Day: October 21, 2022

Zheng, Yi; Obeng, Samuel; Wang, Huiqun; Jali, Abdulmajeed M.; Peddibhotla, Bharath; Williams, Dwight A.; Zou, Chuanchun; Stevens, David L.; Dewey, William L.; Akbarali, Hamid I.; Selley, Dana E.; Zhang, Yan published an article on January 24 ,2019. The article was titled 《Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands》, and you may find the article in Journal of Medicinal Chemistry.Recommanded Product: 59290-82-3 The information in the text is summarized as follows:

μ Opioid receptor (MOR) agonists have been widely applied for treating moderate to severe pain. However, numerous adverse effects have been associated with their application, including opioid-induced constipation (OIC), respiratory depression, and addiction. On the basis of previous work in our laboratory, NAP, a 6β-N-4′-pyridyl substituted naltrexamine derivative, was identified as a peripheral MOR antagonist that may be used to treat OIC. To further explore its structure-activity relationship, a new series of NAP derivatives were designed, synthesized, and biol. evaluated. Among these derivatives, NFP and NYP significantly antagonized the antinociception effect of morphine. Whereas NAP acted mainly peripherally, its derivatives NFP and NYP actually can act centrally. Furthermore, NFP produced significantly lesser withdrawal symptoms than naloxone at similar doses. These results suggest that NFP has the potential to be a lead compound to treat opioid abuse and addiction. The experimental part of the paper was very detailed, including the reaction process of 3-Nitroisonicotinic acid(cas: 59290-82-3Recommanded Product: 59290-82-3)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 59290-82-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Carpenter, Joseph; Wu, Gang; Wang, Ying; Cook, Erica M.; Wang, Tao; Sitkoff, Doree; Rossi, Karen A.; Mosure, Kathy; Zhuo, Xiaoliang; Cao, Gary G.; Ziegler, Milinda; Azzara, Anthony V.; Krupinski, Jack; Soars, Matthew G.; Ellsworth, Bruce Alan; Wacker, Dean A. published 《Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis》.ACS Medicinal Chemistry Letters published the findings.Related Products of 29682-15-3 The information in the text is summarized as follows:

Herein we report the discovery and preclin. biol. evaluation of 6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)-7-azaspiro[3.5]non-1-en-7-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid, compound 1 (BMS-986318), a nonbile acid farnesoid X receptor (FXR) agonist. Compound 1 exhibits potent in vitro and in vivo activation of FXR, has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis. The overall profile of compound 1 supports its continued evaluation. In the experiment, the researchers used Methyl 5-bromopicolinate(cas: 29682-15-3Related Products of 29682-15-3)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 29682-15-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2014,Perato, Serge; De Giorgi, Marcella; Burzicki, Gregory; Legalite, Florent; Rault, Sylvain; Voisin-Chiret, Anne Sophie published 《Focus on microwave assisted halogen-halogen exchange reaction conditions on 2-halopyridines》.Current Microwave Chemistry published the findings.Category: pyridine-derivatives The information in the text is summarized as follows:

This paper describes an optimized microwave irradiation-assisted methodol. for halogen-halogen exchange reactions on various substituted pyridines. The protocol provides an efficient and simple methodol. to improve the reactivity of some positions on the pyridine ring towards metallocatalyzed reactions. Influence of various substituents were explored and limiting factors of reaction highlighted. In addition to this study using 5-Bromo-2-chloropyridine, there are many other studies that have used 5-Bromo-2-chloropyridine(cas: 53939-30-3Category: pyridine-derivatives) was used in this study.

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2016,Ibrahim, Halliru; Bala, Muhammad Dabai published 《Earth abundant metal complexes of donor functionalised N-heterocyclic carbene ligands: synthesis, characterisation and application as amination catalysts》.New Journal of Chemistry published the findings.Computed Properties of C6H7Br2N The information in the text is summarized as follows:

Six new imidazolium salts of the form 3-R-1-picolylimidazolium bromide (1a: R = 4-nitrophenyl, 1b: R = 4-acetylphenyl, 1c: R = 4-cyanophenyl, 1d: R = allyl, 1e: R = butenyl, 1f: R = pentenyl) were synthesized and isolated in high yields. The corresponding Ag-NHC intermediate complexes 2a, 2d, and 2e were transmetalated to yield [M(NHC)2Cl2 M = Co, Ni] complexes in good to excellent yields. The Co-NHC (3a, 3d, 3e) and Ni-NHC (3a’, 3d’, 3e’) complexes were relatively stable in air, insoluble in chlorinated solvents but very soluble in methanol and DMSO. Poorly resolved NMR spectra and magnetic susceptibility values of 2.53 and 2.73 μB for 3d and 3e resp. suggest both to be paramagnetic cobalt complexes. All the imidazolium salts, isolated Ag-NHC complexes and the corresponding Co and Ni-NHC complexes were characterized by spectroscopic and anal. techniques. The complexes are active at low catalyst loading (1 mol%) for the C-N coupling of aniline with Ph bromide under mild reaction conditions. The in situ generated catalyst obtained from a mixture of NiCl2/1a (1:2 molar ratio) initiated the C-N coupling of several aryl amines with substituted aryl bromides bearing a wide variety of functional groups. Good to excellent yields of the desired diaryl amine products were obtained. The yields are comparable to data obtained with palladium catalysts or to data obtained under harsher temperature conditions of Cu mediated Ullman reactions. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Computed Properties of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Computed Properties of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Zhang, Wen-Man; Dai, Jian-Jun; Xu, Jun; Xu, Hua-Jian published 《Visible-Light-Induced C2 Alkylation of Pyridine N-Oxides》.Journal of Organic Chemistry published the findings.Related Products of 103-74-2 The information in the text is summarized as follows:

A photoredox catalytic method has been developed for the direct C2 alkylation of pyridine N-oxides. This reaction is compatible with a range of synthetically relevant functional groups for providing efficient synthesis of a variety of C2-alkylated pyridine N-oxides under mild conditions. Mechanistic studies are consistent with the generation of a radical intermediate along the reaction pathway. The experimental process involved the reaction of 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Related Products of 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Related Products of 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Yao, Qiyi; Kong, Lingkai; Zhang, Fangfang; Tao, Xianghua; Li, Yanzhong published 《Base-Promoted Tandem Reaction towards Conjugated Dienone or Chromone Derivatives with a Cyano Group: Insertion of Alkynes into C-C σ-Bonds of 3-Oxopropanenitriles》.Advanced Synthesis & Catalysis published the findings.Application of 128071-75-0 The information in the text is summarized as follows:

Base-promoted insertion reactions of alkynes into the C-C σ-bonds of α-cyano ketones were established to construct highly functionalized conjugated olefins I [R1 = cyclohexyl, Ph, 4-BrC6H4, 3,4,5-(MeO)3C6H2, etc.; R2 = Ph, 4-ClC6h4, 4-MeC6H4, 4-MeOC6H4; R3 = Ph] or chromone derivatives II [X = CH, N; R3 = t-Bu, Ph; R4 = H, 6-F, 7-F, 6,7-(MeO)2; R5 = Me, n-Bu, Ph, 3,4,5-(MeO)3C6H2, 2-naphthyl, etc.] via transition metal-free tandem reactions. Nucleophilic attack of α-cyano ketones R3C(O)CH2CN to alkynones R1C(O)CCR2 followed by intramol. nucleophilic addition/ring-opening furnished the cyano-containing alkenes I. In the cases of alkynones III (Z = Br, Cl, F) bearing an ortho-halide-substituted aryl ring, a further C-O bond coupling reaction occurred to afford chromone derivatives II in good to high yields. Various alkynones bearing alkyl or aryl substituents were compatible in the reaction. This reaction has the potential to become a general synthetic protocol for the preparation of cyano-substituted olefins and chromones due to the abundance of easily accessible starting materials possessing diverse substituent groups. In the part of experimental materials, we found many familiar compounds, such as 2-Bromonicotinaldehyde(cas: 128071-75-0Application of 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application of 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Awwadi, Firas F.; Turnbull, Mark M.; Alwahsh, Manal I.; Haddad, Salim F. published 《May halogen bonding interactions compete with Cu···Cl semi-coordinate bonds? Structural, magnetic and theoretical studies of two polymorphs of trans-bis(5-bromo-2-chloro pyridine)dichlorocopper(II) and trans-bis(2,5-dichloropyridine)dichlorocopper(II)》.New Journal of Chemistry published the findings.Reference of 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

Two polymorphs of Cu(25dcp)2Cl2 [Cu(25dcp)2Cl2_p1 and Cu(25dcp)2Cl2_p2] and Cu(5b2cp)2Cl2 [Cu(5b2cp)2Cl2_p1 and Cu(5b2cp)2Cl2_p2] were prepared and characterized by single crystal X-ray diffraction (25dcp = 2,5-dichloropyridine and 5b2cp = 5-bromo-2-chloropyridine). The four structures crystallize in the monoclinic crystal system: three of them (Cu(25dcp)2Cl2_p1, Cu(5b2cp)2Cl2_p2 and Cu(25dcp)2Cl2_p2) crystallize in the C2/c space group and the fourth one (Cu(5b2cp)2Cl2_p1) in the C2/m space group. Cu(5b2cp)2Cl2_p1 and Cu(25dcp)2Cl2_p1 are structurally isomorphous. The formation of two polymorphs for each complex is a result of competition between Cl···Cu semi-coordinate bonds and C-X···Cl-Cu (X = Cl or Br) halogen bonding interactions. The formation of C-X···Cl-Cu halogen bonding alone resulted in crystallization of Cu(25dcp)2Cl2_p1 and Cu(5b2cp)2Cl2_p1, whereas the formation of the Cu···Cl semi-coordinate bonds resulted in the formation of Cu(25dcp)2Cl2_p2 and Cu(5b2cp)2Cl2_p2. To our knowledge, these are the first examples in which the competition between the halogen bonding interactions and the semi-coordinate Cu···Cl resulted in the formation of different polymorphs. The calculated electrostatic potential was used to rationalize the formation of the different polymorphs. The magnetic properties of Cu(5b2cp)2Cl2_p1 were studied; it is found to obey an antiferromagnetic chain model. This magnetic behavior was rationalized using the two-halide exchange pathway. Structurally, Cu(5b2cp)2Cl2_p1 forms a chain structure based on Cu-Cl···Cl-Cu interactions. The mapped electron d. with spin d. showed the presence of a spin-d.-end-cap along the Cu-Cl bond. This spin-d.-end-cap corroborates the observed antiferromagnetic interactions. In the experiment, the researchers used 5-Bromo-2-chloropyridine(cas: 53939-30-3Reference of 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Reference of 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Chen, Long; Zhu, Yueyue; Chen, Tieqiao; Liu, Long; Zhang, Ji-Shu; Han, Li-Biao published 《Direct C-OH/P(O)-H dehydration coupling forming phosphine oxides》.Organic & Biomolecular Chemistry published the findings.Reference of 2-(2-Hydroxyethyl)pyridine The information in the text is summarized as follows:

A t-BuONa-mediated C-OH/P(O)-H cross dehydration coupling to produce alkylphosphine oxides is developed. This reaction employed readily available alcs. and P(O)-H compounds as the starting materials, providing an efficient alternative method for constructing sp3 C-P bonds. A reasonable reaction path involving dehydration and subsequent regio-selective hydrophosphorylation of the resulting alkenes was proposed. In the experimental materials used by the author, we found 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Reference of 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Reference of 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Separation Science included an article by Jadda, Ramana; Madhumanchi, Sreenu; Suedee, Roongnapa. Product Details of 141-86-6. The article was titled 《Novel adsorptive materials by adenosine 5′-triphosphate imprinted-polymer over the surface of polystyrene nanospheres for selective separation of adenosine 5′-triphosphate biomarker from urine》. The information in the text is summarized as follows:

The authors have developed a method to assess ATP by adsorptive extraction using surface ATP-imprinted polymer over polystyrene nanoparticles (412 ± 16 nm) for selective recognition/separation from urine. Molecularly imprinted polymer was synthesized by emulsion copolymerization reaction using ATP as a template, functional monomers (methacrylic acid, N-iso-Pr acrylamide, and dimethylamino ethylmethacrylate) and a crosslinker, methylenebisacrylamide. The binding capacities of imprinted and non-imprinted polymers were measured using HPLC with UV detection with a detection limit of 1.6 ± 0.02μM of ATP in the urine. High binding affinity (QMIP, 42.65μmol/g), and high selectivity and specificity to ATP compared to other competitive nucleotides including ADP, AMP, and analogs such as adenosine, adenine, uridine, uric acid, and creatinine were observed The imprinting efficiency of imprinted polymer is 2.11 for urine (QMIP, 100.3μmol/g) and 2.51 for synthetic urine (QMIP, 48.5μmol/g). The extraction protocol was successfully applied to the direct extraction of ATP from spiked human urine indicating that this synthesized molecularly imprinted polymer allowed ATP to be preconcd. while simultaneously interfering compounds were removed from the matrix. These submicron imprinted polymers over nano polystyrene spheres have a potential in the pharmaceutical industries and clin. anal. applications. In the part of experimental materials, we found many familiar compounds, such as 2,6-Diaminopyridine(cas: 141-86-6Product Details of 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Product Details of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemistry – A European Journal included an article by Ramu, Vadde; Upendar Reddy, Gandra; Liu, Jingjing; Hoffmann, Patrick; Sollapur, Rudrakant; Wyrwa, Ralf; Kupfer, Stephan; Spielmann, Christian; Bonnet, Sylvestre; Neugebauer, Ute; Schiller, Alexander. Application In Synthesis of Bis(pyridin-2-ylmethyl)amine. The article was titled 《Two-Photon-Induced CO-Releasing Molecules as Molecular Logic Systems in Solution, Polymers, and Cells》. The information in the text is summarized as follows:

Phototherapeutic applications of carbon monoxide (CO)-releasing mols. are limited because they require harmful UV and blue light for activation. We describe two-photon excitation with NIR light (800 nm)-induced CO-release from two MnI tricarbonyl complexes bearing 1,8-naphthalimide units (1, 2). Complex 2 behaves as a logic OR gate in solution, nonwovens, and in HeLa cells. CO release, indicated by fluorescence enhancement, was detected in solution, nonwoven, and HeLa cells by single- (405 nm) and two-photon (800 nm) excitation. The photophys. properties of 1 and 2 have been measured and supported by DFT and TDDFT quantum chem. calculations Both photoCORMs are stable in the dark in solution and noncytotoxic, leading to promising applications as phototherapeutics with NIR light. The results came from multiple reactions, including the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application In Synthesis of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Application In Synthesis of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem