Day: October 21, 2022

Matsumoto, Kyosuke; Kusaba, Shunsuke; Tanaka, Yuya; Sei, Yoshihisa; Akita, Munetaka; Aritani, Kazushi; Haga, Masa-aki; Yoshizawa, Michito published the artcile< A Peanut-Shaped Polyaromatic Capsule: Solvent-Dependent Transformation and Electronic Properties of a Non-Contacted Fullerene Dimer>, Reference of 329214-79-1, the main research area is palladium pyridylanthracene derivative capsule guest encapsulation fullerene complex preparation; crystal structure palladium pyridylanthracene derivative guest encapsulation fullerene complex; cyclic voltammetry palladium pyridylanthracene derivative guest encapsulation fullerene complex; coordination capsules; encapsulation; fullerenes; radical anions; supramolecular chemistry.

Synthesis of mol. containers capable of incorporating multiple fullerenes remains challenging. Reported here is that room-temperature mixing of metal ions with W-shaped bispyridine ligands featuring polyaromatic panels results in the quant. formation of a peanut-shaped M2L4 capsule. The capsule reversibly converts into two mols. of an ML2 double tube in response to changes in the solvent. Notably, the capsule allows the incorporation of two fullerene mols. into the connected two spherical cavities at room temperature The close proximity yet non-contact of the encapsulated C60 mols., with a separation of 6.4 Å, was revealed by x-ray crystallog. anal. The resultant, unusual fullerene dimer undergoes sequential reduction within the capsule to generate (C60.-)2, C60.-·C602-, and (C602-)2 species. Furthermore, temperature-controlled stepwise incorporation of two C60 mols. into the capsule is demonstrated.

Angewandte Chemie, International Edition published new progress about Cage compounds Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Reference of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sharma, Rahul; Mondal, Avijit; Samanta, Arup; Biswas, Nandita; Das, Babulal; Srimani, Dipankar published the artcile< Well-Defined Ni-SNS Complex Catalyzed Borrowing Hydrogenative α-Alkylation of Ketones and Dehydrogenative Synthesis of Quinolines>, Product Details of C7H7NO, the main research area is nickel catalyst preparation crystal structure; acetophenone alc nickel catalyst alkylation; aryl alkyl ketone preparation green chem; ketone aminophenyl methanol nickel catalyst alkylation; quinoline preparation green chem.

Here presented a synthesis of non-phosphine, easily accessible and bench stable SNS-Ni complexes. The Ni-catalyst was successfully applied for the C-alkylation of ketone enolates to α-alkylated ketones. Primary alc. with different functional groups and various heteroaromatic alcs. were well tolerated. The present catalyst system was efficiently applied to gram scale synthesis and also the green chem. metrics of the reaction were calculated The present protocol was also extended successfully for the synthesis of biol. important quinoline moieties. Finally, various control experiments and deuterium labeled experiments suggested that the reaction proceeds via borrowing hydrogen pathway.

Advanced Synthesis & Catalysis published new progress about Alkylation. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Product Details of C7H7NO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Phuan, P.-W.; Kozlowski, M. C. published the artcile< Product class 8: naphthyridines>, Product Details of C6H6N2O, the main research area is review naphthyridine cyclization ring transformation.

A review of synthetic methods to prepare naphthyridines which include cyclization and ring transformations.

Science of Synthesis published new progress about 55279-29-3. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Product Details of C6H6N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Acharjee, Animesh; Rakshit, Atanu; Chowdhury, Suman; Datta, Indukamal; Barman, Milan Krishna; Ali, Ansar Md.; Saha, Bidyut published the artcile< Micellar catalysed oxidation of hydrophobic fatty alcohol in aqueous medium>, Recommanded Product: 2,2′-Bipyridine, the main research area is octanol micellar catalyst oxidation mechanism kinetics.

Oxidation of a hydrophobic fatty alc. was carried out under pseudo 1st order reaction condition in aqueous micellar medium efficiently. In addition to the dissolution of alc. micelles are found to catalyze the oxidation reaction. Use of promoters further enhanced the rate of the reaction with almost instant completion of the reaction via the formation of active oxidants (AO+). The product was confirmed by IR and NMR study. Fluorescence studies and DLS measurements were done to confirm the formation of AO+. NMR studies were carried out to establish the interaction between the surfactants and 1-Octanol. Calculated activation parameters (ΔH≠, ΔS≠) also support the exptl. findings.

Journal of Molecular Liquids published new progress about Activation enthalpy. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Recommanded Product: 2,2′-Bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Xuefu; Wang, Jun; Ba, Wanyu; Zhang, Suqiu; Lin, Zhenxian; Gao, Ming; Tian, Hua; Ru, Shaoguo published the artcile< Mechanistic revealing of reproductive behavior impairment in male guppy (Poecilia reticulata) induced by environmentally realistic 2,2'-dithiobis-pyridine exposure>, SDS of cas: 2127-03-9, the main research area is transcriptome dithiobis pyridine reproductive behavior impairment Poecilia; (PS)(2); Ecological safety; Mechanism study; Sexual behavior.

Although (PS)2, the primary degradation product of emerging antifouling biocides metal pyrithiones (MePTs), can disrupt the reproductive behavior of fish at an environmentally relevant ng/L level, the underlying mechanism is still largely unknown. This study exposed sexually mature male guppy (Poecilia reticulata) to 20, 200, and 2000 ng/L (PS)2 to explore the compromised effect of (PS)2 on reproductive behavior through a realistic competing scenario. The results showed that (PS)2 suppressed male guppies’ sexual interest to stimulus females, reduced their competitive behavior frequencies toward rival males, and decreased their mating time and frequency. (PS)2 exposure did not affect male guppies’ secondary sexual characteristics or induce estrogenic activity. Whole-brain transcriptome sequencing identified 1070 differentially expressed genes (DEGs) with 872 up-regulated genes, which were functionally enriched into Gene Ontol. terms pertaining to extracellular matrix (ECM) and extracellular region. KEGG enrichment for the DEGs uncovered that the activations of ECM-receptor interaction and focal adhesion pathways could be the underlying mol. mechanism implicated in the (PS)2 induced reproductive behavior impairment. This work would deliver a substantial contribution to the understanding of the ecol. safety of MePTs biocides.

Chemosphere published new progress about Behavior. 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, SDS of cas: 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Anson, Francesca; Kanjilal, Pintu; Thayumanavan, S.; Hardy, Jeanne A. published the artcile< Tracking exogenous intracellular casp-3 using split GFP>, Reference of 2127-03-9, the main research area is green fluorescent protein exogenous intracellular caspase cytosol; apoptosis; caspase; caspase-3; intracellular protein delivery; nanogel; split GFP.

Cytosolic protein delivery promises diverse applications from therapeutics, to genetic modification and precision research tools. To achieve effective cellular and subcellular delivery, approaches that allow protein visualization and accurate localization with greater sensitivity are essential. Fluorescently tagging proteins allows detection, tracking and visualization in cellulo. However, undesired consequences from fluorophores or fluorescent protein tags, such as nonspecific interactions and high background or perturbation to native protein””s size and structure, are frequently observed, or more troublingly, overlooked. Distinguishing cytosolically released mols. from those that are endosomally entrapped upon cellular uptake is particularly challenging and is often complicated by the inherent pH-sensitive and hydrophobic properties of the fluorophore. Monitoring localization is more complex in delivery of proteins with inherent protein-modifying activities like proteases, transacetylases, kinases, etc. Proteases are among the toughest cargos due to their inherent propensity for self-proteolysis. To implement a reliable, but functionally silent, tagging technol. in a protease, we have developed a caspase-3 variant tagged with the 11th strand of GFP that retains both enzymic activity and structural characteristics of wild-type caspase-3. Only in the presence of cytosolic GFP strands 1-10 will the tagged caspase-3 generate fluorescence to signal a non-endosomal location. This methodol. facilitates easy screening of cytosolic vs. endosomally-entrapped proteins due to low probabilities for false pos. results, and further, allows tracking of the resultant cargo′s translocation. The development of this tagged casp-3 cytosolic reporter lays the foundation to probe caspase therapeutic properties, charge-property relationships governing successful escape, and the precise number of caspases required for apoptotic cell death.

Protein Science published new progress about Affinity tags Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Reference of 2127-03-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Winter, Andreas; Endres, Patrick; Schroeter, Erik; Jaeger, Michael; Goerls, Helmar; Neumann, Christof; Turchanin, Andrey; Schubert, Ulrich S. published the artcile< Towards covalent photosensitizer-polyoxometalate dyads-bipyridyl-functionalized polyoxometalates and their transition metal complexes>, Computed Properties of 366-18-7, the main research area is hybrid materials; metal complexes; photocatalysis; polyoxometalates.

A triol-functionalized 2,2′-bipyridine (bpy) derivative has been synthesized and used for the tris-alkoxylation of polyoxometalate (POM) precursors. The resultant POM-bpy conjugates of the Wells-Dawson- and Anderson-type feature a C-C bond as a linkage between the POM and bpy fragments. This structural motif is expected to increase the hydrolytic stability of the compounds This is of particular relevance with respect to the application of POM-bpy metal complexes, as photocatalysts, in the hydrogen-evolution reaction (HER) in an aqueous environment. Accordingly, Rh(III) and Ir(III) complexes of the POM-bpy ligands have been prepared and characterized. These catalyst-photosensitizer dyads have been analyzed with respect to their electrochem. and photophys. properties. Cyclic and square-wave voltammetry, as well as UV/vis absorption and emission spectroscopy, indicated a negligible electronic interaction of the POM and metal-complex subunits in the ground state. However, emission-quenching experiments suggested an efficient intramol. electron-transfer process from the photo-excited metal centers to the POM units to account for the non-emissive nature of the dyads (thus, suggesting a strong interaction of the subunits in the excited state). In-depth photophys. investigations, as well as a functional characterization, i.e., the applicability in the HER reaction, are currently ongoing.

Molecules published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Computed Properties of 366-18-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Morales-Colon, Maria T.; See, Yi Yang; Lee, So Jeong; Scott, Peter J. H.; Bland, Douglas C.; Sanford, Melanie S. published the artcile< Tetramethylammonium Fluoride Alcohol Adducts for SNAr Fluorination>, Recommanded Product: 4,4′-Dichloro-2,2′-bipyridine, the main research area is aryl chloride tetramethylammonium fluoride regioselective nucleophilic aromatic fluorination; aromatic fluoride preparation.

Nucleophilic aromatic fluorination (SNAr) is among the most common methods for the formation of C(sp2)-F bonds. Despite many recent advances, a long-standing limitation of these transformations was the requirement for rigorously dry, aprotic conditions to maintain the nucleophilicity of fluoride and suppress the generation of side products. This report addresses this challenge by leveraging tetramethylammonium fluoride alc. adducts (Me4NF·ROH) as fluoride sources for SNAr fluorination. Through systematic tuning of the alc. substituent (R), tetramethylammonium fluoride tert-amyl alc. (Me4NF·t-AmylOH) was identified as an inexpensive, practical, and bench-stable reagent for SNAr fluorination under mild and convenient conditions (80°C in DMSO, without the requirement for drying of reagents or solvent). A substrate scope of more than 50 (hetero) aryl halides and nitroarene electrophiles was demonstrated.

Organic Letters published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1762-41-0 belongs to class pyridine-derivatives, and the molecular formula is C10H6Cl2N2, Recommanded Product: 4,4′-Dichloro-2,2′-bipyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Guihua; Cao, Jian; Wang, Qian; Zhu, Jieping published the artcile< Desymmetrization of Prochiral Cyclopentenes Enabled by Enantioselective Palladium-Catalyzed Oxidative Heck Reaction>, Formula: C13H15F3N2O, the main research area is desymmetrization cyclopentene enantioselective oxidative Heck palladium catalyst; oxidative Heck arylboronic acid cyclopentene palladium catalyst diastereoselective enantioselective.

In the presence of a catalytic amount of Pd(TFA)2 and a chiral Pyox ligand under oxygen atm., oxidative Heck reaction between arylboronic acids and 4-substituted or 4,4-disubstituted cyclopent-1-enes afforded the chiral arylated products with concurrent creation of two stereocenters in good yields with excellent diastereo- and enantioselectivities.

Organic Letters published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Formula: C13H15F3N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hai, Yang; Geng, Jia-Jia; Li, Peng-Jie; Ma, Wei-Ping; Wang, Cui-Fang; Wei, Mei-Yan; Hou, Xue-Mei; Chen, Guang-Ying; Gu, Yu-Cheng; Liu, Ming; Shao, Chang-Lun published the artcile< Semisynthesis and biological evaluation of (+)-sclerotiorin derivatives as antitumor agents for the treatment of hepatocellular carcinoma>, Recommanded Product: 3-(Aminomethyl)-6-(trifluoromethyl)pyridine, the main research area is hepatocellular cervical carcinoma sclerotiorin antitumor cytotoxicity pharmacokinetics signaling; (+)-Sclerotiorin; AKT and ERK proteins; Antitumor; Hepatocellular carcinoma; Mouse xenograft model.

Hepatocellular carcinoma is one of the most common primary hepatic malignancy. Herein, a series of semisynthesized derivatives (2-30) of the natural product (+)-sclerotiorin (1) was prepared and evaluated the cytotoxic activities against six cancer cell lines. Among them, 3 and 5 were the most effective compounds against human hepatocellular carcinoma Bel-7402 cell line with IC50 values of 1.45 and 1.15 μM, resp. Mol. mechanism study showed that 5 disrupted the mitochondrial membrane potential and induced apoptosis in a caspase-dependent manner. In addition, 5 affected AKT and ERK signaling pathways and induced AKT and ERK proteins degradation through ubiquitin-proteasome system. Furthermore, 5 displayed significant in vivo anticancer effects in the xenograft models with decreasing the tumor mass by 52.5%. The safety evaluation was confirmed by acute toxicity subchronic toxicity tests, paraffin sections of mice organ and blood routine examination Taken together, 5 can be developed as a potential therapeutic agent for hepatocellular carcinoma.

European Journal of Medicinal Chemistry published new progress about Antiproliferative agents. 387350-39-2 belongs to class pyridine-derivatives, and the molecular formula is C7H7F3N2, Recommanded Product: 3-(Aminomethyl)-6-(trifluoromethyl)pyridine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem