Day: October 21, 2022

Li, Bin; Xu, Zhi-Qiang; Xu, Ying-Bo; Yong, Guo-Ping published the artcile< Effects of substituent groups on the crystal structures and luminescence properties of zero-/two-dimensional Zn(II) complexes>, Electric Literature of 350-03-8, the main research area is crystal structure zinc imidazopyridine polymeric monomeric preparation luminescence.

The 3-position substituted imidazo[1,2-a]pyridine ligands C7H4N2Cl-2-(CH:CHC(:O)R)-3 (L1, R = 3-pyridinyl) and (HL2, R = COOH) were facilely synthesized, and used for construction of two novel luminescent Zn(II) complexes, [ZnCl2(L1)2] (1) and [Zn(L2)2]n (2). Single-crystal x-ray diffraction anal. shows that 1 has a zero-dimensional structure, whereas, 2 possesses a two-dimensional polymeric network with rhombic grid motifs. The structural differences between 1 and 2 should be determined by the different substituent groups adjacent to the carbonyl groups of the 3-position substituted imidazo[1,2-a]pyridine ligands. Complex 1 reveals a red shifted emission band, compared to free L1 ligand, whereas, 2 displays a similar emission spectrum as the free HL2 ligand. Such results are also ascribed to substituent group effects and corresponding structural differences.

Inorganic Chemistry Communications published new progress about Crystal structure. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Electric Literature of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stavber, Stojan; Zupan, Marko published the artcile< Reactions of cesium fluoroxysulfate with pyridine>, Name: 3-Chloro-2-methoxypyridine, the main research area is pyridine fluorination cesium fluoroxysulfate solvent effect.

Pyridine readily reacts with CsSO4F in various solvents at room temperature producing a mixture of up to three products (2-fluoropyridine, 2-pyridyl fluorosulfonate and 2-chloro or 2-alkoxypyridine), their distribution strongly depending on the solvent used. Reaction of 3-chloropyridine with CsSO4F in methanol leads regioselectively to 2-methoxy-3-chloropyridine, while 3-methylpyridine was converted into 2-methoxy-3-Me and 2-methoxy-5-methylpyridine in a 2:1 relative ratio.

Tetrahedron Letters published new progress about Fluorination. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Name: 3-Chloro-2-methoxypyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Qin; Lei, Xiaoli; Yin, Zhijian; Deng, Zhihong; Peng, Yiyuan published the artcile< Copper-Catalyzed NaBAr4-Based N-Arylation of Amines>, Synthetic Route of 22961-45-1, the main research area is arylamine preparation; amine tetraaryl borate Cham Lam cross coupling copper catalyst.

NaBAr4 Based Cham-Lam cross-coupling of amines for the synthesis of arylamines RNHAr [R = n-Bu, Ph, benzyl, etc.; Ar = Ph, 4-MeC6H4, 4-ClC6H4, etc.] in the presence of catalytic copper (II) acetate monohydrate in acetonitrile at room temperature under air was described. In particular, the reaction of alkylamine and NaBAr4 proceeded smoothly to offered the corresponding products in good to excellent yields.

Synthesis published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22961-45-1 belongs to class pyridine-derivatives, and the molecular formula is C11H10N2, Synthetic Route of 22961-45-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Ze; Li, Wenwei; Lu, Maolin; Bess, Julian Jr; Chao, Cara W.; Gorman, Jason; Terry, Daniel S.; Zhang, Baoshan; Zhou, Tongqing; Blanchard, Scott C.; Kwong, Peter D.; Lifson, Jeffrey D.; Mothes, Walther; Liu, Jun published the artcile< Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is .

Abstract: The HIV-1 envelope glycoprotein (Env) trimer, composed of gp120 and gp41 subunits, mediates viral entry into cells. Recombinant Env trimers have been studied structurally, but characterization of Env embedded in intact virus membranes has been limited to low resolution Here, we deploy cryo-electron tomog. and subtomogram averaging to determine the structures of Env trimers on aldrithiol-2 (AT-2)-inactivated virions in ligand-free, antibody-bound and CD4-bound forms at subnanometer resolution Tomog. reconstructions document mol. features consistent with high-resolution structures of engineered soluble and detergent-solubilized Env trimers. One of three conformational states previously predicted by smFRET was not observed by cryo-ET, potentially owing to AT-2 inactivation. We did observe Env trimers to open in situ in response to CD4 binding, with an outward movement of gp120-variable loops and an extension of a critical gp41 helix. Overall features of Env trimer embedded in AT-2-treated virions appear well-represented by current engineered trimers.

Nature Structural & Molecular Biology published new progress about 2127-03-9. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sahani, Rajkumar Lalji; Diana-Rivero, Raquel; Vernekar, Sanjeev Kumar V.; Wang, Lei; Du, Haijuan; Zhang, Huanchun; Castaner, Andres Emanuelli; Casey, Mary C.; Kirby, Karen A.; Tedbury, Philip R.; Xie, Jiashu; Sarafianos, Stefan G.; Wang, Zhengqiang published the artcile< Design, synthesis and characterization of HIV-1 CA-targeting small molecules: conformational restriction of PF74>, Computed Properties of 53636-56-9, the main research area is indolyl pyridyl amide preparation antiviral SAR cytotoxicity mol docking; imidazolyl indolyl amide preparation antiviral SAR cytotoxicity mol docking; HIV-1; PF74; capsid protein; conformational constraint; metabolic stability.

Designed and synthesized three series of PF74-like analogs featuring conformational constraints at the aniline terminus or the phenylalanine carboxamide moiety, and characterized them using a biophys. thermal shift assay (TSA), cell-based antiviral and cytotoxicity assays, and in vitro metabolic stability assays in human and mouse liver microsomes. These studies showed that the two series with the phenylalanine carboxamide moiety replaced by a pyridine or imidazole ring can provide viable hits. Subsequent SAR identified an improved analog I which effectively inhibited HIV-1 (EC50 = 0.31μM), strongly stabilized CA hexamer (ΔTm = 8.7°C), and exhibited substantially enhanced metabolic stability (t1/2 = 27 min for 15 vs. 0.7 min for PF74). Metabolic profiles from the microsomal stability assay also indicate that blocking the C5 position of the indole ring could lead to increased resistance to oxidative metabolism

Viruses published new progress about Amides Role: PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 53636-56-9 belongs to class pyridine-derivatives, and the molecular formula is C7H6BrNO2, Computed Properties of 53636-56-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Anisimov, Anton A.; Vysochinskaya, Yulia S.; Kononevich, Yuriy N.; Dolgushin, Fedor M.; Muzafarov, Aziz M.; Shchegolikhina, Olga I. published the artcile< Polyhedral phenylnickelsodiumsiloxanolate transformation in the presence of aromatic nitrogen-containing ligands>, Recommanded Product: 2,2′-Bipyridine, the main research area is nickel sodium polyhedral phenyl siloxanolate complex preparation crystal structure.

Two new polyhedral phenylmetallasiloxane complexes, {[PhSi(O)O-]6(Ni2+)6(Na+)2(μ3-OH)2[PhSi(O)O-]6}•2(BIPY)•4(DMF) (1) and {[PhSi(O)O-]6(Ni2+)3(Na+)6(μ5-OH)2[PhSi(O)O-]5}•7(PY)•2(BuOH)•2(H2O) (2) formed in the process of recrystallization of polyhedral phenylnickelsodiumsiloxane (Na+)2{[PhSi(O)O-]6(Ni2+)4(Na+)4(μ3-OH)2[PhSi(O)O-]6}•16(BuOH) (A) from DMF in the presence of 2,2-bipyridine (complex 1) or from pyridine (complex 2) are described. σ-Donor ligands of the pyridine series (pyridine and 2,2-bipyridine) play a crucial role in the process of dissociation of the initial metallasiloxane framework and its reassembly on a new matrix of metal ions. Not only the metal-containing cationic layer is reconstructed with a change in the number, ratio, and spatial arrangement of nickel and sodium cations, but also changes the size of cyclic siloxane ligands.

Inorganica Chimica Acta published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Recommanded Product: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hu, Ziwei; Banothu, Janardhan; Beesu, Mallesh; Gustafson, Collin J.; Brush, Michael J. H.; Trautman, Kathryn L.; Salyer, Alex C. D.; Pathakumari, Balaji; David, Sunil A. published the artcile< Identification of Human Toll-like Receptor 2-Agonistic Activity in Dihydropyridine-Quinolone Carboxamides>, Computed Properties of 56622-54-9, the main research area is dihydropyridine quinolone carboxamide synthesis SAR TLR2 vaccine adjuvant.

Using a multiplexed, reporter gene-based, high-throughput screen, we identified 9-fluoro-7-hydroxy-3-methyl-5-oxo-N-(pyridin-3-ylmethyl)-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxamide as a TLR2 agonist. Preliminary structure-activity relationship studies on the carboxamide moiety led to the identification of analogs that induce chemokines and cytokines in a TLR2-dependent manner. These results represent new leads for the development of vaccine adjuvants.

ACS Medicinal Chemistry Letters published new progress about Chemokines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 56622-54-9 belongs to class pyridine-derivatives, and the molecular formula is C7H10N2, Computed Properties of 56622-54-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xie, Feng; Li, Yibiao; Chen, Xiuwen; Chen, Lu; Zhu, Zhongzhi; Li, Bin; Huang, Yubing; Zhang, Kun; Zhang, Min published the artcile< Direct synthesis of novel quinoxaline derivatives via palladium-catalyzed reductive annulation of catechols and nitroarylamines>, Product Details of C6H7N3O2, the main research area is catechol nitroarylamine reusable palladium catalyst reductive cyclization; phenazine preparation.

A palladium-catalyzed new hydrogenative annulation reaction of catechols and nitroarylamines, allowing straightforward access to two classes of novel quinoxaline derivatives, was reported. The reaction proceeded with operational simplicity, an easily available catalyst system, a broad substrate scope and without the need for pre-functionalization, which offers the potential for further design of new reductive transformations of renewable resources into value-added products.

Chemical Communications (Cambridge, United Kingdom) published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Product Details of C6H7N3O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sikder, Amrita; Ray, Debes; Aswal, Vinod K.; Ghosh, Suhrit published the artcile< Supramolecular Assembly of a Molecularly Engineered Protein and Polymer>, Computed Properties of 2127-03-9, the main research area is supramol assembly protein polymer; conjugation; hydrogen bonds; polymers; proteins; self-assembly.

Programmable assembly of biomols. is a fast growing research area that aims to emulate nature’s elegance in creating numerous hierarchical self-assembled structures, which are responsible for unimaginably difficult biol. functions. Protein assembly is a particularly challenging task, owing to their structural diversity, conformational heterogeneity, and high mol. weight This article reveals the ability of a supramol. structure-directing unit (SSDU) to regulate the entropically favorable supramol. assembly of a covalently conjugated protein (bovine serum albumin (BSA)) to produce well-defined protein-decorated micelles with remarkably high thermal stability, suppression of the thermal denaturation of the protein, and retention of enzymic activity. Furthermore, a SSDU-appended thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) coassembles with the SSDU-BSA conjugate because, in both cases, assembly was primarily driven by specific mol. recognition between the SSDUs. However, the resulting supramol. protein-polymer conjugate exhibits distinctly different polymersome structure to that of the micellar particle produced by the protein-SSDU conjugate. In this case, the enzymic activity can be significantly suppressed above the lower critical solution temperature of supramolecularly conjugated PNIPAM, possibly due to collapse of the de-solvated polymer chains on the protein surface.

Chemistry – A European Journal published new progress about Bovine serum albumin Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process) (conjugates with 1,4,5,8-naphthalenetetracarboxylic diimide derivative). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Computed Properties of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zeng, Liyao; Yang, Huaxin; Zhao, Menglong; Wen, Jialin; Tucker, James H. R.; Zhang, Xumu published the artcile< C1-Symmetric PNP Ligands for Manganese-Catalyzed Enantioselective Hydrogenation of Ketones: Reaction Scope and Enantioinduction Model>, Application In Synthesis of 350-03-8, the main research area is ferrocene chiral PNP ligand manganese preparation ketone enantioselective hydrogenation.

A family of ferrocene-based chiral PNP ligands I (R = t-Bu, cyclohexyl, Ph, R’ = Ph; R = Ph, R’ = H, i-Pr, PhCH2) has been reported. These tridentate ligands were successfully applied in Mn-catalyzed asym. hydrogenation of ketones with high enantioselectivities (92-99% ee for aryl alkyl ketones) as well as high efficiencies (TON up to 2000). In addition, dialkyl ketones could also be hydrogenated smoothly. Manganese intermediates that might be involved in the catalytic cycle were analyzed. DFT calculation was carried out to help understand the chiral induction model. The Mn/PNP catalyst could discriminate two groups with different steric properties by deformation of the phosphine moiety in the flexible 5-membered ring.

ACS Catalysis published new progress about Density functional theory. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application In Synthesis of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem