Day: October 18, 2022

De Kowalewski, D. G.; Contreras, R. H.; De los Santos, C. published the artcile< Carbon-13 and proton NMR spectra of 2-pyridone derivatives>, Category: pyridine-derivatives, the main research area is NMR pyridone derivative; additivity NMR pyridone.

The 13C- and 1H-NMR of substituted pyridines (e.g. I) were studied to determine through additivity properties of 13C shielding constants and of the 13C-1H spin-spin coupling constants, the structure of the ring and of the lateral chains.

Journal of Molecular Structure published new progress about Additivity. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Patel, Harshkumar H.; Sigman, Matthew S. published the artcile< Palladium-Catalyzed Enantioselective Heck Alkenylation of Acyclic Alkenols Using a Redox-Relay Strategy>, Product Details of C13H15F3N2O, the main research area is alkenyl triflate alkenol acyclic palladium Heck alkenylation catalyst; aldehyde acyclic stereoselective preparation.

We report a highly enantioselective intermol. Heck reaction of alkenyl triflates and acyclic primary or racemic secondary alkenols. The mild reaction conditions permit installation of a wide range of alkenyl groups at positions β, γ, or δ to a carbonyl group in high enantioselectivity. The success of this reaction is attributed to the use of electron-withdrawing alkenyl triflates, which offer selective β-hydride elimination followed by migration of the catalyst through the alkyl chain to give the alkenylated carbonyl products. The synthetic utility of the process is demonstrated by a two-step modification of a reaction product to yield a tricyclic core structure, present in various natural products.

Journal of the American Chemical Society published new progress about Aliphatic aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Product Details of C13H15F3N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sepehri, Nima; Iraji, Aida; Yavari, Ali; Asgari, Mohammad Sadegh; Zamani, Saeed; Hosseini, Samanesadat; Bahadorikhalili, Saeed; Pirhadi, Somayeh; Larijani, Bagher; Khoshneviszadeh, Mahsima; Hamedifar, Halleh; Mahdavi, Mohammad; Khoshneviszadeh, Mehdi published the artcile< The natural-based optimization of kojic acid conjugated to different thio-quinazolinones as potential anti-melanogenesis agents with tyrosinase inhibitory activity>, Category: pyridine-derivatives, the main research area is kojic acid thio quinazolinone mol docking antimelanogenesis tyrosinase inhibition; Cytotoxicity; Hyperpigmentation; Kojic acid; Quinazolinone; Tyrosinase inhibitor.

Melanin pigment and melanogenesis are a two-edged sword. Melanin has a radioprotection role while melanogenesis has undesirable effects. Targeting the melanogenesis pathway, a series of kojyl thioether conjugated to different quinazolinone derivatives I (R = c-Pr, Ph, 2-pyridyl, etc.) were designed, synthesized, and evaluated for their inhibitory activity against mushroom tyrosinase. All the synthesized compounds were screened for their anti-tyrosinase activity and all derivatives displayed better potency than kojic acid as the pos. control. In this regard, compounds I (R = pyridin-2-ylmethyl) and I (R = 2-pyridyl) the most active compounds showed an IC50 value of 0.46 and 0.50μM, resp. In kinetic evaluation against tyrosinase, I (R = pyridin-2-ylmethyl) depicted an uncompetitive inhibition pattern. Designed compounds also exhibited mild antioxidant capacity. Moreover, compounds I (R = pyridin-2-ylmethyl) and I (R = 2-pyridyl) achieved good potency against the B16F10 cell line to reduce the melanin content, while showing limited toxicity against malignant cells. The proposed binding mode of new inhibitors evaluated through mol. docking was consistent with the results of structure-activity relationship anal.

Bioorganic & Medicinal Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Junaid, Ahmad; Lim, Felicia Phei Lin; Zhou, Yvonne Peijun; Chui, Wai Keung; Dolzhenko, Anton V. published the artcile< Fused heterocyclic systems with an s-triazine ring. 34. Development of a practical approach for the synthesis of 5-aza-isoguanines>, Product Details of C6H8N2, the main research area is azaisoguanine fused triazine preparation; azapurine; purine isostere.; triazine; triazole.

In this article, an attempt to develop a practical method for the preparation of 5-aza-isoguanines is reported. Several synthetic approaches were explored to establish a robust general protocol for the preparation of these compounds The significant difference in the reactivity of the C-5 and C-7 electrophilic centers of 1,2,4-triazolo[1,5-a][1,3,5]triazines (5-azapurines) towards nucleophiles was demonstrated. The most practical and general method for the preparation of 5-aza-isoguanines involved a regioselective reaction of ethoxycarbonyl isothiocyanate with a 5-aminotriazole. The intramol. ring closure of the resulted product followed by the S-methylation afforded 7-methylthio-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-one, which could be effectively aminated with various amines. The resulted 5-aza-isoguanines resemble a known purine nucleoside phosphorylase inhibitor and could be interesting for further investigations as potential anticancer agents.

Molecules published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Product Details of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gomes, Emmanuel M.; Franco, Douglas F.; Scarpari, Sergio L.; Colaco, Marcos V.; Ferreira, Monica S.; Freire, Ricardo O.; Marques, Lippy F. published the artcile< Study of energy transfer mechanism in the EuIII and GdIII homobimetallic complexes containing the anti-inflammatory drug naproxen and N,N-donors ligands>, Safety of 2,2′-Bipyridine, the main research area is naproxen homobimetallic complex donors ligand antiinflammatory agent energy transfer.

In this work, we present the synthesis, solid state characterization and complete photoluminescence study of new important homobimetallic lanthanide complexes containing the non-steroidal anti-inflammatory drug (NSAID) naproxen. The anal. and spectroscopic techniques reveals the formation of eight compounds of general formula [Ln2(nap)6(H2O)4] (Eu 1 and Gd 2), [Ln2(nap)6(bpy)2] (Eu 3 and Gd 4), [Ln2(nap)6(4,4′-dmbpy)2] (Eu 5 and Gd 6) and [Ln2(nap)6(phen)2] (Eu 7 and Gd 8), where: nap = naproxen ligand, bpy =2,2′-bipyridine, 4,4′-dmbpy = 4,4′-dimethyl-2,2′-bipyridine and phen = 1,10-phenanthroline. Using the RM1 model, the mol. structures of the EuIII complexes were calculated, with your optimized ground state geometries used to obtain all details involved in the energy transfer process. From the resp. GdIII complexes were obtained the lowest ligand triplet states, proving that the photoluminescence in the EuIII naproxen complexes is proposed to be a ligand sensitized luminescence process. On the other hand, the position of the triplet states also explains the non-effective energy transfer in the TbIII naproxen complexes. The presence of N,N-donors ligands (bpy, 4,4′-dmbpy and phen) results in an 3-4-fold increase in the quantum efficiency when compared with the EuIII complex without nitrogen ligands. The high values of emission quantum efficiency (η ∼ 70 – 98%) show the EuIII complexes can be potential candidates as emitters in biol. assays.

Journal of Luminescence published new progress about Anti-inflammatory agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Safety of 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Song, Jiahan; Si, Yubing; Guo, Wei; Wang, Donghai; Fu, Yongzhu published the artcile< Organosulfide-Based Deep Eutectic Electrolyte for Lithium Batteries>, Product Details of C10H8N2S2, the main research area is dipyridyl disulfide deep eutectic electrolyte lithium battery; 2,2′-dipyridyl disulfide; LiTFSI; deep eutectic electrolyte; ionic conductivity; lithium iron phosphate.

Deep eutectic electrolytes (DEEs) are a new class of electrolytes with unique properties. However, the intermol. interactions of DEEs are mostly dominated by Li···O interactions, limiting the diversity of chem. space and material constituents. Herein, we report a new class of DEEs induced by Li···N interactions between 2,2-dipyridyl disulfide (DpyDS) and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI). The strong ion-dipole interaction triggers the deep eutectic phenomenon, thus liberating the Li+ from LiTFSI and endowing the DEEs with promising ionic conductivity These DEEs show admirable intrinsic safety, which cannot be ignited by flame. The DEE at the molar ratio of DpyDS_LiTFSI=4:1 (abbreviated as DEE-4:1) is electrochem. stable between 2.1 and 4.0 V vs. Li/Li+, and exhibits an ionic conductivity of 1.5×10-4 S cm-1 at 50°C. The Li/LiFePO4 half cell with DEE-4:1 can provide a reversible capacity of 130 mAh g-1 and Coulombic efficiency above 98% at 50°C.

Angewandte Chemie, International Edition published new progress about Battery capacity. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Product Details of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wzgarda-Raj, Kinga; Nawrot, Martyna; Rybarczyk-Pirek, Agnieszka J.; Palusiak, Marcin published the artcile< Ionic cocrystals of dithiobispyridines: the role of I···I halogen bonds in the building of iodine frameworks and the stabilization of crystal structures>, Reference of 2127-03-9, the main research area is cocrystal; crystal structure; halogen bonding; hydrogen bonding; proton sponge; proton transfer; pyridine; quantum chemistry; salt; supramolecular chemistry.

It has been confirmed that mercaptopyridines undergo spontaneous condensation in redox reaction with iodine-forming dithiopyridines. In the solid state, these compounds are protonated at the N atoms and cocrystallize with iodine forming salt structures, namely, 2-[(pyridin-2-yl)disulfanyl]pyridinium triiodide sesquiiodine, C10H9N2S2+·I3-·1.5I2, and 4,4′-(disulfanediyl)dipyridinium pentaiodide triiodide, C10H10N2S22+·I5-·I3-. Dithiopyridine cations are packed among three-dimensional frameworks built from iodide anions and neutral iodine mols., and are linked by hydrogen, halogen and chalcogen interactions. Quantum chem. computations indicated that dithiopyridines exhibit anomalously high nitrogen basicity which qualify them as potential proton sponges.

Acta Crystallographica, Section C: Structural Chemistry published new progress about Cocrystallization. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Reference of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chniti, Sami; Kollar, Laszlo; Benyei, Attila; Takacs, Attila published the artcile< Highly Selective Synthesis of 6-Glyoxylamidoquinoline Derivatives via Palladium-Catalyzed Aminocarbonylation>, Application of C6H8N2, the main research area is quinoline amide preparation chemoselective; iodoquinoline amine carbon monoxide aminocarbonylation palladium catalyst; 6-iodoquinoline; aminocarbonylation; carbon monoxide; double carbonylation; palladium.

The aminocarbonylation of 6-iodoquinoline has been investigated in the presence of large series of amine nucleophiles such as tert-butylamine, cyclohexylamine, furfyrlamine, etc. providing an efficient synthetic route for producing various quinoline-6-carboxamide I (R = cyclohexylaminyl, decan-1-aminyl, 4-methylpiperazin-1-yl, etc.) and quinoline-6-glyoxylamide derivatives II. It was shown, after detailed optimization study, that the formation of amides and ketoamides is strongly influenced by the reaction conditions. Performing the reactions at 40 bar of carbon monoxide pressure in the presence of Pd(OAc)2/2 PPh3, the corresponding 2-ketocarboxamides II were formed as major products (up to 63%). When the monodentate triphenylphosphine was replaced by the bidentate XantPhos, the quinoline-6-carboxamide derivatives I were synthesized almost exclusively under atm. conditions (up to 98%). The isolation and characterization of the new carbonylated products I, II of various structures were also accomplished. Furthermore, the structure of three new mono- and double-carbonylated compounds I, I were unambiguously established by using a single-crystal XRD study.

Molecules published new progress about Amides, oxo Role: SPN (Synthetic Preparation), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Application of C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dong, Dong; Thomas, Nicky; Ramezanpour, Mahnaz; Psaltis, Alkis J.; Huang, Shuman; Zhao, Yulin; Thierry, Benjamin; Wormald, Peter-John; Prestidge, Clive A.; Vreugde, Sarah published the artcile< Inhibition of Staphylococcus aureus and Pseudomonas aeruginosa biofilms by quatsomes in low concentrations>, Name: 1-Hexadecylpyridin-1-ium chloride, the main research area is Staphylococcus Pseudomonas biofilm quatsome; CPC-quatsome; Chronic rhinosinusitis; Pseudomonas aeruginosa; Staphylococcus aureus; biofilm; cetylpyridinium chloride.

This study investigated the inhibition effect of cetylpyridinium chloride (CPC)-quatsomes at low concentrations on both S. aureus and P. aeruginosa biofilms in vitro, as well as their toxicities towards cultured human airway epithelial (NuLi-1) cells. CPC-quatsome and CPC micelle solutions at concentrations of 0.01%, 0.025%, and 0.05% were prepared Confocal laser scanning microscopy (CLSM) was used to investigate the interactions between CPC-quatsomes and S. aureus and P. aeruginosa biofilms. A lactate dehydrogenase (LDH) assay was used to determine the toxicity of CPC-quatsomes on NuLi-1 cells. CPC-quatsome and CPC micelle solutions had significant inhibition effects at all tested concentrations on planktonic S. aureus and P. aeruginosa and their biofilms. In the CLSM study, different interactions between CPC-quatsomes and S. aureus or P. aeruginosa biofilms were observed CPC-quatsomes at low concentrations inhibited S. aureus and P. aeruginosa in both planktonic form and biofilms. No adverse effects on NuLi-1 cells were observed, indicating their promising potential in the treatment of CRS. In our study, CPC-quatsomes at concentrations of 0.01%, 0.025%, and 0.05% had significant inhibition effects on both planktonic and biofilms of S. aureus and P. aeruginosa. The result of this study indicates the promising potential of CPC-quatsome in the treatment of CRS.

Experimental Biology and Medicine (London, United Kingdom) published new progress about Biofilms (microbial). 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Name: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hsu, Nai-Shu; Lee, Cheng-Chung; Kuo, Wen-Chih; Chang, Ya-Wen; Lo, Shin-Yi; Wang, Andrew H.-J. published the artcile< Development of a Versatile and Modular Linker for Antibody-Drug Conjugates Based on Oligonucleotide Strand Pairing>, HPLC of Formula: 2127-03-9, the main research area is linker antibody drug conjugate oligonucleotide pairing.

Linker design is crucial to the success of antibody-drug conjugates (ADCs). In this work, we developed a modular linker format for attaching mol. cargos to antibodies based on strand pairing between complementary oligonucleotides. We prepared antibody-oligonucleotide conjugates (AOCs) by attaching 18-mer oligonucleotides to an anti-HER2 antibody through thiol-maleimide chem., a method generally applicable to any Ig with interchain disulfide bridges. The hybridization of drug-bearing complementary oligonucleotides to our AOCs was rapid, stoichiometric, and sequence-specific. AOCs loaded with cytotoxic payloads were able to selectively target HER2-overexpressing cell lines such as SK-BR-3 and N87, with in vitro potencies similar to that of the marketed ADC Kadcyla (T-DM1). Our results demonstrated the potential of utilizing AOCs as a highly versatile and modular platform, where a panel of well-characterized AOCs bearing DNA, RNA, or various nucleic acid analogs, such as peptide nucleic acids, could be easily paired with any cargo of choice for a wide range of diagnostic or therapeutic applications.

Bioconjugate Chemistry published new progress about Antibody-drug conjugates. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, HPLC of Formula: 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem