Day: October 20, 2022

In 2022,Zhang, Fulin; Zhao, Ruihua; Zhu, Lei; Yu, Yinghua; Liao, Saihu; Wang, Zhi-Xiang; Huang, Xueliang published an article in Cell Reports Physical Science. The title of the article was 《Divergent isoindolinone synthesis through palladium-catalyzed isocyanide bridging C-H activation》.Recommanded Product: 128071-75-0 The author mentioned the following in the article:

An isocyanide-bridging C-H activation through the formation of a five-membered palladacycle was reported. As such, a proximal C-H bond in aldehyde moiety is activated selectively. The subsequent palladium shift and intramol. C=N bond insertion construct a valuable isoindolinone framework. Compared with conventional isocyanide-promoted C-H bond activation, both carbon and nitrogen atoms in isocyanide are engaged in new bond formations. Three types of isoindolinones I [R = t-Bu, cyclohexyl, Bn, etc.; R1 = H, CN; R2 = H, Bn, 2H-1,3-benzodioxol-5-ylmethyl, etc.; R3 = H, F, OMe, etc.; R4 = H, Cl, NH2, etc.; R5 = H, Me, OTs, etc.; -R4R5- = -OCH2O-; -R5R6- = -(CH)4-; R6 = H, OMe, etc.] can be obtained selectively by variations of the reaction conditions. Mechanistic studies shed light on the reaction pathways. The synthetic potential of current methodol. is demonstrated by providing concise routes to key intermediates of indoprofen, indobufen, aristolactams, lennoxamine, and falipamil. The results came from multiple reactions, including the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Seki, Tomotaka; Takeda, Kosuke; Nakayama, Akira published an article in Journal of Physical Chemistry C. The title of the article was 《Ab Initio Molecular Dynamics Simulations for Adsorption Structures of Picolinic Acid at the Water/CeO2 Interface》.Safety of Picolinic acid The author mentioned the following in the article:

An improved understanding of the water/CeO2 interface at the mol. level is critical for developing new applications and materials. In this study, ab initio mol. dynamics (AIMD) simulations were carried out to investigate the adsorption structures of picolinic acid on the CeO2(111) surface in an aqueous environment. Exploration of the adsorption structures of picolinic acid using d. functional theory methods revealed that the N atom of the pyridine ring and the carboxy group are the main adsorption sites. In addition to the monodentate and bidentate adsorption structures, which have been proposed for adsorption structures of carboxylic acids in previous studies, we also found a unique chemisorbed structure in which the C atom of the carboxy group bonds to a surface O atom (C-OS bond). AIMD simulations in an aqueous environment showed that this chemisorbed structure with the C-OS bond spontaneously releases a hydroxide ion from the carboxy group. Exptl. IR spectra also supported this observation. These findings suggest that picolinic acid forms various adsorption structures at the water/CeO2 interface, which could change the reactivity of the CeO2 surface. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Safety of Picolinic acid) was used in this study.

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Safety of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 100-48-1In 2019 ,《New insights on the electronic, magnetic, electric and molecular structure of a bis-(4-cyanopyridine) iron(III) complex with the meso-tetrakis(4-methoxyphenyl)porphyrin》 appeared in Inorganica Chimica Acta. The author of the article were Ben Haj Hassen, Leila; Dhifaoui, Selma; Rousselin, Yoann; Marvaud, Valerie; Stern, Christine; Schulz, Charles E.; Nasri, Habib. The article conveys some information:

The authors have successfully synthesized and characterized a new low-spin iron(III) bis(4-cyanopyridine) complex with a meso-porphyrin substituted in the para positions of the phenyls by the methoxy group, namely the bis(4-cyanopyridine)[meso-tetrakis(4-metoxyphenylporphyrinato)]iron(III) trifluoromethanesulfonate chlorobenzene monosolvate complex with the formula [FeIII(TMPP)(4-CNpy)2]SO3CF3.C6H5Cl(1). This species was characterized through UV-visible, FTIR and Mossbauer spectroscopy as well as by SQUID magnetometry, cyclic voltammetry, and x-ray crystallog. These characterizations indicated that the authors’ synthetic heme model is a low-spin (S = 1/2) coordination compound and especially shows that the structural, electronic and the magnetic properties of complex (1) are closely dominated by the presence of the methoxy σ-donor group at the para positions of the meso-porphyrin. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1SDS of cas: 100-48-1) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.SDS of cas: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 98-98-6In 2019 ,《Half-sandwich iridium(III) complexes with α-picolinic acid frameworks and antitumor applications》 appeared in Journal of Inorganic Biochemistry. The author of the article were Hao, Hailong; Liu, Xicheng; Ge, Xingxing; Zhao, Yao; Tian, Xue; Ren, Ting; Wang, Yan; Zhao, Chengfeng; Liu, Zhe. The article conveys some information:

Eight half-sandwich iridiumIII (IrIII) complexes of the general formula [(η5-Cpxbiph)Ir(ON̂)Cl] (Cpxbiph is tetramethyl(biphenyl)cyclopentadienyl, and the ON̂ is α-picolinic acid chelating ligand and its derivatives) were synthesized and characterized. Compared with cis-platin widely used in clinic, target IrIII complexes showed at most five times more potent antitumor activity against A549 cells by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. IrIII complexes could be transported by serum albumin, bind with DNA, catalyze the oxidation of nicotinamide-adenine dinucleotid (NADH) and induce the production of reactive oxygen species, which confirmed the antitumor mechanism of oxidation IrIII complexes could enter A549 cells followed by an energy-dependent cellular uptake mechanism, meanwhile, target the mitochondria and lysosomes with the Pearson’s colocalization coefficient of 0.33 and 0.74, resp., lead to the lysosomal destruction and the change of mitochondrial membrane potential (ΔΨm), and eventually induce apoptosis. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Related Products of 98-98-6) was used in this study.

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Related Products of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 2-Bromo-5-methylpyridineIn 2020 ,《Synthesis of Decahydrocyclobuta[cd]indene Skeletons: Rhodium(III)-Catalyzed Hydroarylation and Relay Thiophene-Promoted Intramolecular [2+2] Cycloaddition》 appeared in Advanced Synthesis & Catalysis. The author of the article were Gao, Dingding; Wang, Feng; Liu, Xing-Yu; Feng, Kai-Rui; Zhao, Jia-Ying; Wang, Yu-Hui; Yang, Xiao-Di; Tian, Ping; Lin, Guo-Qiang. The article conveys some information:

The preparation of decahydrocyclobuta[cd]indene skeleton was accomplished through rhodium(III)-catalyzed hydroarylation and relay thiophene-promoted intramol. [2+2] cycloaddition This tandem reaction exhibited broad substrate scope (24 examples) and good functional group compatibility. Control experiments revealed the important role of sulfur (S) heteroatom, thus a tentative mechanism with thiophene-promoted double Michael additions was proposed to explain this formal [2+2] cycloaddition Moreover, the resulting polycyclic products displayed potent anti-cancer activities against breast cancer cell lines MDA-MB-468. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Quality Control of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Quality Control of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1692-25-7In 2022 ,《Article on 3-Pyridinylboronic Acid Ameliorates Rotenone-Induced Oxidative Stress Through Nrf2 Target Genes in Zebrafish Embryos》 appeared in Neurochemical Research. The author of the article were Ustundag, Fumet Duygu; Unal, Ismail; Ustundag, Unsal Veli; Cansiz, Derya; Beler, Merih; Karagoz, Atakan; Kara Subasat, Hulya; Alturfan, A. Ata; Mega Tiber, Pinar; Emekli-Alturfan, Ebru. The article conveys some information:

Parkinsons disease (PD) is one of the most common forms of neurodegenerative diseases and research on potential therapeutic agents for PD continues. Rotenone is a neurotoxin that can pass the blood-brain barrier and is used to generate PD models in exptl. animals. Boron is a microelement necessary for neural activity in the brain. Antioxidant, non-cytotoxic, anti-genotoxic, anti-carcinogenic effects of boric acid, the salt compound of boron has been reported before. Boronic acids have been approved for treatment by FDA and are included in drug discovery studies and pyridine boronic acids are a subclass of heterocyclic boronic acids used in drug design and discovery as substituted pyridines based on crystal engineering principles. The aim of our study was to determine the effect of 3-pyridinylboronic acid in rotenone-exposed zebrafish embryos, focusing on oxidant-antioxidant parameters and gene expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2) target genes gclm, gclc, hmox1a, nqo1, and PD related genes, brain-derived neurotrophic factor, dj1, and tnfα. Zebrafish embryos were exposed to Rotenone (10μg/l); Low Dose 3-Pyridinylboronic acid (100μM); High Dose 3-Pyridinylboronic acid (200μM); Rotenone + Low Dose-3-Pyridinylboronic acid (10μg/l + 100μM); Rotenone + High Dose-3-Pyridinylboronic acid (10μg/l + 200μM) in well plates for 96 h post-fertilization (hpf). Our study showed for the first time that 3-pyridinylboronic acid, as a novel sub-class of the heterocyclic boronic acid compound, improved locomotor activities, ameliorated oxidant-antioxidant status by decreasing LPO and NO levels, and normalized the expressions of bdnf, dj1, tnf and Nrf2 target genes hmox1a and nqo1 in rotenone exposed zebrafish embryos. On the other hand, it caused the deterioration of the oxidant-antioxidant balance in the control group through increased lipid peroxidation, nitric oxide levels, and decreased antioxidant enzymes. We believe that these results should be interpreted in the context of the dose-toxicity and benefit-harm relationship of the effects of 3-pyridinylboronic. In the experiment, the researchers used many compounds, for example, Pyridin-3-ylboronic acid(cas: 1692-25-7Related Products of 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Related Products of 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 4-CyanopyridineIn 2022 ,《Electrochemical Ammonium Cation-Assisted Hydropyridylation of Ketone-Activated Alkenes: Experimental and Computational Mechanistic Studies》 appeared in Advanced Synthesis & Catalysis. The author of the article were Yang, Jianjing; Ma, Jing; Yan, Kelu; Tian, Laijin; Li, Bingwen; Wen, Jiangwei. The article conveys some information:

This work described an electrochem. ammonium cation enabled hydropyridylation of ketone-activated alkenes under metal- and exogenous reductant free conditions giving access to β-pyridyl ketones, through dual proton-coupled electron transfer and radical cross-coupling. It featured a broad substrate scope and allows a gram-scale synthesis. Ammonium chloride played various roles in this transformation such as the hydrogen donor, the protonation reagent and electrolyte. In particular, various experiments and d. functional theory (DFT) calculation results showed the mechanism of dual proton-coupled electron transfer followed by radical cross-coupling was the preferred pathway.4-Cyanopyridine(cas: 100-48-1Reference of 4-Cyanopyridine) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Reference of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2022 ,《Ruthenium-Catalyzed Dehydrogenative Functionalization of Alcohols to Pyrroles: A Comparison between Metal-Ligand Cooperative and Non-cooperative Approaches》 appeared in Journal of Organic Chemistry. The author of the article were Guin, Amit Kumar; Mondal, Rakesh; Chakraborty, Gargi; Pal, Subhasree; Paul, Nanda D.. The article conveys some information:

Herein, authors report the synthesis and characterization of two ruthenium-based pincer-type catalysts, I (X = Cl, PF6) and II (R = H, Cl), containing two different tridentate pincer ligands, 2-pyrazolyl-(1,10-phenanthroline) and 2-(phenyldiazenyl)-1,10-phenanthroline; 2-((4-chlorophenyl)diazenyl)-1,10-phenanthroline), and their application in the synthesis of substituted pyrroles via dehydrogenative alc. functionalization reactions. In catalyst I (X = Cl, PF6), the tridentate scaffold 2-pyrazolyl-(1,10-phenanthroline) is apparently redox innocent, and all the redox events occur at the metal center, and the coordinated ligands remain as spectators. In contrast, in catalysts II (R = H, Cl), the coordinated azo-aromatic scaffolds are highly redox-active and known to participate actively during the dehydrogenation of alcs. A comparison between the catalytic activities of these two catalysts was made, starting from the simple dehydrogenation of alcs. to further dehydrogenative functionalization of alcs. to various substituted pyrroles to understand the advantages/disadvantages of the metal-ligand cooperative approach. Various substituted pyrroles were prepared via dehydrogenative coupling of secondary alcs. and amino alcs., and the N-substituted pyrroles were synthesized via dehydrogenative coupling of aromatic amines with cis-2-butene-1,4-diol and 2-butyne-1,4-diol, resp. The experimental process involved the reaction of 2,6-Diaminopyridine(cas: 141-86-6Category: pyridine-derivatives)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C33H24IrN3In 2019 ,《Merging Visible-Light Photoredox and Organoamine Catalysis for the C-3 Difluoroalkylation of Quinoxalin-2(1H)-Ones》 appeared in Asian Journal of Organic Chemistry. The author of the article were Jin, Can; Zhuang, Xiaohui; Sun, Bin; Li, Deyu; Zhu, Rui. The article conveys some information:

A mild and efficient protocol for visible-light and organoamine cocatalyzed difluoroalkylation of quinoxalin-2(1H)-ones with functionalized difluoromethyl bromides was developed. The transformation was carried out at room temperature and gave a variety of C-3 difluoroalkylated quinoxaline-2(1H)-ones in moderate to excellent yields. Moreover, mechanistic studies revealed that this transformation proceeded through a radical-type debrominative coupling process with only need of catalytic amount of diisopropylethylamine (DIPEA). This strategy featured wide functional group tolerance, excellent regioselectivity, mild conditions and operational simplicity. In the experiment, the researchers used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Formula: C33H24IrN3)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Formula: C33H24IrN3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2,5-DibromopyridineIn 2021 ,《Embedding red emitters in the NbO-type metal-organic frameworks for highly sensitive luminescence thermometry over tunable temperature range》 appeared in ACS Applied Materials & Interfaces. The author of the article were Wang, Shuo; Gong, Mengyao; Han, Xue; Zhao, Dian; Liu, Jingwen; Lu, Yantong; Li, Chunxia; Chen, Banglin. The article conveys some information:

The intrinsic advantages of metal-organic frameworks (MOFs), including extraordinarily high porosities, tailorable architectures, and diverse functional sites, make the MOFs platforms for multifunctional materials. In this study, we synthesized two kinds of isostructural NbO-type Zn2+-based MOFs, where two structurally similar tetracarboxylate ligands, 5,5′-(pyrazine-2,5-diyl)diisophthalic acid (H4PZDDI) and 5,5′-(pyridine-2,5-diyl)diisophthalic acid (H4PDDI), with pyridine or pyrazine moieties, were employed as the organic linkers. By embedding the red-emitting cationic units of pyridinium hemicyanine dye 4-[p-(dimethylamino)styryl]-1-methylpyridinium (DSM) and trivalent europium ion (Eu3+), two types of composites, DSM@ZnPZDDI and DSM@ZJU-56 and Eu3+@ZnPZDDI and Eu3+@ZJU-56, were harvested and evaluated for use as potential ratiometric temperature probes. The temperature-responsive luminescence of these dual-emitting composites was investigated, and their representative features of relative sensitivity, temperature resolution, spectral repeatability, and luminescence color change were discussed. Importantly, compared with the DSM-incorporated composites, Eu3+@ZnPZDDI and Eu3+@ZJU-56 show a much wider sensing temperature range and higher relative sensitivities, suggesting the performance of the composites can be engineered by elaborately combining the host and guest units. Given the rich choices of porous MOFs and emitting units, such a strategy can be useful in the design and preparation of multifunctional dual-emitting sensory materials. In the experimental materials used by the author, we found 2,5-Dibromopyridine(cas: 624-28-2Application In Synthesis of 2,5-Dibromopyridine)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Application In Synthesis of 2,5-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem