Day: October 24, 2022

In 2022,Chen, Yan; Gao, Zhanming; Wang, Lei; Li, Jiansheng; Tang, Yutian; Liu, Chun published an article in ACS Applied Polymer Materials. The title of the article was 《Living Supramolecular Polymerization of Ultrastable Kinetic Species of Ir(III) Complexes in Aqueous Media》.COA of Formula: C6H6BrN The author mentioned the following in the article:

Living supramol. polymerization (LSP) has become a key technol. for the progress of materials science. However, under the influence of hydrophobic interaction, the precise kinetic control of LSP in aqueous media is still challenging. The authors report a strategy to realize the LSP of ultrastable kinetic species that is nearly impossible to assemble spontaneously. Due to the strong hydrophobic interaction, the kinetic species of Ir(III) complex 2 (nanoparticles, 2NP) at 90 and 95% H2O contents can exist stably for >50 days at room temperature By mixing the seeds at an 85% H2O content and the suspension of kinetic species at a 95% H2O content in equal volume, LSP can be carried out at a 90% H2O content, and multicycle LSP at a 90% H2O content can be performed successfully. This LSP strategy broadens the practicality of LSP and is implemented by structurally simple Ir(III) complexes, which provides ideas for broadening the monomer scope of LSP. Time-, temperature-, and concentration-dependent spectroscopic results show that the formation of kinetic species 2NP and thermodn. species 2NS (nanosheets) follows the isodesmic model and the cooperative (nucleation-elongation) model, resp., and 2NP are the off-pathway intermediates of 2NS. This study illustrates an ingenious and precise kinetic control on the LSP in aqueous media. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5COA of Formula: C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. COA of Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Chen, Yi; Liu, Di; Wang, Rui; Xu, Li; Tan, Jingyao; Shu, Mao; Tian, Lingfeng; Jin, Yuan; Zhang, Xiaoke; Lin, Zhihua published an article in Journal of Organic Chemistry. The title of the article was 《Bronsted Acid-Catalyzed : Synthesis of Phenanthrenes via Phosphomolybdic Acid as a Catalyst》.Formula: C6H4BrNO The author mentioned the following in the article:

Herein, disclosed a synthetic protocol for the synthesis of phenanthrenes such as I [R = H, Me; R1 = H, Me, OMe, etc.; R2 = H, F, OMe, etc.; R3 = H, OTIPS; R4 = H, F, Cl, etc.] through the CCOM with the inexpensive, nontoxic phosphomolybdic acid as a catalyst. The current annulations could realized carbonyl-olefin, carbonyl-alc., and acetal-alc. in situ CCOM reactions and feature mild reaction conditions, simple manipulation and scalability, making this strategy a promising alternative to the Lewis acid-catalyzed COM reaction.2-Bromonicotinaldehyde(cas: 128071-75-0Formula: C6H4BrNO) was used in this study.

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Formula: C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2017 ,《Magneto-structural correlations in a family of di-alkoxo bridged chromium dimers》 appeared in Dalton Transactions. The author of the article were Fraser, Hector W. L.; Nichol, Gary S.; Velmurugan, Gunasekaran; Rajaraman, Gopalan; Brechin, Euan K.. The article conveys some information:

A series of di-alkoxo bridged Cr(III) dimers were synthesized using pyridine alc. ligands. The structures fall into four general categories and are of formula: [Cr2(OMe)2(pic)4]·0.5MeOH·0.5Et2O (1), [Cr2(hmp)2(pic)2X2] (X = Cl (2), Br (3)), [Cr2(L)2Cl4(A)2]·2S (L = hmp, A = H2O and S = Et2O (4); L = hmp, A = pyridine and S = pyridine (5); L = hmp, A = 4-picoline and no S (6); L = hep, A = H2O and S = MeCN (7)), and [Cr(hmp)(hmpH)Cl2]·MeCN (8). D.c. (d.c.) magnetic susceptibility measurements show relatively weak antiferromagnetic exchange interactions between the Cr(III) centers with J values <|15| cm-1 in all of the complexes measured. DFT calculations performed on complexes 1-8 reproduce both the sign and strength of the exchange interactions found exptl., and confirm that the magnitude and sign of the J value is strongly dependent upon the orientation of the dihedral angle formed between the bridging Cr2O2 plane and the O-R vector of the bridging group (θ), and the Cr-O-Cr-O dihedral angle (ψ). After reading the article, we found that the author used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Category: pyridine-derivatives)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C5H3Br2NIn 2020 ,《Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties》 appeared in Journal of Medicinal Chemistry. The author of the article were Chen, Hao; Deng, Shanshan; Wang, Yuxi; Albadari, Najah; Kumar, Gyanendra; Ma, Dejian; Li, Weimin; White, Stephen W.; Miller, Duane D.; Li, Wei. The article conveys some information:

We recently reported the crystal structure of tubulin in complex with a colchicine binding site inhibitor (CBSI), ABI-231, having 2-aryl-4-benzoyl-imidazole (ABI). Based on this and addnl. crystal structures, here we report the structure-activity relationship study of a novel series of pyridine analogs of ABI-231, with compound 4v being the most potent one (average IC50 ∼ 1.8 nM) against a panel of cancer cell lines. We determined the crystal structures of another potent CBSI ABI-274 and 4v in complex with tubulin and confirmed their direct binding at the colchicine site. 4v inhibited tubulin polymerization, strongly suppressed A375 melanoma tumor growth, induced tumor necrosis, disrupted tumor angiogenesis, and led to tumor cell apoptosis in vivo. Collectively, these studies suggest that 4v represents a promising new generation of tubulin inhibitors.2,6-Dibromopyridine(cas: 626-05-1Computed Properties of C5H3Br2N) was used in this study.

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Computed Properties of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C7H7NOIn 2019 ,《Transition-metal-free catalyzed [3+2] cycloadditions/oxidative aromatization reactions for the synthesis of annulated indolizines》 appeared in New Journal of Chemistry. The author of the article were Zhang, Qianwei; Wang, Bin; Ma, Huifang; Ablajan, Keyume. The article conveys some information:

In this study, transition-metal-free catalyzed [3+2] cycloadditions/oxidative aromatization three-component reactions for the successful direct construction of pyrrolo[3,4-a]indolizine-1,3(2H)-diones via pyridinium ylides are reported. This method utilizes readily available pyridines, acetophenones and maleimides as starting materials in the presence of TBAI (N-tetrabutylammonium iodide)/TBHP (tert-Bu hydroperoxide), with a wide substrate scope and moderate to good yields, avoiding the use of metal catalysts and generation of halides. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9COA of Formula: C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.COA of Formula: C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 128071-75-0In 2017 ,《Approach to 5-substituted 6,7,8,9-tetrahydro-5H-pyrido[3,2-c]azepines》 appeared in Tetrahedron Letters. The author of the article were Subota, Andrii I.; Artamonov, Oleksiy S.; Gorlova, Alina; Volochnyuk, Dmitriy M.; Grygorenko, Oleksandr O.. The article conveys some information:

An approach to 5-substituted 6,7,8,9-tetrahydro-5H-pyrido[3,2-c]azepines via the cyclization of 1-(2-(3-azidopropyl)pyridin-3-yl)alkanones under Staudinger-aza-Wittig reaction conditions is described (I → II using PMe3; R = Ph, 4-FC6H4, i-Pr). The overall reaction sequence includes eight steps and allows for the preparation of gram quantities of the title products. In some cases, the formation of 5,7,8,9-tetrahydrooxepino[4,3-b]pyridine derivatives was observed The experimental process involved the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Recommanded Product: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1692-25-7In 2020 ,《General Access to C-Centered Radicals: Combining a Bioinspired Photocatalyst with Boronic Acids in Aqueous Media》 appeared in ACS Catalysis. The author of the article were Chilamari, Maheshwerreddy; Immel, Jacob R.; Bloom, Steven. The article conveys some information:

Carbon-centered radicals are indispensable building blocks for modern synthetic chem. In recent years, visible light photoredox catalysis has become a promising avenue to access C-centered radicals from a broad array of latent functional groups, including boronic acids. Herein, we present an aqueous protocol wherein water features a starring role to help transform aliphatic, aromatic, and heteroaromatic boronic acids to C-centered radicals with a bioinspired flavin photocatalyst. These radicals are used to deliver a diverse pool of alkylated products, including three pharmaceutically relevant compounds, via open-shell conjugate addition to disparate Michael acceptors. The mechanism of the reaction is investigated by computational studies, deuterium labeling, radical-trapping experiments, and spectroscopic anal. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Recommanded Product: 1692-25-7)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 1692-25-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 98-98-6In 2021 ,《Highly efficient actinide(III)/lanthanide(III) separation by novel pillar[5]arene-based picolinamide ligands: A study on synthesis, solvent extraction and complexation》 appeared in Journal of Hazardous Materials. The author of the article were Cai, Yimin; Ansari, Seraj A.; Fu, Kuirong; Zhu, Beichen; Ma, Haoyang; Chen, Lixi; Conradson, Steven D.; Qin, Song; Fu, Haiying; Mohapatra, Prasanta K.; Yuan, Lihua; Feng, Wen. The article conveys some information:

Selective extraction of highly radiotoxic actinides(III) is an important and challenging task in nuclear wastewater treatment. Many proposed ligands containing S or P atoms have drawbacks including high reagent consumption and possible secondary pollution after incineration. The present work reports five novel pillar[5]arene-based extractants that are anchored with picolinamide substituents of different electronic nature by varying spacer. These ligands reveal highly efficient separation of actinides(III) over lanthanides(III). Specifically, almost all of these ligands could extract Am(III) over Eu(III) selectively at around pH 3.0 (SFAm/Eu > 11) with fast extraction kinetics. Variation of the pyridine nitrogen basicity via changing para-substitution leads to an increase in the distribution ratios by a factor of over 300 times for Am(III) with an electron-withdrawing group compared to those with an electron donating group. Investigation of complexation mechanism by slope anal., NMR, IR, EXAFS, and DFT techniques indicates that each ligand binds two metal ions by pyridine nitrogen and amide oxygen. Finally, these ligands do not show obvious decrease in both extraction and separation ability after being exposed to 250 kGy absorbed gamma radiation. These results demonstrate the potential application of pillar[5]arene-picolinamides for actinide(III) separation In the experiment, the researchers used many compounds, for example, Picolinic acid(cas: 98-98-6Product Details of 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Product Details of 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 4,4′-Dimethyl-2,2′-bipyridineIn 2020 ,《Photoluminescent report on red light emitting europium(III) complexes with heterocyclic acid》 appeared in Spectroscopy Letters. The author of the article were Dhankhar, Priyanka; Bedi, Manisha; Khanagwal, Jyoti; Taxak, Vinod B.; Khatkar, Satyender P.; Doon, Priti Boora. The article conveys some information:

Five luminescent europium (III) carboxylate complexes have been synthesized by using ligand 3-isopropylpyrazole-5-carboxylic acid as primary ligand and 4,4′-dimethyl-2,2′-bipyridyl, 2,2′-bipyridyl, 5,6-dimethyl-1,10-phenanthroline and 1,10-phenanthroline as secondary ligands and characterized through various techniques. These complexes exhibit excellent thermal stability and characteristic europium centered photoemission spectra under the excitation of UV light. Luminescence decay curves, Judd-Ofelt anal., internal quantum efficiency and energy transfer mechanism have also been discussed. The color coordinates and color purity are calculated to investigate red emission of the complexes. The study results reveal that these complexes can be potentially used as red light emitting materials in various optoelectronic devices.4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Name: 4,4′-Dimethyl-2,2′-bipyridine) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Name: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H3Br2NIn 2019 ,《Synthesis of Tetracoordinate Boron-Fused Benzoaceanthrylene Analogs via Tandem Electrophilic C-H Borylation》 was published in Chemistry – An Asian Journal. The article was written by Oda, Susumu; Abe, Hiroaki; Yasuda, Nobuhiro; Hatakeyama, Takuji. The article contains the following contents:

Benzoaceanthrylene analogs with tetracoordinate B at the ring junction were synthesized through tandem electrophilic C-H borylation of 2,6-dinaphthylpyridine followed by nucleophilic substitution. Notably, the [5,6]-annulation occurred selectively over [6,6]-annulation with the assistance of N coordination of the pyridine ring. The x-ray crystallog. anal. revealed the polycyclic skeleton with a distorted tetracoordinate B atom and a unique packing structure with intermol. π-π interaction. The photophys. and electrochem. properties of these benzoaceanthrylene analogs were evaluated by UV-visible spectroscopy and differential pulse voltammetry. The electron affinity of the F-substituted derivative is 3.49 eV from the ionization potential and optical band gap. Thus, this derivative is expected to be a promising n-type semiconducting material. In the experiment, the researchers used many compounds, for example, 2,6-Dibromopyridine(cas: 626-05-1COA of Formula: C5H3Br2N)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. COA of Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem