Day: October 24, 2022

Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromideIn 2019 ,《Synthesis of Iridium(III) and Rhodium(III) Complexes Bearing C8-Metalated Theophylline Ligands by Directed C-H Activation》 was published in Organometallics. The article was written by Tan, Tristan Tsai Yuan; Hahn, F. Ekkehardt. The article contains the following contents:

The directed C-H activation at the C8 position of N-donor tethered theophylline with iridium(III) and rhodium(III) is presented. The donor strength of the N-tethered donor group has been varied. Proligands bearing a strongly donating imidazolin-2-ylidene or the weaker donating pyridine group were both metalated under similar conditions, suggesting that the electron d. at the metal center does not play a significant role in the C-H activation step, which was concluded to proceed via a carboxylate-assisted route. The synthesis and characterization of iridium(III) and rhodium(III) complexes bearing chelating CNHC^Cazolato ligands (M = Ir: [4], M = Rh: [5]) and Npyridine^Cazolato ligands (M = Ir: [7], M = Rh: [8]) are reported. In addition, the NHC complexes which are the precursors to the CNHC^Cazolato complexes (M = Ir: [2], M = Rh: [3]) were isolated and characterized. In the part of experimental materials, we found many familiar compounds, such as 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Application In Synthesis of 2-(Bromomethyl)pyridine hydrobromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C5H7N3In 2019 ,《Synthesis, Characterization and Fluorescence Quantum Yields of Thermally Resisted Shinning Polymers Containing Thiophene and Azomethine Units》 was published in Journal of Fluorescence. The article was written by Temizkan, Kevser; Kaya, Ismet. The article contains the following contents:

Poly(azomethine)s containing thiophene with bridges pyridine, sulfur and oxygen were synthesized in two steps. Before, thiophene centric dialdehyde (DIAL-Th) compound was synthesized via elimination reaction of 4-hydroxy benzaldehyde with thiophene bromide. Then, poly(azomethine)s containing thiophene (PAZ-Th) unit were synthesized from condensation reactions of DIAL-Th with pyridine-3,5-diamine, 4,4′-thiodianiline and 4,4′-oxydianiline. The obtained dialdehyde and poly(azomethine- thiophene)s were ratified by Fourier-transform IR spectroscopy (FT-IR), UV-visible spectroscopy (UV-Vis), hydrogen and carbon NMR spectroscopy. The some properties of poly(azomethine-thiophene)s were investigated such as optic, electronic, surface and thermal. Electrochem. and fluorescence properties of compounds were made by cyclic voltammetry (CV) and fluorescence anal., resp. According to fluorescence measurement, PAZ-Th-1 was interestingly demonstrated five different colors in DMF solution Blue, green, yellow, orange and red were observed at 420, 440, 480, 500 and 520 nm, resp., in this solution The fluorescence quantum yields of PAZ-Th-1 were found. According to thermogravimetric (TG) and differential scanning calorimetry (DSC) analyses, Tonset and glass transition temperature of PAZ-Th-1, PAZ-Th-2 and PAZ-Th-3 were found. Also, surface analyses of synthesized poly(azomethine-thiophene)s were photographed by scanning electron microscope (SEM) at room temperature The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6Electric Literature of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Electric Literature of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Oxidative electropolymerization of iron and ruthenium complexes containing aniline-substituted 2,2′-bipyridine ligands》 was written by Horwitz, Colin P.; Zuo, Qi. Formula: C12H10Cl2N2 And the article was included in Inorganic Chemistry on April 29 ,1992. The article conveys some information:

New bipyridine ligands with pendant aniline groups [4-CH2R-4′-CH2R’-2,2′-bipyridine, where R = NHPh and R’ = H (anilbpy) and R = R’ = NHPh (bis-anilbpy)] and the electrochem. properties of their Fe and Ru complexes, [Fe(anilbpy)3][PF6]2 (4), [Ru(bpy)2(anilbpy)][PF6]2 (5), and [Ru(bpy)2(bis-anilbpy)][PF6]2 (6) [where bpy = 4,4′-Me2-2,2′-bipyridine] are described. All complexes, except 5, form polymer films from an MeCN solution containing 0.1M Bu4NClO4 on Pt and glassy C electrodes; 1-4 are also polymerized onto NESA glass electrodes by repetitively cycling the electrode potential between 0 and 1.1 V or 0 and 1.5 V vs. SSCE. Two new redox couples arising from tail-to-tail and head-to-tail coupling of aniline groups on adjacent monomers are visible in the voltammograms during the film growth process carried out between 0 and 1.1 V. A broad, ill-defined redox couple for the tail-to-tail coupled aniline species is seen in polymer films grown at 1.5 V. The films exhibit voltammetric properties on all electrode materials expected for metal-centered oxidation and ligand-centered reductions when the coated electrodes are transferred to a MeCN solution containing only the supporting electrolyte. The visible spectra of the polymers on conductive glass electrodes show MLCT bands in the same region as the monomers with λmax ∼540 nm for poly-1 and poly-2 and λmax = 460 nm for poly-3 and poly-4. A new absorption band appears at λmax = 720 nm, assignable to a monocation of diphenylamine for films on the conductive glass oxidized to 0.9 V, and its intensity decreases with application of increasing pos. potentials, with a new band appearing at λmax ∼440 nm arising from the 2-electron oxidation products of diphenylamine and benzidine. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4Formula: C12H10Cl2N2)

4,4′-Bis(chloromethyl)-2,2′-bipyridine(cas: 138219-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Formula: C12H10Cl2N2The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis》 was written by Li, Jian-Yuan; Miklossy, Gabriella; Modukuri, Ram K.; Bohren, Kurt M.; Yu, Zhifeng; Palaniappan, Murugesan; Faver, John C.; Riehle, Kevin; Matzuk, Martin M.; Simmons, Nicholas. Safety of 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde And the article was included in Bioconjugate Chemistry on August 21 ,2019. The article conveys some information:

A strategy for DNA-compatible, palladium-catalyzed hydroxycarbonylation of (hetero)aryl halides on DNA-chem. conjugates has been developed. This method generally provided the corresponding carboxylic acids in moderate to very good conversions for (hetero)aryl iodides and bromides, and in poor to moderate conversions for (hetero)aryl chlorides. These conditions were further validated by application within a DNA-encoded chem. library synthesis and subsequent discovery of enriched features from the library in selection experiments against two protein targets. After reading the article, we found that the author used 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde(cas: 1000340-35-1Safety of 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde)

4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde(cas: 1000340-35-1) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Safety of 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Unusual Recognition and Separation of Hydrated Metal Sulfates [M2(μ-SO4)2(H2O)n, M = ZnII, CdII, CoII, MnII] by a Ditopic Receptor》 was written by Ghosh, Tamal Kanti; Dutta, Ranjan; Ghosh, Pradyut. SDS of cas: 31106-82-8This research focused onzinc cadmium cobalt manganese pyridinylmethylaminoethylbutylurea sulfate complex preparation; binding constant transition metal pyridinylmethylaminoethylbutylurea sulfate; crystal structure transition metal pyridinylmethylaminoethylbutylurea sulfate. The article conveys some information:

A ditopic receptor L1, having metal binding bis(2-picolyl) donor and anion binding urea group, is synthesized and explored toward metal sulfate recognition via formation of dinuclear assembly, (L1)2M2(SO4)2. Mass spectrometric anal., 1H-DOSY NMR, and crystal structure anal. reveal the existence of a dinuclear assembly of MSO4 with two units of L1. 1H NMR study reveals significant downfield chem. shift of -NH protons of urea moiety of L1 selectively with metal sulfates (e.g., ZnSO4, CdSO4) due to second-sphere interactions of sulfate with the urea moiety. Variable-temperature 1H NMR studies suggest the presence of intramol. hydrogen bonding interaction toward metal sulfate recognition in solution state, whereas intermol. H-bonding interactions are observed in solid state. In contrast, anions in their tetrabutylammonium salts fail to interact with the urea -NH probably due to poor acidity of the tert-Bu urea group of L1. Metal sulfate binding selectivity in solution is further supported by isothermal titration calorimetric studies of L1 with different Zn salts in DMSO, where a binding affinity is observed for ZnSO4 (Ka = 1.23 × 106), which is 30- to 50-fold higher than other Zn salts having other counteranions in DMSO. Sulfate salts of CdII/CoII also exhibit binding constants in the order of ∼1 × 106 as in the case of ZnSO4. Pos. role of the urea unit in the selectivity is confirmed by studying a model ligand L2, which is devoid of anion recognition urea unit. Structural characterization of four MSO4 [M = ZnII, CdII, CoII, MnII] complexes of L1, i.e., complex 1, [(L1)2(Zn)2(μ-SO4)2]; complex 2, [(L1)2(H2O)2(Cd)2(μ-SO4)2]; complex 3, [(L1)2(H2O)2(Co)2(μ-SO4)2]; and complex 4, [(L1)2(H2O)2(Mn)2(μ-SO4)2], reveal the formation of sulfate-bridged eight-membered crownlike binuclear complexes, similar to one of the concentration-dependent dimeric forms of MSO4 as observed in solid state. Finally, L1 is found to be highly efficient in removing ZnSO4 from both aqueous and semiaq. medium as complex 1 in the presence of other competing ZnII salts via precipitation through crystallization Powder X-ray diffraction anal. has also confirmed bulk purity of complex 1 obtained from the above competitive crystallization experiment In addition to this study using 2-(Bromomethyl)pyridine hydrobromide, there are many other studies that have used 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8SDS of cas: 31106-82-8) was used in this study.

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.SDS of cas: 31106-82-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Visible-Light-Driven, Photoredox-Catalyzed Cascade of ortho-Hydroxycinnamic Esters To Access 3-Fluoroalkylated Coumarins》 was written by Song, Dan; Wang, Chao-Ming; Ye, Zhi-Peng; Xia, Peng-Ju; Deng, Zhi-Xiong; Xiao, Jun-An; Xiang, Hao-Yue; Yang, Hua. Quality Control of fac-Tris(2-phenylpyridine)iridiumThis research focused onvisible light photoredox catalyst cascade ortho hydroxycinnamic ester; fluoroalkylated coumarin preparation. The article conveys some information:

A general and straightforward protocol for di-/perfluoroalkylation of ortho-hydroxycinnamic esters via a photoredox-catalyzed cascade was developed to access a variety of 3-fluoroalkylated coumarins. This method was characterized by all-in-one synthetic design, simplified operation, mild reaction conditions, and broad substrate scope. Moreover, a sequential one-pot procedure starting from com. available salicylaldehyde was also successfully realized to synthesize 3-fluoroalkylated coumarins. The experimental part of the paper was very detailed, including the reaction process of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Quality Control of fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Quality Control of fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesOn March 31, 1997, Epsztajn, J.; Plotka, M. W.; Grabowska, A. published an article in Synthetic Communications. The article was 《Application of organolithium compounds in organic synthesis. Part 19. Synthetic strategies based on aromatic metalation. A concise regiospecific synthesis of 3-halogenated picolinic and isonicotinic acids》. The article mentions the following:

The synthesis of the halogenated picolin- and isonicotinanilides I (R = Cl, Br, iodo, X = N, Y = CH; X = CH, Y = N) (II) via metalation (n-BuLi) of the anilides I (R = H) and then the reaction of the generated bis-lithiated anilides with halogenating agents (CCl3-CCl3, CH2Br-CH2Br, I2) followed by subsequent acidic hydrolysis of II, as a way of regiospecific transformation of picolinic and isonicotinic acids into their C3-halogenated derivatives, is described. In the experiment, the researchers used many compounds, for example, Methyl 3-chloropicolinate(cas: 116383-98-3Category: pyridine-derivatives)

Methyl 3-chloropicolinate(cas: 116383-98-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2017,Vernia, Jennifer E.; Warmin, Mary R.; Krause, Jeanette A.; Tierney, David L.; Baldwin, Michael J. published 《Photochemistry and Anion-Controlled Structure of Fe(III) Complexes with an α-Hydroxy Acid-Containing Tripodal Amine Chelate》.Inorganic Chemistry published the findings.Computed Properties of C6H7Br2N The information in the text is summarized as follows:

The tripodal amine chelate with two pyridyl groups and an α-hydroxy acid (AHA) group, Pyr-TPA-AHA, was synthesized. Different Fe(III) complexes form with this chelate depending upon the counterion of the Fe(III) source used in the synthesis. A dinuclear complex, Fe(III)2(Pyr-TPA-AHA)2(μ-O), 1, and mononuclear complexes Fe(III)(Pyr-TPA-AHA)X (X = Cl- or Br-, 2 and 3, resp.) were synthesized. 2 Can be easily converted to 1 by addition of silver nitrate or a large excess of water. The structure of 1 was solved by x-ray crystallog. (C32H34N6O7Fe2·13H2O, a 14.1236(6), b 14.1236(6), c 21.7469(15) Å, α = β = γ 90.°, tetragonal, P42212, Z = 4). 2 And 3 each have simple quasireversible cyclic voltammograms with E1/2 (vs. aqueous Ag/AgCl) = +135 mV for 2 and +470 for 3 in acetonitrile. The cyclic voltammogram for 1 in acetonitrile has a quasireversible feature at E1/2 = -285 mV and an irreversible cathodic feature at -1140 mV. All three complexes are photochem. active upon irradiation with UV light, resulting in cleavage of the AHA group and reduction of the iron to Fe(II). Photolysis of 1 results in reduction of both Fe(III) ions in the dinuclear complex for each AHA group that is cleaved, while photolysis of 2 and 3 results in reduction of a single Fe(III) for each AHA cleavage. The quantum yields for 2 and 3 are significantly higher than that of 1. The experimental process involved the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Computed Properties of C6H7Br2N)

2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Computed Properties of C6H7Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Nuclear Medicine and Biology included an article by Li, Junling; Gray, Brian D.; Pak, Koon Y.; Ng, Chin K.. Safety of Bis(pyridin-2-ylmethyl)amine. The article was titled 《Targeting phosphatidylethanolamine and phosphatidylserine for imaging apoptosis in cancer》. The information in the text is summarized as follows:

Thus the objective was to determine whether PE-targeting 18F-duramycin and PS-targeting 18F-Zn-DPA could be used for imaging apoptosis. Duramycin and Zn-DPA were labeled with either 18F-Al or 18F-SFB. U937 cells were incubated with four different concentrations of camptothecin (CPT). For assessing the effect of incubation time on uptake, 37 MBq of radiotracer was added to cells incubated for 15, 30, 60, and 120 min at 37°C. Both FITC-Zn-DPA and FITC-duramycin localized mainly on the cell membrane during early apoptosis and then translocated to the inside during late apoptosis. Uptake of FITC-duramycin, however, was higher than that of FITC-Zn-DPA. Cellular uptake of four different radiotracers was also proportional to the degree of apoptosis, increasing slightly over time and reaching a plateau at about 1 h. The blocking experiments demonstrated that uptake in all the control groups was predominantly non-specific, whereas the specific uptake in all the treated groups was at least 50% for both 18F labeled duramycin and Zn-DPA. Both PE-targeting 18F-duramycin and PS-targeting 18F-Zn-DPA could be considered as potential radiotracers for imaging cellular apoptosis. Advances in knowledge and implications for patient care: Cellular data support the further development of radiotracers targeting either PE or PS for imaging apoptosis, which can associate with clin. outcome for cancer patients. In the part of experimental materials, we found many familiar compounds, such as Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Safety of Bis(pyridin-2-ylmethyl)amine)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Safety of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Organic Chemistry Frontiers included an article by Zhou, Chunhui; Hu, Jinsong; Wang, Yuan; Yao, Changguang; Chakraborty, Priyanka; Li, Huaifeng; Guan, Chao; Huang, Mei-Hui; Huang, Kuo-Wei. HPLC of Formula: 141-86-6. The article was titled 《Selective carbonylation of benzene to benzaldehyde using a phosphorus-nitrogen PN3P-rhodium(I) complex》. The information in the text is summarized as follows:

A PN3P pincer pyridinediamine ligand 2,6-(R2PNH)C5H3N (1; R = cyclopentyl, C5H5N = pyridine) bearing dicyclopentylphosphine substituents reacts with [Rh(COD)Cl]2 (COD = 1,5-cyclooctadiene) to produce the complex (PN3P)RhCl (2). Treatment of a benzene solution of 2 with KN(SiMe3)2 stimulates a dearomatization process, and C-H activation of benzene is achieved through the rearomatization of the central pyridine ring. This deprotonation/reprotonation of the NH arm of 2 gives the Ph complex (PN3P)Rh(C6H5) (3). The subsequent introduction of CO gas into 3 yields the benzoyl complex (PN3P)RhCO (C6H5) (4), which can release benzaldehyde upon treatment with diluted HCl solution and regenerates 2. The experimental part of the paper was very detailed, including the reaction process of 2,6-Diaminopyridine(cas: 141-86-6HPLC of Formula: 141-86-6)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.HPLC of Formula: 141-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem