Day: October 20, 2022

Jang, Mingyeong; Lim, Taeho; Park, Byoung Yong; Han, Min Su published an article in 2022. The article was titled 《Metal-Free, Rapid, and Highly Chemoselective Reduction of Aromatic Nitro Compounds at Room Temperature》, and you may find the article in Journal of Organic Chemistry.Formula: C5H5BrN2 The information in the text is summarized as follows:

A metal-free and highly chemoselective method for the reduction of aromatic nitro compounds, RNO2 (R = 4-BrC6H4, quinolin-6-yl, 2-methyl-1,3-benzoxazol-6-yl, etc.) has been described. This reduction was performed using tetrahydroxydiboron [B2(OH)4] as the reductant and 4,4′-bipyridine as the organocatalyst and could be completed within 5 min at room temperature Under optimal conditions, nitro compounds RNO2 with sensitive functional groups, such as vinyl, ethynyl, carbonyl, and halogen, were converted into the corresponding amines, RNH2 with excellent selectivity while avoiding the undesirable reduction of the sensitive functional groups. In the part of experimental materials, we found many familiar compounds, such as 6-Bromopyridin-3-amine(cas: 13534-97-9Formula: C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Yang, Yu-Ting; Tu, Chang-Zheng; Shi, Jun-You; Yang, Xiao-Li; Liu, Jian-Jun; Cheng, Fei-Xiang published an article in Journal of Solid State Chemistry. The title of the article was 《Cu(I)-organic framework as a platform for high-efficiency selective adsorption of methylene blue and reversible iodine uptake》.Safety of 4-Cyanopyridine The author mentioned the following in the article:

A Cu(I)-MOF, {[Cu(4-PTZ)]·(H2O)0.5}n (1), that contains rhombic channels with the size of 10.174 Å x 16.965 Å was obtained based on in situ generated 5-(4-pyridyl)-1H-tetrazole ligand (4-HPTZ). Compound 1 not only displays remarkable capability for selective adsorption toward the organic dye Methylene Blue (149.5 mg g-1), but also shows reversible adsorption of I2 mols. in hexane medium (96.2%). Therefore, compound 1 should be a promising MOF-based bifunctional adsorbent in the field of pollutant removal. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1Safety of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Safety of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Norman, Jacob P.; Larson, Nathaniel G.; Entz, Emily D.; Neufeldt, Sharon R. published an article in Journal of Organic Chemistry. The title of the article was 《Unconventional Site Selectivity in Palladium-Catalyzed Cross-Couplings of Dichloroheteroarenes under Ligand-Controlled and Ligand-Free Systems》.Safety of 2-Bromo-5-methylpyridine The author mentioned the following in the article:

This work represents the first highly selective method with a broad scope for C4-coupling of dihalogenated N-heteroarenes such as 2,4-dichloropyridine, 2,4-dichloroquinoline, 3,5-dichloro-4-phenylpyridazine, etc. where selectivity is clearly under ligand control. Under the optimized conditions, diverse substituted 2,4-dichloropyridines and related compounds undergo cross-coupling to form C4-C(sp2) and C4-C(sp3) bonds using organoboron, -zinc, and -magnesium reagents such as p-methoxyphenylboronic acid, cyclopentylmagnesium bromide, benzothiophenylzinc chloride, etc. The synthetic utility of this method is highlighted in multistep syntheses that combine C4-selective cross-coupling with subsequent nucleophilic aromatic substitution reactions. The majority of the products herein (71%) have not been previously reported, emphasizing the ability of this methodol. to open up underexplored chem. space. Remarkably, this work finds that ligand-free “”Jeffery”” conditions enhance the C4 selectivity of Suzuki coupling by an order of magnitude (>99:1). These ligand-free conditions enable the first C5-selective cross-couplings of 2,5-dichloropyridine and 2,5-dichloropyrimidine. In the experimental materials used by the author, we found 2-Bromo-5-methylpyridine(cas: 3510-66-5Safety of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Safety of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 1539-42-0In 2020 ,《Tridentate bis(2-pyridylmethyl)amine iron catalyst for electrocatalytic proton reduction》 appeared in Inorganica Chimica Acta. The author of the article were Schiffman, Zachary R.; Margonis, Caroline M.; Moyer, Allison; Ott, Michelle; McNamara, William R.. The article conveys some information:

For widespread applicability, successful complexes for catalytic hydrogen generation should be inexpensive and easy to synthesize. To this end, a series of tetradentate Fe(III) polypyridyl monophenolate complexes was recently reported that are stable and active electrocatalysts for reducing protons into hydrogen gas. While these complexes were active for hydrogen generation, the ligands were synthesized in moderate to good yield after multiple synthetic steps. Herein the authors report a tridentate iron dipyridyl amine analog for hydrogen generation that was synthesized in a single synthetic step from com. available materials. The resulting complex is an active electrocatalyst operating at -0.95 V vs. SHE (-1.57 V vs. Fc+/Fc) with a TOF = 16 s-1. The complex is also a precatalyst for photocatalytic hydrogen evolution when paired with fluorescein (chromophore) and triethylamine (sacrificial electron source) in a 1:1 ethanol:water mixture After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0HPLC of Formula: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.HPLC of Formula: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 1134-35-6In 2020 ,《Synthesis of the first mixed ligand Mn (II) and Cd (II) complexes of 4-methoxy-pyridine-2-carboxylic acid, molecular docking studies and investigation of their anti-tumor effects in vitro》 appeared in Applied Organometallic Chemistry. The author of the article were Tamer, Oemer; Mahmoody, Hayatullah; Feyzioglu, Kagan Fehmi; Kilinc, Olca; Avci, Davut; Orun, Oya; Dege, Necmi; Atalay, Yusuf. The article conveys some information:

The first mixed ligand Mn(II) and Cd(II) complexes containing 4-methoxy-pyridine-2-carboxylic acid (4-mpic) and 4,4′-dimethyl-2,2′-bipyridine (dmbpy) were synthesized. The geometric structures of [Mn(4-mpic)2(dmbpy)] (complex 1) and [Cd(4-mpic)2(dmbpy)] (complex 2) were determined by single crystal x-ray diffraction method. FTIR and UV-visible spectra were also recorded to study vibrational and electronic properties of complexes 1 and 2. D. functional theory (DFT) calculations were also carried out to provide a deep understanding in geometric, spectroscopic, electronic and nonlinear optical (NLO) properties of complexes 1 and 2. The first-order hyperpolarizability (β) parameter calculated as 332.9736 × 10-30 esu demonstrated that complex 1 is an extremely promising candidate to NLO materials. Natural bond orbital (NBO) anal. not only verified the distorted octahedral geometries of central metal ions, but also found out the high-energy interactions responsible for biol. activities for complexes 1 and 2. Anti-cancer activities of complexes 1 and 2 were tested on human breast carcinoma cell line MCF-7 (ER and PR pos., HER2 neg.) and the triple neg. breast carcinoma cell line MDA-MB 231 (ER, PR and HER2 neg.). Dose-response relation derived from MTT assays indicates that complexes 1 and 2 are showing concentration-dependent effects, which could suggest a potential use for these drug combinations in cancer cell lines. In the experimental materials used by the author, we found 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6HPLC of Formula: 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.HPLC of Formula: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C7H7NOIn 2022 ,《Unique Pseudo-Cross-Conjugated Mesomeric Betaines via an Iodate-Promoted Reaction of 3,3-Difluorocyclopropenes, Pyridines, and Anilines》 appeared in Journal of Organic Chemistry. The author of the article were Nechaev, Ilya V.; Cherkaev, Georgij V.; Sheremetev, Aleksei B.. The article conveys some information:

A simple method for the synthesis of (E)-3-arylimino-3H-indolizin-4-ium-1-olates by an iodate-promoted multicomponent reaction between 3,3-difluorocyclopropenes, pyridines, and anilines was discovered. The reaction products belong to a limited and underexplored class of pseudo-cross-conjugated heterocyclic mesomeric betaines isoconjugated with odd nonalternant hydrocarbon anions, whose properties were studied. Reversible nucleophilic addition at the C5 position was revealed as their main chem. feature, which had an access to novel fully conjugated 1,5-dioxo-3-arylamino-1,5-dihydroindolizine and tetracyclic 4-oxo-4,6-dihydrocyclopenta[4,5]pyrimido[2,1,6-cd]indolizine ring systems in one step. Both the synthesis of betaines and their transformations demonstrate a high level of functional group compatibility, allowing the ready preparation of a number of structurally attractive compounds for materials or medicinal chem. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 128071-75-0In 2018 ,《Nickel-Catalyzed Tandem Knoevenagel Condensation and Intramolecular Direct Arylation: Synthesis of Pyrazolo[5,1-a]-isoquinoline Derivatives》 appeared in Advanced Synthesis & Catalysis. The author of the article were Dhiman, Shiv; Nandwana, Nitesh Kumar; Saini, Hitesh Kumar; Kumar, Dalip; Rangan, Krishnan; Robertson, Katherine N.; Jha, Mukund; Kumar, Anil. The article conveys some information:

A simple and efficient method for the synthesis of pyrazolo[5,1-a]isoquinoline derivatives has been developed using the nickel-catalyzed reaction of 1-aryl-2-(1H-pyrazol-1-yl)ethan-1-ones and 2-bromo aldehydes [e.g., I + 2-bromobenzaldehyde → II (68%) in presence of Ni(acac)2, PCy3 and K2CO3 in DMSO]. The overall transformation involves tandem Knoevenagel condensation and intramol. direct arylation via activation of the C5-H bond of the pyrazole ring. A series of 27 drug-like aroyl-substituted pyrazolo[5,1-a]isoquinolines has been synthesized in moderate to good yields. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Recommanded Product: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 626-05-1In 2020 ,《Pyridine Bridging Diphenylamine-Carbazole with Linking Topology as Rational Hole Transporter for Perovskite Solar Cells Fabrication》 appeared in ACS Applied Materials & Interfaces. The author of the article were Huang, Peng; Manju; Kazim, Samrana; Sivakumar, Gangala; Salado, Manuel; Misra, Rajneesh; Ahmad, Shahzada. The article conveys some information:

Developing cost-effective and rational hole transporting materials is critical for fabricating high-performance perovskite solar cells (PSCs) and to promote their com. endeavor. We have designed and developed pyridine (core) bridging diphenylamine-substituted carbazole (arm) small mols., named as 2,6PyDANCBZ and 3,5PyDANCBZ. The linking topol. of core and arm on their photophys., thermal, semiconducting, and photovoltaic properties were probed systematically. We found that the 2,6PyDANCBZ shows higher mobility and conductivity along with uniform film-forming ability as compared to 3,5PyDANCBZ. The PSCs fabricated with 2,6PyDANCBZ supersede the performance delivered by Spiro-OMeTAD and importantly also gave improved long-term stability. Our findings put forward small mols. based on core-arm linking topol. for cost-effective hole selective layers designing. In the experiment, the researchers used 2,6-Dibromopyridine(cas: 626-05-1Related Products of 626-05-1)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Related Products of 626-05-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2015 ,《Discovery of a High Affinity and Selective Pyridine Analog as a Potential Positron Emission Tomography Imaging Agent for Cannabinoid Type 2 Receptor》 appeared in Journal of Medicinal Chemistry. The author of the article were Slavik, Roger; Grether, Uwe; Muller Herde, Adrienne; Gobbi, Luca; Fingerle, Jurgen; Ullmer, Christoph; Kramer, Stefanie D.; Schibli, Roger; Mu, Linjing; Ametamey, Simon M.. The article conveys some information:

As part of our efforts to develop CB2 PET imaging agents, we investigated 2,5,6-substituted pyridines as a novel class of potential CB2 PET ligands. A total of 21 novel compounds were designed, synthesized, and evaluated for their potency and binding properties toward human and rodent CB1 and CB2. The most promising ligand 6a was radiolabeled with carbon-11 to yield 16 ([11C]RSR-056). Specific binding of 16 to CB2-pos. spleen tissue of rats and mice was demonstrated by in vitro autogadiog. and verified in vivo in PET and biodistribution experiments Furthermore, 16 was evaluated in a lipopolysaccharid (LPS) induced murine model of neuroinflammation. Brain radioactivity was strikingly higher in the LPS-treated mice than the control mice. Compound 16 is a promising radiotracer for imaging CB2 in rodents. It might serve as a tool for the investigation of CB2 receptor expression levels in healthy tissues and different neuroinflammatory disorders in humans. After reading the article, we found that the author used Methyl 5-bromopicolinate(cas: 29682-15-3Category: pyridine-derivatives)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1122-54-9In 2021 ,《Three-Component Reaction of 3,3-Difluorocyclopropenes, s-Tetrazines, and (benzo) Pyridines》 appeared in Journal of Organic Chemistry. The author of the article were Nechaev, Ilya V.; Cherkaev, Georgij V.; Boev, Nikolay V.; Solyev, Pavel N.. The article conveys some information:

A new three-component reaction leading to 1-α-(pyridyl-2-[1,2,4]triazolyl)-2-alkyl-ethanones has been discovered while studying the reactivity of monosubstituted 3,3-difluorocyclopropenes in an inverse electronic demand Diels-Alder (IEDDA) cycloaddition-cycloreversion sequence with s-tetrazines. The reaction involving the above-mentioned reactants and (benzo)pyridine as a third component results in a complex transformation proceeding in mild conditions in a stoichiometric ratio of reactants and has high functional group tolerance (phenols, amides, ethers, carboxylic acids, ketones, and acrylic esters). As a result, simple pyridines are selectively functionalized at the α-position in good isolated yields. The reaction mechanism includes a rare azaphilic [4 + 2]-cycloaddition step between s-tetrazine and intermediate 1-hydroxyindolizine, suggested after byproduct identification and tracked with a deuterium label. To date, it is only the third known example of skewed azaphilic cycloaddition of tetrazine. The reaction is truly three-component and cannot be effectively performed stepwise. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9Application of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Application of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem