Day: October 24, 2022

In 2022,Lee, Yujeong; Onishi, Yoshiyuki; McPherson, Lisa; Kietrys, Anna M.; Hebenbrock, Marian; Jun, Yong Woong; Das, Ishani; Adimoolam, Shanthi; Ji, Debin; Mohsen, Michael G.; Ford, James M.; Kool, Eric T. published an article in ACS Chemical Biology. The title of the article was 《Enhancing Repair of Oxidative DNA Damage with Small-Molecule Activators of MTH1》.SDS of cas: 2510-22-7 The author mentioned the following in the article:

Here, it is reported that selected tyrosine kinase (TK) inhibitors including nilotinib, employed clin. in the treatment of chronic myeloid leukemia, are activators of the repair enzyme Human MutT Homolog 1 (MTH1). MTH1 cleanses the oxidatively damaged cellular nucleotide pool by hydrolyzing the oxidized nucleotide 8-oxo-2′-deoxyguanosine (8-oxo-dG)TP, which is a highly mutagenic lesion when incorporated into DNA. Structural optimization of analogs of TK inhibitors resulted in compounds such as SU0448, which induces 1000 +/- 100% activation of MTH1 at 10μM and 410 +/- 60% at 5μM. The compounds are found to increase the activity of the endogenous enzyme, and at least one (SU0448) decreases levels of 8-oxo-dG in cellular DNA. The results suggest the possibility of using MTH1 activators to decrease the frequency of mutagenic nucleotides entering DNA, which may be a promising strategy to suppress tumorigenesis in individuals with elevated cancer risks. The experimental process involved the reaction of 4-Ethynylpyridine(cas: 2510-22-7SDS of cas: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. SDS of cas: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Oppermann, Malte; Zinna, Francesco; Lacour, Jerome; Chergui, Majed published an article in Nature Chemistry. The title of the article was 《Chiral control of spin-crossover dynamics in Fe(II) complexes》.Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

Iron-based spin-crossover complexes hold tremendous promise as multifunctional switches in mol. devices. However, real-world technol. applications require the excited high-spin state to be kinetically stable-a feature that has been achieved only at cryogenic temperatures Here the authors demonstrate high-spin-state trapping by controlling the chiral configuration of the prototypical iron(II)tris(4,4′-dimethyl-2,2′-bipyridine) in solution, associated for stereocontrol with the enantiopure Δ- or Λ-enantiomer of tris(3,4,5,6-tetrachlorobenzene-1,2-diolato-κ2O1,O2)phosphorus(V) (P(O2C6Cl4)3- or TRISPHAT) anions. The authors characterized the high-spin-state relaxation using broadband ultrafast CD spectroscopy in the deep UV in combination with transient absorption and anisotropy measurements. The authors find that the high-spin-state decay is accompanied by ultrafast changes of its optical activity, reflecting the coupling to a symmetry-breaking torsional twisting mode, contrary to the commonly assumed picture. The diastereoselective ion pairing suppresses the vibrational population of the identified reaction coordinate, thereby achieving a fourfold increase of the high-spin-state lifetime. More generally, the authors’ results motivate the synthetic control of the torsional modes of iron(II) complexes as a complementary route to manipulate their spin-crossover dynamics. In the experiment, the researchers used many compounds, for example, 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Tang, Jiali; Chen, Yingbi; Wang, Shixing; Kong, Desong; Zhang, Libo published an article in Environmental Research. The title of the article was 《Highly efficient metal-organic frameworks adsorbent for Pd(II) and Au(III) recovery from solutions: Experiment and mechanism》.Name: 2,6-Diaminopyridine The author mentioned the following in the article:

With the boom of modern industry, the demand for precious metals palladium (Pd) and gold (Au) is increasing. However, the discharge of Pd(II) and Au(III) wastewater has caused environmental pollution and shortage of resources. Here, a new metal-organic frameworks adsorbent (MOF-AFH) was synthesized to efficiently sep. Pd(II) and Au(III) from the water. The adsorption behavior of Pd(II) and Au(III) was explored at the same time. When gold and palladium are adsorbed sep., the adsorption capacity of gold and palladium is 389.02 mg/g and 191.27 mg/g, resp. The equilibration time is 3 h. When gold and palladium coexist, the adsorption capacities of Au(III) and Pd(II) are 238.71 and 115.02 mg/g, resp. The exptl. results show that the adsorption of Pd(II) and Au(III) on MOF-AFH is a single-layer chem. adsorption, which is an endothermic process. MOF-AFH has excellent selectivity and after MOF-AFH is repeatedly used 4 times, the removal effect can still reach more than 90%. The adsorption mechanisms include reduction reaction and chelation with N and O-containing functional groups on the adsorbent. There is also electrostatic interaction for Au(III) adsorption. The adsorbent can be used to efficiently recover gold and palladium from wastewater. In the experimental materials used by the author, we found 2,6-Diaminopyridine(cas: 141-86-6Name: 2,6-Diaminopyridine)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Name: 2,6-Diaminopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2,6-DibromopyridineIn 2020 ,《Synthesis of polystyrene-supported Pd(II)-containing macrocyclic complex as a reusable catalyst for chemoselective Suzuki-Miyaura coupling reaction》 appeared in Tetrahedron Letters. The author of the article were Yamamoto, Koji; Nameki, Riku; Sogawa, Hiromitsu; Takata, Toshikazu. The article conveys some information:

A polystyrene-supported Pd complex bearing a cyclic pyridine-2,6-bisiamide ligand was synthesized and its catalytic activity in the Suzuki-Miyaura coupling reaction of 2,6-bromopyridine with 4-methoxyphenylboronic acid in aqueous media was investigated. The solid-supported catalyst exhibited catalytic activity and chemoselectivity that were comparable to those of homogeneous catalyst. The reusability of the solid-supported catalyst was also examined The experimental process involved the reaction of 2,6-Dibromopyridine(cas: 626-05-1Application In Synthesis of 2,6-Dibromopyridine)

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application In Synthesis of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 4-EthynylpyridineIn 2022 ,《Fuel Acid Drives Base Catalysis and Supramolecular Cage-to-Device Transformation under Dissipative Conditions》 appeared in Organic Letters. The author of the article were Mondal, Debabrata; Ghosh, Amit; Paul, Indrajit; Schmittel, Michael. The article conveys some information:

In State-I, a mixture comprising a DABCO-bridged tris(zinc-porphyrin) double decker and a free biped (=slider), catalysis was OFF. Acid addition (TFA or Di-Stefano fuel acid) to State-I liberated DABCO-H+ while generating a highly dynamic slider-on-deck device (State-II). The released DABCO-H+ acted as a base organocatalyst for a Knoevenagel reaction (catalysis ON). The system was reversed to State-I (catalysis OFF) by reducing the acidity in the system (by adding DBU or via the fuel-derived base). In the experiment, the researchers used 4-Ethynylpyridine(cas: 2510-22-7Safety of 4-Ethynylpyridine)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Safety of 4-Ethynylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 1122-54-9In 2019 ,《One-pot metal-free synthesis of 3-CF3-1,3-oxazinopyridines by reaction of pyridines with CF3CO-acetylenes》 appeared in Molecules. The author of the article were Muzalevskiy, Vasiliy M.; Sizova, Zoia A.; Belyaeva, Kseniya V.; Trofimov, Boris A.; Nenajdenko, Valentine G.. The article conveys some information:

The reaction of pyridines with trifluoroacetylated acetylenes was investigated. It was found that the reaction of various pyridines with two mols. of CF3CO-acetylenes proceeded under mild metal-free conditions. As a result, efficient stereoselective synthesis of 3-arylethynyl-3-trifluoromethyl-1,3-oxazinopyridines was elaborated. Target heterocycles were prepared in up to quant. yields. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Product Details of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Product Details of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2020 ,《Failure of 2-pyridinecarboxylic acid, an inhibitor of 1-aminocyclopropane-1-carboxylate oxidase, as a universal flower care agent to extend the vase lifeof cut carnation flowers》 appeared in Horticulture Journal. The author of the article were Satoh, Shigeru; Makino, Keiko; Shimada, Keita; Nomura, Yoshihiro. The article conveys some information:

The 2-Pyridinecarboxylic acid (2-PCA) acts as an inhibitor of ethylene biosynthesis in Arabidopsis thaliana by binding to the active site of 1-aminocyclopropane-1-carboxylate oxidase. In this study, we examined the action of 2-PCA in comparison with the action of 3-PCA, a recently discovered stimulator of flower opening, in cut flowers of the spray-type carnation cultivars, ‘Light Pink Barbara (LPB)’, ‘Carnet’, ‘Collin’, and ‘Zulia’. With ‘LPB’ flowers, 2-PCA at 0.5-5 mM did not prolong the vase life, whereas 3-PCA at 5 mM did so. With the other three cultivars, 3-PCA generally promoted flower opening of all the cultivars. On the other hand, the action of 2-PCA on flower opening and senescence varied with the carnation cultivar and time of harvest, resulting in a shortened, unchanged or lengthened vase life of the flowers. 2-PCA also caused severe bending of flower stems in all cultivars, which lowered the display value of the flowers. The present results showed that 2-PCA is not likely to be a useful flower care agent in carnation flowers. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Category: pyridine-derivatives)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 94928-86-6In 2019 ,《Aroylchlorination of 1,6-Dienes via a Photoredox Catalytic Atom-Transfer Radical Cyclization Process》 appeared in Organic Letters. The author of the article were Zhao, Quan-Sheng; Xu, Guo-Qiang; Liang, Hui; Wang, Zhu-Yin; Xu, Peng-Fei. The article conveys some information:

A method using aroyl chlorides as atom-transfer radical cyclization agents in a novel visible-light photocatalytic aroylchlorination reaction is developed. The overall transformation involves the formation of two new C-C bonds and one new C-Cl bond in a one-pot process. The advantages of this reaction include high atom/step/redox economy, mild conditions, operational simplicity, and broad substrate scopes. The experimental part of the paper was very detailed, including the reaction process of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6SDS of cas: 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. SDS of cas: 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: Methyl 5-bromopicolinateIn 2012 ,《Synthesis of Highly Oxidized Quinolizidine via Reduction of Acylpyridinium Cations, and Total Syntheses of Quinolizidines 207I and 1-epi-207I》 appeared in Organic Letters. The author of the article were Tsukano, Chihiro; Oimura, Atsuko; Enkhtaivan, Iderbat; Takemoto, Yoshiji. The article conveys some information:

A new strategy for synthesizing quinolizidine skeletons by reductive cyclization via acylpyridinium cations was developed. Several functional groups, including carbonyl, silyl, and acetal, were tolerated under mild reaction conditions. For example, reacting the acylpyridinium cations derived from I (R = Me, Ph, Br, CF3) with Ghosez’s reagent and Hantzch ester in the presence of 4Å mol. sieves gave quinolizidines II. The reaction was successfully extended to a one-pot synthesis of a bicyclic compound, and the synthetic strategy was applied to concise total syntheses of quinolizidines 207I and 1-epi-207I, without protecting groups. The experimental part of the paper was very detailed, including the reaction process of Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: fac-Tris(2-phenylpyridine)iridiumIn 2021 ,《A Roadmap Towards Visible Light Mediated Electron Transfer Chemistry with Iridium(III) Complexes》 appeared in ChemPhotoChem. The author of the article were Bevernaegie, Robin; Wehlin, Sara A. M.; Elias, Benjamin; Troian-Gautier, Ludovic. The article conveys some information:

A review. Photo-induced electron transfer chem. between mols. is a central theme in several fields including biol., physics and chem. Specifically, in photoredox catalysis, greater use has been made of iridium(III) complexes as they exhibit ground- and excited-state redox potentials that span a very large range. Unfortunately, most of these complexes suffer from limited visible light absorption properties. This concept article highlights recent developments in the synthesis of iridium(III) complexes with increased visible light absorption properties and their use as candidates for visible light driven redox catalysis. Fundamental tools are provided to enable the independent tuning of the HOMO and LUMO energy levels. Recent examples are given with the hope that this concept article will foster further developments of iridium(III)-based sensitizers for visible light driven reactivity. The experimental process involved the reaction of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Name: fac-Tris(2-phenylpyridine)iridium)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Name: fac-Tris(2-phenylpyridine)iridium

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem