Day: October 24, 2022

In 2022,Messa, Francesco; Dilauro, Giuseppe; Paparella, Andrea Nicola; Silvestri, Lavinia; Furlotti, Guido; Iacoangeli, Tommaso; Perrone, Serena; Salomone, Antonio published an article in Green Chemistry. The title of the article was 《Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C》.Product Details of 2510-22-7 The author mentioned the following in the article:

A general, safe and scalable reductive protocol, based on the in situ generation of H2 from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodol. has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Product Details of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Product Details of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 4-AcetylpyridineIn 2019 ,《CoII Complexes with a Tripyridine Ligand, Containing a 2,6-Di-tert-butylphenolic Fragment: Synthesis, Structure, and Formation of Stable Radicals》 appeared in ACS Omega. The author of the article were Dorofeeva, Victoria N.; Pavlishchuk, Anna V.; Kiskin, Mikhail A.; Efimov, Nikolay N.; Minin, Vadim V.; Lytvynenko, Anton S.; Gavrilenko, Konstantin S.; Kolotilov, Sergey V.; Novotortsev, Vladimir M.; Eremenko, Igor L.. The article conveys some information:

Interaction of tripyridine ligand, bearing 2,6-di-tert-butylphenolic fragment (L, 2,6-di-tert-butyl-4-(3,5-bis(4-pyridyl)pyridyl)phenol) with CoII pivalate or chloride gave 1D coordination polymers [Co(L)Cl2]n·nEtOH (1) and [Co3(L)2(OH)(Piv)5]n (2) or trinuclear complex Co3(H2O)4(L)2Cl6 (3) (Piv- = pivalate). Chem. oxidation of L, 1-3 by PbO2 or K3[Fe(CN)6], as well as exposure of L (in solution or solid state) and 2 (in solid state) to UV-irradiation gave free radicals with g = 2.0024, which probably originated due to oxidation of 2,6-di-tert-butylphenolic groups. These radicals were stable during several days in solutions and more than one month in solid samples. Irradiation and oxidation of the solid samples probably caused formation of the phenoxyl radical only on their surface. It was shown by DFT calculations that exchange coupling between the unpaired electron of the phenoxyl and CoII ions were negligibly weak and could not affect EPR signal of the radical, as well as exchange coupling of CoII ions could not be transmitted by L. The latter conclusion was confirmed by the anal. of magnetic properties of 1: temperature dependency of magnetic susceptibility (χM) of 1 could be simulated by a simple model for isolated CoII ions.4-Acetylpyridine(cas: 1122-54-9Recommanded Product: 4-Acetylpyridine) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Recommanded Product: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 2-(Bromomethyl)pyridine hydrobromideIn 2016 ,《Synthesis and structural analyses of phenylethynyl-substituted tris(2-pyridylmethyl)amines and their copper(II) complexes》 appeared in Dalton Transactions. The author of the article were Lim, Jaebum; Lynch, Vincent M.; Edupuganti, Ramakrishna; Ellington, Andrew; Anslyn, Eric V.. The article conveys some information:

Three new tris(2-pyridylmethyl)amine-based ligands possessing phenylethynyl units were prepared using Sonogashira couplings and substitution reactions. Copper(II) complexes (I) of those tetradentate ligands also were synthesized. Solid-state structures of the six new compounds were determined by single-crystal x-ray diffraction analyses. Examination of the mol. structures of the ligands revealed the expected triangular geometries with virtually undeformed carbon-carbon triple bonds. While the tertiary nitrogen of the free ligands seem to be prevented from participation in supramol. noncovalent interactions by the pyridyl hydrogen at the 3-position, the pyridyl nitrogens play a crucial role in the packing mode of the crystal structure. The nitrogens form weak hydrogen bonds, varied at 2.32-2.66 Å, with the pyridyl hydrogen of its neighboring mol. The [N···H-C] contacts enforce one-dimensional columnar assemblies on ligands that organize into wall-like structures, which in turn assemble into three-dimensional structures through CH-π interactions. Structural analyses of Cu(II) complexes of the ligands revealed propeller-like structures caused by steric crowding of three pyridine ligands. The copper complexes of the ligands having three phenylethynyl substituents showed a remarkably deformed carbon-carbon triple bond enforced by a steric effect of the three Ph groups. Most significantly, a total of seventy noncovalent interactions, classified into twelve types of hydrogen-involving short contacts, were identified. The phenylethynyl substituent participated in forty-two interactions as a hydrogen bond acceptor, and its role was more distinctive in the crystal structures of the Cu(II) complexes. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Reference of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Reference of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 2-(Bromomethyl)pyridine hydrobromideIn 2019 ,《Iron(II) tetrafluoroborate complexes of new tetradentate C-scorpionates as catalysts for the oxidative cleavage of trans-stilbene with H2O2》 appeared in Dalton Transactions. The author of the article were Wang, Denan; Gardinier, James R.; Lindeman, Sergey V.. The article conveys some information:

Attachment of a 2-methylpyridyl group onto the unique 1-nitrogen atom on nitrogen-confused C-scorpionates with either pyrazol-1-yl or 3,5 dimethylpyrazol-1-yl donors gives two new cis-directing tetradentate-N4 ligands (L and L*). The complexes [(L or L*)Fe(CH3CN)2](BF4)2 (1 or 2) were prepared, fully characterized, and investigated for their ability to catalyze the oxidative cleavage of trans-stilbene in CH3CN. Complexes 1 and 2 are capable of catalyzing stilbene cleavage when H2O2 is used as an oxidant but up to six different products are formed, with C:C cleavage products (benzaldehyde and benzoic acid) dominating over four products of oxygen transfer. Catalytic amounts of 1 or 2 enhance the ability for the organic photocatalyst riboflavin tetraacetate to use atm. oxygen and blue light irradiation (450-460 nm) to selectively cleave stilbene to benzaldehyde. However, when benzaldehyde oxidizes further to benzoic acid, the iron species begin giving increasing amounts of stilbene oxygenation products.2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Reference of 2-(Bromomethyl)pyridine hydrobromide) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Reference of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 2,6-DibromopyridineIn 2020 ,《Synthesis of Pyridylsulfonium Salts and Their Application in the Formation of Functionalized Bipyridines》 appeared in Organic Letters. The author of the article were Duong, Vincent K.; Horan, Alexandra M.; McGarrigle, Eoghan M.. The article conveys some information:

An S-selective arylation of pyridylsulfides with good functional group tolerance was developed. To demonstrate synthetic utility, the resulting pyridylsulfonium salts were used in a scalable transition-metal-free coupling protocol, yielding functionalized bipyridines with extensive functional group tolerance. This modular methodol. permits selective introduction of functional groups from com. available pyridyl halides, furnishing sym. and unsym. 2,2′- and 2,3′-bipyridines. Iterative application of the methodol. enabled the synthesis of a functionalized terpyridine with three different pyridine components. In the experimental materials used by the author, we found 2,6-Dibromopyridine(cas: 626-05-1Recommanded Product: 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 2,6-DibromopyridineIn 2020 ,《Tuning Second Coordination Sphere Interactions in Polypyridyl-Iron Complexes to Achieve Selective Electrocatalytic Reduction of Carbon Dioxide to Carbon Monoxide》 was published in Inorganic Chemistry. The article was written by Zee, David Z.; Nippe, Michael; King, Amanda E.; Chang, Christopher J.; Long, Jeffrey R.. The article contains the following contents:

The development of noble-metal-free catalysts capable of electrochem. converting CO2 (CO2) selectively into value-added compounds remains one of the central challenges in catalysis research. Here, the authors present a systematic study of Fe(II) complexes of the functionalized ligands bpyRPY2Me (bpyPY2Me = 6-(1,1-bis(pyridin-2-yl)ethyl)-2,2′-bipyridine) in the pursuit of H2O-stable mol. Fe complexes that are selective for the catalytic formation of CO from CO2. Taking advantage of the inherently high degree of tunability of this ligand manifold, the authors followed a bioinspired approach by installing protic functional groups of varying acidities (-H, -OH, -OMe, -NHEt, and -NEt2) into the ligand framework to systematically modify the 2nd coordination sphere of the Fe center. This family of [(bpyRPY2Me)FeII] complexes was characterized using single-crystal x-ray anal., 1H NMR spectroscopy, and mass spectrometry. Comparative catalytic evaluation of this set of compounds via voltammetry and electrolysis experiments identified [(bpyNHEtPY2Me)Fe]2+ in particular as an efficient, Fe-based, nonheme CO2 electroreduction catalyst that displays significant selectivity for the conversion of CO2 to CO in MeCN solution with 11 M H2O. Probably the NH group acts as a local proton source for cleaving the C-O bond in CO2 to form CO. The complex with the most acidic functional group in the 2nd coordination sphere, [(bpyOHPY2Me)Fe]2+, favors formation of H2 over CO. The authors’ results correlate the selectivity of H2O vs. CO2 reduction to the acidity of the 2nd coordination sphere functional group and emphasize the continued untapped potential that synthetic mol. chem. offers in the pursuit of next-generation CO2 reduction electrocatalysts. The 2nd coordination sphere is systematically altered in polypyridyl-Fe(II) complexes, [(bpyRPY2Me)FeII]2+, with protic functional groups of varying acidities (R = -H, -OH, -OMe, -NHEt, -NEt2). [(BpyNHEtPY2Me)Fe]2+ is an efficient CO2 electroreduction catalyst that is selective for the conversion of CO2 to CO in MeCN solution with 11 M H2O. The complex with the most acidic functional group in the 2nd coordination sphere, [(bpyOHPY2Me)Fe]2+, favors formation of H2 over CO. The results came from multiple reactions, including the reaction of 2,6-Dibromopyridine(cas: 626-05-1Reference of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Reference of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C5H5BrN2In 2019 ,《Lewis-Acid-Catalyzed Direct Nucleophilic Substitution Reaction of Alcohols for the Functionalization of Aromatic Amines》 was published in ChemistrySelect. The article was written by Nayal, Onkar S.; Thakur, Maheshwar S.; Rana, Rohit; Upadhyay, Rahul; Maurya, Sushil K.. The article contains the following contents:

Herein, an efficient catalytic activity of tin(II) triflate for the N-alkylation of secondary anilines with alcs. for the synthesis of tertiary benzylamines I (R1 = H, 3-OMe, 4-Br, etc.; R2 = H, 4-F, 3-Me, etc.; R3 = Me, Et, i-Pr, allyl) was explored. Mechanistic studies suggest that the developed protocol follows direct nucleophilic substitution pathway instead of imine or enamine pathway. The developed method is also useful for the synthesis of secondary amines as well as late stage functionalization of naturally occurring alcs. The experimental part of the paper was very detailed, including the reaction process of 6-Bromopyridin-3-amine(cas: 13534-97-9Electric Literature of C5H5BrN2)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Electric Literature of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromideIn 2022 ,《Group 12 metal complexes of mixed thia/aza and thia/oxa/aza macrocyclic ligands》 was published in Polyhedron. The article was written by Hodorogea, Ana Maria; Silvestru, Anca; Lippolis, Vito; Pop, Alexandra. The article contains the following contents:

The coordination behavior of the macrocyclic ligands N-(2-pyridylmethyl)-[12]aneNS2O (L1) and N-(2-pyridylmethyl)-[12]aneNS3 (L2) ([12]aneNS2O = 1-aza-4,10-dithia-7-oxacyclododecane, [12]aneNS3 = 1-aza-4,7,10-trithia-cyclododecane) was studied in complexation reactions with ZnCl2, CdI2 and HgCl2. The NMR and mass spectra suggest the formation of the ionic species [LMX]2[MX4] [M = Zn, X = Cl, L = L1 (1), L2 (2); M = Cd, X = I, L = L1 (3), L2 (4); M = Hg, X = Cl, L = L1 (5), L2 (6)]. The x-ray diffraction studies confirmed the formation of the new species 3-6, with [LMX]+ cations and [MX4]2- anions, while for the zinc(II) complex 1 the determined structure corresponds to the hydrolysis product of formula [L1Zn]2[ZnCl3]2[Zn2Cl6]·2H2O (1h), with [L1Zn(H2O)]2+ cations and [ZnCl3(H2O)]- and [Zn2Cl6]2- anions. In all complexes the metal ion is hexacoordinated in cations, while in anions the metal is tetrahedrally surrounded by halido ligands. In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 2-(2-Hydroxyethyl)pyridineIn 2022 ,《Ni-Catalyzed Synthesis of Thiocarboxylic Acid Derivatives》 was published in Organic Letters. The article was written by Monteith, John J.; Scotchburn, Katerina; Mills, L. Reginald; Rousseaux, Sophie A. L.. The article contains the following contents:

A Ni-catalyzed cross-coupling of readily accessible O-alkyl xanthate esters or thiocarbonyl imidazolides and organozinc reagents for the synthesis of thiocarboxylic acid derivatives has been developed. This method benefits from a fast reaction time, mild reaction conditions and ease of starting material synthesis. The use of transition metal catalysis to access a diverse range of thiocarbonyl containing compounds provides a useful complementary approach when compared to previously established methodologies. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Name: 2-(2-Hydroxyethyl)pyridine)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Name: 2-(2-Hydroxyethyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Facile synthesis of extended TPA-quinazolinone derivatives and the nonlinear optical properties》 was written by Zheng, Mingming; Zhang, Jiuming; Wang, Wenbiao; Gao, Jianrong; Jia, Jianhong. SDS of cas: 624-28-2This research focused ontriphenylamine quinazolinone derivative synthesis Suzuki cross coupling reaction; fluorescence photophys nonlinear optical property. The article conveys some information:

In this work, four new quinazolinone (QZ)-based compounds containing triphenylamine (TPA) moiety have been synthesized, defined as QZC, QZC-1, QZC-2, QZC-3, for the application of third-order nonlinear optical (NLO) responses. A new design of two-step synthesis has been put forward, the first step is Ullmann reaction with QZ, and the second is connecting QZ and the substituted triphenylamines (TPAs) through a Suzuki cross-coupling reaction to afford the target products. Electrochem. measurement data indicated that the tuning of the HOMO and LUMO energy levels can be easily achieved by introducing and modifying the donor moiety. The NLO properties were evaluated by the Z-scan technique which showed that introduction of a benzene ring as a π bridge could reduce the transmission energy of electrons from a ground state to an excited state, and the added methoxy in TPA moiety could promote the ICT, and improve the third-order NLO properties of mols. Theor. calculations matched well with the electrochem. information and NLO information. The results suggest that the materials based on QZ have potential applications in integrated NLO devices. In the experiment, the researchers used 2,5-Dibromopyridine(cas: 624-28-2SDS of cas: 624-28-2)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.SDS of cas: 624-28-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem