Day: October 20, 2022

《The bioavailability of iron picolinate is comparable to iron sulfate when fortified into a complementary fruit yogurt: a stable iron isotope study in young women》 was written by Sabatier, Magalie; Grathwohl, Dominik; Beaumont, Maurice; Groulx, Karine; Guignard, Laurence F.; Kastenmayer, Peter; Dubascoux, Stephane; Richoz, Janique; Habeych, Edwin; Zeder, Christophe; Moretti, Diego; Zimmermann, Michael B.. Name: Picolinic acid And the article was included in European Journal of Nutrition in 2020. The article conveys some information:

A technol. gap exists for the iron (Fe) fortification of difficult-to-fortify products, such as wet and acid food products containing polyphenols, with stable and bioavailable Fe. Fe picolinate, a novel food ingredient, was found to be stable over time in this type of matrix. The objective of this study was to measure the Fe bioavailability of Fe picolinate in a complementary fruit yogurt. The bioavailability of Fe picolinate was determined using stable iron isotopes in a double blind, randomized cross-over design in non-anemic Swiss women (n = 19; 25.1 ± 4.6 years). Fractional Fe absorption was measured from Fe picolinate (2.5 mg 57Fe per serving in two servings given morning and afternoon) and from Fe sulfate (2.5 mg 54Fe per serving in two servings given morning and afternoon) in a fortified dairy complementary food (i.e. yogurt containing fruits). Fe absorption was determined based on erythrocyte incorporation of isotopic labels 14 days after consumption of the last test meal. Geometric mean (95% CI) fractional iron absorption from Fe picolinate and Fe sulfate were not significantly different: 5.2% (3.8-7.2%) and 5.3% (3.8-7.3%) (N.S.), resp. Relative bioavailability of Fe picolinate vs. Fe sulfate was 0.99 (0.85-1.15). Therefore, Fe picolinate is a promising compound for the fortification of difficult-to-fortify foods, to help meet Fe requirements of infants, young children and women of childbearing age. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Name: Picolinic acid) was used in this study.

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Name: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Biallelic variants in KYNU cause a multisystemic syndrome with hand hyperphalangism》 was written by Ehmke, Nadja; Cusmano-Ozog, Kristina; Koenig, Rainer; Holtgrewe, Manuel; Nur, Banu; Mihci, Ercan; Babcock, Holly; Gonzaga-Jauregui, Claudia; Overton, John D.; Xiao, Jing; Martinez, Ariel F.; Muenke, Maximilian; Balzer, Alexander; Jochim, Judith; El Choubassi, Naji; Fischer-Zirnsak, Bjoern; Huber, Celine; Kornak, Uwe; Elsea, Sarah H.; Cormier-Daire, Valerie; Ferreira, Carlos R.. Application of 98-98-6 And the article was included in Bone (New York, NY, United States) in 2020. The article conveys some information:

Catel-Manzke syndrome is characterized by the combination of Pierre Robin sequence and radial deviation, shortening as well as clinodactyly of the index fingers, due to an accessory ossification center. Mutations in TGDS have been identified as one cause of Catel-Manzke syndrome, but cannot be found as causative in every patient with the clin. diagnosis. We performed a chromosome microarray and/or exome sequencing in three patients with hand hyperphalangism, heart defect, short stature, and mild to severe developmental delay, all of whom were initially given a clin. diagnosis of Catel-Manzke syndrome. In one patient, we detected a large deletion of exons 1-8 and the missense variant c.1282C > T (p.Arg428Trp) in KYNU (NM_003937.2), whereas homozygous missense variants in KYNU were found in the other two patients (c.989G > A (p.Arg330Gln) and c.326G > C (p.Trp109Ser)). Plasma and urine metabolomic anal. of two patients indicated a block along the tryptophan catabolic pathway and urine organic acid anal. showed excretion of xanthurenic acid. Biallelic loss-of-function mutations in KYNU were recently described as a cause of NAD deficiency with vertebral, cardiac, renal and limb defects; however, no hand hyperphalangism was described in those patients, and Catel-Manzke syndrome was not discussed as a differential diagnosis. In conclusion, we present unrelated patients identified with biallelic variants in KYNU leading to kynureninase deficiency and xanthurenic aciduria as a very likely cause of their hyperphalangism, heart defect, short stature, and developmental delay. We suggest performance of urine organic acid anal. in patients with suspected Catel-Manzke syndrome, particularly in those with cardiac or vertebral defects or without mutations in TGDS. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Application of 98-98-6)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Application of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Rhodium(III)-catalyzed switchable C-H acylmethylation and annulation of 2,2′-bipyridine derivatives with sulfoxonium ylides》 was written by Chen, Mengjia; Meng, Haifang; Yang, Fang; Wang, Yani; Chen, Chen; Zhu, Bolin. Category: pyridine-derivatives And the article was included in Organic & Biomolecular Chemistry in 2021. The article conveys some information:

A novel protocol for Rh(III)-catalyzed switchable C-H acylmethylation and annulation of 2,2′-bipyridine derivatives with sulfoxonium ylides was reported. This protocol provided a facile approach to synthesize structurally diverse acylmethylated 2,2′-bipyridine derivatives I [R = i-Pr, Ph, 2-FC6H4, etc.; R1 = H, Me, Br, etc.; R2 = H, Br; R3 = H; R4 = H; R3R4 = CH=CH-CH=CH] and acyl-pyrido[2,3-a]indolizines II [R5 = Ph, 1-naphthyl, 2-furyl, etc.; R6 = H, Br, F, etc.; R7 = H, Br; R8 = H; R9 = H; R8R9 = CH=CH-CH=CH] with a broad range of functional group tolerance. After reading the article, we found that the author used 2,6-Dibromopyridine(cas: 626-05-1Category: pyridine-derivatives)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Yongsheng; Wang, Jincheng; Yang, Zhenjiao; Zhang, Zeng; He, Xiaoyan; Chen, Guoliang; Huang, Gang; Lu, Xiuhong published their research in Journal of Organic Chemistry in 2021. The article was titled 《Hydrazine Hydrate Accelerates Neocuproine-Copper Complex Generation and Utilization in Alkyne Reduction, a Significant Supplement Method for Catalytic Hydrogenation》.Computed Properties of C7H5N The article contains the following contents:

An in situ neocuproine-copper complex formation method was reported. The redox potential of this complex enable it can serve as an ideal redox catalyst in the synthesis of diimine by oxidation of hydrazine hydrate and this technique was successfully applied in the reduction of alkynes. This reduction method displayed a broad functional group tolerance and substrate adaptability as well as the advantages of safety and high efficiency. Especially, nitro, benzyl, boc and sulfur containing alkynes can be reduced to the corresponding alkanes directly, which provides a useful complementary method to traditional catalytic hydrogenation. Besides, this method was applied in the preparation of the Alzheimer’s disease drug CT-1812 and studied the mechanism.4-Ethynylpyridine(cas: 2510-22-7Computed Properties of C7H5N) was used in this study.

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Computed Properties of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Yuanjiang; Lv, Zhaodan; Chen, Feihong; Wang, Xing; Gou, Shaohua published their research in Journal of Medicinal Chemistry in 2021. The article was titled 《Discovery of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine Derivatives as Highly Selective CK2 Inhibitors with Potent Cancer Cell Stemness Inhibition》.HPLC of Formula: 103-74-2 The article contains the following contents:

Multifunctional entities have recently been attractive for the development of anticancer chemotherapeutic drugs. However, such entities with concurrent CK2 along with cancer stem cell (CSC) inhibitory activities are rare in a single small mol. Herein, a series of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine derivatives were synthesized using a known CK2 inhibitor, silmitasertib (CX-4945), as the lead compound Among the resulting compounds, 5-((3-chlorophenyl)amino)-N-(2-hydroxyethyl)benzo[c][2,6]naphthyridine-8-carboxamide exhibited stronger CK2 inhibitory activity with higher Clk2/CK2 selectivity than CX-4945. Significantly, 5-((3-chlorophenyl)amino)-N-(2-hydroxyethyl)benzo[c][2,6]naphthyridine-8-carboxamide could modulate the Akt1(ser129)-GSK-3β(ser9)-Wnt/β-catenin signaling pathway and inhibit the expression of the stemness marker ALDH1A1, CSC surface antigens, and stem genes, showing potent CSC inhibitory activity. Moreover, 5-((3-chlorophenyl)amino)-N-(2-hydroxyethyl)benzo[c][2,6]naphthyridine-8-carboxamide also displayed superior pharmacokinetics and antitumor activity compared with CX-4945 sodium salt, without obvious toxicity. The favorable antiproliferative and antitumor activity of 5-((3-chlorophenyl)amino)-N-(2-hydroxyethyl)benzo[c][2,6]naphthyridine-8-carboxamide, its high inhibitory selectivity for CK2, and its potent inhibition of cancer cell stemness make this mol. a candidate for the treatment of cancer. After reading the article, we found that the author used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2HPLC of Formula: 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. HPLC of Formula: 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dai, Zengjin; Pan, Ying-Min; Wang, Shou-Guo; Zhang, Xumu; Yin, Qin published an article in 2021. The article was titled 《Direct reductive amination of ketones with ammonium salt catalysed by Cp*Ir(III) complexes bearing an amidato ligand》, and you may find the article in Organic & Biomolecular Chemistry.SDS of cas: 1122-54-9 The information in the text is summarized as follows:

A series of half-sandwich Ir(III) complexes bearing an amidato bidentate ligand were conveniently synthesized and applied to the catalytic Leuckart-Wallach reaction to produce racemic α-chiral primary amines. With 0.1 mol% of complex I, a broad range of ketones, including aryl ketones, dialkyl ketones, cyclic ketones, α-keto acids, α-keto esters and diketones, could be transformed to their corresponding primary amines with moderate to excellent yields (40%-95%). Asym. transformation was also attempted with chiral Ir complexes, and 16% ee of the desired primary amine was obtained. Despite the unsatisfactory enantio-control achieved so far, the current exploration might stimulate more efforts towards the discovery of better chiral catalysts for this challenging but important transformation. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9SDS of cas: 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. SDS of cas: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sitte, Elisabeth; Twamley, Brendan; Grover, Nitika; Senge, Mathias O. published an article in 2021. The article was titled 《Investigation of the Reactivity of 1-Azido-3-iodobicyclo[1.1.1]pentane under “”Click”” Reaction Conditions》, and you may find the article in Journal of Organic Chemistry.Recommanded Product: 4-Ethynylpyridine The information in the text is summarized as follows:

The bicyclo[1.1.1]pentane (BCP) unit is under scrutiny as a bioisostere in drug mols. We employed methodologies for the synthesis of different BCP triazole building blocks from one precursor, 1-azido-3-iodobicyclo[1.1.1]pentane, by “”click”” reactions and integrated cycloaddition-Sonogashira coupling reactions. Thereby, we accessed 1,4-disubstituted triazoles such as I (R = 1-pyrenyl, Ph, 4-pyridinyl; R1 = H), 5-iodo-1,4,5-trisubstituted triazoles such as I (R = 1-pyrenyl, Ph, 4-pyridinyl; R1 = I), and 5-alkynylated 1,4,5-trisubstituted triazoles such as I (R = 1-pyrenyl, Ph, 4-pyridinyl; R1 = RCC). This gives entry to the synthesis of multiply substituted BCP triazoles on either a modular or a one-pot basis. These methodologies were further utilized for appending porphyrin moieties onto the BCP core. In the experiment, the researchers used 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Recommanded Product: 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Haller, Paulina; Machado, Ignacio; Torres, Julia; Vila, Agustina; Veiga, Nicolas published an article in 2021. The article was titled 《Fe(III)-Complex-Imprinted Polymers for the Green Oxidative Degradation of the Methyl Orange Dye Pollutant》, and you may find the article in Polymers (Basel, Switzerland).COA of Formula: C12H13N3 The information in the text is summarized as follows:

One of the biggest problems worldwide is the pollution of natural water bodies by dyes coming from effluents used in the textile industry. In the quest for novel effluent treatment alternatives, the aim of this work was to immobilize Fe(III) complexes in molecularly imprinted polymers (MIPs) to produce efficient Fenton-like heterogeneous catalysts for the green oxidative degradation of the methyl orange (MO) dye pollutant. Different metal complexes bearing com. and low-cost ligands were assayed and their catalytic activity levels towards the discoloration of MO by H2O2 were assessed. The best candidates were Fe(III)-BMPA (BMPA = di-(2-picolyl)amine) and Fe(III)-NTP (NTP = 3,3′,3”-nitrilotripropionic acid), displaying above 70% MO degradation in 3 h. Fe(III)-BMPA caused the oxidative degradation through two first-order stages, related to the formation of BMPA-Fe-OOH and the generation of reactive oxygen species. Only the first of these stages was detected for Fe(III)-NTP. Both complexes were then employed to imprint catalytic cavities into MIPs. The polymers showed catalytic profiles that were highly dependent on the crosslinking agent employed, with N,N-methylenebisacrylamide (MBAA) being the crosslinker that rendered polymers with optimal oxidative performance (>95% conversion). The obtained ion-imprinted polymers constitute cheap and robust solid matrixes, with the potential to be coupled to dye-containing effluent treatment systems with synchronous H2O2 injection.Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0COA of Formula: C12H13N3) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. COA of Formula: C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ding, Hong; Pei, Yuan; Li, Yuanqing; Xu, Wen; Mei, Lianghe; Hou, Zeng; Guang, Yiman; Cao, Liyuan; Li, Peizhuo; Cao, Haijing; Bian, Jinlei; Chen, Kaixian; Luo, Cheng; Zhou, Bing; Zhang, Ting; Li, Zhiyu; Yang, Yaxi published an article in 2021. The article was titled 《Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer》, and you may find the article in Bioorganic & Medicinal Chemistry.HPLC of Formula: 128071-75-0 The information in the text is summarized as follows:

Histone acetylation is one of the most essential parts of epigenetic modification, mediating a variety of complex biol. functions. In these procedure, p300/CBP could catalyze the acetylation of lysine 27 on histone 3 (H3K27ac), and had been reported to mediate tumorigenesis and development in a variety of tumors by enhancing chromatin transcription activity. Ovarian cancer, as an extremely malignant tumor, has also been observed to undergo abnormal acetylation of histones. However, whether the treatment of ovarian cancer could be achieved by inhibiting the acetylation activity of p300/CBP on H3K27 has not been well investigated. In this article, we modified the structure of p300/CBP HAT domain inhibitor A-485 and obtained a highly active small mol. known as 13f, which has an IC50 value of 0.49 nM for inhibiting the in vitro enzyme activity of p300, as well as the anti-proliferation IC50 value on ovarian cancer cell line OVCAR-3 was 153 nM. In addition, 13f had strong acetylase family selectivity, good metabolic stability and promising in vivo anti-tumor activity in OVCAR-3 xenograft model. The discovery of 13f revealed a more active chem. entity of the HATs domain of p300/CBP and provided a novel idea for the application of epigenetic inhibitors in the treatment of ovarian cancer. The results came from multiple reactions, including the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0HPLC of Formula: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.HPLC of Formula: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chang, Xingmao; Wang, Zhaolong; Wang, Gang; Liu, Taihong; Lin, Simin; Fang, Yu published an article in 2021. The article was titled 《Perylene Bisimide-Cored Supramolecular Coordination Complexes: Interplay between Ensembles, Excited State Processes, and Aggregation Behaviors》, and you may find the article in Chemistry – A European Journal.Product Details of 2510-22-7 The information in the text is summarized as follows:

Manipulating the optical properties of fluorescent species is challenging owing to complicated and tedious synthetic works. Herein, the photophys. properties of perylene bisimide (PBI) were effectively tuned by varying the geometrical arrangement of PBI moieties within supramol. coordination complexes (SCCs), where a PBI-based dicycle (2) and a trigonal prism (3) were generated via using a typical 90° Pt(II) reagent, cis-(PEt3)2Pt(OTf)2-based coordination-driven self-assembly approach. The ligand, an ortho-tetrapyridiyl-PBI (1), exhibits a moderate fluorescence quantum yield (∼13%) and efficient inter-system crossing (ISC). 2, however, is much more emissive with a fluorescence quantum yield of ∼41%, and the relevant ISC process is significantly hindered. The fluorescence quantum yield of 3 is merely ∼6% due to the observed symmetry-breaking charge separation (SB-CS), which turns to triplet state upon charge recombination. Interestingly, 3 could be fully transformed into 2 by simply adding a suitable amount of a 90° Pt(II)-based neutral triangle. Moreover, 2 tends to form discrete dimers both in crystal and solution states, but 3 does not show the property. Therefore, controlling geometrical arrangement of fluorophores through coordination-driven self-assembly could be taken as another effective way to tune their excited state relaxation pathways and construct high-performance optical mol. materials, which generally have to be prepared via organic synthesis. In the experiment, the researchers used 4-Ethynylpyridine(cas: 2510-22-7Product Details of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Product Details of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem