Day: October 20, 2022

Recommanded Product: 2-Bromo-5-methylpyridineIn 2019 ,《Transition-Metal-Free Synthesis of Fused Quinazolinones by Oxidative Cyclization of N-Pyridylindoles》 appeared in Journal of Organic Chemistry. The author of the article were Garia, Alankrita; Jain, Nidhi. The article conveys some information:

An unprecedented synthesis of fused quinazolinones from N-pyridylindoles under oxidative conditions using a combination of (diacetoxyiodo)benzene and K2S2O8 is reported. The reaction is metal-free, has a broad substrate scope, is operationally simple with short reaction time, and provides 11H-pyrido[2,1-b]quinazolin-11-one derivatives in moderate to high yields. It is believed to proceed via an in situ generated 2-hydroxy-1-(pyridin-2-yl)indolin-3-one as the key reaction intermediate, which undergoes a C-C bond cleavage to produce an electrophilic C-3 site in N-pyridyl indole. Subsequent nucleophilic attack by pyridyl nitrogen results in its cyclization. The results came from multiple reactions, including the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C12H13N3In 2019 ,《Molecular design for novel sensing materials with self-screening interference effect (SSIE): Reversible recognizing Cu2+ in aqueous and biologic samples》 appeared in Sensors and Actuators, B: Chemical. The author of the article were Zhao, Gang; Song, Fangfang; Wei, Gang; Wu, Rongliang; Yan, Zhengquan; Zhang, Fayin; Guang, Shanyi; Xu, Hongyao. The article conveys some information:

In the work, self-screening interference effect (SSIE) was proposed for sensing trace Cu2+ by simply thermodn. control reactions, using dipyridine as self-screening interference group, rhodamine as mother chromophore and cyanuric chloride as connecting bridge. After its UV-vis and fluorescent spectral properties were optimized in detail, it was noted to find that the present sensing material (RACD) could selectively and reversibly react Cu2+ with obvious colorimetric or fluorescent spectral and color changes from colorless to pink or orange-red. Some other concomitant ions, even trivalent Fe3+ or Al3+, had no interferences on it. Under the optimized conditions, RACD could multiple-mode sense trace Cu2+ in aqueous with a detection limit as low as 11.0 nmol/L. Especially with low toxicity, RACD was successfully applied for quant. monitoring Cu2+ and evaluating its toxicity in living cells and bio-tissues. RACD-functionalized paper-strips were also prepared to visibly recognize Cu2+ more conveniently. The selective action mechanism for RACD to Cu2+ was to form some stable 5-membered and 5-membered condensed rings between Cu2+ and O or N atoms. The experimental process involved the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Synthetic Route of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Synthetic Route of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C12H13N3In 2021 ,《Optimization of signal amplification by reversible exchange for polarization of tridentate chelating bis[(2-pyridyl)alkyl]amine》 was published in Analyst (Cambridge, United Kingdom). The article was written by Min, Sein; Chae, Heelim; Jeong, Hye Jin; Kim, Kiwoong; Namgoong, Sung Keon; Jeong, Keunhong. The article contains the following contents:

Signal amplification by reversible exchange (SABRE) is an effective NMR hyperpolarization technique for signal enhancement using para-hydrogen on iridium catalysts. To date, monodentate chelating nitrogen analogs have been predominantly used as substrates for SABRE because of the limited chelating sites of the Ir-catalyst with different mol. orientations. Herein, for the first time, the use of a tridentate chelating ligand (BPEA) containing pyridine moieties and a secondary amine as a SABRE substrate is demonstrated. For the optimization of the tridentate chelating ligand, alkyl chain lengths were varied with the optimization of the external magnetic field and concentrations of three different ligands. Because many chem. multidentate complexes present in nature have scarcely been studied as SABRE substrates, this optimized tridentate chelating ligand structure with the SABRE catalyst and its polarization transfer from para-hydrogen will broaden the scope of hyperpolarizable substrates and help in the investigation of chelating structures for future applications. The experimental process involved the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Computed Properties of C12H13N3)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Computed Properties of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 98-98-6In 2021 ,《Speciation studies of binary and ternary complexes formed with oxidovanadium(IV) ion picolinic acid and some amino acids》 was published in Physics and Chemistry of Liquids. The article was written by De Abreu, Joel; Del Carpio, Edgar; Madden, Waleska; Lubes, Giuseppe; Araujo, Mary Lorena; Lubes, Vito; Hernandez, Lino. The article contains the following contents:

In the present work the chem. speciation of ternary complexes systems formed by VO2+ ion with picolinic acid and the amino acids = a-alanine (HaAla), glycine (HGly), serine (HSer), threonine (HThr), aspartic acid (H2Asp), glutamic acid (H2Glu), histidine (H2His) and cysteine (H2Cys) has been studied. The anal. involved the use of the potentiometric data with the least-squares program LETAGROP in aqueous solution at 25 oC in 1 M NaCl solution The Hydrolysis products (hydroxylated complexes) of the VO2+ ion and the binary complexes formed in VO2+-amino acids and VO2+-picolinic acid systems in aqueous solution at 25 oC in 1 M NaCl solution were determined and analyzed in this work. In the experiment, the researchers used Picolinic acid(cas: 98-98-6SDS of cas: 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.SDS of cas: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《High Triplet Energy Level Achieved by Tuning the Arrangement of Building Blocks in Phosphorescent Polymer Backbones for Furnishing High Electroluminescent Performances in Both Blue and White Organic Light-Emitting Devices》 was written by Liu, Boao; Dang, Feifan; Tian, Zhuanzhuan; Feng, Zhao; Jin, Deyuan; Dang, Wanping; Yang, Xiaolong; Zhou, Guijiang; Wu, Zhaoxin. Formula: C7H6BrNO2This research focused ontriplet energy phosphorescent polymer blue white organic LED; diode blue white emitting organic phosphorescent polymer triplet energy; electroluminescent device organic blue white phosphorescent polymer triplet energy; OLEDs; charge-carrier injection/transporting; functionalization; high triplet energy level; phosphorescent polymers; polymer backbone. The article conveys some information:

A high triplet energy level (ET) of ∼2.83 eV was achieved in a novel polymer backbone through tuning the arrangement of 2 kinds of building blocks, showing enhanced hole injection/transporting capacity. Based on this new polymer backbone with high ET, both blue and white phosphorescent polymers were developed with a trade-off between high ET and enhanced charge-carrier transporting ability. Their photophys. features, electrochem. behaviors, and electroluminescent (EL) properties were characterized. Benefitting from the advantages associated with the novel polymer backbone, the blue phosphorescent polymers show top-ranking EL performances with a maximum luminance efficiency (ηL) of 15.22 cd A-1, corresponding to a power efficiency (ηP) of 12.64 lm W-1, and external quantum efficiency (ηext) of 6.22% and the stable Commission Internationale de L’Eclairage (CIE) coordinates of (0.19, 0.38). Also, blue-orange (B-O) complementary-colored white phosphorescent polymers based on this novel polymer backbone were also obtained showing encouraging EL efficiencies of 12.34 cd A-1, 9.59 lm W-1, and 4.10% in the optimized WOLED together with exceptionally stable CIE coordinates of (Δx = 0.014, Δy = 0.010) in a wide driving voltage range from 4 to 16 V. All of these attractive EL results achieved by these novel phosphorescent polymers show the great potential of this new polymer backbone in developing highly efficient phosphorescent polymers. The experimental process involved the reaction of Methyl 5-bromopicolinate(cas: 29682-15-3Formula: C7H6BrNO2)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Formula: C7H6BrNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Hydrogen-bond-driven thiouracil dissolution in aqueous ionic liquid: A combined microscopic, spectroscopic and molecular dynamics study》 was written by Sahoo, Dipak Kumar; Chand, Apramita; Jena, Subhrakant; Biswal, Himansu S.. Application In Synthesis of Picolinic acidThis research focused onthiouracil choline picolinate hydrogen bond solubility. The article conveys some information:

Ionic liquids (ILs) over the years, have been maneuvered in aiding the dissolution of poorly soluble drugs, boosting their permeation and delivery to the target areas through the physiol. barrier. Herein, the solubility of a simple anti-carcinogenic and anti-thyroid drug 2-thiouracil (TU), with poor solubility in water as well as common organic solvents was explored by employing a biocompatible IL – Choline picolinate ([Ch][Pic]). With field-emission scanning-electron-microscope, NMR and mol.-dynamics (MD) simulation studies, we unleashed the solubility mechanism and dynamics of TU in water and in aqueous IL solution The solubility of TU in the IL was enhanced by 100 times than that of water. Electron microscopy showed time-dependent nano- and microscale self-organization morphol. during the solvation process. NMR and MD simulation revealed a tug of war between TU and water to interact with IL, and hydrogen bonding is the prominent interaction for the enhanced solubility The present results are encouraging and can be extended to other thio-derivatives of nucleobases that are useful for biochem. and pharmaceutical applications. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Application In Synthesis of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Application In Synthesis of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 4-Amino-2-picolineOn September 23, 2021 ,《Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode》 was published in Journal of Medicinal Chemistry. The article was written by Down, Kenneth; Amour, Augustin; Anderson, Niall A.; Barton, Nick; Campos, Sebastien; Cannons, Edward P.; Clissold, Cole; Convery, Maire A.; Coward, John J.; Doyle, Kevin; Duempelfeld, Birgit; Edwards, Christopher D.; Goldsmith, Michael D.; Krause, Jana; Mallett, David N.; McGonagle, Grant A.; Patel, Vipulkumar K.; Rowedder, James; Rowland, Paul; Sharpe, Andrew; Sriskantharajah, Srividya; Thomas, Daniel A.; Thomson, Douglas W.; Uddin, Sorif; Hamblin, J. Nicole; Hessel, Edith M.. The article contains the following contents:

Optimization of a previously reported lead series of PI3Kδ inhibitors with a novel binding mode led to the identification of a clin. candidate compound 31 (GSK251)(I). Removal of an embedded Ames-pos. heteroaromatic amine by reversing a sulfonamide followed by locating an interaction with Trp760 led to a highly selective compound 9 (II). Further optimization to avoid glutathione trapping, to enhance potency and selectivity, and to optimize an oral pharmacokinetic profile led to the discovery of compound 31 (GSK251) that had a low predicted daily dose (45 mg, b.i.d) and a rat toxicity profile suitable for further development. In the part of experimental materials, we found many familiar compounds, such as 4-Amino-2-picoline(cas: 18437-58-6Recommanded Product: 4-Amino-2-picoline)

4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Recommanded Product: 4-Amino-2-picoline

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C5H5BrN2On March 4, 2020, Biot, Nicolas; Bonifazi, Davide published an article in Chemistry – A European Journal. The article was 《Concurring Chalcogen- and Halogen-Bonding Interactions in Supramolecular Polymers for Crystal Engineering Applications》. The article mentions the following:

The engineering of crystalline mol. solids through the simultaneous combination of distinctive non-covalent interactions is an important field of research, as it could allow chemist to prepare materials depicting multi-responsive properties. It is in this context that, pushed by a will to expand the chem. space of chalcogen-bonding interactions, a concept is put forward for which chalcogen- and halogen-bonding interactions can be used simultaneously to engineer multicomponent co-crystals. Through the rational design of crystallizable mols., chalcogenazolo pyridine scaffold (CGP) modules were prepared that, bearing either a halogen-bond acceptor or donor at the 2-position, can interact with suitable complementary mol. modules undergoing formation of supramol. polymers at the solid state. The recognition reliability of the CGP moiety to form chalcogen-bonded dimers allows the formation of heteromol. supramol. polymers through halogen-bonding interactions, as confirmed by single-crystal X-ray diffraction anal. The results came from multiple reactions, including the reaction of 2-Bromopyridin-3-amine(cas: 39856-58-1Synthetic Route of C5H5BrN2)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Synthetic Route of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridineOn November 1, 2013 ,《Chiral Lewis Acid Catalyzed Asymmetric Cycloadditions of Carbonyl Ylides Generated from Diazoimide Derivatives and Their Synthetic Applications to Indolizidine Alkaloids》 appeared in Journal of Organic Chemistry. The author of the article were Suga, Hiroyuki; Hashimoto, Yuta; Yasumura, Shingo; Takezawa, Ryota; Itoh, Kennosuke; Kakehi, Akikazu. The article conveys some information:

Highly enantioselective 1,3-dipolar cycloaddition reactions, catalyzed by chiral Lewis acids, between several 3-(2-alkenoyl)-2-oxazolidinones I (R = H, Me, Et, n-Pr, iso-Pr, OAc) and carbonyl ylides that were generated from N-diazoacetyl lactams II [X = (CH2)n, n = 1, 2, 3] are described. Reactions of N-diazoacetyl lactams that possess 5-, 6-, and 7-membered rings were transformed to the corresponding epoxy-bridged indolizidines, quinolizidines, and 1-azabicyclo[5.4.0]-undecanes with good to high enantioselectivities. Regio- and stereoselective ring-opening of the epoxy-bridged indolizidine cycloadduct gave the corresponding alc. as a single diastereomer. The sequence of asym. cycloaddition followed by ring-opening was applied to the syntheses of several chiral indolizidine derivatives, including (+)-tashiromine (III).2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7Application In Synthesis of 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine) was used in this study.

2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Application In Synthesis of 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Abe, Aki M. M.; Sauerland, Sami J. K.; Koskinen, Ari M. P. published an article in Journal of Organic Chemistry. The title of the article was 《Highly Enantioselective Conjugate Addition of Thiols Using Mild Scandium Triflate Catalysis》.SDS of cas: 410092-98-7 The author mentioned the following in the article:

A Sc complex of the bis[(4S,5S)-diphenyloxazolinyl]pyridine I, diphenyl-PYBOX, catalyzed the asym. conjugate addition reactions between thiols and 3-crotonoyl-2-oxazolidinone to give the corresponding adducts, e.g. butanoyloxazolidine II, in good yields and high enantioselectivity (up to 92% ee). A new improved method for making (4S,5S)-diphenyl PYBOX was presented. The experimental part of the paper was very detailed, including the reaction process of 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7SDS of cas: 410092-98-7)

2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. SDS of cas: 410092-98-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem