Day: October 21, 2022

Li, Guo-Xing; Hu, Xiafei; He, Gang; Chen, Gong published the artcile< Photoredox-mediated remote C(sp3)-H heteroarylation of free alcohols>, Application of C7H7NO2, the main research area is alc heteroaryl preparation regioselective chemoselective; heteroarene aliphatic alc heteroarylation.

An efficient and economical method for remote δ C(sp3)-H heteroarylation of free aliphatic alcs., e.g., cyclobutaneethanol using a hypervalent iodine PFBI-OH oxidant under photoredox catalysis has been reported. The reaction sequence involves in situ alcoholysis of PFBI-OH with alc., generation of an alkoxy radical intermediate by SET reduction, 1,5-HAT, and Minisci-type C-C bond formation. This method uses a slight excess of alcs., can facilitate reaction at δ Me and methylene positions, and has been successfully applied to modification of complex drug mols.

Chemical Science published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application of C7H7NO2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lougiakis, Nikolaos; Marakos, Panagiotis; Pouli, Nicole; Balzarini, Jan published the artcile< Synthesis and antiviral activity evaluation of some novel acyclic C-nucleosides [Erratum to document cited in CA149:402608]>, Quality Control of 22280-62-2, the main research area is erratum pyrazolopyridine acyclonucleoside preparation antiviral antitumor.

On page 775, in the author list, the third author, Nicole Pouli, was incorrectly given as “”Nicole Poul””.

Chemical & Pharmaceutical Bulletin published new progress about Acyclonucleosides Role: PAC (Pharmacological Activity), SPN (Synthetic Preparation), BIOL (Biological Study), PREP (Preparation). 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Quality Control of 22280-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Bo; Bi, Xiuru; Zhou, Jinbo; Li, Changming; Zhao, Peiqing; Meng, Xu published the artcile< Synthesis of Crystalline OMS-2 with Urea Hydrogen Peroxide and its Application in Aerobic Oxidation Reactions>, Category: pyridine-derivatives, the main research area is cryptomelane type manganese oxide preparation pore size crystallinity recyclability; alkane manganese oxide catalyst selective oxidation; ketone preparation; thiol manganese oxide catalyst selective oxidation; disulfide preparation.

Cryptomelane-type manganese oxide (OMS-2) was synthesized successfully using urea hydrogen peroxide (urea.H2O2) as the reductant in an acidic buffer solution As-prepared crystalline material was fully characterized by X-ray diffraction (XRD), Brunauer-Emmett-Teller method (BET), XPS, SEM (SEM) and high resolution transition electron microscopy(HRTEM). The results demonstrate that OMS-2 has nanofiber with short nanorod morphologies, very rich oxygen vacancy defected and more exposed crystal facets compared with ones synthesized with other H2O2-containing reductants. These unique properties made nanostructural OMS-2 an excellent heterogeneous catalyst in aerobic oxidation reactions, such as selective oxidation of mercaptan and oxygenation of alkylarenes.

ChemistrySelect published new progress about Crystallinity. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Shenzhen; Carter, Emily A. published the artcile< Optimal functionalization of a molecular electrocatalyst for hydride transfer>, SDS of cas: 3796-23-4, the main research area is optimal functionalization mol electrocatalyst hydride transfer; carbon dioxide reduction; catalyst functionalization; hydride transfer.

Optimization of hydride transfer (HT) catalysts to enhance rates and selectivities of (photo)electroreduction reactions could be a crucial component of a sustainable chem. industry. Here, the authors analyze how ring functionalization of the adsorbed transient intermediate 2-pyridinide (2-PyH) and predicted to form in situ from pyridine (Py) in acidified H2O at a cathode surface and to be the key to selective reduction and enhanced catalytic activity. Reducing the electron d. on 2-PyH could limit this protonation, with the trade-off that it may become less active for HT from 2-PyH. The authors explore here how Py functionalization affects the electron distribution and in turn tunes the catalytic performance of 2-PyH*. The authors indeed find that electron-withdrawing groups could enhance the stability of 2-PyH by reducing its electron d. on the ring. Also, the change in the number of electrons on the substituting group of the hydride donor is a good descriptor for both the stability against protonation and the magnitude of the HT barrier. The authors studied the effect of substituent on the process.

Proceedings of the National Academy of Sciences of the United States of America published new progress about Electrochemical reaction catalysts. 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, SDS of cas: 3796-23-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cai, Mingzhong; Luo, Chengkai; Xu, Caifeng; Huang, Bin published the artcile< Recyclable Pd2dba3/XPhos/PEG-2000 System for Efficient Borylation of Aryl Chlorides: Practical Access to Aryl Boronates>, Computed Properties of 329214-79-1, the main research area is green palladium xphos polyethylene glycol catalyst borylation aryl chloride; aryl boronate preparation green.

Pd2dba3/XPhos in poly(ethylene glycol) (PEG-2000) is shown to be a highly stable and efficient catalyst for the borylation of aryl chlorides with bis(pinacolato)diboron. The borylation reaction proceeds smoothly at 110°, delivering a wide variety of aryl boronates in good to excellent yields with high functional group tolerance. The crude products were easily isolated via simple extraction of the reaction mixture with cyclohexane. Moreover, both expensive Pd2dba3 and XPhos in PEG-2000 system could be readily recycled and reused more than six times without loss of catalytic efficiency.

Synthesis published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Computed Properties of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Du, Zhengyin; Li, Zuopeng; Deng, Youquan published the artcile< Synthesis and characterization of sulfonyl-functionalized ionic liquids>, Computed Properties of 21876-43-7, the main research area is ionic liquid sulfonyl functionalized preparation media catalyst.

Novel sulfonyl-functionalized ionic liquids with -SO3H and -SO2Cl groups were designed, synthesized, and characterized. Being strong acidic substances, these ionic liquids have great potential as media and catalysts in many acid-catalyzed reactions.

Synthetic Communications published new progress about Imidazolium compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Computed Properties of 21876-43-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ye, Shanghui; Wu, Congjin; Gu, Pengfei; Xiang, Tai; Zhang, Senyu; Jing, Tongtong; Wang, Shi; Yang, Xiaodi; Li, Yonghua; Huang, Wei published the artcile< A benzoindole-cored building block for deep blue fluorescent materials: synthesis, photophysical properties, and applications in organic light-emitting diodes>, Formula: C6H8N2, the main research area is benzoindole cored blue fluorescent material organic light emitting diode; LED organic benzoindole cored blue fluorescent material; electroluminescent device organic benzoindole cored blue fluorescent material.

Deep blue fluorescent materials are crucial in the commercialization of organic light-emitting diodes (OLEDs) for full-color displays or solid-state lighting sources. Aromatic ring compounds based on a newly designed 2-(pyridine-4-yl)-3-phenyl-1H-benzo[g]indole core, were synthesized, on which donor (D) and acceptor (A) groups are bonded in a Y-typed configuration, forming a D-π-A-π-D structure. The electronic structure and photophys. properties were explored, as well as the applications in the blue OLEDs. Multi-state couplings exist between the D-π-A-π-D 3 moieties, resulting in high luminescence quantum yield ≤76.1% peaking at ∼410 nm, and depressed efficiency roll-off at high luminance. The deep blue OLEDs based on CzCNBPyIp emitter exhibits stable emission peaking at 416 nm with negligible efficiency roll-off at high luminance range of 1,000-10,000 cd m-2, and corresponding CIEx,y = (0.162, 0.085) and maximum EQE = 2.6%, making it among the highest performance solution processed deep blue fluorescent devices. This work provides an alternative method for the deep blue fluorescent materials design toward solution processing OLEDs.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Electron acceptors. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Formula: C6H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Inai, Makoto; Ouchi, Hitoshi; Asahina, Aya; Asakawa, Tomohiro; Hamashima, Yoshitaka; Kan, Toshiyuki published the artcile< Practical total syntheses of acromelic acids A and B>, Name: 3-Bromo-2-chloro-6-methoxypyridine, the main research area is natural product acromelic acid total regioselective enantioselective synthesis pyrrolidine; reductive amination ortho lithiation bromination dichloropyridine; nitroalkene asym conjugate addition ketoester nickel catalyst epimerization.

Practical total syntheses of acromelic acids A and B, which were scarce natural products isolated from toxic mushroom by Shirahama and Matsumoto, were accomplished in 13 (36% total yield) and 17 steps (6.9% total yield), resp., from 2,6-dichloropyridine. Beginning with regioselective transformation of sym. 2,6-dichloropyridine by either ortho-lithiation or bromination, nitroalkenes (I) (R1 = CO2Me, OMe; R2 = OMe, CO2t-Bu) were provided. Stereoselective construction of the vicinal stereocenters at the C-3, 4 positions of acromelic acids A and B was performed by a Ni-catalyzed asym. conjugate addition of α-ketoesters to the nitroalkenes. Construction of the pyrrolidine ring was accomplished in a single operation via a sequence consisting of reduction of the nitro group, intramol. condensation with the ketone, and reduction of the resulting ketimine.

Chemical & Pharmaceutical Bulletin published new progress about Amino acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 777931-67-6 belongs to class pyridine-derivatives, and the molecular formula is C6H5BrClNO, Name: 3-Bromo-2-chloro-6-methoxypyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Liping; Hilton, Margaret J.; Zhang, Xinhao; Norrby, Per-Ola; Wu, Yun-Dong; Sigman, Matthew S.; Wiest, Olaf published the artcile< Mechanism, Reactivity, and Selectivity in Palladium-Catalyzed Redox-Relay Heck Arylations of Alkenyl Alcohols>, Recommanded Product: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole, the main research area is palladium catalyzed redox relay Heck arylation alkenyl alc mechanism.

The enantioselective Pd-catalyzed redox-relay Heck arylation of acyclic alkenyl alcs. allows access to various useful chiral building blocks from simple olefinic substrates. Mechanistically, after the initial migratory insertion, a succession of β-hydride elimination and migratory insertion steps yields a saturated carbonyl product instead of the more general Heck product, an unsaturated alc. Here, we investigate the reaction mechanism, including the relay function, yielding the final carbonyl group transformation. M06 calculations predict a ΔΔG# of 1 kcal/mol for the site selectivity and 2.5 kcal/mol for the enantioselectivity, in quant. agreement with exptl. results. The site selectivity is controlled by a remote electronic effect, where the developing polarization of the alkene in the migratory insertion transition state is stabilized by the C-O dipole of the alc. moiety. The enantioselectivity is controlled by steric repulsion between the oxazoline substituent and the alc.-bearing alkene substituent. The relay efficiency is due to an unusually smooth potential energy surface without high barriers, where the hydroxyalkyl-palladium species acts as a thermodn. sink, driving the reaction toward the carbonyl product. Computational predictions of the relative reactivity and selectivity of the double bond isomers are validated exptl.

Journal of the American Chemical Society published new progress about Alkenyl alcohols Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Recommanded Product: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lv, Tengteng; Song, Tongxiang; Liu, Huijie; Peng, Ruibing; Jiang, Xiamin; Zhang, Weiwei; Han, Qingxi published the artcile< Isolation and characterization of a virulence related Vibrio alginolyticus strain Wz11 pathogenic to cuttlefish, Sepia pharaonis>, HPLC of Formula: 366-18-7, the main research area is Vibrio Sepia virulence hemolysin gene; Bacterial swarming; Haemolysin; Sepia pharaonis; Siderophore production; Vibrio alginolyticus.

Vibrio alginolyticus is a ubiquitous marine opportunistic pathogen that can infect various hosts in marine environment. In the present study, V. alginolyticus strain Wz11 was isolated from diseased cuttlefish, Sepia pharaonis, with 20% of promoted death and high survival capacity in skin mucus and tissue liquid Its growth, siderophore production, and expressions of haemolysin and swarming related genes were characterized under iron limited conditions. The minimal inhibitory concentration (MIC) of 2,2-dipyridyl (DP) to V. alginolyticus strain Wz11 was 640μM. While growth of V. alginolyticus strain Wz11 was inhibited by DP, production of iron-seizing substances, haemolytic activity and swarming motility were increased. Moreover, expressions of haemolysin related genes tlh, tdh and vah and flagellar related genes flgH, fliC, fliD and fliS were also characterized using real-time reverse transcriptase PCR. Expression of tdh was up-regulated to 7.7-fold, while expressions of tlh and vah were down-regulated to 0.016-fold and 0.03-fold, resp. The expression of fliC, flgH, fliD and fliS was up-regulated to 4.9-, 3.8-, 8.6- and 4.5-fold, resp. Concluded from our results suggested that V. alginolyticus strain Wz11 was considered as a potential pathogen of S. pharaonis, and iron level played an important role in the production of iron-seizing substances, and activities of haemolysin and bacterial swarming as well as their related gene expressions.

Microbial Pathogenesis published new progress about Aeromonas hydrophila. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, HPLC of Formula: 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem