I) together with an unexpected product, 4-chloro-2-chloromethyl-6-pyrimidone (II). Further examples of this new synthesis of 2-substituted 4-chloro-6-pyrimidones were obtained with fluoro- and bromoacetonitrile, α-bromopropionitrile, and acetonitrile. Propio- and butyronitrile each gave a mixture of pyridine and pyrimidine product, while various other nitriles gave only the pyridine products. The expected fully substituted pyrimidone was obtained from fluoroacetonitrile and chloromalonyl chloride, and from dibromoacetonitrile with bromomalonyl chloride. Some novel halogen-transfer reactions were encountered in other cases.

Journal of the Chemical Society [Section] C: Organic published new progress about Nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 14121-36-9 belongs to class pyridine-derivatives, and the molecular formula is C5HCl4N, Application of C5HCl4N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N. published the artcile< Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning>, SDS of cas: 22280-62-2, the main research area is fluorinated pyridinealdoxime preparation treatment organophosphorus nerve agent poisoning; sarin poisoning fluorinated pyridinealdoxime preparation treatment.

Fluoroheterocyclic aldoximes were screened as therapeutic agents for the treatment of anticholinesterase poisoning. 2-Fluoropyridine-3- and -6-aldoxime and 3-fluoropyridine-2- and -4-aldoxime were synthesized. Attempts to obtain 3,5,6-trifluoropyridine-2,4-bis(aldoxime) and -2-aldoxime, however, proved unsuccessful. Pentafluorobenzaldoxime was prepared by oximation of pentafluorobenzaldehyde. Acid dissociation constants (pKa) and second-order rate constants (kox-) of the fluorinated pyridinealdoximes towards sarin were measured. 2,3,5,6-Tetrafluoropyridine-4-aldoxime had the best profile: its kox- approached that of the therapeutic oxime P2S (310 vs. 120 l mol-1 min-1), but its higher pKa (9.1 vs. 7.8) fell short of the target figure of 8 required for reactivation of inhibited acetylcholinesterase in vivo. N-alkylation of the fluorinated pyridine-aldoximes may reduce their pKa nearer to 8 and enhance their therapeutic potential.

Journal of Fluorine Chemistry published new progress about Antidotes. 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, SDS of cas: 22280-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cotton, Simon A.; Raithby, Paul R.; Schiffers, Stephanie; Teat, Simon J.; Warren, John E. published the artcile< The Synthesis and Structure of a Scandium Nitrate Hydroxy-Bridged Dimeric Complex Supported by Bipyridyl Ligands †>, Application of C10H8N2, the main research area is crystal structure; eight coordinate complex; hydroxy group; nitrate complex; scandium complex.

The current discussion on whether scandium, yttrium and lanthanum should represent Group 3 in the Periodic Table or whether lutetium should replace lanthanum in the group has prompted us to further explore the structural chem. of the Group 3 elements and compare the coordination numbers and coordination geometries adopted. The steric and electronic properties of the coordinated ligands have a major influence on the structures adopted. We report the synthesis and crystal structure determination of an unusual dinuclear scandium complex [(bipy)(NO3)2Sc(μ-OH)2Sc(NO3)2(bipy)] obtained by the reaction of hydrated scandium nitrate with 2,2′-bipyridyl (bipy) in either ethanol or nitromethane. The crystal structure of the complex shows that the scandium centers are eight coordinate, and the structure obtained contrasts with related complexes found in the lanthanide series [Ln(bipy)2(NO3)3] and [Ln(phen)2(NO3)3] (phen = phenanthroline) and in [M(terpy)(NO3)3] (M = Sc, Er-Lu), where these complexes are all mononuclear.

Molecules published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Arya, Kritika; Kumar, Sudesh; Arya, Anand Kumar; Kumar, Mahendra published the artcile< Ionic Liquid [PyN(CH2)4SO3H][CH3PhSO3] Mediated & Promoted Eco-Friendly One-Pot Domino Synthesis of Benzothiazolopyrano/Chromenopyrimidine Derivatives>, Application In Synthesis of 21876-43-7, the main research area is benzothiazolopyranopyrimidinone preparation green chem; aldehyde aminobenzothiazole pyrone multicomponent domino heterocyclization pyridinium ionic liquid; benzothiazolochromenopyrimidinone preparation green chem; hydroxycoumarin aldehyde aminobenzothiazole multicomponent domino heterocyclization pyridinium ionic liquid; pyridinium toluenesulfonic acid ionic liquid catalyst preparation.

The pyridinium based p-toluenesulfonic acid functionalized [Py(CH2)4SO3H][CH3PhSO3] ionic liquid has been employed as eco-friendly solvent cum promoter for the multicomponent domino heterocyclization of substituted 2-aminobenzothiazoles I (R1 = H, Me; R2 = H, Me; R3 = H, Me, Br; R4 = H, Me) with 4-hydroxy-6-methyl-2-pyrone/4-hydroxycoumarin and aryl aldehydes 4-R5C6H4CHO (R5 = MeO, Cl) to produce benzothiazolo[2,3-b]pyrano [3,4-e]pyrimidin-4-ones II and benzothiazolo[2,3-b]chromeno[3,4-e]pyrimidin-6-ones III in excellent yields. The Bronsted acidic ionic liquid could be reused five-times without a significant loss of catalytic activity. The protocol proves to be efficient and facile in terms of high yields, operational simplicity, reduced reaction time and ease of recovery of the reaction medium.

Current Organocatalysis published new progress about Benzothiazoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Application In Synthesis of 21876-43-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem