Conde, Nerea’s team published research in Advanced Synthesis & Catalysis in 2016 | 53636-56-9

Advanced Synthesis & Catalysis published new progress about Carboxylic acids, alkynyl Role: RCT (Reactant), RACT (Reactant or Reagent). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Product Details of C7H6BrNO2.

Conde, Nerea; SanMartin, Raul; Herrero, Maria Teresa; Dominguez, Esther published the artcile< Palladium NNC Pincer Complex as an Efficient Catalyst for the Cycloisomerization of Alkynoic Acids>, Product Details of C7H6BrNO2, the main research area is alkynoic acid cycloisomerization palladium NNC pincer complex catalyst.

A two-step (nucleophilic substitution/palladation by oxidative addition) sequence provides a high-yielding access to a non-sym. palladium NNC pincer complex. A number of terminal and internal alkynoic acids with different substitution patterns at the α- and β-positions are regio- and diastereoselectively cycloisomerized to the corresponding exocyclic enol lactones in the presence of exceedingly low amounts of the latter palladium complex, so that unprecedented turnover numbers and frequencies ranging from 1000,000 to 700,000 and from 41,667 to 9722 h-1, resp., are achieved. The optimized protocol, based on the use of a catalytic amount of triethylamine as base, allows an easy real-time monitoring of the reaction by NMR spectroscopy. Several pieces of evidence in favor of the direct participation of the above pincer complex as the catalyst of the reaction were gathered from kinetic and poisoning experiments

Advanced Synthesis & Catalysis published new progress about Carboxylic acids, alkynyl Role: RCT (Reactant), RACT (Reactant or Reagent). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Product Details of C7H6BrNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xie, Caixia’s team published research in Journal of Organic Chemistry in 2017-04-07 | 21901-29-1

Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Recommanded Product: 2-Amino-3-nitro-6-picoline.

Xie, Caixia; Zhang, Zeyuan; Li, Danyang; Gong, Jian; Han, Xushuang; Liu, Xuan; Ma, Chen published the artcile< Dimethyl Sulfoxide Involved One-Pot Synthesis of Quinoxaline Derivatives>, Recommanded Product: 2-Amino-3-nitro-6-picoline, the main research area is nitrogen heterocycle fused quinoxaline green synthesis DMSO solvent reactant; pyrroloquinoxaline; indoloquinoxaline; pyrroloquinoline; benzimidazoquinazoline synthesis.

An efficient, green, and novel method for the synthesis of N-heterocycle-fused quinoxalines is reported herein. DMSO was used as both a reactant and a solvent in this reaction. A wide range of products in moderate to excellent yields were obtained, including pyrrolo[1,2-a]quinoxalines, indolo[1,2-a]quinoxalines, 1H-pyrrolo[3,2-c]quinolines, and benzo[4,5]imidazo[1,2-c]quinazolines.

Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Recommanded Product: 2-Amino-3-nitro-6-picoline.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Dan-Yang’s team published research in Advanced Science (Weinheim, Germany) in 2020 | 2127-03-9

Advanced Science (Weinheim, Germany) published new progress about Aqueous solutions, electrolyzed water. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, SDS of cas: 2127-03-9.

Wang, Dan-Yang; Si, Yubing; Guo, Wei; Fu, Yongzhu published the artcile< Long Cycle Life Organic Polysulfide Catholyte for Rechargeable Lithium Batteries>, SDS of cas: 2127-03-9, the main research area is rechargeable lithium battery organic polysulfide catholyte; dipyridyl polysulfide; lithium batteries; molecular dynamic simulations; organosulfide; ultra performance liquid chromatographyquadrupole time‐of‐flight‐mass spectrometry (UPLC‐QTof‐MS).

Herein, a spectrum of dipyridyl polysulfides (Py2Sx, 3 ≤ x ≤ 8) is prepared in electrolyte by a one-pot synthesis method from dipyridyl disulfide (Py2S2) and elemental sulfur. It renders up to seven dipyridyl polysulfides (i.e., Py2S3, Py2S4, Py2S5, Py2S6, Py2S7, and Py2S8) which show fully reversible electrochem. behavior in lithium batteries. In the discharge, the initial lithiation occurs at 2.45 V leading to the breakage of Sα-Sβ bonds in Py2Sx and formation of lithium 2-pyridinethiolate, in which lithium is coordinated in between N and S atoms. The left sulfur species act as elemental sulfur, showing two voltage plateaus at 2.3 and 2.1 V. The mol. dynamics simulations show the attraction between pyridyl groups and lithium polysulfides/sulfide via N···Li···S bonds, which enable good retention of soluble discharge products within electrodes and stable cycling performance. In the recharge, low-order Py2Sx (e.g., Py2S3, Py2S4, and Py2S5) remain as the charged products. The mixture catholyte exhibits superlong cycle life at 1C rate with 1200 cycles and 70.5% capacity retention.

Advanced Science (Weinheim, Germany) published new progress about Aqueous solutions, electrolyzed water. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, SDS of cas: 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ghosh, Kajari’s team published research in Green Chemistry in 2015 | 832735-54-3

Green Chemistry published new progress about Alkoxycarbonylation. 832735-54-3 belongs to class pyridine-derivatives, and the molecular formula is C18H22BNO3, Category: pyridine-derivatives.

Ghosh, Kajari; Molla, Rostam Ali; Iqubal, Asif Md.; Islam, S. M. published the artcile< A mesoporous organosilica grafted Pd catalyst (MOG-Pd) for efficient base free and phosphine free synthesis of tertiary butyl esters via tertiary-butoxycarbonylation of boronic acid derivatives without using carbon monoxide>, Category: pyridine-derivatives, the main research area is silica palladium preparation alkoxycarbonylation catalyst green chem.

A mesoporous organosilica grafted palladium(II) catalyst was synthesized and characterized using various spectroscopic techniques. Its catalytic activity was evaluated for the synthesis of tert-Bu esters by tert-butoxycarbonylation of boronic acid derivatives The tert-Bu esters were obtained directly from boronic acid pinacol esters and di-tert-Bu dicarbonate. The reaction was optimized by varying the bases, temperatures and solvents (green chem. method). The catalyst was very stable and could be facilely recovered and reused six times with no significant decrease in its activity and selectivity. The synthesis of the target compounds was achieved using mesoporous-silica-supported furanmethanimine-palladium diacetate (i.e., Schiff-base-imine-palladium complex) as a catalyst. The starting materials included dicarbonic acid 1,3-bis(1,1-dimethylethyl) ester and 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine derivatives, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarbonitrile (nitrile), 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarboxylic acid ester (pyridine), 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline, 4,4,5,5-tetramethyl-2-(2-methylphenyl)-1,3,2-dioxaborolane derivatives, 4,4,5,5-tetramethyl-2-(2-thienyl)-1,3,2-dioxaborolane (thiophene derivative). The title compounds thus formed included 2-pyridinecarboxylic acid 1,1-dimethylethyl ester, 3-pyridinecarboxylic acid 1,1-dimethylethyl ester, 4-pyridinecarboxylic acid 1,1-dimethylethyl ester, 3,5-pyridinedicarboxylic acid 3-(1,1-dimethylethyl) 5-Et ester, 4-quinolinecarboxylic acid 1,1-dimethylethyl ester, benzoic acid 1,1-dimethylethyl ester derivatives

Green Chemistry published new progress about Alkoxycarbonylation. 832735-54-3 belongs to class pyridine-derivatives, and the molecular formula is C18H22BNO3, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tang, Yinghong’s team published research in Analyst (Cambridge, United Kingdom) in 2021 | 366-18-7

Analyst (Cambridge, United Kingdom) published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Synthetic Route of 366-18-7.

Tang, Yinghong; Zhai, Jingying; Chen, Qinghan; Xie, Xiaojiang published the artcile< Ruthenium bipyridine complexes as electrochemiluminescent transducers for ionophore-based ion-selective detection>, Synthetic Route of 366-18-7, the main research area is .

We report here a method to determine target ion concentrations (with Na+ as a model) based on ionophores and electrochemiluminescence (ECL). Ruthenium bipyridine complexes were released from thin polymeric films (plasticized poly(vinyl chloride) also containing a sodium ionophore) into the sample solution following an explicit ion-exchange process (between Na+ and the ruthenium complex). Two signal transducers, tris(2,2′-(pCF3)bipyridine)ruthenium(II) (Ru(p-CF3-bpy)32+) and tris(2,2′-bipyridyl)dichlororuthenium(II) (Ru(bpy)32+), were examined using the sensing film, with the latter providing a more sensitive detection range (ca. 1 to 100 μM) than that of the more hydrophobic one (0.01 to 1 mM). While the ionophore (Na+ ionophore X) offered excellent selectivity to the method, the ruthenium complexes made the measurements independent of the sample pH. Furthermore for complex biol. samples such as blood serum, an indirect approach of measuring the ECL of the remaining ruthenium complexes helps avoid background matrix interference to the ECL production at the working electrode, making the ECL method more attractive for real complex samples.

Analyst (Cambridge, United Kingdom) published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Synthetic Route of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Esch, Patrick’s team published research in Analyst (Cambridge, United Kingdom) in 2020 | 350-03-8

Analyst (Cambridge, United Kingdom) published new progress about C-C bond, double. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, HPLC of Formula: 350-03-8.

Esch, Patrick; Heiles, Sven published the artcile< Investigating C-C positions and hydroxylation sites in lipids using Paterno-Buechi functionalization mass spectrometry>, HPLC of Formula: 350-03-8, the main research area is double carbon bond lipid oxidation Paterno Buechi functionalization MS; Sacha inchi oil triglyceride oxidation Paterno Buechi functionalization MS.

Lipid oxidation plays a major role in biochem. processes and nutrition. Structural changes during oxidation can lead to alterations of lipid functions. Rancidification and production of secondary lipid messengers are well-known examples for the impact of oxidation on lipid function. Especially lipids with a high degree of unsaturation are prone to oxidize. In order to investigate structural changes of lipids upon oxidation, we here introduce a photochem. Paterno-Buechi functionalization workflow and subsequent mass spectrometric anal. for anal. of unsaturated, oxidized lipids. Results for hydroxylated fatty acids and triglycerides containing isolated and conjugated C-C bonds will be presented making use of 3-acetylpyridine as a photochem. active compound Photochem. derivatization is performed in nano-electrospray emitter tips in 30 s resulting in the formation of oxetanes without inducing light-triggered oxidation of analytes. Collisional-activation of photoproducts facilitates selective cleavage of oxetane moieties. Resulting fragment ions not only allow the determination of C-C bond locations for isolated and conjugated C-C bonds but also restrict the site of oxidation By registering the mass shift in some fragment ions of +15.99 Da due to hydroxylation, the oxidized sections of lipids can be identified. In order to demonstrate its anal. robustness, the method is applied to determine the structural impact of non-selective ambient oxidation on fatty acids, triglycerides and complex triglyceride mixtures obtained from Sacha inchi oil.

Analyst (Cambridge, United Kingdom) published new progress about C-C bond, double. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, HPLC of Formula: 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stauffer, Kenneth J’s team published research in Journal of Medicinal Chemistry in 2005-04-07 | 53636-56-9

Journal of Medicinal Chemistry published new progress about Anticoagulants. 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Category: pyridine-derivatives.

Stauffer, Kenneth J.; Williams, Peter D.; Selnick, Harold G.; Nantermet, Philippe G.; Newton, Christina L.; Homnick, Carl F.; Zrada, Matthew M.; Lewis, S. Dale; Lucas, Bobby J.; Krueger, Julie A.; Pietrak, Beth L.; Lyle, Elizabeth A.; Singh, Rominder; Miller-Stein, Cynthia; White, Rebecca B.; Wong, Bradley; Wallace, Audrey A.; Sitko, Gary R.; Cook, Jacquelyn J.; Holahan, Marie A.; Stranieri-Michener, Maria; Leonard, Yvonne M.; Lynch, Joseph J. Jr.; McMasters, Daniel R.; Yan, Youwei published the artcile< 9-Hydroxyazafluorenes and Their Use in Thrombin Inhibitors>, Category: pyridine-derivatives, the main research area is hydroxyazafluorene derivative preparation thrombin inhibitor anticoagulant thrombosis crystal structure.

Optimization of a previously reported thrombin inhibitor, 9-hydroxy-9-fluorenylcarbonyl-L-prolyl-trans-4-aminocyclohexylmethylamide (1), by replacing the aminocyclohexyl P1 group provided a new lead structure, 9-hydroxy-9-fluorenylcarbonyl-L-prolyl-2-aminomethyl-5-chlorobenzylamide (2), with improved potency (Ki = 0.49 nM for human thrombin, 2× APTT = 0.37 μM in human plasma) and pharmacokinetic properties (F = 39%, iv T1/2 = 13 h in dogs). An effective strategy for reducing plasma protein binding of 2 and improving efficacy in an in vivo thrombosis model in rats was to replace the lipophilic fluorenyl group in P3 with an azafluorenyl group. Systematic investigation of all possible azafluorenyl P3 isomers and azafluorenyl-N-oxide analogs of 2 led to the identification of an optimal compound, 3-aza-9-hydroxyfluoren-9(R)-ylcarbonyl-L-prolyl-2-aminomethyl-5-chlorobenzylamide (I), with high potency (Ki = 0.40 nM, 2× APTT = 0.18 μM), excellent pharmacokinetic properties (F = 55%, T1/2 = 14 h in dogs), and complete efficacy in the in vivo thrombosis model in rats (inhibition of FeCl3-induced vessel occlusions in six of six rats receiving an i.v. infusion of 10 μg/kg/min of I). The stereochem. of the azafluorenyl group in I was determined by x-ray crystallog. anal. of its N-oxide derivative bound in the active site of human thrombin.

Journal of Medicinal Chemistry published new progress about Anticoagulants. 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Schmid, Lucius’s team published research in Journal of the American Chemical Society in 2022-01-19 | 396092-82-3

Journal of the American Chemical Society published new progress about [2+2] Cycloaddition reaction. 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Quality Control of 396092-82-3.

Schmid, Lucius; Glaser, Felix; Schaer, Raoul; Wenger, Oliver S. published the artcile< High Triplet Energy Iridium(III) Isocyanoborato Complex for Photochemical Upconversion, Photoredox and Energy Transfer Catalysis>, Quality Control of 396092-82-3, the main research area is photochem upconversion photoredox energy transfer catalysis; High Triplet Energy Iridium Isocyanoborato Complex.

Cyclometalated Ir(III) complexes are often chosen as catalysts for challenging photoredox and triplet-triplet-energy-transfer (TTET) catalyzed reactions, and they are of interest for upconversion into the UV spectral range. However, the triplet energies of commonly employed Ir(III) photosensitizers are typically limited to values around 2.5-2.75 eV. Here, we report on a new Ir(III) luminophore, with an unusually high triplet energy near 3.0 eV owing to the modification of a previously reported Ir(III) complex with isocyanoborato ligands. Compared to a nonborylated cyanido precursor complex, the introduction of B(C6F5)3 units in the second coordination sphere results in substantially improved photophys. properties, in particular a high luminescence quantum yield (0.87) and a long excited-state lifetime (13.0 μs), in addition to the high triplet energy. These favorable properties (including good long-term photostability) facilitate exceptionally challenging organic triplet photoreactions and (sensitized) triplet-triplet annihilation upconversion to a fluorescent singlet excited state beyond 4 eV, unusually deep in the UV region. The new Ir(III) complex photocatalyzes a sigmatropic shift and [2 + 2] cycloaddition reactions that are unattainable with common transition metal-based photosensitizers. In the presence of a sacrificial electron donor, it furthermore is applicable to demanding photoreductions, including dehalogenations, detosylations, and the degradation of a lignin model substrate. Our study demonstrates how rational ligand design of transition-metal complexes (including underexplored second coordination sphere effects) can be used to enhance their photophys. properties and thereby broaden their application potential in solar energy conversion and synthetic photochem.

Journal of the American Chemical Society published new progress about [2+2] Cycloaddition reaction. 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Quality Control of 396092-82-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Tian-Hua’s team published research in Journal of Solid State Chemistry in 2021-06-30 | 350-03-8

Journal of Solid State Chemistry published new progress about Crystal structure. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.

Zhang, Tian-Hua; Bai, Chao; Hu, Huai-Ming; Zhang, Jun-Lin; Li, Xuan-Yue; Wang, Xiaofang; Wang, Bo-Zhou published the artcile< Cadmium(II) and cobalt(II) coordination compounds based on a benzenesulfonic terpyridine ligand: Syntheses, structures, luminescent sensing and magnetic properties>, Recommanded Product: 1-(Pyridin-3-yl)ethanone, the main research area is cadmium cobalt terpyridinylbenzenesulfonate complex preparation luminescent probe; magnetic susceptibility cadmium cobalt terpyridinylbenzenesulfonate complex; crystal structure cadmium cobalt terpyridinylbenzenesulfonate complex.

Five coordination compounds based on a new ligand with terpyridyl and benzenesulfonyl groups, [Cd(STP)2]n (1), [Cd(STP)Cl(H2O)]n·2nH2O (2), [Cd(STP)Br(H2O)]n·2nH2O (3), [Co(STP)2]n (4), [Co(STP)2(H2O)4]·H2O (5) (HSTP = 2-(3,2′:6′,3”-terpyridin-4′-yl)benzenesulfonic acid) were synthesized and characterized by FT-IR, elemental anal., and single crystal X-ray diffraction. Compounds 1 and 4 exhibit a (3,6)-connected 2D layer structure with 3,6L40 topol. network and point symbol of {3·62}{66·96·123}. Compounds 2 and 3 display a 3D topol. network with fsc-3 network and point symbol of {4·6·8}{4·62·83}. Compound 5 shows a discrete mononuclear structure. The structural diversity of compounds 1-5 indicates that counter anions, pH values and coordination modes of STP- anions are significant influence on the final structures. Investigation of luminescent property indicates that compound 3 can be used as a recycled probe with high sensitivity and selectivity to detect acetone and Cr2O72- anion. The KSV of compound 3 for acetone and Cr2O72- anion are 1.295 x 104 M-1 and 5.79 x 102 M-1, resp. The PXRD and UV-Vis spectra indicates that the quenching mechanism of compound 3 toward Cr2O72- anion can be attributed to light competitive absorption. Addnl., magnetic property of compounds 4 and 5 was investigated. The difference of magnetic interactions between compounds 4 and 5 may be caused by different coordination fields.

Journal of Solid State Chemistry published new progress about Crystal structure. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tjosaas, Freddy’s team published research in Molecules in 2006-03-31 | 876919-08-3

Molecules published new progress about 876919-08-3. 876919-08-3 belongs to class pyridine-derivatives, and the molecular formula is C7H6FNO2, Product Details of C7H6FNO2.

Tjosaas, Freddy; Fiksdahl, Anne published the artcile< A simple synthetic route to methyl 3-fluoropyridine-4-carboxylate by nucleophilic aromatic substitution>, Product Details of C7H6FNO2, the main research area is fluoride nucleophilic aromatic substitution nitro group nitropyridinecarboxylate.

The nitro group of Me 3-nitropyridine-4-carboxylate has successfully been replaced by a fluoride anion via nucleophilic aromatic substitution to give the 3-fluoropyridine-4-carboxylate.

Molecules published new progress about 876919-08-3. 876919-08-3 belongs to class pyridine-derivatives, and the molecular formula is C7H6FNO2, Product Details of C7H6FNO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem