Day: October 21, 2022

Morales-Colon, Maria T.; See, Yi Yang; Lee, So Jeong; Scott, Peter J. H.; Bland, Douglas C.; Sanford, Melanie S. published their research in Organic Letters in 2021. The article was titled 《Tetramethylammonium Fluoride Alcohol Adducts for SNAr Fluorination》.Recommanded Product: 53939-30-3 The article contains the following contents:

Nucleophilic aromatic fluorination (SNAr) is among the most common methods for the formation of C(sp2)-F bonds. Despite many recent advances, a long-standing limitation of these transformations was the requirement for rigorously dry, aprotic conditions to maintain the nucleophilicity of fluoride and suppress the generation of side products. This report addresses this challenge by leveraging tetramethylammonium fluoride alc. adducts (Me4NF·ROH) as fluoride sources for SNAr fluorination. Through systematic tuning of the alc. substituent (R), tetramethylammonium fluoride tert-amyl alc. (Me4NF·t-AmylOH) was identified as an inexpensive, practical, and bench-stable reagent for SNAr fluorination under mild and convenient conditions (80°C in DMSO, without the requirement for drying of reagents or solvent). A substrate scope of more than 50 (hetero) aryl halides and nitroarene electrophiles was demonstrated. The experimental part of the paper was very detailed, including the reaction process of 5-Bromo-2-chloropyridine(cas: 53939-30-3Recommanded Product: 53939-30-3)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Recommanded Product: 53939-30-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Appa, Rama Moorthy; Lakshmidevi, Jangam; Naidu, Bandameeda Ramesh; Venkateswarlu, Katta published their research in Molecular Catalysis in 2021. The article was titled 《Pd-catalyzed oxidative homocoupling of arylboronic acids in WEPA: A sustainable access to symmetrical biaryls under added base and ligand-free ambient conditions》.Safety of 2-Pyridinylboronic acid The article contains the following contents:

A quick and eco-friendly protocol for the synthesis of biaryls, e.g., I by an oxidative (aerobic) homocoupling of arylboronic acids RB(OH)2 (R = C6H5, pyridin-2-yl, 2-thienyl, etc.) using Pd(OAc)2 in water extract of pomogranate ash (WEPA) as an efficient agro-waste(bio)-derived aqueous (basic) media is described. The reactions were executed at ambient aerobic conditions in the absence of external base and ligand to result sym. biaryls in excellent yields. The use of renewable media with an effective exploitation of waste, short reaction times, excellent yields of products, easy separation of the products, unnecessating the external base, oxidant, ligand or volatile organic solvents and ambient reaction conditions are the vital insights of the present protocol.2-Pyridinylboronic acid(cas: 197958-29-5Safety of 2-Pyridinylboronic acid) was used in this study.

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Safety of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bhattacharyya, Arnab; Jameei, Aida; Saha, Rupak; Garai, Aditya; Karande, Anjali A.; Chakravarty, Akhil R. published their research in Dalton Transactions in 2021. The article was titled 《BODIPY-linked cis-dichlorido zinc(II) conjugates: the strategic design of organelle-specific next-generation theranostic photosensitizers》.Recommanded Product: 1539-42-0 The article contains the following contents:

Dipicolylamine (dpa) based cis-dichlorido zinc(II) complexes [Zn(L1-3)Cl2] (1-3), where L2 and L3 are non-iodo and di-iodo BODIPY-appended dpa in 2 and 3, and L1 is dpa in control complex 1, were prepared and characterized and their photocytotoxicity was studied. Complexes 2 and 3 were developed as potential substitutes for zinc(II)-porphyrins/phthalocyanines that are photodynamic therapeutic agents with moderate activity owing to their inherent hydrophobicity and aggregation-induced deactivation mechanism. In authors approach, they strategically designed hybrid inorganic-organic zinc-BODIPY conjugates as theranostic photosensitizers. The structurally characterized diamagnetic Zn(II) cis-dichlorido complexes mimic cisplatin and serve as new-generation photosensitizers with enhanced aqueous solubility and mito-DNA targeting propensity while imparting significant physiol. stability to the heavy atom tethered BODIPY ligand, L3. The BODIPY complexes showed a visible band near 500 nm (ε ~34 000-44 000 dm3 mol-1 cm-1) and an emission band at 507 nm for 2 in 1% DMSO-Dulbecco’s phosphate buffered saline. The labile chlorido ligands (ΛM ~200 S m2 mol-1 in 9 : 1 H2O-DMSO) generated pos. charged complexes inside the cellular medium enabling them to cross the mitochondrial membrane for this organelle-selective localization and singlet oxygen-mediated apoptotic photocytotoxicity at nanomolar concentrations for 3 in HeLa and MCF-7 cells in light (400-700 nm), while being less active in the dark.Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sidharaj, N.; Rajarajan, G.; Senthil, M. published their research in Materials Today: Proceedings in 2021. The article was titled 《Synthesis, characterization and Ion-exchange properties of 4, 4 oxy-dianiline, 2,6 diamino-pyridine with formaldehyde terpolymer》.Product Details of 141-86-6 The article contains the following contents:

A new terpolymer ligand (DAPR) was synthesized based on condensation polymerization techniques. DAPR was named by 4,4 oxy-dianiline and 2,6 diamino-pyridine with formaldehyde. The taken monomers mole ratio is 1:1:2 in the reaction medium of DMF. The solubility behavior of the terpolymer samples have been studied in various solvents. The prepared terpolymer ligand was characterized by elemental anal., FTIR, 1H & 13C NMR and TGA studies. The synthesized terpolymer ligand mol. formula identified by elemental anal. and the most probable structure confirmed by the spectral studies of FTIR, 1H & 13C NMR. The SEM image used to establish the outward of the ligand. The thermal decomposition and thermal strength of DAPR ligand was carried out by thermo gravimetric anal. (TG-DTA). The chelation ion exchange studies of the terpolymer for the definite metal ions were also carried out by batch equipoise way under the estimation of metal ion uptake at diverse electrolytes. The experimental process involved the reaction of 2,6-Diaminopyridine(cas: 141-86-6Product Details of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Product Details of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Feuerstein, Wolfram; Breher, Frank published an article in 2021. The article was titled 《Non-palindromic (C^C^D) gold(III) pincer complexes are not accessible by intramolecular oxidative addition of biphenylenes – an experimental and quantum chemical study》, and you may find the article in Dalton Transactions.Quality Control of 2-(Bromomethyl)pyridine hydrobromide The information in the text is summarized as follows:

Gold(I) complexes [(ArL)AuCl], [(ArL)Au(IPr)][SbF6] and [(Ar-NHC)2Au][SbF6] [ArL = 1-biphenylylmethylphosphine, 2-(1-biphenylyl)pyridine; IPr = 1,3-bis(2,6-diisopropylphenyl)-2-imidazolylidene; Ar-NHC = 1-(1-biphenylyl)-3-ethyl-2-imidazolylidene] were prepared by reaction of gold(I) precursors with donor-substituted biphenylenes. The oxidative addition of donor-substituted biphenylenes with gold(I) precursors to give gold(III) pincer CCD complexes was not observed unlike the known additions of unsubstituted biphenylenes; the reasons of this behavior are evaluated by DFT calculations We herein report on the synthesis of biphenylenes substituted with a pyridine (N), a phosphine (P) and a carbene (C’) donor as well as a carbene donor with addnl. pyridine in the lateral position. We describe the synthesis and structures of derived gold(I) complexes, which we tried to use for the synthesis of non-palindromic [(C-C-D)AuIII] pincer complexes by means of an intramol. oxidative addition of the strained biphenylene ring. However, the anticipated formation of gold(III) complexes failed due to kinetic and thermodn. reasons, which we extensively investigated by quantum chem. calculations Furthermore, we shed light on the oxidative addition of biphenylene to two different gold(I) systems reported in the literature. Our comprehensive quantum-chem. anal. is complemented by NMR experiments The results came from multiple reactions, including the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Quality Control of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Larsen, Christian; Lundberg, Petter; Tang, Shi; Rafols-Ribe, Joan; Sandstroem, Andreas; Mattias Lindh, E.; Wang, Jia; Edman, Ludvig published an article in 2021. The article was titled 《A tool for identifying green solvents for printed electronics》, and you may find the article in Nature Communications.Reference of fac-Tris(2-phenylpyridine)iridium The information in the text is summarized as follows:

The emerging field of printed electronics uses large amounts of printing and coating solvents during fabrication, which commonly are deposited and evaporated within spaces available to workers. It is in this context unfortunate that many of the currently employed solvents are non-desirable from health, safety, or environmental perspectives. Here, we address this issue through the development of a tool for the straightforward identification of functional and “”green”” replacement solvents. In short, the tool organizes a large set of solvents according to their Hansen solubility parameters, ink properties, and sustainability descriptors, and through systematic iteration delivers suggestions for green alternative solvents with similar dissolution capacity as the current non-sustainable solvent. We exemplify the merit of the tool in a case study on a multi-solute ink for high-performance light-emitting electrochem. cells, where a non-desired solvent was successfully replaced by two benign alternatives. The green-solvent selection tool is freely available at: www.opeg-umu.se/green-solvent-tool. In the part of experimental materials, we found many familiar compounds, such as fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Reference of fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cammack, Claudina X.; Pratt, Harry D.; Small, Leo J.; Anderson, Travis M. published an article in 2021. The article was titled 《A higher voltage Fe(II) bipyridine complex for non-aqueous redox flow batteries》, and you may find the article in Dalton Transactions.Related Products of 1134-35-6 The information in the text is summarized as follows:

Non-aqueous redox flow batteries (RFBs) offer the possibility of higher voltage and a wider working temperature range than their aqueous counterpart. Here, we optimize the established 2.26 V Fe(bpy)3(BF4)2/Ni(bpy)3(BF4)2 asym. RFB to lessen capacity fade and improve energy efficiency over 20 cycles. We also prepared a family of substituted Fe(bpyR)3(BF4)2 complexes (R = -CF3, -CO2Me, -Br, -H, -tBu, -Me, -OMe, -NH2) to potentially achieve a higher voltage RFB by systematically tuning the redox potential of Fe(bpyR)3(BF4)2, from 0.94 V vs. Ag/AgCl for R = OMe to 1.65 V vs. Ag/AgCl for R = CF3 (ΔV = 0.7 V). A series of electronically diverse sym. and asym. RFBs were compared and contrasted to study electroactive species stability and efficiency, in which the unsubstituted Fe(bpy)3(BF4)2 exhibited the highest stability as a catholyte in both sym. and asym. cells with voltage and coulombic efficiencies of 94.0% and 96.5%, and 90.7% and 80.7%, resp. The results came from multiple reactions, including the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Related Products of 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Related Products of 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Salomon, Fernando F.; Vega, Nadia C.; Jurado, Jose Piers; Moran Vieyra, Faustino E.; Tirado, Monica; Comedi, David; Campoy-Quiles, Mariano; Cattaneo, Mauricio; Katz, Nestor E. published an article in 2021. The article was titled 《Heteroleptic Ruthenium(II) Complexes with 2,2′-Bipyridines Having Carbonitriles as Anchoring Groups for ZnO Surfaces: Syntheses, Physicochemical Properties, and Applications in Organic Solar Cells》, and you may find the article in Inorganic Chemistry.Related Products of 1134-35-6 The information in the text is summarized as follows:

Heteroleptic ruthenium (II) complexes were used for sensitizing ZnO surfaces in organic solar cells (OSCs) as mediators with photoactive layers. The complexes [Ru(4,4′-X2-bpy)(Mebpy-CN)2]2+ (with X = -CH3, -OCH3 and -N(CH3)2; bpy = 2,2′-bipyridine; Mebpy-CN = 4-methyl-2,2′-bipyridine-4′-carbonitrile) were synthesized and studied by anal. and spectroscopical techniques. Spectroscopic, photophys., and electrochem. properties were tuned by changing the electron-donating ability of the -X substituents at the 4,4′-positions of the bpy ring and rationalized by quantum mech. calculations These complexes were attached through nitrile groups to ZnO as interfacial layer in an OSC device with a PBDB-T:ITIC photoactive layer. This modified inorganic electron transport layer generates enhancement in photoconversion of the solar cells, reaching up to a 23% increase with respect to the unsensitized OSCs. The introduction of these dyes suppresses some degradative reactions of the nonfullerene acceptor due to the photocatalytic activity of zinc oxide, which was maintained stable for about 11 mo. Improving OSC efficiencies and stabilities can thus be achieved by a judicious combination of new inorganic and organic materials. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Related Products of 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Related Products of 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kumar, Ravi; Rawal, Parveen; Banerjee, Indrani; Pada Nayek, Hari; Gupta, Puneet; Panda, Tarun K. published an article in 2022. The article was titled 《Catalytic Hydroboration and Reductive Amination of Carbonyl Compounds by HBpin using a Zinc Promoter》, and you may find the article in Chemistry – An Asian Journal.Computed Properties of C7H7NO The information in the text is summarized as follows:

The chemoselective hydroboration of aldehydes and ketones, catalyzed by Zinc(II) complexes [κ2-(PyCH:NR)ZnX2] (1, R = CPh3, X = Cl; 2, R = 2,6-iPr2C6H3, X = I), by pinacolborane (HBpin) at ambient temperature and under solvent-free conditions, which produced the corresponding borate esters in high yield, is reported. Zinc metal complexes 1 and 2 were derived in 80-90% yield from the reaction of iminopyridine [PyCH:NR] with anhydrous zinc dichloride in dichloromethane at room temperature The solid-state structures of both zinc complexes were confirmed using X-ray crystallog. Zinc complex 1 was also used as a competent pre-catalyst in the reductive amination of carbonyl compounds with HBpin under mild and solvent-free conditions to afford a high yield (up to 97%) of the corresponding secondary amines. The wider substrate scope of both reactions was explored. Catalytic protocols using zinc as a pre-catalyst demonstrated an atom-economic and green method with diverse substrates bearing excellent functional group tolerance. Computational studies established a plausible mechanism for catalytic hydroboration. In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ju, Han; Hou, Lingxin; Zhao, Fabao; Zhang, Ying; Jia, Ruifang; Guizzo, Laura; Bonomini, Anna; Zhang, Jiwei; Gao, Zhen; Liang, Ruipeng; Bertagnin, Chiara; Kong, Xiujie; Ma, Xiuli; Kang, Dongwei; Loregian, Arianna; Huang, Bing; Liu, Xinyong; Zhan, Peng published an article in 2022. The article was titled 《Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity》, and you may find the article in Journal of Medicinal Chemistry.Recommanded Product: 197958-29-5 The information in the text is summarized as follows:

With our continuous endeavors in seeking neuraminidase (NA) inhibitors, we reported herein three series of novel oseltamivir amino derivatives with the goal of exploring the druggable chem. space inside the 150-cavity of influenza virus NAs. Among them, around half of the compounds in series C were demonstrated to be better inhibitors against both wild-type and oseltamivir-resistant group-1 NAs than oseltamivir carboxylate (OSC). Notably, compounds 12d, 12e, 15e, and 15i showed more potent or equipotent antiviral activity against H1N1, H5N1, and H5N8 viruses compared to OSC in cellular assays. Furthermore, compounds 12e and 15e exhibited high metabolic stability in human liver microsomes (HLMs) and low inhibitory effect on main cytochrome P 450 (CYP) enzymes, as well as low acute/subacute toxicity and certain antiviral efficacy in vivo. Also, pharmacokinetic (PK) and mol. docking studies were performed. Overall, 12e (I) and 15e (II) possess great potential to serve as anti-influenza candidates and are worthy of further investigation. In the experiment, the researchers used many compounds, for example, 2-Pyridinylboronic acid(cas: 197958-29-5Recommanded Product: 197958-29-5)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Recommanded Product: 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem