Day: October 26, 2022

Carballo, Rosa; Fernandez-Hermida, Nuria; Lago, Ana B.; Rodriguez-Hermida, Sabina; Vazquez-Lopez, Ezequiel M. published an article in 2012, the title of the article was Supramolecular networks through second-sphere coordination based on 1D metal-4,4′-dipyridyldisulfide coordination polymers and hydrogenfumarate or sulfonate anions.Quality Control of Pyridine-3-sulfonic acid And the article contains the following content:

Four H-bonded assemblies [M(dpds)2(OH2)2]A2·nH2O (A = anion) are described. These assemblies result from the 2nd-sphere coordination interactions between the 1-dimensional coordination polymers [M(dpds)2(OH2)2]2+, M = Zn(II), and Cu(II), dpds = 4,4′-dipyridyldisulfide, and the pyridine-3-sulfonate (3pySO3-) or hydrogenfumarate (Hfum-) anions. Significantly, supramol. structural variations are observed depending on the presence of H2O lattice mols., which formed discrete aggregates when the Hfum- anion was used. The effects of geometrical variations in the building blocks are also evident on using Jahn-Teller-distorted divalent Cu(II) ions or regular octahedral species based on Zn(II) ions. The 2nd-sphere effects on the stabilization of the compounds are illustrated by TGA experiments The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Quality Control of Pyridine-3-sulfonic acid

The Article related to preparation copper zinc dipyridyldisulfide complex pyridinesulfonate fumarate anion, crystal structure copper zinc dipyridyldisulfide complex pyridinesulfonate fumarate anion, supramol structure copper zinc dipyridyldisulfide complex pyridinesulfonate fumarate anion and other aspects.Quality Control of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 30, 2019, Liu, Jin-jian; Li, Jing published an article.Reference of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide The title of the article was Photochromism of stable crystalline 3D Cd-viologen coordination polymers. And the article contained the following:

Recent studies have demonstrated the efficient synthesis of photochromic coordination polymers by assembly of viologens and metal centers. In order to enrich this system, in-depth research should be conducted on the impact of metal centers, but related research is rare. On the basis of two photochromic viologen-based compounds, two new photochromic coordination polymers are prepared by introducing cadmium ions. In this study, four novel host-guest compounds based on viologen cations (EV2+ = 1,1′-bis(ethyl)-4,4′-bipyridinium dication, PV2+ = 1,1′-bis(propyl)-4,4′-bipyridinium dication) and 1,3,5-benzenetricarboxylic acid (H3BTC) have been synthesized and structurally characterized, [(EV)0.5(H2BTC)]·H2O (1), [(PV)(H2BTC)2]·2H2O (2), {(EV)0.5[Cd(BTC)(H2O)]·2H2O}n (3), {(PV)0.5[Cd(BTC)(H2O)]·2H2O}n (4). Compounds 1 and 2 feature the isolated structure, where uncoordinated H2BTC- units connect to viologen cations by supramol. interactions. Compounds 3 and 4 feature the three-dimensional (3D) anionic MOFs of {[Cd(BTC)(H2O)]-}n with viologen cations inserted in the framework. As expected, incorporating the viologen fragment into the framework results in predefined photochromism of four compounds It is worth noting that the introduction of cadmium ions will directly improve the photosensitive behaviors and protect the photo-generated radicals. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Reference of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide

The Article related to alkylbipyridinium benzenetricarboxylate viologen cadmium coordination polymer preparation photochromism structure, crystal mol structure cadmium viologen coordination polymer, photochromism alkylbipyridinium benzenetricarboxylate viologen cadmium coordination polymer and other aspects.Reference of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 30, 1989, Fife, Wilmer K.; Mubasher, Amal Al published an article.Synthetic Route of 109660-12-0 The title of the article was Multistep functionalization of insoluble copolymers of 4-vinylpyridine. Synthesis and characterization of two new metal ion-binding resins. And the article contained the following:

A com. available macroreticular resin containing 73 mol % 4-vinylpyridine crosslinked with 21 mol % divinylbenzene (I) was successfully derivatized at the pyridine rings by a multi-step synthetic pathway. First-time application of reactions well established for monomeric pyridine derivatives (N-oxidation, Reissert-Henze cyanation, and 2-oxazoline formation) to a copolymer of 4-vinylpyridine furnished the new functionalized resins, I-4-vinyl-2-(4,4-dimethyl-2-oxazolinyl)pyridine copolymer (II) and I-4-vinyl-2-pyridinecarboxylic acid copolymer (III) in yields for functionalization of pyridine residues of 58% in each case. Estimates of formation constants for 1:1 complexes of Cu(II) and Ni(II) ions with the oxazolinylpyridine and 2-pyridinecarboxylate residues of the new resins were obtained with a competitive spectrophotometric method. The formation constants for the Cu(II)- and Ni(II)-II complexes were 107.7 M-1 for Cu(II) and 105.8 M-1 for Ni(II). The formation constants for the Cu(II) and Ni(II) complexes with III were 108.8 and 105.5 M-1, resp. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Synthetic Route of 109660-12-0

The Article related to vinylpyridine divinylbenzene copolymer metal complex, oxazolinylpyridine divinylbenzene copolymer metal complex, pyridinecarboxylate divinylbenzene copolymer metal complex, copper vinylpyridine divinylbenzene copolymer complex, nickel vinylpyridine divinylbenzene copolymer complex and other aspects.Synthetic Route of 109660-12-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 7, 1998, Ankersen, Michael; Dorwald, Florenzio Zaragoza; Stidsen, Carsten Enggaard; Crider, Albert Michael published a patent.Product Details of 199522-66-2 The title of the patent was Preparation of thiourea derivatives and related compounds as constrained somatostatin agonists and antagonists. And the patent contained the following:

The title compounds B(CH2)nNA(CH2)mYNR1C(:X)E [I; A = (un)substituted aryl; B = (un)substituted aryl; E = heterocyclyl, amino; R1 = H, (un)substituted C1-6 alkyl; X = S, O, NR3; R3 = H, COPh, cyano; Y = bond, etc.; m = 0-6; n = 0-3], somatostatin agonists and antagonists (no data) useful for treating medical disorders related to binding to human somatostatin receptor subtypes, and their pharmaceutically acceptable salts were prepared and claimed. For example, amination of 2,5-dibromopyridine with H2NCH2CH2NH2 in pyridine gave N-1-(5-bromopyrid-2-yl)ethane-1,2-diamine which was benzylated with 3,4-dichlorobenzyl chloride in DMSO in the presence of NaH and the product condensed with CS2 in the presence of dicyclohexylcarbodiimide in THF to give 2-[N-(5-bromopyrid-2-yl)-N-(3,4-dichlorobenzyl)]aminoethyl isothiocyanate. Addition of the latter with 4-[4(5)-imidazolyl]piperidine-2HCl in THF in the presence of Et3N gave a title compound I. The experimental process involved the reaction of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine(cas: 199522-66-2).Product Details of 199522-66-2

The Article related to thiourea derivative preparation somatostatin agonist, imidazolylpiperidinecarbothioic acid bromopyridinyldichlorobenzylaminoethylamide, ethanediamine amination dibromopyridine somatostatin agonist preparation, bromopyridylethanediamine preparation benzylation dichlorobenzyl chloride and other aspects.Product Details of 199522-66-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 29, 2015, Basinger, Jillian; Bookser, Brett; Chen, Mi; Chung, Demichael; Gupta, Varsha; Hudson, Andrew; Kaplan, Alan; Na, James; Renick, Joel; Santora, Vincent published a patent.Related Products of 908267-63-0 The title of the patent was Preparation of substituted 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole and 4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine compounds as GlyT1 inhibitors. And the patent contained the following:

The title compounds I [R1 = CO2H, C(O)NH2, SO2(alkyl), etc.; R2 = H, halo, alkyl, etc.; R3 = H, alkyl, haloalkyl, etc.; R4 = H, F, alkyl, etc.; R5 = alkyl, haloalkyl, alkoxy, etc.; X = (CR)1-2; R = H, alkyl], useful in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by GlyT1 activity; treating neurol. disorders, CNS disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training; and treating other disorders, including pain and alc.-dependence, were prepared E.g., a multi-step synthesis of II, starting from tert-Bu 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate and 1-fluoro-4-iodobenzene, was described. The exemplified compounds I were their GlyT1 inhibitory activity (data given). Pharmaceutical composition comprising I is disclosed. The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).Related Products of 908267-63-0

The Article related to pyrrolopyrazole pyrazolopyridine preparation glyt1 inhibitor neurol disorder treatment, cns agent cognition enhancer neuroprotection pyrrolopyrazole pyrazolopyridine preparation glyt1, dementia neurodegenerative disease stroke motor deficit pyrrolopyrazole pyrazolopyridine preparation and other aspects.Related Products of 908267-63-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Jian; Hayward, John J.; Gumbau-Brisa, Roger; Wallis, John D.; Stoeckli-Evans, Helen; Pilkington, Melanie published an article in 2015, the title of the article was Probing the reactivity of a 2,2′-bipyridyl-3,3′-bis-imine ligand by X-ray crystallography.Synthetic Route of 75449-26-2 And the article contains the following content:

The reactivity of a Schiff-base bis-imine ligand 3 (N3,N3-bis(2-pyridinylmethylene)[2,2′-bipyridine]3,3′-diamine) is probed by x-ray diffraction studies. Its susceptibility to hydrolysis, oxidation and nucleophilic addition reactions of 3 is demonstrated by the isolation of the methanol adduct 4 and two diazepine heterocycles 5 and 6. This reactivity is also reflected in the mol. structures of two coordination complexes isolated by the reaction of 3 with M(hfac)2 salts, to afford [Cu(5)(hfac)(tfa)] (8) and [Zn(6)(hfac)2] (9), where Hhfac = hexafluoroacetylacetone and tfa = trifluoroacetic acid. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Synthetic Route of 75449-26-2

The Article related to crystal structure bipyridylbisimine schiff base preparation, bipyridylbisimine schiff base hydrolysis oxidation nucleophilic addition reaction product, zinc copper bipyridylbisimine schiff base complex crystal structure preparation, copper bipyridylbisimine schiff base magnetic property and other aspects.Synthetic Route of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 2, 2022, Cai, Bicheng; Gong, Liang; Zhu, Yiying; Kong, Lingmei; Ju, Xiaoman; Li, Xue; Yang, Xiaodong; Zhou, Hongyu; Li, Yan published an article.Recommanded Product: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Identification of Gossypol Acetate as an Autophagy Modulator with Potent Anti-tumor Effect against Cancer Cells. And the article contained the following:

Autophagy, an evolutionarily conserved process, is intricately involved in many aspects of human health and a variety of human diseases, including cancer. Discovery of small-mol. autophagy modulators with potent anticancer effect would be of great significance. To this end, a natural product library consisting of 170 natural compounds were screened as autophagy modulators with potent cytotoxicity in our present study. Among these compounds, gossypol acetate (GAA), the mostly used medicinal form of gossypol, was identified. GAA effectively increased the number of autophagic puncta in GFP-LC3B-labeled 293T cells and significantly decreased cell viability in different cancer cells. In A549 cells, GAA at concentrations below 10 μM triggered caspase-independent cell death via targeting autophagy, as evidenced by elevated LC3 conversion and decreased p62/SQSTM1 levels. Knocking down of LC3 significantly attenuated GAA-induced cell death. Mechanistically, GAA at low concentrations induced autophagy through targeting AMPK-mTORC1-ULK1 signaling. Interestingly, high concentrations of GAA induced LC3 conversion, p62 accumulation, and yellow autophagosome formation, indicating that GAA at high concentrations blocked autophagic flux. Mechanistically, GAA decreased intracellular ATP level and suppressed lysosome activity. Exogenous ATP partially reversed the inhibitory effect of GAA on autophagy, suggesting that decreased ATP level and lysosome activity might be involved in the blocking of autophagy flux by GAA. Collectively, our present study reveals the mechanisms by which GAA modulates autophagy and illustrates whether autophagy regulation by GAA is functionally involved in GAA-induced cancer cell death. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Recommanded Product: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to drug screening gossypol acetate autophagy cancer, atp, adenosine 5′-monophosphate (amp)-activated protein kinase (ampk), apoptosis, autophagy, cancer cell death, gossypol acetate, lysosome, mammalian target of rapamycin complex-1 (mtorc1), unc-51-like autophagy-activating kinase 1 (ulk1) and other aspects.Recommanded Product: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rieder, Samuel; Melendez, Camilo; Denes, Fabrice; Jangra, Harish; Mulliri, Kleni; Zipse, Hendrik; Renaud, Philippe published an article in 2021, the title of the article was Radical chain monoalkylation of pyridines.SDS of cas: 908267-63-0 And the article contains the following content:

The monoalkylation of N-methoxypyridinium salts with alkyl radicals generated from alkenes (via hydroboration with catecholborane), alkyl iodides (via iodine atom transfer) and xanthates to afford alkylated quinoline derivatives R-R1 [R = 4-methylquinolinyl, 4-Cl-quinolinyl, 3-Br-quinolinyl, etc.; R1 = Et, iPr, cyclohexyl, etc.] and pyridine derivatives R2-R3 [R2 = 4-phenylpyridinyl, 4-tBu-pyridinyl, 4-Br-pyridinyl, etc.; R3 = iPr, 1-adamantyl, cyclohexyl, etc.] was reported. The reaction proceeded under neutral conditions since no acid was needed to activate the heterocycle and no external oxidant was required. A rate constant for the addition of a primary radical to N-methoxylepidinium >107 M-1 s-1 was exptl. determined This rate constant was more than one order of magnitude larger than the one measured for the addition of primary alkyl radicals to protonated lepidine demonstrating the remarkable reactivity of methoxypyridinium salts toward radicals. The reaction was used for the preparation of unique pyridinylated terpenoids and was extended to a three-component carbopyridinylation of electron-rich alkenes including enol esters, enol ethers and enamides. The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).SDS of cas: 908267-63-0

The Article related to alkylated pyridine derivative preparation, pyridine derivative alkene monoalkylation, alkyl iodide pyridine derivative monoalkylation, xanthate pyridine derivative monoalkylation, derivative pyridine alkylated preparation, ester alkene pyridine derivative three component carbopyridinylation and other aspects.SDS of cas: 908267-63-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 31, 1994, Inaba, Minoru; Ogumi, Zempachi; Takehara, Zen-ichiro published an article.Synthetic Route of 52243-87-5 The title of the article was Application of the solid polymer electrolyte method to organic electrochemistry XVII. Indirect electrochemical debromination using viologens as microscopic phase-transfer mediators. And the article contained the following:

Solid polymer electrolyte (SPE) composite electrodes using a perfluorinated ion-exchange membrane (Nafion), which is known to be microscopically separated into hydrophilic and hydrophobic domains, were prepared Various N,N’-dialkyl-4-4′-bipyridinium salts (viologens) were incorporated in the SPE composite electrodes as phase transfer mediators. Electrochem. debromination of meso-1,2-dibromo-1,2-diphenylethane was carried out on the SPE composite electrodes. The results were compared with those obtained in an emulsion system consisting of water and dichloromethane. Of the viologen compounds tested, Pr viologen was the most effective mediator for the SPE composite electrode, while octyl viologen dibromide was the most effective mediator in the emulsion system. The active species for the debromination in the emulsion system is a doubly reduced neutral form of viologen that was generated by the disproportionation of cation radicals. The disproportionation constant, Kd, of octyl viologen cation radical in a two-phase system consisting of water and dichloromethane is 809. The reaction mechanism on the SPE composite electrode was discussed, and probably the active species was generated by disproportionation at the microscopically heterogeneous interface between the hydrophilic and hydrophobic domains of the Nafion. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Synthetic Route of 52243-87-5

The Article related to indirect electrochem debromination phase transfer mediator, dibromodiphenylethane electrochem debromination composite electrode, viologen dibromodiphenylethane electrodebromination, catalyst viologen dibromodiphenylethane electrodebromination, disproportionation octylviologen radical cation and other aspects.Synthetic Route of 52243-87-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Thongpaen, Jompol; Schmid, Thibault E.; Toupet, Loic; Dorcet, Vincent; Mauduit, Marc; Basle, Olivier published an article in 2018, the title of the article was Directed ortho C-H borylation catalyzed using Cp*Rh(III)-NHC complexes.Computed Properties of 1349171-28-3 And the article contains the following content:

Cp*Rh(NHC) complexes I(R = iBu, iPr, Me), derived from L-amino acids, with bulky chiral bidentate NHC-carboxylate ligands were efficiently synthesized and fully characterized including solid-state structures. These unprecedented rhodium(III) complexes demonstrated high selectivity in pyridine-directed ortho-C-H borylation of arenes under mild conditions. The experimental process involved the reaction of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine(cas: 1349171-28-3).Computed Properties of 1349171-28-3

The Article related to directed borylation arylpyridine rhodium chiral nhc catalyst preparation phenol, phenol preparation pyridyl directed borylation oxidation rhodium nhc catalyst, crystal structure rhodium chiral nhc carboxylate half sandwich complex, mol structure rhodium chiral nhc carboxylate half sandwich complex and other aspects.Computed Properties of 1349171-28-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem