Day: October 20, 2022

Lan, Chunling Blue; Auclair, Karine published the artcile< Ammonium Chloride-Promoted Rapid Synthesis of Monosubstituted Ureas under Microwave Irradiation>, COA of Formula: C6H8N2, the main research area is amine potassium cyanate ammonium chloride microwave irradiation green chem; urea preparation.

Ammonium chloride promoted the reaction between amines and potassium cyanate to generate monosubstituted ureas in water. This method proceeded rapidly under microwave irradiation and tolerates a broad range of functional groups. Unlike previous strategies, it was compatible with other nucleophiles, acid-labile moieties and most of the common protecting groups. The products precipitate out of solution, allowing facile isolation without column chromatog.

European Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, COA of Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Man; Luo, Yan; Zeng, Weijia; Yang, Xiaoqing; Chen, Tingting; Zhang, Lulu; He, Xiaoyan; Yi, Xiuguang; Li, Yongxiu; Yi, Xiaoqing published the artcile< A co-delivery system based on a dimeric prodrug and star-shaped polymeric prodrug micelles for drug delivery>, Application of C10H8N2S2, the main research area is paclitaxel reduced glutathione dimeric polymeric prodrug delivery system; dimeric prodrug; drug delivery; high drug loading; polymeric prodrug micelles; reduction-sensitive.

Chemotherapy is one of the commonly used therapies for the treatment of malignant tumors. Insufficient drug-loading capacity is the major challenge for polymeric micelle-based drug delivery systems of chemotherapy. Here, the redox-responsive star-shaped polymeric prodrug (PSSP) and the dimeric prodrug of paclitaxel (PTX) were prepared Then the dimeric prodrug of PTX (diPTX, diP) was loaded into the core of the star-shaped polymeric prodrug micelles of PSSP by hydrophobic interaction forming the redox-responsive prodrug micelles of diPTX@PSSP for intracellular drug release in tumor cells. The hydrodynamic diameter of diPTX@PSSP nanoparticles was 114.3 nm ± 2.1 (PDI = 0.219 ± 0.016), and the micelles had long-term colloidal stability and the drugloading content (DLC) of diPTX and PTX is 16.7 and 46.9%, resp. The prepared micelles could broke under the reductive microenvironment within tumor cells, as a result, the dimeric prodrug of diP and polymeric prodrug micelles of PSSP were rapidly disassembled, leading to the rapid release of intracellular drugs. In vitro release studies showed that under the condition of reduced glutathione (GSH) (10 mM), the release of PTX was significantly accelerated with approx. 86.6% released within 21 h, and the released PTX in cytoplasm could promote the disintegration of microtubules and induce cell apoptosis. These results indicated that the new type of this reduction-sensitive nanodrug delivery system based on dimeric prodrug@polymeric prodrug micelles would be a promising technol. in chemotherapy.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Cytotoxicity. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application of C10H8N2S2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nagieva, I. T.; Ali-zadeh, N. I.; Nagiev, T. M. published the artcile< Coherent synchronization of pyridine dimerization reactions and decomposition of ""green oxidants""- H2O2 and N2O>, Synthetic Route of 366-18-7, the main research area is pyridine dimer preparation.

The reaction of pyridine oxidation by hydrogen peroxide and nitrous oxide under homogeneous conditions, in the gas phase, without the use of catalysts, at atm. pressure, was exptl. investigated. Areas of selective oxidation of pyridine with hydrogen peroxide and nitrous oxide were established, and optimal conditions were found for obtaining valuable raw materials required in the petrochem., chem., and pharmaceutical industries.

Azerbaidzhanskii Khimicheskii Zhurnal published new progress about Dimerization. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Synthetic Route of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fizer, Oksana; Fizer, Maksym; Sidey, Vasyl; Studenyak, Yaroslav published the artcile< Predicting the end point potential break values: A case of potentiometric titration of lipophilic anions with cetylpyridinium chloride>, Category: pyridine-derivatives, the main research area is Predicting end point potential break values potentiometric titration.

The applicability of cetylpyridinium chloride for potentiometric titration of lipophilic anions has been studied. The specially developed cetylpyridinium-selective plasticized electrode has been used for the investigation of the mechanism of interaction between the cetylpyridinium cation and lipophilic anions, which obviously goes through the association reaction resulting in the formation of water-insoluble precipitates The investigated 54 anions were placed in the selectivity row that strongly correlates with lipophilicity. Addnl., an attempt has been made to find a simple and reliable descriptor suitable for prediction of the value of the end point potential break and thus indicating the applicability of the described potentiometric method for determination of untested lipophilic anions of interest. It has been established that despite being well known lipophilicity estimators, molar weight, octanol-water distribution coefficient logP, logarithm of solubility logS, and hydrophilicity-lipophilicity index can not be sep. used for directly predicting the end point potential break values. However, simultaneous anal. of the above descriptors by using the multiple linear regression technique has resulted in the development of a reasonable QSPR model for the estimation of the potential break values near the end point.

Microchemical Journal published new progress about Chemical potential. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lai, Long-Li; Lin, Pen-Yuan; Wang, Jy-Shih; Hwu, Jih Ru; Shiao, Min-Jen; Tsay, Shwu-Chen published the artcile< Substituent effect on the chlorination of 2-alkoxypyridines to give 2-chloropyridines under Vilsmeier-Haack conditions>, Synthetic Route of 13472-84-9, the main research area is substituent effect chlorination alkoxypyridine.

Various substituted 2-alkoxypyridines were converted into the corresponding 2-chloropyridines in 28-91% yield by use of POCl3 and DMF. Me, halogen, ester and nitro groups displayed an activating effect and an amino group exhibited a deactivating effect.

Journal of Chemical Research, Synopses published new progress about Chlorination. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Synthetic Route of 13472-84-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Singh, Anuradha; Teegardin, Kip; Kelly, Megan; Prasad, Kariate S.; Krishnan, Sadagopan; Weaver, Jimmie D. published the artcile< Facile synthesis and complete characterization of homoleptic and heteroleptic cyclometalated Iridium(III) complexes for photocatalysis>, Application of C33H21F3IrN3, the main research area is iridium complex photocatalyst synthesis.

This study describes an improved synthesis for homoleptic iridium(III) 2-phenylpyridine based photocatalysts that allows rapid access to these compounds in good to high yields which have recently become a vital component within the field of catalysis. A number of heteroleptic iridium(III) 2-phenylpyridine photocatalysts are synthesized and studied for their photophys. and electrochem. properties. The emission energies span the range of 473-560 nm and reduction potentials from -2.27 V to -1.23 V and oxidation potentials ranging from 1.81 V to 0.69 V. This study provides the calculated excited state properties and comment on the role of these properties in designing catalytic cycles.

Journal of Organometallic Chemistry published new progress about Photocatalysis. 370878-69-6 belongs to class pyridine-derivatives, and the molecular formula is C33H21F3IrN3, Application of C33H21F3IrN3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dolui, Dependu; Mir, Ab Qayoom; Dutta, Arnab published the artcile< Probing the peripheral role of amines in photo- and electrocatalytic H2 production by molecular cobalt complexes>, Formula: C6H8N2, the main research area is peripheral amine photo electrocatalysis hydrogen evolution cobalt complex catalyst.

The incorporation of amine functionality in the periphery of a synthetic cobaloxime core induces excellent photo-(TON 180) and electrocatalytic H2 production (TOF 4330 s-1) in aqueous solution The primary amine group displays a superior influence on the catalysis compared to a secondary amine group with an analogous cobaloxime template.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amino group. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Segawa, Yasutomo; Levine, David R.; Itami, Kenichiro published the artcile< Topologically Unique Molecular Nanocarbons>, Electric Literature of 366-18-7, the main research area is topol mol nanocarbon organic mol.

As new forms of carbon are unearthed, they invariably transform the scientific landscape. Numerous researchers have been inspired to discover the unique characteristics of these fascinating materials, consistently leading to the development of important technol. innovations in materials science. Recently, studies on the preparation of mol. nanocarbons (small mol. analogs of larger carbon nanostructures) by precision organic synthesis have attracted much attention. Cycloparaphenylene (CPP), the substructure of carbon nanotubes (CNTs), is the oldest of such organic mols., and since 2008 the successful synthesis of CPP dramatically advanced the synthetic chem. of mol. nanocarbons. In fact, as pioneering research, we succeeded in producing carbon nanotubes using seed CPP mols. in 2013. This method represented an important landmark in the quest for controlling the diameter of CNTs via utilization of a well-defined small mol. as a template. Other avenues of research on graphene nanoribbons and partial structures of fullerenes such as corannulene and sumanene are also highly active at the current time. On the other hand, carbon forms with nontrivial topologies, i.e., topol. nanocarbons, are virtually unexplored. In addition to the 3D network structures represented by the Mackay crystal, many topol. complex structures have been envisioned. To date, there is no rational approach toward the bottom-up synthesis of these carbon structures. As with the case of fullerenes and CNTs, access to these unique carbon structures should undoubtedly revolutionize a wide range of sciences. This Account highlights our efforts toward the synthesis of topol. unique mol. nanocarbons. Starting from CPP as the topol. simple subunit, we have successfully created novel mol. nanocarbons that have more complexed topologies. The first topic is carbon nanobelts, fully fused cylinder-shaped mol. nanocarbons representing the segment structure of armchair-type CNTs. The second topic is carbon nanocages, mol. nanocarbons having a “”three-holed”” topol. representing the joint unit of branched CNTs. The third and fourth topics are all-benzene catenanes consisting of two CPP rings and an all-benzene trefoil knot topol. related to a carbon nanotorus. The world of nanocarbon mols. is only limited by our imagination and creativity. As history has proved, the synthesis of new forms of carbon and topol. complex mols. has always subsequently led to new fields and applications associated with their unforeseen properties and functions.

Accounts of Chemical Research published new progress about Carbon nanotubes. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Electric Literature of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chinna Ayya, Swamy .P.; Varenikov, Andrii; de Ruiter, Graham published the artcile< Chiral Imidazo[1,5-a]pyridine-Oxazolines: A Versatile Family of NHC Ligands for the Highly Enantioselective Hydrosilylation of Ketones>, Recommanded Product: 1-(Pyridin-3-yl)ethanone, the main research area is chiral imidazopyridineoxazoline bidentate ligand preparation cyclometalation rhodium complex; rhodium imidazopyridineoxazoline bidentate carbene complex preparation catalyst hydrosilylation ketone; alc chiral enantioselective preparation.

Herein the authors report the synthesis and application of a versatile class of N-heterocyclic carbene ligands based on an imidazo[1,5-a]pyridine-3-ylidine backbone that is fused to a chiral oxazoline auxiliary. The key step in the synthesis of these ligands involves the installation of the oxazoline functionality via a microwave-assisted condensation of a cyano-azolium salt with a wide variety of 2-amino alcs. The resulting chiral bidentate NHC-oxazoline ligands form stable complexes with Rh(I) that are efficient catalysts for the enantioselective hydrosilylation of structurally diverse ketones. The corresponding secondary alcs. are isolated in good yields (typically >90%) with good to excellent enantioselectivities (80-95% ee). The reported hydrosilylation occurs at ambient temperatures (40°), with excellent functional group tolerability. Even ketones bearing heterocyclic substituents (e.g., pyridine or thiophene) or complex organic architectures are hydrosilylated efficiently, which is discussed further.

Organometallics published new progress about Alcohols, chiral Role: SPN (Synthetic Preparation), PREP (Preparation). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guo, Wenjing; Fu, Zhiyou; Zhang, Zhiyong; Wang, Hao; Liu, Shasha; Feng, Weiying; Zhao, Xiaoli; Giesy, John P. published the artcile< Synthesis of Fe3O4 magnetic nanoparticles coated with cationic surfactants and applications in Sb(V) removal from water>, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride, the main research area is synthesis Fe3O4 magnetic nanoparticle coated cationic surfactant Sb removal; Adsorption; Fe(3)O(4); Magnetic nanoparticle; Sb(V); Surfactant.

Antimony (Sb) pollution was an emerging environmental risk in several contaminated waters, whereas its removal still presented as a severe challenge due to the lack of efficient adsorbent and its further removal mechanism. In this study, synthesized absorbents, Fe3O4 magnetic nanoparticles (Fe-MNPs) modified and dispersed with commonly used cationic surfactants, were applied to remove Sb contamination in real surface waters, its synthesized conditions, removal performance and mechanism were investigated by using batch experiments and characterization analyses. Optimum conditions on Sb(V) (the dominant form is Sb(OH)-6) removal by modified adsorbents were obtained as: cetylpyridinium chloride (CPC) coated on Fe-MNPs, mass ratio of Fe-MNPs: CPC = 4:1 and pH = 3-5. Magnetic properties of synthesized adsorbent were not affected, dispersibility was enhanced after fabrication of CPC, that indicated the Fe-MNPs@CPC could be separated and reused with external magnetic field. The adsorption efficiency of this low-cost adsorbent coated with CPC was superior than several traditional adsorbents. The practical application of Fe-MNPs@CPC in five types real waters from the Xikuangshan (XKS) Sb mine area and regeneration experiments by 1 M (mol/L) NaOH solution further confirm its practicability and reusability. Removal experiment results, XPS and Fourier transform IR spectroscopy (FT-IR) spectra suggested that electrostatic attraction and surface bonding might responsible for the Sb(V) removal by Fe-MNPs modified with cationic surfactants.

Science of the Total Environment published new progress about Adsorbents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Recommanded Product: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem