Day: October 26, 2022

Cheng, Jianjun; Deming, Timothy J. published an article in 1999, the title of the article was Enantioselective polymerization of 5-benzyl glutamate N-carboxyanhydride using chiral nickel(0) initiators.Application In Synthesis of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine And the article contains the following content:

Enantioselective polymerization of 5-benzyl glutamate NCA was investigated using chiral bidentate nitrogen ligands in combination with a nickel zero initiation system. We found that ligands having mixed pyridine-oxazoline structures gave excellent control of mol. weight and narrow mol. weight distributions. Moderately high enantioselectivities were induced when chiral 2-pyridinyl oxazoline ligands were utilized. The highest enantioselectivity was found with (4S)-4-tert-butyl-(2-pyridinyl)-2-oxazoline. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Application In Synthesis of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine

The Article related to polybenzyl glutamate preparation catalyst nickel, benzyl glutamate carboxyanhydride polymerization nickel catalyst, enantioselective polymerization catalyst nickel, pyridine ligand nickel polymerization catalyst, oxazoline ligand nickel polymerization catalyst and other aspects.Application In Synthesis of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mondal, Dipanjan; Sardar, Gopa; Kabra, Dinesh; Balakrishna, Maravanji S. published an article in 2022, the title of the article was 2,2′-Bipyridine derived doubly B- N fused bisphosphine-chalcogenides, [C5H3N(BF2){NCH2P(E)Ph2}]2 (E = O, S, Se): tuning of structural features and photophysical studies.Product Details of 75449-26-2 And the article contains the following content:

2,2′-Bipyridine based bisphosphine [C5H3N{N(H)CH2PPh2}]2 (1) and its bischalcogenide derivatives [C5H3N{N(H)CH2P(E)Ph2}]2 (2, E = O; 3, E = S; 4, E = Se) were synthesized, and further reacted with BF3·Et2O/Et3N to form doubly B-N fused compounds [C5H3N(BF2){NCH2P(E)Ph2}]2 (5, E = O; 6, E = S; 7, E = Se) in excellent yields. The influence of the P=E bonds on the electronic properties of the doubly B-N fused systems and their structural features were investigated in detail, supported by extensive exptl. and computational studies. Compound 6 exhibited a very high quantum yield of ϕ = 0.56 in CH2Cl2, whereas compound 7 showed a least quantum yield of ϕ = 0.003 in acetonitrile. D. functional theory (DFT) calculations demonstrated that the LUMO/HOMO of compounds 5-7 mostly delocalized over the entire π-conjugated frameworks. The involvement of PE bonds in the HOMO energy level of these compounds follows the order: PO < PS < PSe. Time-correlated single photon counting (TCSPC) experiments of compounds 5-7 revealed the singlet lifetime of 4.26 ns for 6, followed by 4.03 ns for 5 and a lowest value of 2.18 ns (τ1) and 0.47 ns (τ2) with a double decay profile for 7. The authors' findings provide important strategies for the design of highly effective B-N bridged compounds and tuning their photophys. properties by oxidizing phosphorus with different chalcogens. Compounds 5 and 6 have been employed as green emitters (λem = 515 nm) in fluorescent organic light-emitting diodes (OLEDs). For compound 5, doped into the poly(9-vinylcarbazole) (PVK) matrix with 5 wt% doping concentration, nearly 90 Cd m-2 luminance with 0.022% external quantum efficiency (EQE) was achieved. The best performance was observed for compound 6 doped into PVK by 1 wt% having a maximum luminance of 350 Cd m-2 and a similar EQE value. The experimental process involved the reaction of [2,2'-Bipyridine]-3,3'-diamine(cas: 75449-26-2).Product Details of 75449-26-2

The Article related to boron bipyridinylbisphosphinylchalcogenide complex preparation frontier mol orbital fluorescence lifetime, fluorescence oled redox potential boron bipyridinylbisphosphinylchalcogenide complex, crystal structure boron bipyridinylbisphosphinylchalcogenide complex and other aspects.Product Details of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 9, 2006, Kelly, Michael G.; Kincaid, John; Kaub, Carl J. published a patent.Related Products of 39919-70-5 The title of the patent was Preparation of fused heterocyclic compounds for preventing and treating various diseases. And the patent contained the following:

The title compounds I [A, B = (un)substituted CH2, CO or CS; Y = (un)substituted CH2; W = CR4, N; Z = O, NR2; L = (hetero)alkylene; R1 = carbocyclyl or heterocyclyl; R2 = H, alkyl, cycloalkyl; R3 = carbocyclyl or heterocyclyl; R4 = H, alkyl, acyl, etc.; R5 = R4, Z’-L’-R4 (wherein Z’ = a bond, O, S, etc.; L’ = alkylene)], useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others, were prepared and formulated. E.g., a multi-step synthesis of II, starting from Et 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride, was given. The exemplified compounds I were tested in calcium uptake assay (P2X2 and P2X3) and % inhibition data were given for representative compounds I. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Related Products of 39919-70-5

The Article related to fused heterocycle pyridopyrimidinamine preparation purinoceptor antagonist analgesic antiinflammatory anxiolytic, cognition enhancer pyridopyrimidinamine preparation purinoceptor antagonist, antidepressant pyridopyrimidinamine preparation purinoceptor antagonist and other aspects.Related Products of 39919-70-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 31, 2013, Ueno, Hirokazu; Yamamoto, Takashi; Takashita, Ryuta; Yokoyama, Ryohei; Sugiura, Toshihiko; Kageyama, Shunsuke; Ando, Ayatoshi; Eda, Hiroyuki; Eviryanti, Agung; Miyazawa, Tomoko; Kirihara, Aya; Tanabe, Itsuya; Nakamura, Tarou; Noguchi, Misato; Shuto, Manami; Sugiki, Masayuki; Dohi, Mizuki published a patent.Application In Synthesis of 4-Bromo-2-isopropylpyridine The title of the patent was Preparation of N-(4-sulfonamidobenzoyl)-L-phenylalanine and N-(4-sulfonamidobenzoyl)-3-(pyridin-2-yl)-L-alanine derivatives as α4-integrin inhibitors. And the patent contained the following:

There are provided L-phenylalanine and 3-(pyridin-2-yl)-L-alanine derivatives having terminal sulfonamide groups and heterocyclic groups [I; A = Q, Q1, Q2; Arm = cycloalkane or aromatic ring containing 0-4 heteroatoms selected from O, S, and N; R1, R2, R3, R11, R12, R13, R14, R21, R22, R23, R24, R25 = group A, H, lower alkylamino, lower alkylamino-lower alkyl; group A = halo, HO, each hydroxy- or halo-(un)substituted lower alkyl, alkenyl, alkynyl, or alkylthio, NO2, NH2, CO2H, lower alkyloxycarbonyl, CONH2, lower alkanoyl, aroyl, lower alkylsulfonyl, SO2NH2, ammonium group; B = (un)substituted lower alkoxy, HO, hydroxyamino; R41 = H, lower alkyl; a, b, c, d = CR31, CR32, CR33, CR34; e, f, g, h = CR35, CR36, CR37, CR38; R31-R38 = H, halo, lower alkyl, lower alkoxy, NO2; wherein one or two of a, b, c, and d = N atom; one or two of e, f, g, and h = N atom; at least one of R31-R34 = halo or lower alkyl; D = each (un)substituted Ph or heterocyclyl; E = group A, lower alkylaminoalkylene, (un)substituted 5- or 6-membered heterocyclyl, or substituted CONH2; or lower alkylcarbonyl and lower alkyloxycarbonyl in E group are linked to Ph of D group to form a ring] or pharmaceutically acceptable salts thereof. These compounds have excellent α4-integrin-inhibiting activity with high selectivity for α4β7-integrin over α4β1-integrin. They are useful for the treatment or prevention of inflammatory diseases related to α4β7 integrin-dependent adhesion process. Thus, 100 mg Me 4-(1-methyl-2,4-dioxo-1,4-dihydropyrido[3,4-d]pyrimidin-3(2H)-yl)-L-phenylalaninate and 89.0 mg 2,6-difluoro-4-[[[5-(1H-1,2,4-triazol-1-yl)pyridin-2-yl]sulfonyl]amino]benzoic acid were suspended in 2.0 mL CH2Cl2, treated with 133 mg HATU and 0.160 mL diisopropylethylamine, stirred at room temperature for 2 h, and concentrated under reduced pressure to give, after purification using reversed phase HPLC, Me N-[2,6-difluoro-4-([[5-(1H-1,2,4-triazol-1-yl)pyridin-2-yl]sulfonyl]amino)benzoyl]-4-(1-methyl-2,4-dioxo-1,4-dihydropyrido[3,4-d]pyrimidin-3(2H)-yl)-L-phenylalaninate (II; R = Me) tris(trifluoroacetate). II.3CF3CO2H (R = Me) (25.0 mg) was treated with 2.0 mL 4 N HCl/dioxane solution and 2.0 mL H2O, stirred at 80° for 1 h, and concentrated to give, after purification using reversed phase HPLC, II.3CF3CO2H (R = H). II (R = H) (free base) inhibited the binding of MAdCAM to human RPMI-8866 cells expressing α4β7 integrin and that of MAdCAM to human RPMI-8866 cells expressing α4β1 integrin with IC50 of 0.060 and nM, resp., and 220-fold inhibition selectivity for α4β7 integrin. The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).Application In Synthesis of 4-Bromo-2-isopropylpyridine

The Article related to sulfonamidobenzoylhenylalanine preparation selective alpha 4 beta 7 integrin inhibitor, inflammatory disease treatment prevention sulfonamidobenzoylhenylalanine preparation, sulfonamidobenzoylpyridinylalanine preparation selective alpha 4 beta 7 integrin inhibitor and other aspects.Application In Synthesis of 4-Bromo-2-isopropylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Carballo, Rosa; Fernandez-Hermida, Nuria; Lago, Ana B.; Rodriguez-Hermida, Sabina; Vazquez-Lopez, Ezequiel M. published an article in 2012, the title of the article was Supramolecular networks through second-sphere coordination based on 1D metal-4,4′-dipyridyldisulfide coordination polymers and hydrogenfumarate or sulfonate anions.Quality Control of Pyridine-3-sulfonic acid And the article contains the following content:

Four H-bonded assemblies [M(dpds)2(OH2)2]A2·nH2O (A = anion) are described. These assemblies result from the 2nd-sphere coordination interactions between the 1-dimensional coordination polymers [M(dpds)2(OH2)2]2+, M = Zn(II), and Cu(II), dpds = 4,4′-dipyridyldisulfide, and the pyridine-3-sulfonate (3pySO3-) or hydrogenfumarate (Hfum-) anions. Significantly, supramol. structural variations are observed depending on the presence of H2O lattice mols., which formed discrete aggregates when the Hfum- anion was used. The effects of geometrical variations in the building blocks are also evident on using Jahn-Teller-distorted divalent Cu(II) ions or regular octahedral species based on Zn(II) ions. The 2nd-sphere effects on the stabilization of the compounds are illustrated by TGA experiments The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Quality Control of Pyridine-3-sulfonic acid

The Article related to preparation copper zinc dipyridyldisulfide complex pyridinesulfonate fumarate anion, crystal structure copper zinc dipyridyldisulfide complex pyridinesulfonate fumarate anion, supramol structure copper zinc dipyridyldisulfide complex pyridinesulfonate fumarate anion and other aspects.Quality Control of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 30, 2019, Liu, Jin-jian; Li, Jing published an article.Reference of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide The title of the article was Photochromism of stable crystalline 3D Cd-viologen coordination polymers. And the article contained the following:

Recent studies have demonstrated the efficient synthesis of photochromic coordination polymers by assembly of viologens and metal centers. In order to enrich this system, in-depth research should be conducted on the impact of metal centers, but related research is rare. On the basis of two photochromic viologen-based compounds, two new photochromic coordination polymers are prepared by introducing cadmium ions. In this study, four novel host-guest compounds based on viologen cations (EV2+ = 1,1′-bis(ethyl)-4,4′-bipyridinium dication, PV2+ = 1,1′-bis(propyl)-4,4′-bipyridinium dication) and 1,3,5-benzenetricarboxylic acid (H3BTC) have been synthesized and structurally characterized, [(EV)0.5(H2BTC)]·H2O (1), [(PV)(H2BTC)2]·2H2O (2), {(EV)0.5[Cd(BTC)(H2O)]·2H2O}n (3), {(PV)0.5[Cd(BTC)(H2O)]·2H2O}n (4). Compounds 1 and 2 feature the isolated structure, where uncoordinated H2BTC- units connect to viologen cations by supramol. interactions. Compounds 3 and 4 feature the three-dimensional (3D) anionic MOFs of {[Cd(BTC)(H2O)]-}n with viologen cations inserted in the framework. As expected, incorporating the viologen fragment into the framework results in predefined photochromism of four compounds It is worth noting that the introduction of cadmium ions will directly improve the photosensitive behaviors and protect the photo-generated radicals. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Reference of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide

The Article related to alkylbipyridinium benzenetricarboxylate viologen cadmium coordination polymer preparation photochromism structure, crystal mol structure cadmium viologen coordination polymer, photochromism alkylbipyridinium benzenetricarboxylate viologen cadmium coordination polymer and other aspects.Reference of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 30, 1989, Fife, Wilmer K.; Mubasher, Amal Al published an article.Synthetic Route of 109660-12-0 The title of the article was Multistep functionalization of insoluble copolymers of 4-vinylpyridine. Synthesis and characterization of two new metal ion-binding resins. And the article contained the following:

A com. available macroreticular resin containing 73 mol % 4-vinylpyridine crosslinked with 21 mol % divinylbenzene (I) was successfully derivatized at the pyridine rings by a multi-step synthetic pathway. First-time application of reactions well established for monomeric pyridine derivatives (N-oxidation, Reissert-Henze cyanation, and 2-oxazoline formation) to a copolymer of 4-vinylpyridine furnished the new functionalized resins, I-4-vinyl-2-(4,4-dimethyl-2-oxazolinyl)pyridine copolymer (II) and I-4-vinyl-2-pyridinecarboxylic acid copolymer (III) in yields for functionalization of pyridine residues of 58% in each case. Estimates of formation constants for 1:1 complexes of Cu(II) and Ni(II) ions with the oxazolinylpyridine and 2-pyridinecarboxylate residues of the new resins were obtained with a competitive spectrophotometric method. The formation constants for the Cu(II)- and Ni(II)-II complexes were 107.7 M-1 for Cu(II) and 105.8 M-1 for Ni(II). The formation constants for the Cu(II) and Ni(II) complexes with III were 108.8 and 105.5 M-1, resp. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Synthetic Route of 109660-12-0

The Article related to vinylpyridine divinylbenzene copolymer metal complex, oxazolinylpyridine divinylbenzene copolymer metal complex, pyridinecarboxylate divinylbenzene copolymer metal complex, copper vinylpyridine divinylbenzene copolymer complex, nickel vinylpyridine divinylbenzene copolymer complex and other aspects.Synthetic Route of 109660-12-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 7, 1998, Ankersen, Michael; Dorwald, Florenzio Zaragoza; Stidsen, Carsten Enggaard; Crider, Albert Michael published a patent.Product Details of 199522-66-2 The title of the patent was Preparation of thiourea derivatives and related compounds as constrained somatostatin agonists and antagonists. And the patent contained the following:

The title compounds B(CH2)nNA(CH2)mYNR1C(:X)E [I; A = (un)substituted aryl; B = (un)substituted aryl; E = heterocyclyl, amino; R1 = H, (un)substituted C1-6 alkyl; X = S, O, NR3; R3 = H, COPh, cyano; Y = bond, etc.; m = 0-6; n = 0-3], somatostatin agonists and antagonists (no data) useful for treating medical disorders related to binding to human somatostatin receptor subtypes, and their pharmaceutically acceptable salts were prepared and claimed. For example, amination of 2,5-dibromopyridine with H2NCH2CH2NH2 in pyridine gave N-1-(5-bromopyrid-2-yl)ethane-1,2-diamine which was benzylated with 3,4-dichlorobenzyl chloride in DMSO in the presence of NaH and the product condensed with CS2 in the presence of dicyclohexylcarbodiimide in THF to give 2-[N-(5-bromopyrid-2-yl)-N-(3,4-dichlorobenzyl)]aminoethyl isothiocyanate. Addition of the latter with 4-[4(5)-imidazolyl]piperidine-2HCl in THF in the presence of Et3N gave a title compound I. The experimental process involved the reaction of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine(cas: 199522-66-2).Product Details of 199522-66-2

The Article related to thiourea derivative preparation somatostatin agonist, imidazolylpiperidinecarbothioic acid bromopyridinyldichlorobenzylaminoethylamide, ethanediamine amination dibromopyridine somatostatin agonist preparation, bromopyridylethanediamine preparation benzylation dichlorobenzyl chloride and other aspects.Product Details of 199522-66-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 29, 2015, Basinger, Jillian; Bookser, Brett; Chen, Mi; Chung, Demichael; Gupta, Varsha; Hudson, Andrew; Kaplan, Alan; Na, James; Renick, Joel; Santora, Vincent published a patent.Related Products of 908267-63-0 The title of the patent was Preparation of substituted 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole and 4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine compounds as GlyT1 inhibitors. And the patent contained the following:

The title compounds I [R1 = CO2H, C(O)NH2, SO2(alkyl), etc.; R2 = H, halo, alkyl, etc.; R3 = H, alkyl, haloalkyl, etc.; R4 = H, F, alkyl, etc.; R5 = alkyl, haloalkyl, alkoxy, etc.; X = (CR)1-2; R = H, alkyl], useful in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by GlyT1 activity; treating neurol. disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training; and treating other disorders, including pain and alc.-dependence, were prepared E.g., a multi-step synthesis of II, starting from tert-Bu 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate and 1-fluoro-4-iodobenzene, was described. The exemplified compounds I were their GlyT1 inhibitory activity (data given). Pharmaceutical composition comprising I is disclosed. The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).Related Products of 908267-63-0

The Article related to pyrrolopyrazole pyrazolopyridine preparation glyt1 inhibitor neurol disorder treatment, cns agent cognition enhancer neuroprotection pyrrolopyrazole pyrazolopyridine preparation glyt1, dementia neurodegenerative disease stroke motor deficit pyrrolopyrazole pyrazolopyridine preparation and other aspects.Related Products of 908267-63-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Jian; Hayward, John J.; Gumbau-Brisa, Roger; Wallis, John D.; Stoeckli-Evans, Helen; Pilkington, Melanie published an article in 2015, the title of the article was Probing the reactivity of a 2,2′-bipyridyl-3,3′-bis-imine ligand by X-ray crystallography.Synthetic Route of 75449-26-2 And the article contains the following content:

The reactivity of a Schiff-base bis-imine ligand 3 (N3,N3-bis(2-pyridinylmethylene)[2,2′-bipyridine]3,3′-diamine) is probed by x-ray diffraction studies. Its susceptibility to hydrolysis, oxidation and nucleophilic addition reactions of 3 is demonstrated by the isolation of the methanol adduct 4 and two diazepine heterocycles 5 and 6. This reactivity is also reflected in the mol. structures of two coordination complexes isolated by the reaction of 3 with M(hfac)2 salts, to afford [Cu(5)(hfac)(tfa)] (8) and [Zn(6)(hfac)2] (9), where Hhfac = hexafluoroacetylacetone and tfa = trifluoroacetic acid. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Synthetic Route of 75449-26-2

The Article related to crystal structure bipyridylbisimine schiff base preparation, bipyridylbisimine schiff base hydrolysis oxidation nucleophilic addition reaction product, zinc copper bipyridylbisimine schiff base complex crystal structure preparation, copper bipyridylbisimine schiff base magnetic property and other aspects.Synthetic Route of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem