Day: October 19, 2022

Khodjoyan, Silva; Remadna, Edwyn; Dossmann, Heloise; Lesage, Denis; Gontard, Geoffrey; Forte, Jeremy; Hoffmeister, Henrik; Basu, Uttara; Ott, Ingo; Spence, Philip; Waller, Zoe A. E.; Salmain, Michele; Bertrand, Benoit published their research in Chemistry – A European Journal in 2021. The article was titled 《[(C C)Au(N N)]+ Complexes as a New Family of Anticancer Candidates: Synthesis, Characterization and Exploration of the Antiproliferative Properties》.Reference of 4,4′-Dimethyl-2,2′-bipyridine The article contains the following contents:

A library of eleven cationic gold(III) complexes of the general formula [(C C)Au(N N)]+ when C C is either biphenyl or 4,4-ditertbutyldiphenyl and N N is a bipyridine, phenanthroline or dipyridylamine derivative have been synthesized and characterized. Contrasting effects on the viability of the triple neg. breast cancer cells MDA-MB-231 was observed from a preliminary screening. The antiproliferative activity of the seven most active complexes were further assayed on a larger panel of human cancer cells as well as on non-cancerous cells for comparison. Two complexes stood out for being either highly active or highly selective. Eventually, reactivity studies with biol. meaningful amino acids, glutathione, higher order DNA structures and thioredoxin reductase (TrxR) revealed a markedly different behavior from that of the well-known coordinatively isomeric [(C N C)Au(NHC)]+ structure. This makes the [(C C)Au(N N)]+ complexes a new class of organogold compounds with an original mode of action. In the experiment, the researchers used many compounds, for example, 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Reference of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Reference of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lu, Ye; Liu, Dong; Lin, Yue-Jian; Li, Zhen-Hua; Hahn, F. Ekkehardt; Jin, Guo-Xin published an article in 2021. The article was titled 《An “”All-in-One”” Synthetic Strategy for Linear Metalla[4]Catenanes》, and you may find the article in Journal of the American Chemical Society.SDS of cas: 2510-22-7 The information in the text is summarized as follows:

One fascinating and challenging synthetic target in the field of mech. interlocked mols. is the family of linear [4]catenanes, which are topol. identical to the logo of automobile maker Audi. Herein, we report an “”all-in-one”” synthetic strategy for the synthesis of linear metalla[n]catenanes (n = 2-4) by the coordination-driven self-assembly of Cp*Rh-based (Cp* = η5-pentamethylcyclopentadienyl) organometallic rectangle π-donors and tetracationic organic cyclophane π-acceptors. We selected the pyrenyl group as the π-donor unit, leading to homogeneous metalla[2]catenanes and cyclic metalla[3]catenanes via π-stacking interactions. By taking advantage of the strong electrostatic interactions between π-donor units and π-acceptor units, a heterogeneous metalla[2]catenanes and linear metalla[3]catenanes, resp., could be obtained by the simple stirring of homogeneous metalla[2]catenanes with a suitable tetracationic cyclophane. On this basis, this “”all-in-one”” synthetic strategy was further used to realize a quant. one-step synthesis of a linear metalla[4]catenanes via the self-assembly of cyclic metalla[3]catenanes and tetracationic cyclophanes. All heterogeneous metalla[n]catenanes (n = 2-4) were fully characterized by single-crystal X-ray anal., NMR spectroscopy and electrospray ionization mass spectrometry. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Chen, Ruikun; Hu, Pengwei; Xian, Yuxi; Hu, Xianhai; Zhang, Guobing published an article in Macromolecular Rapid Communications. The title of the article was 《Incorporation of Sequence Aza-Substitution and Thiophene Bridge in Linear Conjugated Polymers Toward Highly Efficient Photo-Catalytic Hydrogen Evolution》.COA of Formula: C5H3Br2N The author mentioned the following in the article:

The hydrogen evolution performance of organic photo-catalysts is lagged by numerous factors, such as the narrow photon absorption window, low charge transport, and so on. In this paper, four linear conjugated polymers are designed and synthesized based on dibenzothiophene-S,S-dioxide as an acceptor, and aza-substituted thiophene-phenyl-thiophene with different substitution numbers as co-units. The polymers with the thiophene bridge and aza-substitution exhibit broad visible absorption because of the extended conjugated length and improved planar structures resulting from the intramol. non-covalent interactions (S···N or CH···N). The mono-substitution polymer without the addition of any co-catalysts shows the highest photo-catalytic performances with the hydrogen evolution rates of 8950 and 7388 μmol g-1 h-1 under the UV-vis (>295 nm) and visible (>420 nm) irradiation, resp. The corresponding apparent quantum yields are as high as 8.34, 5.37, and 1.96% for the 420, 500, and 550 nm monochromatic light irradiation, resp., which are much higher than those of the classic polymer (P7) without thiophene bridge and aza-substitution. This work indicats that the incorporation of thiophene bridge enhances visible absorption and aza-substitution optimized co-planarity and activate reactive sites, which should be an effective strategy to improve the photo-catalytic performance of linear conjugated polymers. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dibromopyridine(cas: 624-28-2COA of Formula: C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.COA of Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Pothireddy, Mohanreddy; Bhukta, Swadhapriya; Babu, P. Vijaya; Thirupathi, Barla; Dandela, Rambabu published an article in Synthetic Communications. The title of the article was 《Synthetic method to access fluorinated 2-benzylpyridines by using Negishi coupling reaction》.Application In Synthesis of 2-Bromo-5-methylpyridine The author mentioned the following in the article:

The 2-benzylpyridines scaffolds I (R = 4-Me, 3-Cl, 2-trifluoromethyl, etc.) have been found in various drugs, bioactive natural products, and medicinally important compounds This manuscript comprises the synthesis of various fluorinated analogs of 2-benzylpyridine compounds I by using a Negishi coupling reaction as a key reaction. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-methylpyridine(cas: 3510-66-5Application In Synthesis of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application In Synthesis of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Mahato, Shreya; Rawal, Parveen; Devadkar, Ajitrao Kisan; Joshi, Mayank; Roy Choudhury, Angshuman; Biswas, Bhaskar; Gupta, Puneet; Panda, Tarun K. published an article in Organic & Biomolecular Chemistry. The title of the article was 《Hydroboration and reductive amination of ketones and aldehydes with HBpin by a bench stable Pd(II)-catalyst》.Formula: C7H7NO The author mentioned the following in the article:

A palladium(II) complex [(κ4-{1,2-C6H4(N:CHC6H4O2)2})Pd] (1) supported by a dianionic salen ligand [1,2-C6H4(NCH-C6H4O)2]2- (L) was synthesized and used as a mol. pre-catalyst in the hydroboration of aldehydes and ketones. The mol. structure of Pd(II) complex 1 was established by single-crystal x-ray diffraction anal. Complex 1 was tested as a competent pre-catalyst in the hydroboration of aldehydes and ketones with pinacolborane (HBpin) to produce corresponding boronate esters in excellent yields at ambient temperature under solvent-free conditions. Further, the complex 1 proved to be a competent catalyst in the reductive amination of aldehydes with HBpin and primary amines under mild and solvent-free conditions to afford a high yield (up to 97%) of corresponding secondary amines. Both protocols provided high conversion, superior selectivity and broad substrate scope, from electron-withdrawing to electron-donating and heterocyclic substitutions. A computational study based on d. functional theory (DFT) revealed a reaction mechanism for Pd-catalyzed hydroboration of carbonyl species in the presence of HBpin. The protocols also uncovered the dual role of HBpin in achieving the hydroboration reaction. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Formula: C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Formula: C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Han, Sang Hoon; Goins, Christopher M.; Arya, Tarun; Shin, Woo-Jin; Maw, Joshua; Hooper, Alice; Sonawane, Dhiraj P.; Porter, Matthew R.; Bannister, Breyanne E.; Crouch, Rachel D.; Lindsey, A. Abigail; Lakatos, Gabriella; Martinez, Steven R.; Alvarado, Joseph; Akers, Wendell S.; Wang, Nancy S.; Jung, Jae U.; Macdonald, Jonathan D.; Stauffer, Shaun R. published an article in Journal of Medicinal Chemistry. The title of the article was 《Structure-based optimization of ML300-derived, noncovalent inhibitors targeting the severe acute respiratory syndrome coronavirus 3CL protease (SARS-CoV-2 3CLpro)》.Reference of 2-Pyridinylboronic acid The author mentioned the following in the article:

Starting from the MLPCN probe compound ML300, a structure-based optimization campaign was initiated against the recent severe acute respiratory syndrome coronavirus (SARS-CoV-2) main protease (3CLpro). X-ray structures of SARS-CoV-1 and SARS-CoV-2 3CLpro enzymes in complex with multiple ML300-based inhibitors, including the original probe ML300, were obtained and proved instrumental in guiding chem. toward probe compound 41 (I)(CCF0058981). The disclosed inhibitors utilize a noncovalent mode of action and complex in a noncanonical binding mode not observed by peptidic 3CLpro inhibitors. In vitro DMPK profiling highlights key areas where further optimization in the series is required to obtain useful in vivo probes. Antiviral activity was established using a SARS-CoV-2-infected Vero E6 cell viability assay and a plaque formation assay. I demonstrates nanomolar activity in these resp. assays, comparable in potency to remdesivir. These findings have implications for antiviral development to combat current and future SARS-like zoonotic coronavirus outbreaks. In addition to this study using 2-Pyridinylboronic acid, there are many other studies that have used 2-Pyridinylboronic acid(cas: 197958-29-5Reference of 2-Pyridinylboronic acid) was used in this study.

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Reference of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Patel, Paresh N.; Desai, Dipen H.; Patel, Nilam C.; Deshmukh, Amar G. published an article in Journal of Molecular Structure. The title of the article was 《Efficient multicomponent processes for synthesis of novel poly-nuclear hetero aryl substituted terpyridine scaffolds: Single crystal XRD study》.Synthetic Route of C7H7NO The author mentioned the following in the article:

Authors studied the synthesis of novel terpyridine scaffolds from poly-nuclear and hetero-aryl aldehydes by the multicomponent condensation reactions with various acetyl pyridine derivatives in the presence of ammonium hydroxide. Comparative studies of two different processes catalyzed by potassium hydroxide and pyrrolidine have been performed and presented in this report. The structures of all the newly prepared terpyridine mols. have been well established by preforming various spectral anal. and single crystal XRD studies for selected mols. This approach addressed some structural miscellany concerns currently facing in photo-luminescent chem., and the derived hybrid pyridines could be used as suitable precursors for the synthesis of related photo-luminescent systems. The prepared scaffolds as such and their d-block or f-block metal complexes and coordination polymers may provide an efficient candidate for photo-luminescent chem. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Synthetic Route of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Schiltz, Pauline; Casaretto, Nicolas; Auffrant, Audrey; Gosmini, Corinne published an article in Chemistry – A European Journal. The title of the article was 《Cobalt Complexes Supported by Phosphinoquinoline Ligands for the Catalyzed Hydrosilylation of Carbonyl Compounds》.Related Products of 1122-54-9 The author mentioned the following in the article:

Alkoxysilanes ArCHMeOSiHPh2 were prepared by hydrosilylation of acetophenones ArCOMe with SiH2Ph2 catalyzed by cobalt(II) 8-phosphinoquinoline (8-R2Pquin, L; R = iPr, Ph) complexes [(8-R2Pquin)CoBr2] and [(8-R2Pquin)2CoBr][PF6]. P,N phosphinoquinoline based ligands differing by the nature of the phosphorus substituent (iPr, Ph) were employed to synthesize a series of cobalt(II) complexes ([LCoBr2], [L2CoBr](PF6) and [L’2CoBr](PF6)). The complex [(8-Ph2Pquin)2CoBr][PF6] was obtained in high yield and characterized among others by X-ray anal. and elemental anal. Complex [(8-iPr2Pquin)2CoBr][PF6] showed a very good catalytic activity for the hydrosilylation of various ketones. The catalysis proceeds at a low catalytic loading (1 mol %) with only 1 equiv of Ph2SiH2 in mild conditions and was efficient with aliphatic or aromatic ketones giving moderate to excellent yields of the corresponding silylated ether. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 2,6-DiaminopyridineIn 2019 ,《Space-Confined Polymerization: Controlled Fabrication of Nitrogen-Doped Polymer and Carbon Microspheres with Refined Hierarchical Architectures》 appeared in Advanced Materials (Weinheim, Germany). The author of the article were Wang, Tao; Sun, Yan; Zhang, Liangliang; Li, Kaiqian; Yi, Yikun; Song, Shuyan; Li, Mingtao; Qiao, Zhen-An; Dai, Sheng. The article conveys some information:

The construction of refined architectures plays a crucial role in performance improvement and application expansion of advanced materials. The synthesis of carbon microspheres with a refined hierarchical structure is still a problem in synthetic methodol., because it is difficult to achieve the necessary delicate control of the interior structure and outer shell across the microscale to nanoscale. Nitrogen-doped multichamber carbon (MCC) microspheres with a refined hierarchical structure are realized here via a surfactant-directed space-confined polymerization strategy. The MCC precursor is not the traditional phenolic resol but a new kind of 2,6-diaminopyridine-based multichamber polymer (MCP) with a high nitrogen content up to 20%. The morphol. and sizes of MCP microspheres can be easily controlled by a dual-surfactant system. The as-synthesized MCC with a highly microporous shell, a multichamber inner core, and beneficial N-doping can serve as a promising supercapacitor material. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Recommanded Product: 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Recommanded Product: 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C12H12N2In 2020 ,《A paramagnetic oxalato-bridged binuclear copper(II) complex as an effective catalase inhibitor. Spectroscopic and molecular docking studies》 appeared in Journal of Molecular Structure. The author of the article were Shahraki, Somaye; Razmara, Zohreh; Shiri, Fereshteh. The article conveys some information:

A binuclear oxalato-bridged Cu complex formulated as [μ-(ox){Cu(Mebpy) (NO3) (H2O)} 2] (Mebpy is 5,5′-dimethyl-2,2′-dipyridyl and ox is oxalate) was synthesized through an environment-friendly reaction under ultrasound irradiation This complex was selected to study its mol. interactions with bovine liver catalase (BLC) using exptl. and mol. modeling methods. The enzymic activity of BLC decreased to 34.6% when the concentration of the above complex is 9.0 × 10-5 M. The fluorescence results showed that Cu complex could bind with BLC with a relatively strong affinity (Kb = 2.61 and 2.67 × 107 M-1 at 300 and 310 K, resp.). Due to Cu complex interactions, the intrinsic fluorescence of the BLC was quenched by a static quenching mechanism and hydrogen bonds and van der Waals forces were the main active forces in the interaction process. The results of mol. modeling were in good agreement with the exptl. data and showed that there is one binding site for Cu complex on BLC. Also, the in vitro antioxidant activity of the Cu complex was evaluated against 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH.). Cu complex presented moderate antioxidant activity (IC50 = 25 mg L-1) in comparison with ascorbic acid. In addition to this study using 4,4′-Dimethyl-2,2′-bipyridine, there are many other studies that have used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Computed Properties of C12H12N2) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Computed Properties of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem