Day: October 24, 2022

《Well-defined, linear, wholly aromatic polymers with controlled content and position of pyridine moieties in macromolecules from one-pot, room temperature, metal-free step-polymerizations》 was published in Polymer Chemistry in 2020. These research results belong to Cetina-Mancilla, Enoc; Olvera, Lilian I.; Balmaseda, Jorge; Forster, Michael; Ruiz-Trevino, F. Alberto; Cardenas, Jorge; Vivaldo-Lima, Eduardo; Zolotukhin, Mikhail G.. Name: 4-Acetylpyridine The article mentions the following:

Synthesis of processable, aromatic pyridine-containing polymers has always been a great challenge. Here, we report for the first time a robust, low-cost synthesis of well defined, high mol. weight, linear, wholly aromatic polymers with rigid ether-bond-free aryl backbones, where the proportion and position of pyridine moieties and spacer lengths between them in the macromols. are fully controlled. The polymers, in nearly quant. yields, were obtained by one-pot, room temperature, metal-free, non-stoichiometric superacid catalyzed step-polymerization of 4-acetylpyridine (and its mixtures with 2,2,2-trifluoroacetophenone) with multiring aromatic hydrocarbons: biphenyl, meta- and para-terphenyl, and para-quaterphenyl, in the mixture of trifluoromethanesulfonic acid with methylene chloride and trifluoroacetic acid. The polymers are highly soluble in most common solvents and form flexible and tough films with tensile strength in the range of 72-92 MPa. 1H and 13C NMR analyses of the synthesized polymers revealed high regio-selectivity of the polymer forming reaction affording linear structures with para-substitution in the phenylene fragments of the main chains. The mol. weights of the polymers ranged from 20 000 to 100 000 g mol-1, whereas the polydispersity is generally well below 2. The polymers exhibited also high thermostability with Tg > 400°, weight loss temperatures (N2, onset) ca. 485°, char yields of 70-75 at 800° and high chem. stability. Room temperature reactions of the polymers with methyl(trifluoromethylsulfonate) afford the N-methylated cationic polymers. Certain studies on the phys. properties and gas separation of the polymers are highlighted. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9Name: 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Name: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《S1PR2 inhibitors potently reverse 5-FU resistance by downregulating DPD expression in colorectal cancer》 was published in Pharmacological Research in 2020. These research results belong to Zhang, Yu-Hang; Luo, Dong-Dong; Wan, Sheng-Biao; Qu, Xian-Jun. Computed Properties of C5H6BNO2 The article mentions the following:

In this study, S1PR2 was reckoned as a brand-new GPCR target for designing inhibitors to reverse 5-FU resistance. Herein a series of pyrrolidine pyrazoles as the S1PR2 inhibitors were designed, synthesized and evaluated for their activities of anti-FU-resistance. Among them, the most promising compound JTE-013, exhibited excellent inhibition on DPD expression and potent anti-FU-resistance activity in various human cancer cell lines, along with the in vivo HCT116DPD cells xenograft model, in which the inhibition rate of 5-FU was greatly increased from 13.01%-75.87%. The underlying mechanism was uncovered that JTE-013 demonstrated an anti-FU-resistance activity by blocking S1PR2 internalization to the endoplasmic reticulum (ER), which inhibited the degradation of 5-FU into α-fluoro-β-alanine (FBAL) by downregulating tumoral DPD expression. Overall, JTE-013 could serve as the lead compound for the discovery of new anti-FU-resistance drugs. This study provides novel insights that S1PR2 inhibitors could sensitize 5-FU therapy in colorectal cancer. The experimental process involved the reaction of Pyridin-3-ylboronic acid(cas: 1692-25-7Computed Properties of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Computed Properties of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Influence of Ligand Denticity and Flexibility on the Molecular Copper Mediated Oxygen Reduction Reaction》 was written by Smits, Nicole W. G.; van Dijk, Bas; de Bruin, Iris; Groeneveld, Samantha L. T.; Siegler, Maxime A.; Hetterscheid, Dennis G. H.. Electric Literature of C12H13N3 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

To date, the Cu complex with the tris(2-pyridylmethyl)amine (tmpa) ligand (Cu-tmpa) catalyzes the ORR with the highest reported turnover frequency (TOF) for any mol. Cu catalyst. To gain insight into the importance of the tetradentate nature and high flexibility of the tmpa ligand for efficient four-electron ORR catalysis, the redox and electrocatalytic ORR behavior of the Cu complexes of 2,2′:6′,2”-terpyridine (terpy) and bis(2-pyridylmethyl)amine (bmpa) (Cu-terpy and Cu-bmpa, resp.) were studied. With a combination of cyclic voltammetry and rotating ring disk electrode measurements, the presence of the terpy and bmpa ligands results in a decrease in catalytic ORR activity and an increase in faradaic efficiency for H2O2 production The lower catalytic activity is the result of a stabilization of the CuI state of the complex compared to the earlier reported Cu-tmpa catalyst. This stabilization is most likely caused by the lower electron donating character of the tridentate terpy and bmpa ligands compared to the tetradentate tmpa ligand. The Laviron plots of the redox behavior of Cu-terpy and Cu-bmpa indicated that the formation of the ORR active catalyst involves relatively slow electron transfer kinetics which is caused by the inability of Cu-terpy and Cu-bmpa to form the preferred tetrahedral coordination geometry for a CuI complex easily. The authors’ study illustrates that both the tetradentate nature of the tmpa ligand and the ability of Cu-tmpa to form the preferred tetrahedral coordination geometry for a CuI complex are of utmost importance for ORR catalysis with very high catalytic rates. Redox and electrocatalytic ORR behavior of the mononuclear Cu complexes of 2,2′:6′,2”-terpyridine (terpy) and bis(2-pyridylmethyl)amine (bmpa) in neutral aqueous buffer solution: High faradaic efficiencies for H2O2 production were revealed along the ORR active potential window using the rotating ring disk electrode (RRDE), and the foot-of-the-wave anal. (FOWA) was applied to describe the catalytic activity quant. Addnl., the stability of the catalysts under operating conditions receives considerable attention.Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Electric Literature of C12H13N3) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Electric Literature of C12H13N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Formation, stability and catalase-like activity of mononuclear manganese(II) and oxomanganese(IV) complexes in protic and aprotic solvents》 was written by Kripli, Balazs; Garda, Zoltan; Solyom, Bernadett; Tircso, Gyula; Kaizer, Jozsef. Category: pyridine-derivatives And the article was included in New Journal of Chemistry in 2020. The article conveys some information:

Synthetic compounds as biomimics of catalase enzymes may have potential biomedical applications as therapeutic agents for the detoxification of H2O2 and may give further information about the role of metal cofactors during the dismutation process. In this work, authors present the synthesis and characterization of manganese(II) and oxomanganese(IV) complexes of a pentadentate ligand (N4Py* = N,N-bis(2-pyridylmethyl)-1,2-di(2-pyridyl)ethylamine), [MnII(N4Py*)(CH3CN)](CF3SO3)2 (1) and [MnIV(O)(N4Py*)](CF3SO3)2 (2). Detailed pH-potentiometric titrations were also performed in order to gain insights into the complexation properties of the N4Py* ligand, and the equilibrium model used for fitting the pH-potentiometric titration data for the [Mn(N4Py*)]2+ complex was confirmed by 1H-NMR relaxometry at 0.49 T field strength and 25°. Complex 1 has been shown to catalyze the dismutation of H2O2 into O2 and H2O in both aprotic (MeCN and DMF) and protic (TFE and buffered H2O) solvents. The reactivity of 1 was higher in protic solvents, which was markedly influenced by the pH, and it revealed a Michaelis-Menten behavior at pH 10.5 at 298 K. A mononuclear oxomanganese(IV) complex, 2, as a possible intermediate in the catalytic process, was also prepared, and its stability and reactivity towards H2O2 was also investigated in TFE and buffered H2O/TFE solutions The stoichiometric oxidation of H2O2 with 2 provided clear evidence (solvent isotope effect (SIE) of 6.2, pH dependence, saturation kinetics, etc.) of the rate-determining hydrogen atom transfer (HAT) mechanism between the H2O2 and oxomanganese(IV) species. The present results provide one of the first examples of a non-heme MnIVO complex that shows a catalase-like reaction in water. The experimental part of the paper was very detailed, including the reaction process of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Category: pyridine-derivatives)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Highly efficient OLED device based on the double emissive layer with an EQE about 39%》 was written by Sharma, Arvind; Das, T. D.. Safety of fac-Tris(2-phenylpyridine)iridium And the article was included in Optik (Munich, Germany) in 2020. The article conveys some information:

Computational simulation study for dual -active scheme OLED (organic light-emitting diode) is validated with the attribution of two colors: firstly, BEPP which functions as fluorescence emission layer and secondly TCTA: Ir(ppy)3 as phosphorescent emission layer (TCTA: Ir(ppy)3) for intensifying the exciton operation. The device architecture for the OLED is further improved with the accreditation of doubly active layers exhibiting the maximum external quantum efficiency (EQE) upto 39% (D1 device) corresponding to CIE chromaticity coordinates (0.57, 0.42). The simulated device offers higher EQE than previously reported results of EQE about 30% by Wang et al. [25]. Concurrently, the role of viewing angle is also observed on electroluminance emission, as the EL spectrum is red shifted by ∼ 6 nm and peaks are depicted at 508 nm and 600 nm wavelength with an increased viewing angle. However, at the condition of increasing viewing angle, FWHM also becomes wider, as it is the noticeable change in the intensity ratio between the two emission peaks of the device. Lastly, the effects of dipole orientation on optical emission are further studied as a function of ETL-TPBi thickness for isotropic, TM, and TE mode optical channels, resp. in air. The device outcoupled efficiency is found more sensitive for TM mode than the rest in the study. Therefore, the result suggests that the dual-active scheme significantly improved device performance and offers a better outcome for device fabrication. The experimental process involved the reaction of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Safety of fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Safety of fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Martell, Mark; Ocheje, Michael U.; Gelfand, Benjamin S.; Rondeau-Gagne, Simon; Welch, Gregory C. published their research in New Journal of Chemistry in 2021. The article was titled 《Sidechain engineering of N-annulated perylene diimide molecules》.Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide The article contains the following contents:

The synthesis and characterization of six new N-annulated perylene diimide (N-PDI) mols. consisting of different alkyl-based heteroatom and waxy infused sidechains is reported. Amino, urea, quaternary Me ammonium, iminopyridine, hexadecyl and pyridine moieties were all appended to the pyrrolic N-position of N-annulated PDI. These N-PDI derivatives have been synthesized using facile SN2 chem. resulting in high yields and without the need for purification via column chromatog. To further demonstrate the functional diversification offered by N-PDI we appended a cyano group to the 6,7-bay positions opposite the N-annulation site and tested utility in organic field effect transistor devices. Complete characterization of these N-PDI derivatives was completed using UV-Vis spectroscopy, cyclic voltammetry and solubility determination to observe how the appended sidechains affect structure-properties relationships. The experimental part of the paper was very detailed, including the reaction process of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wu, Ye-bin; Wu, You-zhi; Wu, Jian; Xu, Dan; Jiang, Hui; Chang, Wen-wu; Ma, Chang-you published their research in Journal of Organic Chemistry in 2021. The article was titled 《Copper-Catalyzed Regioselective Coupling of Tosylhydrazones and 2-Pyridones: A Strategy for the Production of N-Alkylated Compounds》.Synthetic Route of C7H7NO The article contains the following contents:

The highly regioselective N-alkylation reaction of 2-pyridones was achieved through hydrazone chem., especially for substrates with bulky secondary alkyl groups. Herein, a copper-catalyzed regioselective coupling of tosylhydrazones and 2-pyridones/isoquinolinones for the synthesis of N-alkylated compound such as N-alkylated pyridones I [R = CH(Me)(4-MeOC6H4), R1 = H, CN, C(O)OMe; R2 = H, OMe; R3 = H, F, Br] isoquinolinones II [R1 = H, Me; R2 = Ph, 3-O2NC6H4, 2-ClC6H4, etc.] was described. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Synthetic Route of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yadav, Eqvinshi; Khatana, Anil Kumar; Sebastian, Sharol; Gupta, Manoj K. published their research in New Journal of Chemistry in 2021. The article was titled 《DAP derived fatty acid amide organogelators as novel carrier for drug incorporation and pH-responsive release》.Related Products of 141-86-6 The article contains the following contents:

Inflammation is associated with many different class of diseases and NSAIDs (non-steroidal anti-inflammatory drugs) are mostly preferred for long-term use. Although they are safe to use, some serious side effects are associated with these class of compounds; therefore, local drug delivery is an option to minimize the side effects. In this study, we have designed a new gel formulation for topical and transdermal applications of the NSAIDs with enhanced properties. For this purpose, low mol. mass DAP (2,6-diaminopyridine) derived fatty acid amides with varying alkyl chain lengths are synthesized. These fatty acid amides form stable self-assembled aggregates in organic solvents as well as in organic and aqueous solvent mixtures affording organogels and bigels, resp. The min. gelation concentration (MGC) of the organic gel is 0.5% w/v, which behaves as a super gelator. The various functionality present in the DAP-derived fatty acid amide gelators play an important role in the self-aggregation such as pyridine moiety stack through π-π and alkyl chain via van der Waals interactions resulting in the formation of stable organo and bigels network. The prepared organogel emulsions with these fatty acid amides are capable to encapsulate and release the drug mol. ibuprofen at room temperature without altering its structure and activity. Therefore, these analogs can be successfully utilized in pharmaceutical industries as a novel drug delivery carrier.2,6-Diaminopyridine(cas: 141-86-6Related Products of 141-86-6) was used in this study.

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Related Products of 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Su; Li, Rui; Zhang, Zhichao; Gu, Minyang; Zhu, Hongyan; Fang, Jing; Ji, Zhiwen; Xu, Xiaodong; Tang, Liming published an article in 2021. The article was titled 《Analysis of mutagenic components of oxidative hair dyes with the Ames test》, and you may find the article in Human & Experimental Toxicology.Application In Synthesis of 2,6-Diaminopyridine The information in the text is summarized as follows:

Oxidative hair dyes consist of two components (I and II) that are mixed before use. Aromatic amines in component I and their reaction with hydrogen peroxide after mixing them with component II have been of primary concern. In addition, two in vitro genotoxicity assays are still required for the approval of the final products of oxidative hair dyes in China, and the substance in the oxidative hair dye that causes the high rate of pos. results in genotoxicity tests, especially the Ames test, has not been fully elucidated. In this study, we analyzed the formulation of 55 different oxidative hair dyes from 7 color series and performed Ames tests in the strain TA98 with the S9 mix (oxidative hair dyes Number 1-30) and in strain TA97a without the S9 mix (oxidative hair dyes Number 31-55). We found that toluene-2,5-diamine sulfate (2,5-diaminotoluene sulfate, DATS) in component I may be the cause of mutagenicity in TA98, and hydrogen peroxide in component II may be the cause of mutagenicity in TA97a, and their pos. concentrations were consistent with those that we calculated from Ames tests. The results suggest that the pos. results for the oxidative hair dye in the Ames test were inevitable because of the existence of DATS in component I and of hydrogen peroxide in component II. Therefore, we should carry out safety assessments on each raw material and carry out risk assessments on the final products of oxidative hair dyes instead of genotoxicity tests in China. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Application In Synthesis of 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Application In Synthesis of 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stevens, Matthew P.; Spray, Emily; Vitorica-Yrezabal, Inigo J.; Singh, Kuldip; Timmermann, Vanessa M.; Sotorrios, Lia; Macgregor, Stuart A.; Ortu, Fabrizio published an article in 2022. The article was titled 《Synthesis, characterisation and reactivity of group 2 complexes with a thiopyridyl scorpionate ligand》, and you may find the article in Dalton Transactions.Computed Properties of C7H5N The information in the text is summarized as follows:

Herein we report the reactivity of the proligand tris(2-pyridylthio)methane (HTptm) with various Alk. Earth (AE) reagents: (1) dialkylmagnesium reagents and (2) AE bis-amides (AE = Mg-Ba). Heteroleptic complexes of general formulas [Mg(Tptm)(R)] (R = Me, Bu) and [AE(Tptm)(NR2)] (AE = Mg-Ba; R = SiMe3) were targeted from the reaction of HTptm with R2Mg or [AE(NR2)2]2. Reaction of the proligand with dialkylmagnesium reagents led to formation of [{Mg(κ3C,N,N-CBu{S-C5H4N}2)(μ-S-C5H4N)}2] (1) and [{Mg(κ3C,N,N-CMe{S-C5H4N}2)(μ-OSiMe3)}2] (2) resp., as a result of a novel transfer of an alkyl group onto the methanide carbon with concomitant C-S bond cleavage. However, reactivity of bis-amide precursors for Mg and Ca did afford the target species [AE(Tptm)(NR2)] (3-AE; AE = Mg-Ca), although these proved susceptible to ligand degradation processes. DFT calculations show that alkyl transfer in the putative [Mg(Tptm)(Bu)] (1m’) system and amide transfer in 3-Ca is a facile process that induces C-S bond cleavage in the Tptm ligand. The complexes 3-Mg and 3-Ca were also tested as catalysts for the hydrophosphination of selected alkenes and alkynes, including the first example of mono-hydrophosphination of 4-ethynylpyridine which was achieved with high conversions and excellent regio- and stereochem. control. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7Computed Properties of C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Computed Properties of C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem