Day: October 24, 2022

Recommanded Product: 4-Amino-2-picolineOn March 18, 2020, Chen, Ying-Chu; Faver, John C.; Ku, Angela F.; Miklossy, Gabriella; Riehle, Kevin; Bohren, Kurt M.; Ucisik, Melek N.; Matzuk, Martin M.; Yu, Zhifeng; Simmons, Nicholas published an article in Bioconjugate Chemistry. The article was 《C-N Coupling of DNA-Conjugated (Hetero)aryl Bromides and Chlorides for DNA-Encoded Chemical Library Synthesis》. The article mentions the following:

DNA-encoded chem. library (DECL) screens are a rapid and economical tool to identify chem. starting points for drug discovery. As a robust transformation for drug discovery, palladium-catalyzed C-N coupling is a valuable synthetic method for the construction of DECL chem. matter; however, currently disclosed methods have only been demonstrated on DNA-attached (hetero)aromatic iodide and bromide electrophiles. We developed conditions utilizing an N-heterocyclic carbene-palladium catalyst that extends this reaction to the coupling of DNA-conjugated (hetero)aromatic chlorides with (hetero)aromatic and select aliphatic amine nucleophiles. In addition, we evaluated steric and electronic effects within this catalyst series, carried out a large substrate scope study on two representative (hetero)aryl bromides, and applied this newly developed method within the construction of a 63 million-membered DECL.4-Amino-2-picoline(cas: 18437-58-6Recommanded Product: 4-Amino-2-picoline) was used in this study.

4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Recommanded Product: 4-Amino-2-picoline

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dykeman, Ryan R.; Yan, Ning; Scopelliti, Rosario; Dyson, Paul J. published an article on February 7 ,2011. The article was titled 《Enhanced rate of arene hydrogenation with imidazolium functionalized bipyridine stabilized rhodium nanoparticle catalysts》, and you may find the article in Inorganic Chemistry.Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridine The information in the text is summarized as follows:

The imidazolium functionalized bipyridine compounds, {4,4′-bis[7-(2,3-dimethylimidazolium)heptyl]-2,2′-bipyridine}2+ ([BIHB]2+) and {4,4′-bis[(1,2-dimethylimidazolium)methyl]-2,2′-bipyridine}2+ ([BIMB]2+), were prepared and used as Rh nanoparticle stabilizers. The dispersed Rh nanoparticles were used as catalysts in the biphasic hydrogenation of various arene substrates. The catalytic activity was strongly influenced by the stabilizer employed and followed the trend [BIHB]2+ > bipy > [BIMB]2+. The steric and electronic characteristics of the imidazolium functionalized bipyridine ligands were assessed via the synthesis of rhenium carbonyl complexes, which facilitated the rationalization of the catalytic properties of the nanoparticles. The results came from multiple reactions, including the reaction of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridine)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Application In Synthesis of 4,4′-Bis(chloromethyl)-2,2′-bipyridine Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Multiple electrochemically accessible colour states in surface-confined metal-organic monolayers: stepwise embedding of individual metal centres》 were Laschuk, Nadia O.; Ahmad, Rana; Ebralidze, Iraklii I.; Poisson, Jade; Gaspari, Franco; Easton, E. Bradley; Zenkina, Olena V.. And the article was published in Materials Advances in 2021. Application In Synthesis of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine The author mentioned the following in the article:

Sequential covalent embedding of cobalt, osmium, and iron complexes of 4′-(pyridin-4-yl)-2,2′ :6′ ,2”- terpyridine to surface-enhanced supports pre-functionalized with a templating layer results in hetero-bimetallic (Os-Fe and Co-Fe) and hetero-trimetallic (Co-Os-Fe) monolayer materials. During sequential embedding, each subsequent metal complex deposits onto unoccupied sites of the templating layer leading to densely packed functional materials. Electrochem. and XPS results show that the packing d. of Fe(II) species on the surface of the resulting materials is higher than those of pre-deposited Co(II) and Os(II) isostructural complexes. Moreover, according to Raman spectroscopy results, Fe-containing mols. experience steric hindrance when anchored to sequentially deposited Os- or Co-Os materials. The oxidation states of the metal centers in these materials can be successively electrochem. changed resulting in distinct color-to-color transitions. Importantly, monolayer materials formed on the conductive surface-enhanced indium-tin-oxide support can operate as entire working electrodes, which, in combination with a polymer gel electrolyte and an indium tin oxide/glass counter electrode, result in two-electrode electrochromic devices (ECDs). Upon operation these devices demonstrate some deterioration of the change in optical d. (ΔOD), however, this deterioration is mostly due to gel electrolyte decomposition The nature of the material allows easy replacement of the electrolyte and the counter electrode. Re-assembly of Co-Fe ECD using a new gel electrolyte and an ITO-glass counter electrode results in almost complete ΔOD recuperation. In the experiment, the researchers used 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Application In Synthesis of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Application In Synthesis of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Buysse, Ann M.; Nugent, Benjamin M.; Wang, Nick X.; Benko, Zoltan; Breaux, Nneka; Rogers, Richard; Zhu, Yuanming published 《Studies toward understanding the SAR around the sulfoximine moiety of the sap-feeding insecticide sulfoxaflor》.Pest Management Science published the findings.Name: 5-Bromo-2-chloropyridine The information in the text is summarized as follows:

BACKGROUND : The discovery of sulfoxaflor (IsoclastTM active) stemmed from a novel scaffold-based approach toward identifying bioactive mols. It exhibits broad-spectrum control of many sap-feeding insect pests, including aphids, whiteflies, hoppers and Lygus. Systematic modifications of the substituents flanking each side of the sulfoximine moiety were carried out to determine whether these changes would improve potency. Structure-activity relationship (SAR) studies showed that, with respect to the methylene linker, both mono- and disubstitution with alkyl groups of varying sizes as well as cyclic analogs exhibited excellent control of cotton aphids. However, against green peach aphids a decrease in activity was observed with substituents larger than Et as well as larger cycloalkyl groups. At the terminal tail there appeared to be a narrow steric tolerance as well, with linear groups or small rings more active against green peach aphids than bulkier groups. A novel series of compounds exploring the substituents flanking the sulfoximine moiety of sulfoxaflor were prepared and tested for bioactivity against cotton aphids and green peach aphids. SAR studies indicated that a decrease in green peach aphid potency was observed at the methylene linker as well as at the terminal tail with bulkier substituents. A quant.structure-activity relationship anal. of the compounds revealed significant correlation of activity with two mol. descriptors, vol (volumeof a mol.) and GCUT_SMR_3 (molar refractivity). This predictive model helps to explain the observed activity with the various substituents. After reading the article, we found that the author used 5-Bromo-2-chloropyridine(cas: 53939-30-3Name: 5-Bromo-2-chloropyridine)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Name: 5-Bromo-2-chloropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Current Organic Synthesis included an article by Chen, Mingwei; Hu, Jinyu; Tang, Xiaoli; Zhu, Qiming. Name: 4,4′-Dimethyl-2,2′-bipyridine. The article was titled 《Piperazine as an Inexpensive and Efficient Ligand for Pd-Catalyzed Homocoupling Reactions to Synthesize Bipyridines and Their Analogues》. The information in the text is summarized as follows:

In the present work, a promising approach for preparation of bipyridines and their (hetero) aromatic analogs I (Ar = 2-pyridyl, 4-O2NC6H4, quinolin-2-yl, etc.) via a Pd-catalyzed reductive homocoupling reaction with simple piperazine as a ligand is discussed . The combination of Pd(OAc)2 and piperazine in DMF was observed to form an excellent catalyst system and efficiently catalyzed the homocoupling of azaarenyl halides, in which DMF was used as the solvent without excess reductants although stoichiometric reductant was generally required to generate the low-oxidation-state active metal species in the catalytic cycles. In this case, good to excellent yields of bipyridines were obtained in the presence of 2.5 mol% of Pd(OAc)2 and 5 mol% of piperazine, using K3PO4 as a base in DMF at 140°C. The coupling reaction was operationally simple and displayed good substrate compatibility.4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Name: 4,4′-Dimethyl-2,2′-bipyridine) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Name: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Physical Chemistry C included an article by Xu, Xing; Lai, Lei; Jiang, Jiahong; He, Zhiqiao; Song, Shuang. Recommanded Product: 2,6-Diaminopyridine. The article was titled 《C,N-Codoped TiO2 with a Nitrogen-Doped Carbon Coating Derived from 2,6-Diaminopyridine for Visible Light-Induced Photocatalytic Hydrogen Evolution》. The information in the text is summarized as follows:

Nitrogen-doped carbon-wrapped C,N-codoped TiO2 (CN@C,N-TiO2) was successfully prepared using a facile and efficient method involving hydrolysis and calcination under Ar using tetra-Bu titanate and 2,6-diaminopyridine as the precursors. XPS and valence band XPS measurements reveal the successful codoping of interstitial carbon and nitrogen into TiO2, which leads to a visible-light absorption of up to ∼550 nm in the UV-vis diffuse reflectance spectra. Raman spectra and high-resolution TEM results show that N-doped carbon exists on the surface of C,N-TiO2, which gives rise to the efficient separation of photoexcited charge carriers, as determined by photoluminescence and electrochem. impedance spectroscopy. Benefiting from the combined effects of a surface-coated N-doped carbon layer and C,N-codoping, the photocatalyst calcined at 450° exhibits remarkable visible-light activity toward the hydrogen evolution reaction in the water splitting process with a H2 production rate of 833.2 μmol h-1 g-1 under 94 mW cm-2 visible-light illumination (λ > 420 nm). Moreover, the representative CN@C,N-TiO2 sample can maintain its activity for at least 40 h. After reading the article, we found that the author used 2,6-Diaminopyridine(cas: 141-86-6Recommanded Product: 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Recommanded Product: 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Materials Today: Proceedings included an article by Zou, Faxing; Chen, Shaojun. Safety of 2,6-Diaminopyridine. The article was titled 《A Novel 2,6-Diaminopyridine-base Polymer with Thermo-/Water-responsive Shape Memory Effect》. The information in the text is summarized as follows:

Shape memory polymers with multiple stimuli have obtained increasing attention. This study illustrates a strategy for synthesizing polymers with thermo-/water-responsive shape memory effect. The novel polymer with excellent nature was proved to synthesized correctly using 2,6-diaminopyridine (DAP), polyethylene glycol (PEG1000) and hexamethylene diisocyanate (HDI). The result shows that the thermal stability of polyurethane can be improved with increasing of the DAP, embed into mol. chain. Moreover, the polymer which possesses excellent thermo-responsive, can be deformed and restored when in contact with water. The finding in this contribution, strongly promote diversified applications of shape-memory polymers, especially in engineering fields. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Safety of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,New Journal of Chemistry included an article by Meti, Puttavva; Nagaraju, Goli; Yang, Jung-Won; Jung, Sun Hwa; Gong, Young-Dae. Application In Synthesis of 4-Ethynylpyridine. The article was titled 《Synthesis of dipyrrolopyrazine-based sensitizers with a new π-bridge end-capped donor-acceptor framework for DSSCs: a combined experimental and theoretical investigation》. The information in the text is summarized as follows:

The strategy of developing organic dyes with exceptional optical, thermal, and stable photovoltaic properties has attracted substantial attention in the replacement of high-cost traditional dyes in DSSCs. Herein, we synthesized four dyes with a D-π-A configuration in order to study the variation produced in the optical, thermal, redox and photovoltaic properties by substitution of different donors and acceptors in the dipyrrolopyrazine (DPP) system. These push-pull systems are based on a pyrrolopyrazine spacer, end-capped with donors (N,N-dimethylamine, and thiophene) and acceptors (pyridine, -COOH, and -CN). The multidisciplinary study concerning the optical, thermal, redox, and photovoltaic characterization of the dyes reveals that compound 3a exhibits the best overall conversion efficiency as a sensitizer in TiO2 dye sensitized solar cells. The theor. calculations together with exptl. data allow us to quantify the charge transfer character of dyes. The results came from multiple reactions, including the reaction of 4-Ethynylpyridine(cas: 2510-22-7Application In Synthesis of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Resolution of minor size differences in a family of heteroleptic coordination cages by trapped ion mobility ESI-MS》 were Ebbert, Kristina E.; Schneider, Laura; Platzek, Andre; Drechsler, Christoph; Chen, Bin; Rudolf, Robin; Clever, Guido H.. And the article was published in Dalton Transactions in 2019. Related Products of 2510-22-7 The author mentioned the following in the article:

A complex system of heteroleptic coordination cages based on the combination of 4 bis-monodentate ligands whose backbones only slightly differ in shape and length is reported. Cis-[Pd2L2L’2] assemblies cleanly form after addition of PdII cations to a 1:1 mixture of 2 shape-complementary ligands, each. When 3 or even all 4 ligands are used in combination, the unambiguous discrimination of all individual species in the product mixture becomes difficult by conventional NMR spectroscopic and mass spectrometric methods. Due to steric constraints, the system is restricted to the formation of 10 different coordination cages in total, 2 of which are isomeric. High-resolution trapped ion mobility mass spectrometry (TIMS) allows the clear differentiation of all 10 species. Observed size trends could be readily reproduced by the calculation of theor. values for collisional cross sections (CCS) from geometry-optimized models. After reading the article, we found that the author used 4-Ethynylpyridine(cas: 2510-22-7Related Products of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Related Products of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Role of the kynurenine pathway and the endocannabinoid system as modulators of inflammation and personality traits》 were Heilman, Patrick; Hill, Matthew N.; Coussons-Read, Mary; Brundin, Lena; Coccaro, Emil F.. And the article was published in Psychoneuroendocrinology in 2019. Quality Control of Picolinic acid The author mentioned the following in the article:

Kynurenine pathway metabolites and endocannabinoids both exert potent regulatory effects on the immune system, but the relationship between these mols. is unknown. The role of these immunobiol. mediators in emotionality and personality traits is not previously characterized. Interleukin-6 (IL-6), 2-arachidonoylglycerol (2-AG) and picolinic acid (PIC) were measured in the plasma of phys. healthy individuals who had history of mood, anxiety, and personality disorders (n = 96) or who had no history of any psychiatric disorder (n = 56) by DSM-5 Criteria. Dimensional assessments of personality were performed using the Eysenck Personality Questionnaire (EPQ) and the Tridimensional Personality Questionnaire (TPQ). Plasma IL-6 levels were significantly associated with plasma 2-AG levels and plasma PIC levels across all subjects. PIC levels were also neg. associated with 2-AG levels across all subjects, independent of IL-6 levels. In our anal. of the biol. determinants of personality factors, we identified significant associations between IL-6 and novelty seeking assessment, and between PIC and neuroticism assessment. These data provide evidence of a biol. link between metabolites of the kynurenine pathway, the endocannabinoid system and IL-6 and suggest that these factors may influence personality traits. After reading the article, we found that the author used Picolinic acid(cas: 98-98-6Quality Control of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Quality Control of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem