Day: October 21, 2022

The author of 《A simple approach to indeno-coumarins via visible-light-induced cyclization of aryl alkynoates with diethyl bromomalonate》 were Li, Qingrui; Yin, Yunnian; Li, Yabo; Zhang, Jianye; Huang, Mengmeng; Kim, Jung Keun; Wu, Yangjie. And the article was published in Organic Chemistry Frontiers in 2019. Quality Control of fac-Tris(2-phenylpyridine)iridium The author mentioned the following in the article:

Visible-light-induced triple-domino cyclization between aryl alkynoates R1C6H4OC(O)CCC6H4R2 (R1 = H, 2-Cl, 3-tert-Bu, etc.; R2 = H, 4-Me, 4-Cl, 4-F, 4-OMe) and di-Et bromomalonate was developed for the synthesis of indeno-coumarins I (R3 = H, 1-Cl, 4-tert-Bu, 2-tert-Bu, etc.; R4 = H, 9-Me, 9-F, 9-Cl, 9-MeO). This one-pot method substantially simplified the production process for indeno-coumarins I and a series of indeno-coumarins could be isolated in moderate to high yields. It was found that the obtained indeno-coumarins I could be used as addnl. photosensitizers to initiate this transformation. A possible radical mechanism accompanying the processes of electron transfer and energy transfer is proposed based on the results of ESI-MS anal., cyclic voltammetry, Stern-Volmer quenching experiments and control experiments The photoluminescence properties (emission spectra and quantum yields) of the obtained indeno-coumarins I were investigated.fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Quality Control of fac-Tris(2-phenylpyridine)iridium) was used in this study.

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Quality Control of fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Phosphate and polyphosphate anion recognition by a dinuclear copper(II) complex of an unsymmetrical squaramide》 were Esteves, Catarina V.; Costa, Judite; Esteban-Gomez, David; Lamosa, Pedro; Bernard, Helene; Platas-Iglesias, Carlos; Tripier, Raphael; Delgado, Rita. And the article was published in Dalton Transactions in 2019. Safety of Bis(pyridin-2-ylmethyl)amine The author mentioned the following in the article:

In the search for receptors suitable for the recognition of phosphate or polyphosphate anions, a new unsym. squaramide-based ligand bearing dipicolylamine (dpa) and ethylpiperazine units (L) (I) was designed and prepared The acid-base reactions of L, its copper(II) complexation behavior and the binding of phosphate and polyphosphate anions by the copper(II) complexes used as receptors were evaluated. 1H and 13C NMR titrations of L performed in D2O allowed the determination of its protonation sequence. The ligand L is able to coordinate two copper(II) cations forming thermodynamically stable dinuclear complexes likely having two water mols. bound to each metal center, as supported by DFT calculations Coordinated water mols. can be replaced by the O-donors of the phosphate/polyphosphate anions. The potentiometric studies showed that at 2 : 1 Cu2+ : L ratio the dinuclear [Cu2LH-1]3+ species predominates from pH ∼ 5 to ∼7, and hydroxodinuclear species prevail at pH > 7. 1H NMR experiments in both H2O/D2O 9 : 1 volume/volume and in DMSO proved that copper(II) coordination provokes deprotonation of the squaramide NH bound to the ethylpiperazine moiety, resulting in [Cu2LH-1]3+ species. The dicopper(II) complexes of L, [Cu2LH-i]4-i, were used as the receptor for the uptake of some phosphate and polyphosphate anions. The receptor presents very high association constants with HPPi3- and ATP4- and the determined Keff showed that at physiol. pH ATP4- is selectively taken from an aqueous solution containing phenylphosphate (PhPO42-), aminoethylphosphate (Haep-), AMP2- and ADP3-, but HPPi3- strongly interferes. DFT calculations suggest that the strong interaction with HPPi3- and ATP4- is related to the simultaneous coordination of the polyphosphate unit to the two copper(II) centers. In the experimental materials used by the author, we found Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Safety of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Safety of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Discovery of a Dual Tubulin Polymerization and Cell Division Cycle 20 Homologue Inhibitor via Structural Modification on Apcin》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Huang, Pan; Le, Xiangyang; Huang, Fei; Yang, Jie; Yang, Haofeng; Ma, Junlong; Hu, Gaoyun; Li, Qianbin; Chen, Zhuo. Category: pyridine-derivatives The article mentions the following:

Apcin is one of the few compounds that have been previously reported as a Cdc20 specific inhibitor, although Cdc20 is a very promising drug target. We reported here the design, synthesis, and biol. evaluations of 2,2,2-trichloro-1-aryl carbamate derivatives as Cdc20 inhibitors. Among these derivatives, compound 9f(I) was much more efficient than the pos. compound apcin in inhibiting cancer cell growth, but it had approx. the same binding affinity with apcin in SPR assays. It is possible that another mechanism of action might exist. Further evidence demonstrated that compound 9f also inhibited tubulin polymerization, disorganized the microtubule network, and blocked the cell cycle at the M phase with changes in the expression of cyclins. Thus, it induced apoptosis through the activation of caspase-3 and PARP. In addition, compound 9f inhibited cell migration and invasion in a concentration-dependent manner. These results provide guidance for developing the current series as potential new anticancer therapeutics. The experimental part of the paper was very detailed, including the reaction process of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Category: pyridine-derivatives)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《AIBN for Ru-catalyzed meta-CAr-H alkylation》 was published in Organic Chemistry Frontiers in 2020. These research results belong to Yang, Suling; Yan, Bingxu; Zhong, Lei; Jia, Chunqi; Yao, Dan; Yang, Chunli; Sun, Kai; Li, Gang. Reference of 2-Bromo-5-methylpyridine The article mentions the following:

The meta-CAr-H alkylation of arenes with radicals produced from AIBN in the presence of a RuCl3 catalyst was presented. This development not only confirmed that ruthenium-catalyzed meta-CAr-H bond functionalization was a radical process, but also provided an efficient and practical strategy for the preparation of aromatic compounds containing a nitrile group, which were prevalent in a diverse range of biol. active mols. and other functional materials. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Reference of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Reference of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Redox-neutral photocatalytic radical cascade cyclization for the synthesis of CH2CN/CF2COOEt/CF3 containing benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-one derivatives》 was published in Journal of Organic Chemistry in 2020. These research results belong to Liu, Liang; Yang, De-Yong; He, Yan-Hong; Guan, Zhi. Application of 94928-86-6 The article mentions the following:

A novel method for the synthesis of benzo[4,5]imidazo[2,1-a]isoquinoline derivatives I (R = CH2CN, CF3, CF2COOEt; R1 = H, 9,10-diMe; R2 = H, 3-Me, 3-Cl, etc.) via visible-light-induced radical cascade cyclization is described. By using N-methacryloyl-2-phenylbenzimidazoles and diverse radical precursors, various benzo[4,5]imidazo[2,1-a]isoquinoline derivatives containing CH2CN/CF2COOEt/CF3 can be formed in good to excellent yields under mild reaction conditions. The method exhibits good functional group tolerance and a wide range of substrate scope.fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Application of 94928-86-6) was used in this study.

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application of 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Mechanistic Study on a BINOL-Coumarin-Based Probe for Enantioselective Fluorescent Recognition of Amino Acids》 was published in Journal of Organic Chemistry in 2020. These research results belong to Wu, Xuedan; Wang, Qin; Dickie, Diane; Pu, Lin. HPLC of Formula: 31106-82-8 The article mentions the following:

A detailed investigation was conducted on the reaction of a 1,1′-bi-2-naphthol-coumarin-based fluorescent probe with amino acids. On the basis of the studies, including fluorescence spectroscopy, 1H NMR, UV-vis, mass spectroscopy, single-crystal X-ray anal., and mol. modeling, it was found that the distinctively different fluorescent responses of the probe toward the amino acid at the two excitation wavelengths are due to two different reaction pathways that generate different intermediates and products. In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8HPLC of Formula: 31106-82-8) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.HPLC of Formula: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis, characterization and SAR studies of bis(imino)pyridines as antioxidants, acetylcholinesterase inhibitors and antimicrobial agents》 was published in Bioorganic Chemistry in 2020. These research results belong to Milosevic, Milena D.; Marinkovic, Aleksandar D.; Petrovic, Predrag; Klaus, Anita; Nikolic, Milica G.; Prlainovic, Nevena Z.; Cvijetic, Ilija N.. Application of 141-86-6 The article mentions the following:

A series of sixteen bis(imino)pyridines (BIPs) I [R = Ph, 2-quinolyl, 1-naphthyl, etc.] was synthesized starting from 2,6-diaminopyridine and aromatic aldehydes, and evaluated for their antioxidant, antibacterial, antifungal and acetylcholinesterase (AChE) inhibitory activities. The formation of stable, carbon-centered radical cations in a solution was confirmed by ESR spectroscopy and DFT calculations The in vitro antioxidant potency was evaluated using four assays: free radical scavenging activity (DPPH and ABTS), reducing power and total antioxidant capacity assay. BIPs demonstrated excellent antioxidant properties, and two derivatives proved to be more potent than reference antioxidants (ascorbic acid and Trolox) in all assays. DFT calculations on ωB97XD/6-311++g(d,p) level of theory provided valuable insights into the radical scavenging mechanism of BIPs. For hydroxyl-substituted BIPs, hydrogen atom transfer (HAT) was a predominant mechanism, while the single electron transfer coupled with proton transfer (SET-PT) governed the antioxidant activity of other derivatives Intramol. hydrogen bonding (IHB) played an important role in the mechanism of antioxidant activity as revealed by noncovalent interaction anal. and rotational barrier calculations The spin d. of radical cations was localized on carbon atoms of a pyridine ring, which corroborated with g-factors and multiplicity obtained from ESR anal. The most potent compound I [R = 2-pyridyl] exhibited moderate inhibitory activity toward AChE (IC50 = 20 ± 4μM), while mol. docking suggested binding at the peripheral anionic site of AChE with the MMFF94 binding enthalpy of -43.4 kcal/mol. Moderate in vitro antimicrobial activity of BIPs had been determined against several pathogenic bacterial strains: Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus and clin. isolate of methicillin resistant S. aureus (MRSA). The antifungal activity of BIPs toward Candida albicans was also confirmed. The similarity ensemble approach combined with mol. docking suggested leucyl aminopeptidase as the probable antimicrobial target for the three most potent BIP derivatives I [R = 2-HOC6H4, 8-OH-2-quinolyl, 2-pyridyl]. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Application of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Ynamide-Mediated Intermolecular Esterification》 was written by Wang, Xuewei; Yang, Yang; Zhao, Yongli; Wang, Sheng; Hu, Wenchang; Li, Jinmei; Wang, Zihao; Yang, Fengling; Zhao, Junfeng. Quality Control of 2-(2-Hydroxyethyl)pyridine And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

An ynamide-mediated one-pot, two-step intermol. esterification via the condensation of carboxylic acids with nucleophilic hydroxyl species is reported. A broad substrate scope with respect to carboxylic acids, alcs., and phenols is observed The α-acyloxyenamide intermediates formed by the addition of carboxylic acids to ynamides proved to be effective acylating reagents for the esterification of alc. and phenol derivatives with the assistance of base catalysis. Notably, the racemization of the α-chiral center of carboxylic acids can be avoided. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Quality Control of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shen, Jiaxuan; Zhang, Yipin; Yu, Yanjiang; Wang, Manman published their research in Organic Chemistry Frontiers in 2021. The article was titled 《Metal-free visible-light-induced photoredox-catalyzed intermolecular pyridylation/phosphinoylation of alkenes》.Quality Control of 4-Cyanopyridine The article contains the following contents:

Reported here is an intermol. pyridylation/phosphinoylation of alkenes using 4-cyanopyridine and diphenylphosphine oxide under visible-light-induced organic photoredox catalysis. The reaction occurs under mild metal-free conditions, possessing a broad substrate scope. The protocol can be practiced on a gram scale and applied to the modification of natural product-derived and medicinally relevant complex mols. containing a styrene unit. Mechanistic investigations suggest that triethylamine serves as both single-electron transfer (SET) and hydrogen atom transfer (HAT) agents. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanopyridine(cas: 100-48-1Quality Control of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Quality Control of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Konovalova, Irina S.; Muzyka, Ekaterina N.; Urzhuntseva, Victoriya V.; Shishkina, Svitlana V. published their research in Structural Chemistry in 2021. The article was titled 《Role of intermolecular interactions in formation of mono- and diaminopyridine crystals: study from the energetic viewpoint》.Computed Properties of C5H7N3 The article contains the following contents:

Abstract: The regularities of crystal structure organization in a series of mono- and diaminopyridines possessing biol. activities were studied using an approach based on comparison of interaction energies between mols. calculated by ab initio quantum chem. method. The presence of the pyridine nitrogen atom causes the formation of N-H…Npyr hydrogen bond which is the strongest in all the studied structures. Being amphiphilic in hydrogen bond formation, the amino group possesses acceptor properties only in meta-position to the pyridine nitrogen atom in mono-aminopyridines. The presence of the two amino groups results in increasing of acceptor properties of both ones. The N-H… Nlp hydrogen bonds bind primary BSM (basic structural motif) in the structures of 2,5-diaminopyridine, 2,4-diaminopyridine and 3,4-diamonpyridine and form the primary BSM alongside with N-H…Npyr hydrogen bond in the structure of 2,3-diaminopyridine. The helical primary basic structural motif and double helical secondary basic structural motif in the 2,3-diaminopyridine crystal structure are very similar to the DNA helix and double helix. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Computed Properties of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Computed Properties of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem