Day: October 21, 2022

Kumar, Ajay; Sahoo, Subash Chandra; Mehta, Surinder Kumar; Soni, Parmod; Sharma, Vishal; Kataria, Ramesh published the artcile< A luminescent Zn-MOF for the detection of explosives and development of fingerprints>, Related Products of 3731-53-1, the main research area is zinc metal organic framework explosive detection fingerprint.

A luminescent 3D metal-organic framework [Zn(NDA)(AMP)] = PUC1 (where, NDA = naphthalene-2,6-dicarboxylic acid and AMP = 4-aminomethyl pyridine) was synthesized under solvothermal conditions. The synthesized 3D framework was fully characterized with the help of different anal. techniques such as SCXRD, FTIR, TGA, PXRD, SEM, BET, etc. PUC1 exhibited a strong emission peak at 371 nm when excited at 290 nm and the resulting emission was efficiently quenched in the presence of various organic explosive substances like pentaerythritol tetranitrate (PETN), 2,4,6-trinitrophenyl-N-methylnitramine (Tetryl), trinitrotoluene (TNT), 1,3,5-trinitroperhydro-1,3,5-triazine (RDX), and 1,3,5,7-tetranitro-1,3,5,7-tetrazoctane (HMX). PUC1 revealed highly sensitive and selective detection of PETN and Tetryl with high quenching constant values of 0.1 x 106 and 0.12 x 105 M-1 and low detection limits of 0.315 and 0.404 μM resp. The strong luminescent properties of PUC1 lead to its successful application in the development of latent fingermarks on different non-porous surfaces using the powder dusting method. The accuracy and applicability of the synthesized material were determined by developing fingerprints by using secretions from eccrine and apocrine glands on a glass slide and various other surfaces, followed by dusting the surfaces. The results so obtained were found to be very accurate and promising.

Analytical Methods published new progress about Crystallinity. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hameed P, Shahul; Chinnapattu, Murugan; Shanbag, Gajanan; Manjrekar, Praveena; Koushik, Krishna; Raichurkar, Anandkumar; Patil, Vikas; Jatheendranath, Sandesh; Rudrapatna, Suresh S.; Barde, Shubhada P.; Rautela, Nikhil; Awasthy, Disha; Morayya, Sapna; Narayan, Chandan; Kavanagh, Stefan; Saralaya, Ramanatha; Bharath, Sowmya; Viswanath, Pavithra; Mukherjee, Kakoli; Bandodkar, Balachandra; Srivastava, Abhishek; Panduga, Vijender; Reddy, Jitender; Prabhakar, K. R.; Sinha, Achyut; Jimenez-Diaz, Maria Belen; Martinez, Maria Santos; Angulo-Barturen, Inigo; Ferrer, Santiago; Sanz, Laura Maria; Gamo, Francisco Javier; Duffy, Sandra; Avery, Vicky M.; Magistrado, Pamela A.; Lukens, Amanda K.; Wirth, Dyann F.; Waterson, David; Balasubramanian, V.; Iyer, Pravin S.; Narayanan, Shridhar; Hosagrahara, Vinayak; Sambandamurthy, Vasan K.; Ramachandran, Sreekanth published the artcile< Aminoazabenzimidazoles, a Novel Class of Orally Active Antimalarial Agents>, Category: pyridine-derivatives, the main research area is aminoazabenzimidazole preparation SAR antimalarial Plasmodium.

Whole-cell high-throughput screening of the AstraZeneca compound library against the asexual blood stage of Plasmodium falciparum (Pf) led to the identification of amino imidazoles, a robust starting point for initiating a hit-to-lead medicinal chem. effort. Structure-activity relation studies followed by pharmacokinetics optimization resulted in the identification of (I) as an attractive lead with good oral bioavailability. Compound I was efficacious (ED90 of 28.6 mg·kg-1) in the humanized P. falciparum mouse model of malaria (Pf/SCID model). Representative compounds displayed a moderate to fast killing profile that is comparable to that of chloroquine. This series demonstrates no cross-resistance against a panel of Pf strains with mutations to known antimalarial drugs, thereby suggesting a novel mechanism of action for this chem. class.

Journal of Medicinal Chemistry published new progress about Antimalarials. 21901-29-1 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rincon, A.; Kumar, S.; Ritz, C. W.; Jackson, J. S.; Jackson, C. R.; Frye, J. G.; Hinton, A. Jr.; Singh, M.; Cosby, D. E.; Cox, N. A.; Thippareddi, H. published the artcile< Antimicrobial interventions to reduce Salmonella and Campylobacter populations and improve shelf life of quail carcasses>, Reference of 123-03-5, the main research area is Coturnix Campylobacter shelf life carcass; Campylobacter; Salmonella; antimicrobial; quail carcass; shelf life.

Quail (Coturnix japonica) is processed and marketed as fresh meat, with limited shelf life. The objective of this study was to evaluate the efficacy of antimicrobial interventions during slaughter on reducing Salmonella and Campylobacter contamination and to determine the microbiol. shelf life of quail during refrigerated (4°C) storage. Three antimicrobials, peracetic acid (400 ppm; PAA), Citrilow (pH 1.2), and Cecure (cetylpyridinium chloride [CPC], 450 ppm), along with a water and no-treatment control were evaluated. Quail carcasses (n = 75) were inoculated with a cocktail of nalidixic acid-resistant Salmonella Typhimurium and gentamicin-resistant Campylobacter coli. After 30 min of attachment time, quail carcasses were submerged in each antimicrobial solution for 20 s with air agitation. Noninoculated quail carcasses (n = 25) were similarly treated, packaged, and stored under refrigeration (4°C). Aerobic plate counts (APC), psychrotroph counts (PC), Enterobacteriaceae counts (ENT), total coliform counts (TCC), and Escherichia coli counts on quail carcasses were determined on 1, 4, 7, and 10 d. Salmonella and Campylobacter populations were determined by plating on Petrifilm APC supplemented with 200-ppm nalidixic acid and Campy Cefex agar supplemented with 200-ppm gentamycin, resp. No significant reductions in (P > 0.01 log cfu/mL) in APC, PC, ENT, TCC, and E. coli counts were observed on carcasses submerged in water. However, treatments with PAA, Citrilow, and CPC significantly reduced (P ≤ 0.05) Salmonella and Campylobacter coli contamination. Citrilow showed greater (P ≤ 0.05) reduction in Salmonella and Campylobacter population (1.90 and 3.82 log cfu/mL reduction, resp.) to PAA and CPC. Greater (P ≤ 0.05) reductions in APC, PC, ENT, TCC, and E. coli counts (2.22, 1.26, 1.47, 1.52, and 1.59 log cfu/mL, resp.) were obtained with the application of CPC. Application of antimicrobial interventions resulted in a reduction in Campylobacter and Salmonella, APC, PC, and ENT populations after treatments (day 0) and throughout the storage period (day 10). Use of antimicrobial interventions after slaughter can improve the microbiol. safety and shelf life of quail.

Poultry Science published new progress about Animal carcass. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Reference of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

de Campos, Nathalia R.; Simosono, Cintia A.; Landre Rosa, Iara M.; da Silva, Rafaela M. R.; Doriguetto, Antonio C.; do Pim, Walace D.; Gomes Simoes, Tatiana R.; Valdo, Ana Karoline S. M.; Martins, Felipe T.; Sarmiento, Charlie V.; Nunes, Wallace C.; Guedes, Guilherme P.; Pedroso, Emerson F.; Pereira, Cynthia L. M.; Stumpf, Humberto O.; Lloret, Francesc; Julve, Miguel; Marinho, Maria Vanda published the artcile< Building-up host-guest helicate motifs and chains: a magneto-structural study of new field-induced cobalt-based single-ion magnets>, Electric Literature of 2127-03-9, the main research area is cobalt chloride hexahydrate dipyridyldisulfide magnetostructural correlation single ion magnet.

In this work, we present the synthetic pathway, a refined structural description, complete solid-state characterization and the magnetic properties of four new cobalt(II) compounds of formulas [Co(H2O)6][Co2(H2mpba)3]·2H2O·0.5dmso (1), [Co(H2O)6][Co2(H2mpba)3]·3H2O·0.5dpss (2), [Co2(H2mpba)2(H2O)4]n·4nH2O (3), and [Co2(H2mpba)2(CH3OH)2(H2O)2]n·0.5nH2O·2ndpss (4) [dpss = 2,2′-dipyridyldisulfide and H4mpba = 1,3-phenylenebis(oxamic) acid], where 2 and 4 were obtained from [Co(dpss)Cl2] (Pre-I) as the source of cobalt(II). All four compounds are air-stable and were prepared under ambient conditions. 1 and 2 were obtained from a slow diffusion method [cobalt(II) : H2mpba2- molar ratio used 1 : 1] and their structures are made up of [Co2(H2mpba)3]2- anionic helicate units and [Co(H2O)6]2+ cations, exhibiting supramol. three-dimensional structures. Interestingly, a supramol. honeycomb network between the helicate units interacting with each other through R22(10) type hydrogen bonds occurs in 2 hosting one co-crystallized dpss mol. On the other hand, for the first time, linear (3) and zigzag (4) cobalt(II) chains were isolated by slow evaporation of stirred solutions of mixed solvents with cobalt(II) : H2mpba2- in 1 : 2 molar ratio at room temperature Magnetic measurements of Pre-I revealed a quasi magnetically isolated S = 3/2 spin state with a significant second-order spin-orbit contribution as expected for tetrahedrally coordinated cobalt(II) ions. The anal. of the variable temperature static (dc) magnetic susceptibility data through first- (1 and 3) and second-order spin-orbit coupling models (2 and 4) reveals the presence of magnetically non-interacting high-spin cobalt(II) ions with easy-axis (1 and 4)/easy-plane magnetic anisotropies (2 and 4) with low rhombic distortions. Dynamic (ac) magnetic measurements for Pre-I and 1-4 below 8.0 K show that they are examples of field-induced Single-Ion Magnets (SIMs).

Dalton Transactions published new progress about Alternating current. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Electric Literature of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Akporji, Nnamdi; Thakore, Ruchita R.; Cortes-Clerget, Margery; Andersen, Joel; Landstrom, Evan; Aue, Donald H.; Gallou, Fabrice; Lipshutz, Bruce H. published the artcile< N2Phos - an easily made, highly effective ligand designed for ppm level Pd-catalyzed Suzuki-Miyaura cross couplings in water>, Electric Literature of 13472-84-9, the main research area is phosphine biaryl ligand preparation crystal structure mol; biaryl preparation; aryl halide arylboronic acid Suzuki Miyaura palladium catalyst.

A new biaryl phosphine-containing ligand from an active palladium catalyst for ppm level Suzuki-Miyaura couplings to afford biaryls, was enabled by an aqueous micellar reaction medium. A wide array of functionalized substrates including aryl/heteroaryl bromides were amenable, as were, notably, chlorides. The catalytic system was both general and highly effective at low palladium loadings (1000-2500 ppm or 0.10-0.25 mol%). D. functional theory calculations suggested that greater steric congestion in N2Phos induced increased steric crowding around the Pd center, helping to destabilize the 2 : 1 ligand-Pd(0) complex more for N2Phos than for EvanPhos (and less bulky ligands), and thereby favoring formation of the 1 : 1 ligand-Pdo complex that is more reactive in oxidative addition to aryl chlorides.

Chemical Science published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Electric Literature of 13472-84-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Proctor, Rupert S. J.; Chuentragool, Padon; Colgan, Avene C.; Phipps, Robert J. published the artcile< Hydrogen Atom Transfer-Driven Enantioselective Minisci Reaction of Amides>, Quality Control of 93-60-7, the main research area is amide heteroarene chiral phosphoric acid diacetyl light Minisci reaction; heteroarenyl alkyl amide stereoselective preparation.

Minisci-type reactions constitute one of the most powerful methods for building up complexity around basic heteroarenes. The most desirable variants involve formal oxidative coupling of a C-H bond on each partner, leading back to the simplest possible starting materials. We herein disclose a method that enables such a coupling of linear amides and heteroarenes with full control of enantioselectivity at the newly formed stereocenter as well as site selectivity on both the heteroarene and the amide. This is achieved by the use of a chiral phosphoric acid catalyst in conjunction with diacetyl as a combined hydrogen atom transfer reagent and oxidant. Diacetyl is directly photoexcitable, and thus, no extraneous photocatalyst is required: an added feature that contributes to the simplicity and practicality of the protocol.

Journal of the American Chemical Society published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Quality Control of 93-60-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xiao, Zhiwei; Wang, Lu; Wei, Junjie; Ran, Chongzhao; Liang, Steven H.; Shang, Jingjie; Chen, Guang-Ying; Zheng, Chao published the artcile< Visible-light induced decarboxylative coupling of redox-active esters with disulfides to construct C-S bonds>, Application In Synthesis of 2127-03-9, the main research area is aryldisulfide hydroxyphthalimide ester preparation ruthenium photocatalyst decarboxylative coupling; benzenethiosulfonate hydroxyphthalimide ester preparation ruthenium photocatalyst decarboxylative coupling; aryl thioether preparation.

A novel method was established for the construction of C-S bonds using redox-active esters with disulfides in the presence of Ru-photoredox catalyst. This method exhibited remarkable functional group tolerance across a wide scope of substrates. Under mild conditions, a structurally diverse array of aryl alkyl sulfides was successfully and efficiently obtained through decarboxylative cross-coupling.

Chemical Communications (Cambridge, United Kingdom) published new progress about Decarboxylation catalysts (photochem.). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application In Synthesis of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Romines, Karen R.; Freeman, George A.; Schaller, Lee T.; Cowan, Jill R.; Gonzales, Steve S.; Tidwell, Jeffrey H.; Andrews, Clarence W. III; Stammers, David K.; Hazen, Richard J.; Ferris, Robert G.; Short, Steven A.; Chan, Joseph H.; Boone, Lawrence R. published the artcile< Structure-Activity Relationship Studies of Novel Benzophenones Leading to the Discovery of a Potent, Next Generation HIV Nonnucleoside Reverse Transcriptase Inhibitor>, Synthetic Route of 22280-62-2, the main research area is AntiAIDS reverse transcriptase inhibitor benzophenone preparation structure activity HIV1; AIDS antiviral reverse transcriptase inhibitor benzophenone preparation HIV1.

Despite the progress of the past two decades, there is still considerable need for safe, efficacious drugs that target human immunodeficiency virus (HIV). This is particularly true for the growing number of patients infected with virus resistant to currently approved HIV drugs. Our high throughput screening effort identified a benzophenone template as a potential nonnucleoside reverse transcriptase inhibitor (NNRTI). This manuscript describes our extensive exploration of the benzophenone structure-activity relationships, which culminated in the identification of several compounds with very potent inhibition of both wild type and clin. relevant NNRTI-resistant mutant strains of HIV. These potent inhibitors include 70h (GW678248), which has in vitro antiviral assay IC50 values of 0.5 nM against wild-type HIV, 1 nM against the K103N mutant associated with clin. resistance to efavirenz, and 0.7 nM against the Y181C mutant associated with clin. resistance to nevirapine. Compound 70h has also demonstrated relatively low clearance in i.v. pharmacokinetic studies in three species, and it is the active component of a drug candidate which has progressed to phase 2 clin. studies.

Journal of Medicinal Chemistry published new progress about AIDS (disease). 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Synthetic Route of 22280-62-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Forlani, Luciano; Cristoni, Giampiero; Boga, Carla; Todesco, Paolo E.; Del Vecchio, Erminia; Selva, Simona; Monari, Magda published the artcile< Reinvestigation of the tautomerism of some substituted 2-hydroxypyridines>, Formula: C5H4ClNO, the main research area is UV NMR spectrometry tautomerism substituted hydroxypyridines LFER; crystallog nitropyridinone.

The tautomerism of some substituted 2-hydroxypyridines is investigated by UV/Vis- and 1H-, and 13C-NMR spectroscopic methods, with the aid of the N-Me and O-Me fixed parents. NMR spectroscopic data do not allow discrimination between the two tautomeric forms (with the exception of the unsubstituted 2-hydroxypyridine), while UV/Vis-data permit the quant. determination, in different solvents, of the amounts of the two forms. The electronic substituent effect and the change of solvent are discussed. An X-Ray diffraction study carried out on a crystal of 2-hydroxy-5-nitropyridine (7) reveals that this compound, in the solid state, is in the oxo-form.

ARKIVOC (Gainesville, FL, United States) [online computer file] published new progress about Crystal structure. 73018-09-4 belongs to class pyridine-derivatives, and the molecular formula is C5H4ClNO, Formula: C5H4ClNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vogt, David B.; Seath, Ciaran P.; Wang, Hengbin; Jui, Nathan T. published the artcile< Selective C-F Functionalization of Unactivated Trifluoromethylarenes>, Related Products of 3796-23-4, the main research area is difluoroalkylarene preparation; trifluoromethylarene alkene photocatalytic alkylation.

Fluorinated organic mols. are pervasive within the pharmaceutical and agrochem. industries due to the range of structural and physicochem. properties that fluorine imparts. Currently, the most abundant methods for the synthesis of the aryl-CF2 functionality have relied on the deoxyfluorination of ketones and aldehydes using expensive and poorly atom economical reagents. Here, we report a general method for the synthesis of aryl-CF2R and aryl-CF2H compounds through activation of the corresponding trifluoromethyl arene precursors. This strategy is enabled by an endergonic electron transfer event that provides access to arene radical anions that lie outside of the catalyst reduction potential. Fragmentation of these reactive intermediates delivers difluorobenzylic radicals that can be intercepted by abundant alkene feedstocks or a hydrogen atom to provide a diverse array of difluoalkylaroms.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Related Products of 3796-23-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem