Day: October 18, 2022

Nivoliers, F.; Decormeille, A.; Godard, A.; Queguiner, G. published the artcile< 6H-indolo[3,2-b]naphthyridines. Aza-analogs of ellipticine>, Reference of 55279-29-3, the main research area is indolonaphthyridine; cyclocondensation indole aminopyridinecarboxaldehyde.

The indolonaphthyridines I (X = N, X1 = X2 = CH; X = X2 = CH, X1 = N; X = X1 = CH, X2 = N) were prepared by cyclocondensation of the indole II with the corresponding pyridines. E.g., II reacted with 1 mol equiv 3-aminopyridine-2-carboxaldehyde in MeOH/KOH at room temperature for 3 days gave I (X = N, X1 = X2 = CH). Quaternization of I with MeI occurred at the terminal pyridine ring.

Tetrahedron Letters published new progress about Cyclocondensation reaction. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Reference of 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lee, Jiawen; Fan, Jun; Koh, An-Ping; Joslyn Cheang, Wan-Jun; Yang, Ming-Chung; Su, Ming-Der; So, Cheuk-Wai published the artcile< Amidinato Isopropylmethylamidosilylene-Catalyzed Hydroboration of Carbonyl Compounds>, Product Details of C7H7NO, the main research area is amidinato isopropylmethylamidosilylene catalyzed hydroboration carbonyl compound; borate ester preparation.

This study describes the use of an amidinato isopropylmethylamidosilylene [LSiN(Me)iPr] (1, L = PhC(NtBu)2) to catalyze hydroboration of carbonyl compounds Compound 1 (loading: 5-10 mol%) was an efficient catalyst for the chemoselective hydroboration of aldehydes (average yield = 97%, average TOF = 8.8 h-1) and ketones (average yield = 97%, average TOF = 1.7 h-1) with pinacolborane (HBpin) in C6D6 at 90° to form borate esters. Mechanistic studies show that the Si lone pair electrons on 1 and the B vacant p orbital of HBpin activates the C:O double bond of aldehydes and ketones, the intermediates of which undergoes hydroboration to yield borate esters and regenerate compound 1.

European Journal of Inorganic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Product Details of C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cheng, Chia-Chung; Yan, Shou-Jen published the artcile< The Friedlander synthesis of quinolines>, Electric Literature of 55279-29-3, the main research area is review Friedlander synthesis quinoline.

A review of the article The Friedlander synthesis of quinolines.

Organic Reactions (Hoboken, NJ, United States) published new progress about Friedlander synthesis. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Electric Literature of 55279-29-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Xiaonan; Hu, Xuejun; Zhang, Li; Xu, Xi; Sakurai, Takashi published the artcile< Nicotinamide mononucleotide administration after sever hypoglycemia improves neuronal survival and cognitive function in rats>, Product Details of C7H7NO, the main research area is brain injury nicotinamide mononucleotide hypoglycemia neuron survival; Cognitive impairment; Hypoglycemia; Neuronal survival; Nicotinamide mononucleotide; PARP-1; ROS.

Here we investigated whether NMN could reduce brain injury after severe hypoglycemia. We used a rat model of insulin-induced severe hypoglycemia and injected NMN (500 mmg/kg, i.p., one week) following 30 min of severe hypoglycemia, at the time of glucose administration. ROS accumulation, PARP-1 activation, NAD+ and ATP levels in hippocampus were also measured. Cognitive function was assessed using the Morris water maze 6 wk after severe hypoglycemia. The addition of NMN reduced neuron death by 83 ± 3% (P < 0.05) after severe hypoglycemia. The hippocampal LTP was significantly reduced by severe hypoglycemia but showed recovery in the NMN addition group. NMN treatment also attenuated the severe hypoglycemia-induced spatial learning and memory impairment. Mech., we showed that NMN administration decreased ROS accumulation, suppressed PARP-1 activation, and restored levels of NAD+ and ATP in hippocampus. All these protective effects were reversed by 3-acetylpyridine (3-AP), which generates inactive NAD+. In summary, NMN administration following severe hypoglycemia could ameliorate neuronal damage and cognitive impairment caused by severe hypoglycemia. These results suggest that NMN may be a promising therapeutic drug to prevent hypoglycemia-induced brain injury. Brain Research Bulletin published new progress about Biological memory. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Product Details of C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ando, Shin; Hirota, Yurina; Matsunaga, Hirofumi; Ishizuka, Tadao published the artcile< Nickel-catalyzed N-arylation of amines with arylboronic acids under open air>, COA of Formula: C11H10N2, the main research area is arylamine preparation; amine arylboronic acid Chan Lam coupling nickel catalyst.

Novel NHC-Ni complex was developed and used for the synthesis of arylamines via Chan-Lam coupling of amines with arylboronic acids. This novel NHC-Ni complex in combination with 4,4′-dimethyl-2,2′-bipyridine, however, proved to be an effective catalyst that lowered the required catalyst loading to only 2.0 mol%. The robustness of NHC complexes toward oxidative conditions and high level of σ-donating ability of NHC ligands could be reason for catalysis.

Tetrahedron Letters published new progress about Arylation. 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, COA of Formula: C11H10N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Rongrong; Peng, Qiyao; Wan, Dan; Yu, Chao; Zhang, Yuan; Hou, Yi; Luo, Quan; Li, Xiong; Zhang, Shuihan; Xie, Lin; Ou, Pinghua; Peng, Yongbo published the artcile< Construction of a lysosome-targetable ratiometric fluorescent probe for H2O2 tracing and imaging in living cells and an inflamed model>, HPLC of Formula: 3731-53-1, the main research area is hydrogen peroxide cell lysosome ratiometric fluorescent imaging.

Hydrogen peroxide (H2O2), an important reactive oxygen species (ROS) with unique destructive oxidation properties, can be produced in lysosomes to fight off pathogens. Although many fluorescent probes have been developed for the detection and imaging of H2O2, the development of a ratiometric fluorescent probe for H2O2 detection and imaging in lysosomes and an inflammation model remains rather scarce. Therefore, it is important to develop an efficient tool for monitoring H2O2 in inflamed tissues to evaluate the physiol. and pathol. relationship between inflammation and lysosomal H2O2. In this work, a new naphthalimide-based lysosome-targeting fluorescent probe (NPT-H2O2) for ratiometric detection and imaging was developed in vitro and in vivo. The probe exhibited two wellresolved emission peaks separated by 125 nm, rapid response (<40 s), and high selectivity and sensitivity toward H2O2, as well as low cytotoxicity in vitro. Inspired by prominent features of these results, we further successfully applied NPT-H2O2 for H2O2 imaging with a dual-channel in living cells, demonstrating that our probe NPT-H2O2 was targeted in the lysosomes. Finally, NPT-H2O2 was used for H2O2 detection in inflamed tissues and achieved satisfactory results. We predict that our probe can be used as a powerful tool to reveal the relationship between physiol. and pathol. of inflammation and lysosomal H2O2. RSC Advances published new progress about Absorption spectra. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, HPLC of Formula: 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Grozavu, Alexandru; Hepburn, Hamish B.; Smith, Philip J.; Potukuchi, Harish K.; Lindsay-Scott, Peter J.; Donohoe, Timothy J. published the artcile< The reductive C3 functionalization of pyridinium and quinolinium salts through iridium-catalysed interrupted transfer hydrogenation>, Category: pyridine-derivatives, the main research area is pyridinium salt formaldehyde iridium catalyst regioselective reductive hydroxymethylation; quinolinium salt formaldehyde iridium catalyst regioselective reductive hydroxymethylation; tetrahydropyridine preparation; tetrahydroquinoline preparation.

Aromatic rings are ubiquitous in organic chem. and form the basis of many com. products. Despite the numerous routes available for the preparation of aromatic compounds, there remain few methods that allow their conversion into synthetically useful partially saturated derivatives and even fewer that allow new C-C bonds to be formed at the same time. Here we set out to address this problem and uncover a unique catalytic partial reduction reaction that forms partially saturated azaheterocycles from aromatic precursors. In this reaction, methanol and formaldehyde are used for the reductive functionalization of pyridines and quinolines using catalytic iridium; thus, inexpensive and renewable feedstocks are utilized in the formation of complex N-heterocycles. By harnessing the formation of a nucleophilic enamine intermediate, the C-C bond-forming process reverses the normal pattern of reactivity and allows access to the C3 position of the arene. Mechanistic investigations using D-labeling experiments reveal the source of hydride added to the ring and show the reversible nature of the iridium-hydride addition

Nature Chemistry published new progress about C-C bond formation. 876919-08-3 belongs to class pyridine-derivatives, and the molecular formula is C7H6FNO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Takeuchi, Toshifumi; Mori, Kisho; Sunayama, Hirobumi; Takano, Eri; Kitayama, Yukiya; Shimizu, Taku; Hirose, Yuzuki; Inubushi, Sachiko; Sasaki, Ryohei; Tanino, Hirokazu published the artcile< Antibody-Conjugated Signaling Nanocavities Fabricated by Dynamic Molding for Detecting Cancers Using Small Extracellular Vesicle Markers from Tears>, Name: 1,2-Di(pyridin-2-yl)disulfane, the main research area is antibody breast cancer diagnosis extracellular vesicle marker tear.

Small extracellular vesicles (sEVs) are reliable biomarkers for early cancer detection; however, conventional detection methods such as immune-based assays and microRNA analyses are not very sensitive and require sample pretreatments and long anal. time. Here, the authors developed a mol. imprinting-based dynamic molding approach to fabricate antibody-conjugated signaling nanocavities capable of size recognition. This enabled the establishment of an easy-to-use, rapid, sensitive, pretreatment-free, and noninvasive sEV detection platform for efficient sEV detection-based cancer diagnosis. An apparent dissociation constant was estimated to be 2.4 × 10-16 M, which was ~1000 times higher than that of com. immunoassays (anal. time, 5 min/sample). The authors successfully used tears for the first time to detect cancer-related intact sEVs, clearly differentiating between healthy donors and breast cancer patients, as well as between samples collected before and after total mastectomy. The nanoprocessing strategy can be easily repurposed for the specific detection of other types of cancer by changing the conjugated antibodies, thereby facilitating the establishment of liquid biopsy for early cancer diagnosis.

Journal of the American Chemical Society published new progress about Antibodies and Immunoglobulins Role: ARG (Analytical Reagent Use), BUU (Biological Use, Unclassified), DGN (Diagnostic Use), ANST (Analytical Study), USES (Uses), BIOL (Biological Study). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Name: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kalkman, Eric D.; Mormino, Michael G.; Hartwig, John F. published the artcile< Unusual Electronic Effects of Ancillary Ligands on the Perfluoroalkylation of Aryl Iodides and Bromides Mediated by Copper(I) Pentafluoroethyl Complexes of Substituted Bipyridines>, Safety of 4,4′-Dichloro-2,2′-bipyridine, the main research area is Perfluoroalkylation aryl halides Copper pentafluoroethyl complex Bipyridines LFER; kinetics Perfluoroalkylation aryl halides Copper pentafluoroethyl complex Bipyridines.

Several perfluoroalkylcopper compounds have been reported previously that serve as reagents or catalysts for the perfluoroalkylation of aryl halides. However, the relationships between the reactivity of such complexes and the electronic properties of the ancillary ligands are unknown, and such relationships are not well-known in general for copper complexes that mediate or catalyze cross coupling. We report the synthesis and characterization of a series of pentafluoroethylcopper(I) complexes ligated by bipyridine ligands possessing varied electronic properties. In contrast to the limited existing data on the reactivity of L2Cu(I)-X complexes bearing amine and pyridine-type ligands in Ullmann-type aminations with aryl halides, the reactions of aryl halides with pentafluoroethylcopper(I) complexes bearing systematically varied bipyridine ligands were faster for complexes bearing less electron-donating bipyridines than for complexes bearing more electron-donating bipyridines. Anal. of the rates of reaction and the relative populations of the neutral complexes and ionic complexes formed by these reagents in solution suggests that this effect of electronics on the reaction rate results from an unusual trend of faster oxidative addition of aryl halides to complexes containing less electron-donating ligands than to those containing more electron-donating ligands.

Journal of the American Chemical Society published new progress about Activation enthalpy. 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Safety of 4,4′-Dichloro-2,2′-bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Meneses-Sanchez, Manuel; Turo-Cortes, Ruben; Bartual-Murgui, Carlos; da Silva, Ivan; Munoz, M. Carmen; Real, Jose Antonio published the artcile< Enhanced Interplay between Host-Guest and Spin-Crossover Properties through the Introduction of an N Heteroatom in 2D Hofmann Clathrates>, Formula: C10H8N2, the main research area is transition metal Hofmann clathrate preparation host guest spin crossover; crystal structure iron bipyridine palladium platinum cyano Hofmann clathrate.

Controlled modulation of the spin-crossover (SCO) behavior through the sorption-desorption of invited mols. is an extensively exploited topic because of its potential applications in mol. sensing. For this purpose, understanding the mechanisms by which the spin-switching properties are altered by guest mols. is of paramount importance. Here, the authors show an exptl. approach revealing a direct probe of how the interplay between SCO and host-guest chem. is noticeably activated by chem. tuning the host structure. Thus, the axial ligand 4-phenylpyridine (4-PhPy) in the 2-dimensional Hofmann clathrates {Fe(4-PhPy)2[M(CN)4]} (PhPyM; M = Pt, Pd) is replaced by 2,4-bipyridine (2,4-Bipy), resulting in the isomorphous compounds {Fe(2,4-Bipy)2[M(CN)4]} (BipyM; M = Pt, Pd), which basically differ from the former in that they have a noncoordinated N heteroatom in the ancillary aromatic substituent, i.e., 2-pyridyl instead of Ph. Chem., magnetic, calorimetric, and structural characterizations demonstrate that this subtle chem. composition change provokes outstanding modifications not only in the capability to adsorb small guests as H2O or MeOH but also in the extent to which these guests affect the SCO characteristics.

Inorganic Chemistry published new progress about Adsorption. 581-47-5 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem