Day: October 18, 2022

Jian, Wenyuan; Jin, Zhengyu; Yang, Jing; Meng, Guozhe; Liu, Hongfang; Liu, Hongwei published the artcile< Anticorrosion and antibiofouling performance of in-situ prepared layered double hydroxide coating modified by sodium pyrithione on aluminum alloy 7075>, SDS of cas: 3811-73-2, the main research area is sodium pyrithione layered double hydroxide anticorrosion antibiofouling coating alloy.

The anticorrosion and antibiofouling of marine engineering equipments have strong demands, especially for antibiofouling. In this work, an in-situ growth layered double hydroxide (LDH) coating on aluminum alloys (AA) 7075 was prepared and then modified by sodium pyrithione (SPT) to increase the anticorrosion and antibiofouling performance. Results indicated that CoAl-LDHs and CoAl-LDHs-SPT coatings had been successfully prepared according to TEM, XRD, XPS, Raman spectra, and SEM anal. results. The (0 1 2) plane of LDHs with a interplanar spacing of 0.26 nm was recognized from TEM images. The content of SPT in CoAl-LDHs-SPT is 38.79 weight%. Electrochem. impedance spectroscopy (EIS) and polarization curves demonstrate that the corrosion resistance of AA 7075 was largely improved in the presence of CoAl-LDHs and CoAl-LDHs-SPT coatings while the anticorrosion performance of CoAl-LDHs-SPT coating was better. The corrosion resistance of Co-Al LDHs-SPT coating increased by about two orders of magnitude compared with the bare AA 7075. The surface anal. results show that only a few Pseudomonas aeruginosa and Spirulina cells attached to the CoAl-LDHs coating surface, and no biofouling cells were observed for the CoAl-LDHs-SPT coating. Co-Al LDHs-SPT coating possessed the best anticorrosion and antibiofouling properties due to the presence of SPT compared with the CoAl-LDHs coating.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about Anion exchange. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, SDS of cas: 3811-73-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hasan, M. Shamim; Chopra, Divykriti; Damm, Anika; Koprivova, Anna; Kopriva, Stanislav; Meyer, Andreas J.; Mueller-Schuessele, Stefanie; Grundler, Florian M. W.; Siddique, Shahid published the artcile< Glutathione contributes to plant defence against parasitic cyst nematodes>, Formula: C10H8N2S2, the main research area is glutathione plant defense parasitic cyst nematode; glutathione; nematode; plant-parasitic nematode; redox; syncytium.

Cyst nematodes (CNs) are an important group of root-infecting sedentary endoparasites that severely damage many crop plants worldwide. An infective CN juvenile enters the host′s roots and migrates towards the vascular cylinder, where it induces the formation of syncytial feeding cells, which nourish the CN throughout its parasitic stages. Here, we examined the role of glutathione (L-γγ-glutamyl-L-cysteinyl-glycine) in Arabidopsis thaliana on infection with the CN Heterodera schachtii. Arabidopsis lines with mutations pad2, cad2, or zir1 in the glutamate-cysteine ligase (GSH1) gene, which encodes the first enzyme in the glutathione biosynthetic pathway, displayed enhanced CN susceptibility, but susceptibility was reduced for rax1, another GSH1 allele. Biochem. anal. revealed differentially altered thiol levels in these mutants that was independent of nematode infection. All glutathione-deficient mutants exhibited impaired activation of defense marker genes as well as genes for biosynthesis of the antimicrobial compound camalexin early in infection. Further anal. revealed a link between glutathione-mediated plant resistance to CN infection and the production of camalexin on nematode infection. These results suggest that glutathione levels affect plant resistance to CN by fine-tuning the balance between the cellular redox environment and the production of compounds related to defense against infection.

Molecular Plant Pathology published new progress about 18S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Formula: C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ou, Wei; Zou, Ru; Han, Mengting; Yu, Lei; Su, Chenliang published the artcile< Tailorable carbazolyl cyanobenzene-based photocatalysts for visible light-induced reduction of aryl halides>, Computed Properties of 3796-23-4, the main research area is dehalogenation arylation photocatalyst carbazole.

Herein, a series of carbazolyl cyanobenzene (CCB)-based organic photocatalysts with a broad range of photoredox capabilities were designed and synthesized, allowing precise control of the photocatalytic reactivity for the controllable reduction of aryl halides via a metal-free process. The screened-out CCB (5CzBN), a metal-free, low-cost, scalable and sustainable photocatalyst with both strong oxidative and reductive ability, exhibits superior performance for both dehalogenation and C-C bond-forming arylation reactions.

Chinese Chemical Letters published new progress about Arylation. 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Computed Properties of 3796-23-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Qin, Qi-Pin; Wang, Zhen-Feng; Tan, Ming-Xiong; Huang, Xiao-Ling; Zou, Hua-Hong; Zou, Bi-Qun; Shi, Bei-Bei; Zhang, Shu-Hua published the artcile< Complexes of lanthanides(III) with mixed 2,2'-bipyridyl and 5,7-dibromo-8-quinolinoline chelating ligands as a new class of promising anti-cancer agents>, Application of C10H8N2, the main research area is cervical ovarian cancer lanthanide III metal chelation.

Five novel lanthanides(III) complexes, [Lu(Me)(MBrQ)2NO3] (MeMBrQ-Lu), [Ho(MeO)(MBrQ)2NO3] (MeOMBrQ-Ho), [Ho(Me)(MBrQ)2NO3] (MeMBrQ-Ho), [La(Me)2(BrQ)2NO3] (MeBrQ-La) and [Sm(Me)(BrQ)2(CH3OH)NO3] (MeBrQ-Sm) were synthesized in which 2,2′-bipyridyl (4,4′-dimethyl-2,2′-bipyridyl (Me) and 4,4′-dimethoxy-2,2′-bipyridine (MeO)) and 5,7-dibromo-8-quinolinoline derivatives (5,7-dibromo-2-methyl-8-quinolinol (MBrQ-H) and 5,7-dibromo-8-quinolinol (BrQ-H)) act as chelating ligands. The in vitro cytotoxic activities of five Ln(III) complexes have been studied with SK-OV-3/DDP, NCI-H460 and HeLa cancer cells. MeMBrQ-Lu, MeOMBrQ-Ho, MeMBrQ-Ho, MeBrQ-La and MeBrQ-Sm show higher cytotoxicity against the HeLa cells than cisplatin (13.11 ± 0.53 μM). In particular, the MeOMBrQ-Ho and MeMBrQ-Ho complexes exhibit superior cytotoxic activity, with IC50 values at 1.00 ± 0.34 nM and 125.00 ± 1.08 nM. We further demonstrate that MeOMBrQ-Ho and MeMBrQ-Ho inhibit the proliferation of HeLa cells by inhibiting telomerase and targeting mitochondria to induce DNA damage-mediated apoptosis. In addition, MeOMBrQ-Ho significantly inhibits tumor growth with a tumor growth inhibition rate (IR) of 50.8% in a HeLa mouse xenograft model. Taken together, MeOMBrQ-Ho is a novel lanthanide(III) complex with promising antitumor activity.

Metallomics published new progress about Antitumor agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wu, Wen Xin; Liu, Hu Cheng; Jin, Wei Jun published the artcile< Halogen Bonding Adsorbent Pyridine N-oxides for Iodine Capture in Water>, Recommanded Product: 2-Mercaptopyridinen-oxide sodiumsalt, the main research area is anthracene naphthaline pyridine oxide adsorbent single crystal surface structure; SC-SC transformation; halogen bonds; iodine capture; nonporous materials; pyridine N-oxide.

Rapid capture of 129I with high volatility and toxicity in the environment has attracted much attention. Herein we reported a firstly synthesized nonporous material: pyridine N-oxides (NTPO and ATPO) as iodine adsorbent. Both of NTPO and ATPO exhibit remarkable performance on the adsorption of iodine in aqueous solution, vapor state and organic solvents. Upon the capture of iodine, pyridine N-oxides were transformed to binary cocrystals combined with the pyridine N-oxides and iodine which is driven by halogen bond between iodine and oxygen atoms. Moreover, pyridine N-oxides shows high chem., thermal and moisture stability.

Chemistry – A European Journal published new progress about Adsorption. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Recommanded Product: 2-Mercaptopyridinen-oxide sodiumsalt.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tong, Xiaogang; Shi, Bingfei; Liu, Qian; Huo, Yanman; Xia, Chengfeng published the artcile< Retro-biosynthetic construction of corynanthe alkaloid skeletons from rhynchophylline alkaloids>, Quality Control of 93-60-7, the main research area is retro biosynthetic Wagner Meerwein rearrangement rhynchophylline corynanthe alkaloid.

Rhynchophylline alkaloids are bio-synthesized from corynanthe alkaloids via an oxidative rearrangement. We demonstrate here that corynanthe alkaloids could be generated from rhynchophylline alkaloids in a retro-biosynthetic manner via a Wagner-Meerwein rearrangement [e.g., I → II (85%) in presence of TFA in DCM]. A series of corynanthe analogs were afforded with good functional group tolerance and satisfactory yields.

Organic & Biomolecular Chemistry published new progress about Biomimetic synthesis (retro-biomimetic). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Quality Control of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Meng; Mu, Yan-Fei; Yao, Shuang; Guo, Song; Guo, Xiang-Wei; Zhang, Zhi-Ming; Lu, Tong-Bu published the artcile< Photosensitizing single-site metal-organic framework enabling visible-light-driven CO2 reduction for syngas production>, Recommanded Product: 2,2′-Bipyridine, the main research area is photosensitizing MOF carbon reduction syngas.

Photocatalytic CO2 reduction into syngas (CO and H2) is one of sustainable strategies for recycling CO2 into value-added products. Herein, a simple and effective two-step self-assembly process was developed to functionalize phosphorescent metal-organic framework (MOF) with single site catalyst. The resulting (Co/Ru)n-UiO-67(bpydc) supplied mol. platform to enable fast multielectron injection from photosensitizers (PSs) to Co-catalyst, leading to the first MOF-based composite photocatalyst for efficient syngas production with a yield of 13,600μmol·g-1 (H2 : CO = 2 : 1) in 16 h, 29.2-fold higher than that of its homogeneous counterpart. The H2/CO ratios can be well controlled by carefully adjusting the molar ratio of PS/catalyst in the MOF platform and the water content in the photocatalytic system. This work provides a prospective strategy for recycling CO2 into H2-rich syngas by merging PSs and single-site catalysts into a MOF platform.

Applied Catalysis, B: Environmental published new progress about Photocatalysts. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Recommanded Product: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ren, Linning; Wang, Manman; Fang, Benyao; Yu, Wenquan; Chang, Junbiao published the artcile< Iodine-mediated oxidative N-N coupling of secondary amines to hydrazines>, Product Details of C11H10N2, the main research area is aromatic secondary amine iodine mediator oxidative dimerization; diaryl hydrazine preparation.

An I2-mediated N-N coupling reaction was established for oxidative dimerization of N-aryl aminopyridines to a variety of novel hydrazine derivatives under mild conditions. This synthetic method does not required the use of transition metals and was conveniently carried out on a gram scale. It was also applicable to diphenylamine and N-alkyl aniline substrates.

Organic & Biomolecular Chemistry published new progress about Hydrazines Role: SPN (Synthetic Preparation), PREP (Preparation). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Product Details of C11H10N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Haixian; Song, Feifei; Dong, Caihong; Yu, Luodan; Chang, Cai; Chen, Yu published the artcile< Co-delivery of nanoparticle and molecular drug by hollow mesoporous organosilica for tumor-activated and photothermal-augmented chemotherapy of breast cancer>, Safety of 1,2-Di(pyridin-2-yl)disulfane, the main research area is diethyldithiocarbamate hybrid hollow mesoporous organosilica nanoparticle chemotherapy breast cancer; Breast cancer; Copper; Disulfiram; Mesoporous organosilica; Photothermal.

In comparison with traditional therapeutics, it is highly preferable to develop a combinatorial therapeutic modality for nanomedicine and photothermal hyperthermia to achieve safe, efficient, and localized delivery of chemotherapeutic drugs into tumor tissues and exert tumor-activated nanotherapy. Biocompatible organic-inorganic hybrid hollow mesoporous organosilica nanoparticles (HMONs) have shown high performance in mol. imaging and drug delivery as compared to other inorganic nanosystems. Disulfiram (DSF), an alc.-abuse drug, can act as a chemotherapeutic agent according to its recently reported effectiveness for cancer chemotherapy, whose activity strongly depends on copper ions. In this work, a therapeutic construction with high biosafety and efficiency was proposed and developed for synergistic tumor-activated and photothermal-augmented chemotherapy in breast tumor eradication both in vitro and in vivo. The proposed strategy is based on the employment of HMONs to integrate ultrasmall photothermal CuS particles onto the surface of the organosilica and the mol. drug DSF inside the mesopores and hollow interior. The ultrasmall CuS acted as both photothermal agent under near-IR (NIR) irradiation for photonic tumor hyperthermia and Cu2+ self-supplier in an acidic tumor microenvironment to activate the nontoxic DSF drug into a highly toxic diethyldithiocarbamate (DTC)-copper complex for enhanced DSF chemotherapy, which effectively achieved a remarkable synergistic in-situ anticancer outcome with minimal side effects. This work provides a representative paradigm on the engineering of combinatorial therapeutic nanomedicine with both exogenous response for photonic tumor ablation and endogenous tumor microenvironment-responsive in-situ toxicity activation of a mol. drug (DSF) for augmented tumor chemotherapy.

Journal of Nanobiotechnology published new progress about Animalia. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Safety of 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Marcelo, Goncalo A.; Montpeyo, David; Novio, Fernando; Ruiz-Molina, Daniel; Lorenzo, Julia; Oliveira, Elisabete published the artcile< Luminescent silicon-based nanocarrier for drug delivery in colorectal cancer cells>, Name: 1,2-Di(pyridin-2-yl)disulfane, the main research area is luminescent silicon nanocarrier drug delivery colorectal cancer cell.

Nanocarriers sensitive to exogenous or endogenous stimuli emerged as an attractive alternative to target drug delivery, with inorganic silica mesoporous nanoparticles (MNs) playing a core role in the development of a new generation of non-toxic and tuneable nanocarriers. A sensitive nanovector (NANO1) comprising luminescent silicon quantum dots (SiQDs) and functionalized with MNs was synthesized and loaded with doxorubicin (DOX). NANO1 nanoparticles have a size of 74 ± 10 nm and DOX loading percentages of ca. 43%. As a control sample, a similar nanocarrier (NANO2), without SiQDs, was also synthesized and loaded with DOX. Release profile studies, in PBS, revealed the strong NANO1@DOX pH-dependant behavior, with a pH 5.0 favoring the release of DOX to percentages of ca. 70%. Cytotoxicity assessments of both free and DOX-loaded nanocarriers were evaluated in human cell lines of colon, revealing both free drug and drug-loaded nanoparticles to be concentration-dependent.

Dyes and Pigments published new progress about Antitumor agents. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Name: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem