Day: October 20, 2022

In 2019,Advanced Synthesis & Catalysis included an article by Zhu, Tong-Hao; Zhang, Xiao-Chen; Cui, Xian-Lu; Zhang, Ze-Yu; Jiang, Hui; Sun, Shan-Shan; Zhao, Li-Li; Zhao, Kai; Loh, Teck-Peng. Electric Literature of C33H24IrN3. The article was titled 《Direct C(sp2)-H Arylsulfonylation of Enamides via Iridium(III)-Catalyzed Insertion of Sulfur Dioxide with Aryldiazonium Tetrafluoroborates》. The information in the text is summarized as follows:

An iridium(III)-catalyzed three-component reaction of enamides e.g., N-benzyl-N-(1-phenylvinyl)acetamide, aryldiazonium tetrafluoroborates ArN2BF4 [Ar = 4-FC6H4, naphthalen-1-yl, 2-methyloxycarbonyl-thiophen-3-yl, etc.], and 1,4-diazabicyclo[2.2.2]octane bis(sulfur dioxide) (DABSO) for the direct C(sp2)-H arylsulfonylation of enamides e.g., (E)-N-benzyl-N-(1-phenyl-2-(phenylsulfonyl)vinyl)acetamide is developed. This transformation provides a robust and straightforward approach for preparing a diverse array of β-amidovinyl sulfones in moderate to excellent yields and high stereoselectivities without Light-emitting diode (LED) radiation. This transformation also features mild conditions, broad substrate scopes, and excellent functional group tolerance. After reading the article, we found that the author used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Electric Literature of C33H24IrN3)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Electric Literature of C33H24IrN3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Organic Chemistry included an article by Zhao, Yun-Long; Cheng, Ying. COA of Formula: C6H4BrNO. The article was titled 《Construction of Complex Bisether-Bridged Medium-Sized Cyclic Compounds from o-(1-(Acyloxy)propargyl)benzaldehydes under Base and Acid Catalysis》. The information in the text is summarized as follows:

The authors report herein the authors’ serendipitous discovery of the rapid and straightforward accesses to unprecedented diverse complex mol. structures from readily available starting materials. Catalyzed by 1,8-diazabicyclo[5.4.0]undec-7-ene under mild conditions, o-(1-(acyloxy)propargyl)benzaldehyde underwent efficient and selective dimerization reactions to produce novel complex bisether-bridged tricyclic products. The reactions proceeded most probably through dimerizations between 3-methylene-3H-isochromene intermediate and its zwitterionic resonance structures which were generated from a concerted 6-π electrocyclic ring closure reaction from the initially formed (2-formylphenyl)allene intermediates derived directly from o-(1-(acyloxy)propargyl)benzaldehydes. Treatment of the resulting product simply with NaOEt in ethanol and aqueous HCl, resp., enabled further development of complex mol. diversities. In the experiment, the researchers used many compounds, for example, 2-Bromonicotinaldehyde(cas: 128071-75-0COA of Formula: C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.COA of Formula: C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Inorganic Chemistry Communications included an article by Shi, Shihang; Duan, Jiaru; Jiang, Jun; Chen, Lijuan; Zhao, Junwei. Related Products of 98-98-6. The article was titled 《A novel inorganic-organic hybrid 3d-4f heterometallic germanotungstate based on saturated Keggin-type [α-GeW12O40]4- polyanion》. The information in the text is summarized as follows:

An arrestive 2-picolinic acid functionalized 3d-4f heterometallic germanotungstate based on plenary α-Keggin [GeW12O40]4- polyanion [Cu2(PA)3(H2O)3][Gd(H2O)8]0.5[Cu2(PA)3(H2O)4]H0.5[α-GeW12O40]·5H2O (1) was synthesized by reaction of Na2WO4·2H2O, GeO2, Gd(NO3)3·6H2O, CuCl2·2H2O and 2-picolinic acid (HPA) in aqueous solution The polyoxoanion unit of 1 consists of a plenary Keggin [α-GeW12O40]4- anion with a decorated [Cu2(PA)3(H2O)3]+ cation and a decorated 3d-4f heterometallic {[Gd(H2O)8]0.5[Cu2(PA)3(H2O)4]}2.5+ segment and neighboring polyoxoanion units are further expanded into a 1-D chain alignment through unique bridging di-copper [Cu2(PA)3(H2O)3]+ linkers. Furthermore, the electrochem. properties of the 1@CMWCNTs-Nafion/GCE electrochem. sensor was investigated, which shows a good stability and a good sensing performance toward the dopamine detection. This research offers the possibility of organic-inorganic hybrid heterometallic germanotungstates for serving as electrode response materials.Picolinic acid(cas: 98-98-6Related Products of 98-98-6) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Related Products of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Logic gate behavior and intracellular application of a fluorescent molecular switch for the detection of Fe3+ and cascade sensing of F- in pure aqueous media》 were Dwivedi, Romi; Singh, Divya P.; Singh, Saumya; Singh, Ashish K.; Chauhan, Brijesh S.; Srikrishna, S.; Singh, Vinod P.. And the article was published in Organic & Biomolecular Chemistry in 2019. Electric Literature of C5H7N3 The author mentioned the following in the article:

The nature and coordination sites of the Schiff base 3,3′-(1E,1′E)-(1,3-phenylenebis(azan-1-yl-1-ylidene))bis(methan-1-yl-1-ylidene)dinaphthalen-2-ol (APHN) were tuned by its selective reduction to design a highly efficient fluorescent probe, 3,3′-(pyridine-2,6-diylbis(azanediyl))bis(methylene)dinaphthalen-2-ol (RAPHN). The structures of APHN, RAPHN, and the RAPHN-Fe3+ complex were satisfactorily modeled from the results of d. functional theory (DFT) and time-dependent DFT (TD-DFT) calculations RAPHN worked in pure aqueous medium as a turn on-off-on probe of Fe3+ and F-. The fluorescence nature of the probe in the presence and absence of Fe3+/F- was regulated by a set of mechanisms including -CH=N isomerization and LMCT. A 2 : 1 (M : L) binding stoichiometry was established from a fluorescence Job′s plot and further substantiated from HR-MS studies. The limits of detection of RAPHN for Fe3+ and RAPHN-Fe3+ for F- were found to be 2.49 × 10-7 M and 1.09 × 10-7 M, resp. The RAPHN probe caused no cytotoxicity in gut tissue of Drosophila even at high concentrations The probe displayed excellent bioimaging applications for detection of Fe3+ and F- in gut tissue of Drosophila. A combinatorial logic gate was constructed for the proper understanding of the working principle of RAPHN. In the experiment, the researchers used 2,6-Diaminopyridine(cas: 141-86-6Electric Literature of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Electric Literature of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Engineering Redox Activity in Conjugated Microporous Polytriphenylamine Networks Using Pyridyl Building Blocks toward Efficient Supercapacitors》 were Li, Huixin; Lyu, Wei; Liao, Yaozu. And the article was published in Macromolecular Rapid Communications in 2019. Name: 2,6-Diaminopyridine The author mentioned the following in the article:

Nitrogen-rich conjugated microporous polymers (CMPs) with tunable porosities and reversible redox properties have received increasing interest as electrode materials for supercapacitors. Herein, pyridyl building blocks with different substitutions are selected to synthesize four amine-linked conjugated microporous polytriphenylamine (PTPA) networks via Buchwald-Hartwig cross-coupling reaction engineering the redox activity of PTPAs. The structures, porosities, and redox activities of these four PTPAs are investigated. The electrochem. characterization results show that PTPA obtained using 2,5-diaminopyridine dihydrochloride (i.e., PTPA-25) displays the highest specific capacitances ≤ 335 F g-1 in 1.0 M H2SO4 at a c.d. of 0.5 A g-1. Upon 5000 cycles, PTPA-25 maintains good initial capacitances ≤ 65%, nearly 100% Coulombic efficiencies at a c.d. of 2 A g-1, and high rate properties (remained a high capacitance of 250 F g-1 at 10 A g-1). The effect of different substitutions of pyridyl on the redox activities of the synthesized PTPA electrodes is further proposed, which would give insight into engineering the performance of CMPs-based supercapacitors.2,6-Diaminopyridine(cas: 141-86-6Name: 2,6-Diaminopyridine) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Name: 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis, Biological Evaluation, and Molecular Docking of Arylpyridines as Antiproliferative Agent Targeting Tubulin》 was published in ACS Medicinal Chemistry Letters in 2020. These research results belong to He, JiaPeng; Zhang, Mao; Tang, Lv; liu, Jie; Zhong, JiaHong; Wang, Wenya; Xu, Jiang-Ping; Wang, Hai-Tao; Li, Xiao-Fang; Zhou, Zhong-Zhen. SDS of cas: 128071-75-0 The article mentions the following:

Mimicking different pharmacophoric units into one scaffold is a promising structural modification tool to design new drugs with enhanced biol. properties. To continue our research on the tubulin inhibitors, the synthesis and biol. evaluation of arylpyridine derivatives are described herein. Among these compounds, 6-arylpyridines bearing benzo[d]imidazole side chains at the 2-position of pyridine ring displayed selective antiproliferative activities against HT-29 cells. More interestingly, 2-trimethoxyphenylpyridines, e.g., I, bearing benzo[d]imidazole and benzo[d]oxazole side chains displayed more broad-spectrum antitumor activities against all tested cancer cell lines. I bearing a 6-methoxybenzo[d]oxazole group exhibited comparable activities against A549 and U251 cells to combretastatin A-4 (CA-4) and lower cytotoxicities than CA-4 and 5-Fu. Further investigations revealed I displays strong tubulin polymerization inhibitory activity (IC50 = 2.1μM) and effectively binds at the colchicine binding site and arrests the cell cycle of A549 in the G2/M phase by disrupting the microtubules network. In the experiment, the researchers used 2-Bromonicotinaldehyde(cas: 128071-75-0SDS of cas: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.SDS of cas: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Chemosensing of Guanosine Triphosphate Based on a Fluorescent Dinuclear Zn(II)-Dipicolylamine Complex in Water》 was published in Inorganic Chemistry in 2020. These research results belong to Bazany-Rodriguez, Ivan J.; Salomon-Flores, Maria K.; Bautista-Renedo, Joanatan M.; Gonzalez-Rivas, Nelly; Dorazco-Gonzalez, Alejandro. Recommanded Product: Bis(pyridin-2-ylmethyl)amine The article mentions the following:

Guanosine triphosphate (GTP) is a key biomarker of multiple cellular processes and human diseases. The new fluorescent dinuclear complex [Zn2(L)(S)][OTf]4, 1 (asym. ligand, L = 5,8-Bis{[bis(2-pyridylmethyl)amino] methyl}quinoline, S = solvent, and OTf = triflate anion) was synthesized and studied in-depth as a chemosensor for nucleoside polyphosphates and inorganic anions in pure water. Additions at neutral pH of nucleoside triphosphates, guanosine diphosphate, guanosine monophosphate, and pyrophosphate (PPi) to 1 quench its blue emission (λem = 410 nm) with a pronounced selectivity toward GTP over other anions, including ATP (ATP), uridine triphosphate (UTP), and cytidine triphosphate (CTP). The efficient quenching response by the addition of GTP was observed in the presence of coexisting species in blood plasma and urine with a detection limit of 9.2 μmol L-1. GTP also shows much tighter binding to the receptor 1 on a submicromolar level. On the basis of multiple spectroscopic tools (1H, 31P NMR, UV-vis, and fluorescence) and DFT calculations, the binding mode is proposed through three-point recognition involving the simultaneous coordination of the N7 atom of the guanosine motif and two phosphate groups to the two Zn(II) atoms. Spectroscopic studies, MS-ESI, and DFT suggested that GTP bound to 1 in 1:1 and 2:2 models with high overall binding constants of log β1 (1:1) = 6.05 ± 0.01 and log β2 = 10.91 ± 0.03, resp. The optical change and selectivity are attributed to the efficient binding of GTP to 1 by the combination of a strong electrostatic contribution and synergic effects of coordination bonds. Such GTP selectivity of an asym. metal-based receptor in water is still rare. The blue fluorescent Zn(II)-dinuclear complex, 1, based on the new 5,8-bis{[bis(2-pyridylmethyl)amino]methyl}quinoline ligand was designed, synthesized, and studied in depth as a chemosensor for nucleoside polyphosphates (NPPs) in neutral pure water. The fluorescence emission of 1 is affected strongly by the NPPs with pronounced selectivity toward guanosine triphosphate (GTP). This optical change is the result of the coordination of GTP to 1 through three-point recognition. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Recommanded Product: Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A State-of-the-Art Heterogeneous Catalyst for Efficient and General Nitrile Hydrogenation》 was published in Chemistry – A European Journal in 2020. These research results belong to Formenti, Dario; Mocci, Rita; Atia, Hanan; Dastgir, Sarim; Anwar, Muhammad; Bachmann, Stephan; Scalone, Michelangelo; Junge, Kathrin; Beller, Matthias. Synthetic Route of C6H4N2 The article mentions the following:

Cobalt-doped hybrid materials consisting of metal oxides and carbon derived from chitin were prepared, characterized and tested for industrially relevant nitrile hydrogenations. The optimal catalyst supported onto MgO showed, after pyrolysis at 700°C, magnesium oxide nanocubes decorated with carbon-enveloped Co nanoparticles. This special structure allows for the selective hydrogenation of diverse and demanding nitriles to the corresponding primary amines under mild conditions (e.g. 70°C, 20 bar H2). The advantage of this novel catalytic material is showcased for industrially important substrates, including adipodinitrile, picolinonitrile, and fatty acid nitriles. Notably, the developed system outperformed all other tested com. catalysts, for example, Raney Nickel and even noble-metal-based systems in these transformations. In addition to this study using 4-Cyanopyridine, there are many other studies that have used 4-Cyanopyridine(cas: 100-48-1Synthetic Route of C6H4N2) was used in this study.

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Synthetic Route of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Femtomolar detection of Cu2+ ions in solution using super-Nernstian FET-sensor with a lipid monolayer as top-gate dielectric》 was published in Sensors and Actuators, B: Chemical in 2020. These research results belong to Kenaan, A.; Brunel, F.; Raimundo, J.-M.; Charrier, A. M.. Product Details of 1539-42-0 The article mentions the following:

The development of ions sensors with low limit of detection and high sensitivity and selectivity is required in many fields of application and still remains a challenge. We report on the first dual-gated field effect transistor sensor with an engineered lipid monolayer as top gate dielec. The sensor was designed and fabricated for the specific detection of Cu2+ using the Di-2-picolylamine as recognition unit. The lipid monolayer was reticulated to achieve high mech. and dielec. stability over device operation. The resulting sensor exhibits exceptional performances with a limit of detection at 10 femtomolar, with a linear dependency over 10 decades and a super-Nernstian sensitivity of ∼100 mV/decade. We also show that the lipid layer forms a good barrier to ions trapping, hence providing a high stability of the sensor over measurements. In the experiment, the researchers used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Product Details of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Product Details of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Fluorescent donor-acceptor psoralen cruciforms by consecutive Suzuki-Suzuki and Sonogashira-Sonogashira one-pot syntheses》 was written by Geenen, Sarah R.; Schumann, Torben; Mueller, Thomas J. J.. Recommanded Product: 4-Ethynylpyridine And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

Two novel donor-acceptor cruciform topologies are efficiently synthesized by site-selective Suzuki-Suzuki and Sonogashira-Sonogashira multicomponent reactions starting from a bromo-triflato-functionalized psoralen scaffold. In addition to tunability of photophys. properties, such as absorption and emission, many derivatives possess partially high relative fluorescence quantum yields in solution and fluoresce strongly in the solid state. Addnl., the promising compounds show solvatochromism and acidochromic effects. In addition, 8-p-anisyl-5-p-cyanophenyl-substituted psoralen exhibits aggregation-induced emission properties. Exptl. (applying the Lippert-Mataga model) and computationally (TD-DFT calculations), the pronounced charge transfer character of the longest wavelength absorption band was confirmed. In the experiment, the researchers used 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem