Day: October 19, 2022

Reference of fac-Tris(2-phenylpyridine)iridiumIn 2019 ,《Photoredox-catalyzed cascade annulation of N-propargylindoles with sulfonyl chlorides: access to 2-sulfonated 9H-pyrrolo[1,2-a]indoles》 appeared in Organic & Biomolecular Chemistry. The author of the article were Zhang, Pengbo; Shi, Shanshan; Gao, Xia; Han, Shuang; Lin, Jinming; Zhao, Yufen. The article conveys some information:

A photoredox-catalyzed cascade radical reaction of N-propargylindoles I (R1 = H, 6-Me, 7-Me, 5-MeO, 6-F, 6-Cl, 5-Cl; R2 = H, CN, CF3, Me, MeO, F, Cl, Br, I; R3 = H, Me) and sulfonyl chlorides ArS(O)2Cl (Ar = 4-methylphenyl, naphthalen-1-yl, thiophen-2-yl, etc.) to 2-sulfonated 9H-pyrrolo[1,2-a]indoles II (R4 = 7-MeO, 7-Cl, 9-Me, etc.) was described. By the direct use of com. available sulfonyl chlorides as radical precursors, this transformation proceeded smoothly to afford the corresponding products in moderate to good yields under external oxidant-free conditions at room temperature In the experimental materials used by the author, we found fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Reference of fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Reference of fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 4-AcetylpyridineIn 2021 ,《Manganese-catalyzed homogeneous hydrogenation of ketones and conjugate reduction of α,β-unsaturated carboxylic acid derivatives: A chemoselective, robust, and phosphine-free in situ-protocol》 was published in Applied Catalysis, A: General. The article was written by Vielhaber, Thomas; Topf, Christoph. The article contains the following contents:

A user-friendly and glove-box-free catalytic protocol for the manganese-catalyzed hydrogenation of ketones RC(O)R1 (R = Ph, 2-chlorophenyl, pyridin-3-yl, etc.; R1 = Me, Et, Ph, etc.; RR1 = -(CH2)5-, -(CH2)4-), 3-methylcyclohexan-1-one, isophorone and 1-indanone and conjugated C=C-bonds of esters and nitriles R2C(R3)=C(R4)R5 (R2 = Ph, 4-bromophenyl, 3-cyanophenyl, etc.; R3 = H, Ph; R4 = methoxycarbonyl, (prop-2-en-1-yloxy)carbonyl, Ph, etc.; R5 = H, ethoxycarbonyl, CN) was communicated. The resp. catalyst is readily assembled in situ from the privileged [Mn(CO)5Br] precursor and cheap 2-picolylamine. The catalytic transformations were performed in the presence of t-BuOK whereby the corresponding hydrogenation products were obtained in good to excellent yields. The described system offers a brisk and atom-efficient access to both secondary alcs. (RCH(OH)R1, cyclohexanol, 3,5,5-trimethylcyclohex-2-en-1-ol and 1-indanol) and saturated esters R2(R3)CHCH(R4)R5 avoiding the use of oxygen-sensitive and expensive phosphine-based ligands. In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Recommanded Product: 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C5H5BrN2In 2018 ,《Ligand-free Iron(II)-Catalyzed N-Alkylation of Hindered Secondary Arylamines with Non-activated Secondary and Primary Alcohols via a Carbocationic Pathway》 was published in Advanced Synthesis & Catalysis. The article was written by Nayal, Onkar S.; Thakur, Maheshwar S.; Kumar, Manoranjan; Kumar, Neeraj; Maurya, Sushil K.. The article contains the following contents:

Secondary benzylic alcs. represent a challenging class of substrates for N-alkylation of amines. Herein, the authors describe an iron(II)-catalyzed eco-friendly protocol for N-alkylation of secondary arylamines with secondary benzyl alcs. through a carbocationic pathway instead of the known borrowing hydrogen transfer (BHT) approach. Transiently generated carbocations, produced from alcs. via self-condensation, were coupled with arylamines to provide highly functionalized amine products. The scope of this methodol. involves N-alkylation of primary, secondary and heterocyclic amines with primary/secondary benzylic, allylic and heterocyclic alcs., which are common key structures in numerous pharmaceuticals drugs. The method can also be easily adopted for the amination of various natural products. In the experimental materials used by the author, we found 6-Bromopyridin-3-amine(cas: 13534-97-9Formula: C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 2,6-DiaminopyridineIn 2021 ,《Toward Robust, Tough, Self-Healable Supramolecular Elastomers for Potential Application in Flexible Substrates》 was published in ACS Applied Materials & Interfaces. The article was written by Fan, Jianfeng; Huang, Jiarong; Gong, Zhou; Cao, Liming; Chen, Yukun. The article contains the following contents:

A robust, tough, and self-healable elastomer is a promising candidate for substrate in flexible electronic devices, but there is often a trade-off between mech. properties (robustness and toughness) and self-healing. Here, a poly(dimethylsiloxane) (PDMS) supramol. elastomer is developed based on metal-coordinated bonds with relatively high activation energy. The strong metal-coordination complexes and their corresponding ionic clusters acting as the crosslinking points strengthen the resultant supramol. networks, which achieves superior mech. robustness (2.81 MPa), and their consecutive dynamic rupture and reconstruction efficiently dissipate strain energy during the stretching process, which leads to an impressive fracture toughness (32 MJ/m3). Addnl., the reversible intermol. interactions (weak hydrogen bonds and strong sacrificial coordination complexes/clusters) can break and re-form upon heating; thus, the elastomer self-heals at a moderate temperature with the highest healing efficiency of 95%. As such, the potential of the as-prepared supramol. elastomer for a substrate material of flexible electronic devices is discovered. The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6Quality Control of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Quality Control of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of fac-Tris(2-phenylpyridine)iridiumIn 2020 ,《Multiscale Simulation of Photoluminescence Quenching in Phosphorescent OLED Materials》 was published in Advanced Theory and Simulations. The article was written by Symalla, Franz; Heidrich, Shahriar; Friederich, Pascal; Strunk, Timo; Neumann, Tobias; Minami, Daiki; Jeong, Daun; Wenzel, Wolfgang. The article contains the following contents:

Bimol. exciton-quenching processes such as triplet-triplet annihilation (TTA) and triplet-polaron quenching play a central role in phosphorescent organic light-emitting diode (PhOLED) device performance and are, therefore, an essential component in computational models. However, the experiments necessary to determine microscopic parameters underlying such processes are complex and the interpretation of their results is not straightforward. Here, a multiscale simulation protocol to treat TTA is presented, in which microscopic parameters are computed with ab initio electronic structure methods. With this protocol, virtual photoluminescence experiments are performed on a prototypical PhOLED emission material consisting of 93 wt% of 4,4′,4″”-tris(N-carbazolyl)triphenylamine and 7 wt% of the green phosphorescent dye fac-tris(2-phenylpyridine)iridium. A phenomenol. TTA quenching rate of 8.5 × 10-12 cm3 s-1, independent of illumination intensity, is obtained. This value is comparable to exptl. results in the low-intensity limit but differs from exptl. rates at higher intensities. This discrepancy is attributed to the difficulties in accounting for fast bimol. quenching during exciton generation in the interpretation of exptl. data. This protocol may aid in the exptl. determination of TTA rates, as well as provide an order-of-magnitude estimate for device models containing materials for which no exptl. data are available. In the experimental materials used by the author, we found fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Safety of fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Safety of fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 29682-15-3In 2016 ,《Structure-activity relationship study of 4-(thiazol-5-yl)benzoic acid derivatives as potent protein kinase CK2 inhibitors》 was published in Bioorganic & Medicinal Chemistry. The article was written by Ohno, Hiroaki; Minamiguchi, Daiki; Nakamura, Shinya; Shu, Keito; Okazaki, Shiho; Honda, Maho; Misu, Ryosuke; Moriwaki, Hirotomo; Nakanishi, Shinsuke; Oishi, Shinya; Kinoshita, Takayoshi; Nakanishi, Isao; Fujii, Nobutaka. The article contains the following contents:

Two classes of modified analogs of 4-(thiazol-5-yl)benzoic acid-type CK2 inhibitors were designed. The azabenzene analogs, pyridine- and pyridazine-carboxylic acid derivatives, showed potent protein kinase CK2 inhibitory activities [IC50 (CK2α) = 0.014-0.017 μM; IC50 (CK2α’) = 0.0046-0.010 μM]. Introduction of a 2-halo- or 2-methoxy-benzyloxy group at the 3-position of the benzoic acid moiety maintained the potent CK2 inhibitory activities [IC50 (CK2α) = 0.014-0.016 μM; IC50 (CK2α’) = 0.0088-0.014 μM] and led to antiproliferative activities [CC50 (A549) = 1.5-3.3 μM] three to six times higher than those of the parent compound In addition to this study using Methyl 5-bromopicolinate, there are many other studies that have used Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: 29682-15-3) was used in this study.

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Recommanded Product: 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Coordination polymers driven by 2,5-dibromoterephthalic acid and chelating co-ligands: Syntheses, structures and luminescent properties》 was written by Zhang, Xinghao; Zhang, Yaowen; Jiao, Shaoshao; Song, Xiuyan; Li, Shaoxiang; Liu, Kang; Wang, Lei. Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridineThis research focused onzinc cobalt dibromoterephthalato bipyridine complex photoelectron crystal structure fluorescence. The article conveys some information:

Four coordination polymers, namely, [Zn(DBT)(4,4′-dmbpy)(H2O)]n (1), [Co(DBT)(2,2′-bpy)(H2O)]n (2), [Zn(DBT)(2,2′-bpy)]n (3), [Zn(DBT)0.5(2,2′-bpy)2·(HDBT-)]n (4) (H2DBT = 2,5-dibromoterephthalic acid, 4,4′-dmbpy = 4,4′-dimethyl-2,2′-bipyridyl and 2,2′-bpy = 2,2′-bipyridyl) were synthesized under solvothermal conditions and characterized by single crystal x-ray diffraction, powder x-ray diffraction, elemental anal., IR and thermogravimetric (TG) anal. These four compounds remained stable until 150°, and the major quality loss (83-90%) occurred between 150 and 700°. In mixed ligands system, the main ligand H2DBT exhibits monodentate or bidentate bridging coordination modes and the auxiliary ligands 4,4′-dmbpy and 2,2′-bpy both possess bidentate chelate coordination modes. An objective of this study was to investigate the pivotal role of chelating ligands in the formation of low dimensional structures. As the bipyridyl ligands occupy the coordination site, compounds 1-3 all display two dimensional structures and 4 shows 1-dimensional chains, of which compounds 1 and 2 are isomorphic. The hydrogen bonds and π-π stacking work together in the formation of 3-dimensional supramol. structure of these four compounds Besides, the authors investigated their photoluminescence properties in the solid state at room temperature 1, 3 And 4 exhibited good fluorescence performance, and their strong emission peaks were located at 447 nm (λex = 285 nm) for 1, 427 nm (λex = 330 nm) for 3, and 412 nm (λex = 310 nm) for 4. The results came from multiple reactions, including the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Lactide polymerization using sterically encumbered, flexible zinc complex》 was written by Dordahan, Fatemeh; Schaper, Frank. Reference of Bis(pyridin-2-ylmethyl)amineThis research focused onzinc complex catalyst preparation lactide polymerization. The article conveys some information:

4-(Tert-Butyl)-2-trityl-6-(di-(2-picolyl)amine)phenol, LH, was prepared from paraformaldehyde, 4-(tert-butyl)-2-tritylphenol, and di-(2-picolyl)amine. Reaction with Zn(N(SiMe3)2)2 gave LZnN(SiMe3)2. The complex was shown by X-ray diffraction study, variable temperature NMR, and DFT calculations to coordinate only one pyridine ligand, which allows for fast and facile complex isomerisation. LZnN(SiMe3)2 was active in rac-lactide polymerization, but in contrast to previous complexes of this type, it did not show any evidence for isotactic monomer enchainment via a catalytic-site mediated chain-end control mechanism. Addition of alc. led to increased activity, but the complex was unstable in the presence of free alc. In the experiment, the researchers used many compounds, for example, Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Reference of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Reference of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Mechanistic study of carboxylic acid and phosphate ester cleavage by oximate metal complexes surpassing the limiting reactivity of highly basic free oximate anions》 was written by Lugo-Gonzalez, Jose Carlos; Gomez-Tagle, Paola; Flores-Alamo, Marcos; Yatsimirsky, Anatoly K.. Name: 2-(Bromomethyl)pyridine hydrobromideThis research focused onzinc cadmium oximate complex preparation crystal structure chem stability; cleavage catalyst zinc cadmium oximate complex. The article conveys some information:

Two tridentate and one tetradentate new ligands containing the terminal oxime group separated from secondary amino and pyridine groups as addnl. binding sites by two or three methylene groups were prepared Their acid-base properties, as well as the composition and stability of their complexes with Zn(II) and Cd(II) ions, were determined by potentiometric and spectrophotometric titrations The x-ray structure of a Cd(II) complex of a related tridentate oxime ligand previously studied in solution was determined All oximate complexes show high reactivity in the cleavage of aryl acetates, paraoxon, parathion and 4-nitrophenyl di-Ph phosphate, with rate constants significantly surpassing the limiting rate constants observed for highly basic free oximate anions. The second-order rate constants for individual oximate complexes in solution are assigned to each ligand, metal cation and substrate. The results of the cleavage of 4-substituted Ph acetates were analyzed in terms of Bronsted correlations with the leaving group pKa, which demonstrated a change in the rate determining step from the nucleophilic attack to the leaving group departure upon an increase in the leaving group basicity. The zero slope of the Bronsted correlation for the nucleophilic attack indicates transition state stabilization through electrophilic assistance by the metal ion. This interpretation is supported by metal selectivity in the relative efficiency of the cleavage of paraoxon and parathion. The existence of the alpha-effect in ester cleavage by coordinated oximates is confirmed by an anal. of the Bronsted correlations with the nucleophile basicity for metal bound oximate and alkoxo or hydroxo nucleophiles. The very high reactivity of the oximate complexes of the new ligands is attributed to transition state stabilization and to the removal of the solvational imbalance of oximate anions that impedes the expected increase in the reactivity of highly basic free anions. In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Name: 2-(Bromomethyl)pyridine hydrobromide) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Name: 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Oxidative ammonolysis of β- and γ-picoline on modified vanadium-titanium oxide catalysts》 was written by Vorobyev, P. B.; Mikhailovskaya, T. P.; Kadirbekov, K. A.; Kurmakyzy, R.. Application of 100-48-1This research focused onvanadium titanium chromium tin iron oxide oxidative ammonolysis catalyst; nicotinonitrile isonicotinonitrile preparation; selectivity vanadium titanium oxide catalyst oxidative ammonolysis picoline. The article conveys some information:

The modifying effect of chromium (III), tin (IV) and iron (III) oxide additives to the binary V-Ti-oxide system in the reaction of oxidative ammonolysis of β- and γ-picolines was investigated. Relation of the studied oxide systems catalytic activity on the calculated values of proton affinity for the vanadyl oxygen of their surface, which is involved in the deprotonation of Me substituents converted to a nitrile group, has been established. The experimental part of the paper was very detailed, including the reaction process of 4-Cyanopyridine(cas: 100-48-1Application of 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Application of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem