Day: October 20, 2022

In 2019,Journal of Molecular Structure included an article by Ishak, Syarmila; Yeap, Guan-Yeow; Shanmugapriya; Sasidharan, Sreenivasan; Ito, Masato M.. Recommanded Product: 1539-42-0. The article was titled 《Synthesis, molecular structure and cytotoxic studies of fluorene compound with potential anti-cancer properties》. The information in the text is summarized as follows:

A new fluorene derivative, I has been successfully synthesized through condensation reaction of bis(2-pyridylmethyl)amine and 2,7-bis-bromomethyl-9,9-dihexyl-9H-fluorene with exceptionally good yield. The mol. structure of the synthesized compound was well characterized by NMR (NMR), IR (FTIR), UV-vis absorption and fluorescence techniques. The in-vitro anticancer activity of the title compound against human cervical (HeLa) cancer cell line was validated wherein the target mol. exhibits IC50 value of 28.58 μg/mL (37.76 μM). The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemistry – A European Journal included an article by Sinha, Narayan; Champagne, Pier Alexandre; Rodriguez, Michael J.; Lu, Yu; Kopach, Michael E.; Mitchell, David; Organ, Michael G.. Quality Control of 5-Bromo-2-chloropyridine. The article was titled 《One-Pot Sequential Kumada-Tamao-Corriu Couplings of (Hetero)Aryl Polyhalides in the Presence of Grignard-Sensitive Functional Groups Using Pd-PEPPSI-IPentCl》. The information in the text is summarized as follows:

We report a general and rapid chemoselective Kumada-Tamao-Corriu (KTC) cross-coupling of aryl bromides in the presence of chlorides or triflates with functionalized Grignard reagents at 0 °C in 15 min by using Pd-PEPPSI-IPentCl (C4) [e.g., 1-bromo-4-chlorobenzene + (4-cyanophenyl)magnesium bromide → 4′-chlorobiphenyl-4-carbonitrile (91% isolated) in presence of C4 (I)].. Nucleophiles and electrophiles (or both) can contain Grignard-sensitive functional groups (-CN, -COOR, etc.). Control experiments together with DFT calculations suggest that transmetallation is rate limiting for the selective cross-coupling of Br in the presence of Cl/OTf with functionalized Grignard reagents. One-pot sequential KTC/KTC cross-couplings with bromo-chloro arenes have been demonstrated for the first time. We also report the one-pot sequential KTC/Negishi cross-couplings using C4 showcasing the versatility of this methodol.5-Bromo-2-chloropyridine(cas: 53939-30-3Quality Control of 5-Bromo-2-chloropyridine) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Quality Control of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Organic Chemistry included an article by Nakafuku, Kohki M.; Twumasi, Raymond K.; Vanitcha, Avassaya; Wappes, Ethan A.; Namitharan, Kayambu; Bekkaye, Mathieu; Nagib, David A.. Reference of 2-(2-Hydroxyethyl)pyridine. The article was titled 《Development of an Imine Chaperone for Selective C-H Functionalization of Alcohols via Radical Relay》. The information in the text is summarized as follows:

The design of a radical relay chaperone to promote selective C-H functionalizations is described. A saccharin-based imine was found to be uniquely suited to effect C-H amination of alcs. via an in situ generated hemiaminal. This radical chaperone facilitates the mild generation of an N-centered radical while also directing its regioselective H atom transfer (HAT) to the β carbon of an alc. Upon β C-H halogenation, aminocyclization, and reductive cleavage, an NH2 is formally added vicinal to an alc. The development, synthetic utility, and chemo-, regio-, and stereoselectivity of this imine chaperone-mediated C-H amination is presented herein. In the experiment, the researchers used many compounds, for example, 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Reference of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Reference of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Synthesis of fluoroalkylated alkynes via visible-light photocatalysis》 were Iqbal, Naila; Iqbal, Naeem; Han, Sung Su; Cho, Eun Jin. And the article was published in Organic & Biomolecular Chemistry in 2019. Related Products of 94928-86-6 The author mentioned the following in the article:

Fluoroalkylated alkynes R1CCR2 [R1 = Ph, 4-FC6H4, 3-thienyl, 2-pyridyl, etc.; R2 = EtO2CCF2, CF3, n-C4F9, (EtO)2P(O)CF2, etc.], which are versatile building blocks for the synthesis of various biol. active organofluorine compounds, were synthesized from easily available alkynyl halides R1CCX (X = Br, I) and fluoroalkyl halides R2X by visible-light photocatalysis. Addition of fluoroalkyl radicals to alkynes and subsequent dehalogenation selectively yielded fluoroalkylated alkynes. In the experiment, the researchers used many compounds, for example, fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Related Products of 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Ruthenium-catalyzed synthesis of indole derivatives from N-aryl-2-aminopyridines and alpha-carbonyl sulfoxonium ylides》 were Cui, Xin-Feng; Ban, Zi-Hui; Tian, Wa-Fa; Hu, Fang-Peng; Zhou, Xiao-Qiang; Ma, Hao-Jie; Zhan, Zhen-Zhen; Huang, Guo-Sheng. And the article was published in Organic & Biomolecular Chemistry in 2019. Category: pyridine-derivatives The author mentioned the following in the article:

Indole is a ubiquitous structural motif with important applications in many areas of chem. Given this, a simple and efficient Ru(II)-catalyzed synthesis of indoles I (R = Ph, 4-FC6H4, 3-ClC6H4, 2-thienyl, cyclohexyl, etc., R1 = H, 5-Me, 5-MeO, 6-F, 5-Me-6-Cl, etc., R2 = H, 5-Me, 4-Me, 5-Cl, 5-Br) via intermol. annulation of N-aryl-2-aminopyridines and sulfoxonium ylides was proposed and accomplished. Excellent selectivity and good functional group tolerance of this transformation were observed This protocol provides easy access to a wide variety of useful indoles in the presence of a com. available [Ru(p-cymene)Cl2]2 catalyst. A possible mechanism for the reaction pathway was also proposed. More importantly, this reaction will offer a useful method for the construction of enantioenriched indole frameworks. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Category: pyridine-derivatives)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Strategic Approach on N-Oxides in Gold Catalysis – A Case Study》 were Schiessl, Jasmin; Stein, Philipp M.; Stirn, Judith; Emler, Kirsten; Rudolph, Matthias; Rominger, Frank; Hashmi, A. Stephen K.. And the article was published in Advanced Synthesis & Catalysis in 2019. Safety of 2,6-Dibromopyridine The author mentioned the following in the article:

An extensive kinetic study of selected key reactions of (oxidative) gold catalysis concentrates on the decrease of the catalytic activity due to inhibition of the gold(I) catalyst caused by pyridine derivatives that were obtained as byproducts if N-oxides are applied as oxygen donors. The choice of the examined pyridine derivatives and their corresponding N-oxides has been made regardless of their com. availability; particular attention has been paid to the practical benefit which up to now has been neglected in most of the reaction screenings. The test reactions were monitored by GC and 1H NMR spectroscopy. The received reaction constants provide information concerning a correlation between the electronic structure of the heterocycle and the catalytic activity. Based on the collected kinetic data, it was possible to develop a basic set of three N-oxides which have to be taken into account in further oxidative gold(I)-catalyzed reactions. The experimental part of the paper was very detailed, including the reaction process of 2,6-Dibromopyridine(cas: 626-05-1Safety of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Safety of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors》 were Huang, Chao; Xiong, Juan; Guan, Hui-Da; Wang, Chang-Hong; Lei, Xinsheng; Hu, Jin-Feng. And the article was published in Bioorganic & Medicinal Chemistry in 2019. Quality Control of 2-Pyridinylboronic acid The author mentioned the following in the article:

Nonracemic hydroxydihydroisobenzopyranones such as I, analogs of (R)-5-methylmellein, were prepared and tested as inhibitors of monoamine oxidase A (MAO-A). Most of the hydroxydihydrobenzopyranones selectively inhibited MAO-A with IC50 values of 60 nM to 29 μM; I was the most potent and selective analog prepared, with IC50 values of 60 nM for MAO-A and >50 μM for MAO-B. Mol. docking calculations of I in the active sites of MAO-A and MAO-B were performed; the kinetics of inhibition of MAO-A by I were determined In the experimental materials used by the author, we found 2-Pyridinylboronic acid(cas: 197958-29-5Quality Control of 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Quality Control of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Diimidazo[4,5-b:4′,5′-e]pyridine: synthesis and nucleophilic aromatic substitution reaction》 were Razorenov, Dmitriy Yu.; Makulova, Sophia A.; Fedyanin, Ivan V.; Lyssenko, Konstantin A.; Skupov, Kirill M.; Volkova, Yulia A.; Ponomarev, Ivan I.; Ponomarev, Igor I.. And the article was published in Mendeleev Communications in 2019. Synthetic Route of C5H7N3 The author mentioned the following in the article:

The compound 1,7-dihydrodiimidazo[4,5-b:4′,5′-e]pyridine obtained by reductive heterocyclization was N-arylated with 4-fluoronitrobenzene to form two regioisomers I and II in 7 : 3 ratio. This N-arylation is considered as a model reaction for the polymer synthesis. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Synthetic Route of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Synthetic Route of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Screening oxime libraries by means of mass spectrometry (MS) binding assays: Identification of new highly potent inhibitors to optimized inhibitors γ-aminobutyric acid transporter 1》 were Kern, Felix; Wanner, Klaus T.. And the article was published in Bioorganic & Medicinal Chemistry in 2019. Synthetic Route of C6H4BrNO The author mentioned the following in the article:

Generation and screening of oxime libraries by competitive MS Binding Assays represents a powerful tool for the identification of new compounds, with affinity to mGAT1, the most abundant plasma membrane bound GABA transporter in the CNS. By screening a guvacine derived oxime library, new potent inhibitors of mGAT1 had been revealed. Oxime libraries generated by reaction of a large excess of a rac-nipecotic acid derivative displaying a hydroxylamine functionality in which various aldehydes under suitable conditions, were examined for new potent inhibitors of mGAT1. The pKi values obtained of the best hits were compared with those of related compounds displaying a guvacine instead of a nipecotic acid subunit as hydrophilic moiety. Amongst the new compounds one of the most affine ligands of mGAT1 known so far (pKi = 8.55 ± 0.04) was found. The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Synthetic Route of C6H4BrNO)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Synthetic Route of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《(2-Fluoroallyl)boration of Ketones with (2-Fluoroallyl)boronates》 was published in Journal of Organic Chemistry in 2020. These research results belong to Novikov, Maxim A.; Bobrova, Angelina Yu.; Mezentsev, Igor A.; Medvedev, Michael G.; Tomilov, Yury V.. Category: pyridine-derivatives The article mentions the following:

Efficient routes toward activation of gem-chlorofluorocyclopropane-derived (2-fluoroallyl)boronates for allylboration of various ketones including functionalized and low-reactive ones were developed. Increasing the B electrophilicity by the transformation of a boronate moiety into a borinic ester with BuLi/trifluoroacetic anhydride (TFAA) makes (2-fluoroallyl)boration of acetyl arenes/hetarenes and aliphatic ketones possible with high diastereoselectivity. For low-reactive or sterically hindered ketones (e.g., benzophenone, adamantanone), CuF-based catalysts were developed: (NHC)CuF·HF and (NHC)CuOTf in the presence of an excess of KHF2 (NHC = IPr, SIPr, IPrCl). The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9Category: pyridine-derivatives)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem